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  1. Article: Gut microbiota-involved metabolism and intestinal absorption mechanisms in decreasing bioaccessibility of triadimefon in strawberry and grape

    Liu, Yu-Ying / Zhang, Si-Dong / Xiao, Jin-Jing / Feng, Wen-Zhe / Wei, Dong / Deng, Ya-Jing / Cao, Hai-Qun / Shi, Yan-Hong

    Food chemistry. 2022 Mar. 30, v. 373

    2022  

    Abstract: Gut microbiota-involved metabolism and intestinal absorption affecting bioaccessibility of triadimefon in strawberry and grape were investigated for the first time by coupling the in vitro digestion model with the Caco-2 cell model. Results showed that ... ...

    Abstract Gut microbiota-involved metabolism and intestinal absorption affecting bioaccessibility of triadimefon in strawberry and grape were investigated for the first time by coupling the in vitro digestion model with the Caco-2 cell model. Results showed that the gut microbiota decreased the bioaccessibility of triadimefon in strawberry by 31.00% but failed in grape, probably due to a negative modulation of the colon bacterial activity by dietary components in grapes. A strain of triadimefon-degrading bacteria, Stenotrophomonas maltophilia, was isolated from the gut microbiota and its degradation products were profiled. This study also clarified a significant reduction in transepithelial transport (up to 32.81%) of triadimefon as a result of the barrier effect of gut microbiota. These findings provide new insights on the function of the gut microbiota in pesticide bioaccessibility and highlight the importance of including gut microbiota in pesticide residue risk assessments.
    Keywords Stenotrophomonas maltophilia ; bioavailability ; colon ; digestion ; food chemistry ; grapes ; human cell lines ; intestinal absorption ; intestinal microorganisms ; metabolism ; microbial activity ; models ; pesticide residues ; risk ; strawberries ; triadimefon
    Language English
    Dates of publication 2022-0330
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2021.131575
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  2. Article ; Online: Gut microbiota-involved metabolism and intestinal absorption mechanisms in decreasing bioaccessibility of triadimefon in strawberry and grape.

    Liu, Yu-Ying / Zhang, Si-Dong / Xiao, Jin-Jing / Feng, Wen-Zhe / Wei, Dong / Deng, Ya-Jing / Cao, Hai-Qun / Shi, Yan-Hong

    Food chemistry

    2021  Volume 373, Issue Pt B, Page(s) 131575

    Abstract: Gut microbiota-involved metabolism and intestinal absorption affecting bioaccessibility of triadimefon in strawberry and grape were investigated for the first time by coupling the in vitro digestion model with the Caco-2 cell model. Results showed that ... ...

    Abstract Gut microbiota-involved metabolism and intestinal absorption affecting bioaccessibility of triadimefon in strawberry and grape were investigated for the first time by coupling the in vitro digestion model with the Caco-2 cell model. Results showed that the gut microbiota decreased the bioaccessibility of triadimefon in strawberry by 31.00% but failed in grape, probably due to a negative modulation of the colon bacterial activity by dietary components in grapes. A strain of triadimefon-degrading bacteria, Stenotrophomonas maltophilia, was isolated from the gut microbiota and its degradation products were profiled. This study also clarified a significant reduction in transepithelial transport (up to 32.81%) of triadimefon as a result of the barrier effect of gut microbiota. These findings provide new insights on the function of the gut microbiota in pesticide bioaccessibility and highlight the importance of including gut microbiota in pesticide residue risk assessments.
    MeSH term(s) Caco-2 Cells ; Fragaria ; Gastrointestinal Microbiome ; Humans ; Intestinal Absorption ; Triazoles ; Vitis
    Chemical Substances Triazoles ; triadimefon (1HW039CJF0)
    Language English
    Publishing date 2021-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2021.131575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

    Order via subito

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    Inter-library loan at ZB MED

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  3. Article: Gut microbiota influence on oral bioaccessibility and intestinal transport of pesticides in Chaenomeles speciosa

    Shi, Yan-Hong / Xiao, Jin-Jing / Liu, Yu-Ying / Deng, Ya-Jing / Feng, Wen-Zhe / Wei, Dong / Liao, Min / Cao, Hai-Qun

    Food chemistry. 2021 Mar. 01, v. 339

    2021  

    Abstract: There is limited research focusing on the effects of human gut microbiota on the oral bioaccessibility and intestinal absorption of pesticide residues in food. In the present study, we use a modified setup of the Simulator of the Human Intestinal ... ...

    Abstract There is limited research focusing on the effects of human gut microbiota on the oral bioaccessibility and intestinal absorption of pesticide residues in food. In the present study, we use a modified setup of the Simulator of the Human Intestinal Microbial Ecosystem for the determination of pesticide residue bioaccessibility in Chaenomeles speciosa, and a Caco-2 cell model of human intestinal absorption. Results showed that gut microbiota played a dual role based their effects on contaminant release and metabolism in the bioaccessibility assay, and Lactobacillus plantarum was one of key bacterial species in the gut microbiota that influenced pesticide stability significantly. The addition of L. plantarum to the system reduced the relative amounts (by 11.40–86.51%) of six pesticides. The interaction between the food matrix and human gut microbiota led to different absorption rates, and the barrier effects increased with an increase in incubation time.
    Keywords Chaenomeles speciosa ; Lactobacillus plantarum ; absorption ; assays ; bioavailability ; food chemistry ; food matrix ; human cell lines ; humans ; intestinal absorption ; intestinal microorganisms ; intestines ; metabolism ; models ; pesticide residues ; pesticides ; research
    Language English
    Dates of publication 2021-0301
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-light
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2020.127985
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

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  4. Article ; Online: Gut microbiota influence on oral bioaccessibility and intestinal transport of pesticides in Chaenomeles speciosa.

    Shi, Yan-Hong / Xiao, Jin-Jing / Liu, Yu-Ying / Deng, Ya-Jing / Feng, Wen-Zhe / Wei, Dong / Liao, Min / Cao, Hai-Qun

    Food chemistry

    2020  Volume 339, Page(s) 127985

    Abstract: There is limited research focusing on the effects of human gut microbiota on the oral bioaccessibility and intestinal absorption of pesticide residues in food. In the present study, we use a modified setup of the Simulator of the Human Intestinal ... ...

    Abstract There is limited research focusing on the effects of human gut microbiota on the oral bioaccessibility and intestinal absorption of pesticide residues in food. In the present study, we use a modified setup of the Simulator of the Human Intestinal Microbial Ecosystem for the determination of pesticide residue bioaccessibility in Chaenomeles speciosa, and a Caco-2 cell model of human intestinal absorption. Results showed that gut microbiota played a dual role based their effects on contaminant release and metabolism in the bioaccessibility assay, and Lactobacillus plantarum was one of key bacterial species in the gut microbiota that influenced pesticide stability significantly. The addition of L. plantarum to the system reduced the relative amounts (by 11.40-86.51%) of six pesticides. The interaction between the food matrix and human gut microbiota led to different absorption rates, and the barrier effects increased with an increase in incubation time.
    MeSH term(s) Bacteria/metabolism ; Caco-2 Cells ; Gastrointestinal Microbiome/drug effects ; Humans ; Intestinal Mucosa/cytology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/microbiology ; Lactobacillus plantarum/drug effects ; Lactobacillus plantarum/isolation & purification ; Neonicotinoids/metabolism ; Neonicotinoids/pharmacology ; Nitro Compounds/metabolism ; Nitro Compounds/pharmacology ; Organothiophosphorus Compounds/metabolism ; Organothiophosphorus Compounds/pharmacology ; Pesticides/chemistry ; Pesticides/metabolism ; Pesticides/pharmacology ; Rosaceae/chemistry ; Rosaceae/metabolism ; Thiamethoxam/metabolism ; Thiamethoxam/pharmacology
    Chemical Substances Neonicotinoids ; Nitro Compounds ; Organothiophosphorus Compounds ; Pesticides ; imidacloprid (3BN7M937V8) ; phoxim (6F5V775VPO) ; Thiamethoxam (747IC8B487)
    Language English
    Publishing date 2020-09-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2020.127985
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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