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Article ; Online: Research on Delamination Damage Quantification Detection of CFRP Bending Plate Based on Lamb Wave Mode Control.

Yu, Quanpeng / Zhou, Shiyuan / Cheng, Yuhan / Deng, Yao

2024 Volume 24, Issue 6

Abstract: The carbon-fiber-reinforced polymer (CFRP) bending structure is widely used in aviation. The emergence and spread of delamination damage will decrease the safety of in-service bending structures. Lamb waves can effectively identify delamination damage as ...

Abstract	The carbon-fiber-reinforced polymer (CFRP) bending structure is widely used in aviation. The emergence and spread of delamination damage will decrease the safety of in-service bending structures. Lamb waves can effectively identify delamination damage as a high-damage-sensitivity detection tool. For this present study, the signal difference coefficient (
Language	English
Publishing date	2024-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24061790
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lifibrate attenuates blood-brain barrier damage following ischemic stroke via the MLCK/p-MLC/ZO-1 axis.

Duan, Yu / Deng, Yao / Tang, Feng / Li, Jian

Aging

2024 Volume 16, Issue 7, Page(s) 6135–6146

Abstract: Dysfunction of tight junction proteins-associated damage to the blood-brain barrier (BBB) plays an important role in the pathogenesis of ischemic stroke. Lifibrate, an inhibitor of cholinephosphotransferase (CPT), has been used as an agent for serum ... ...

Abstract	Dysfunction of tight junction proteins-associated damage to the blood-brain barrier (BBB) plays an important role in the pathogenesis of ischemic stroke. Lifibrate, an inhibitor of cholinephosphotransferase (CPT), has been used as an agent for serum lipid lowering. However, the protective effects of Lifibrate in ischemic stroke and the underlying mechanism have not been clearly elucidated. Here, we employed an
MeSH term(s)	Animals ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Ischemic Stroke/metabolism ; Ischemic Stroke/pathology ; Ischemic Stroke/drug therapy ; Zonula Occludens-1 Protein/metabolism ; Zonula Occludens-1 Protein/genetics ; Mice ; Male ; Humans ; Myosin-Light-Chain Kinase/metabolism ; Myosin Light Chains/metabolism ; Disease Models, Animal ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Mice, Inbred C57BL ; Signal Transduction/drug effects ; Neuroprotective Agents/pharmacology ; Cell Line ; Infarction, Middle Cerebral Artery/metabolism
Chemical Substances	Zonula Occludens-1 Protein ; Myosin-Light-Chain Kinase (EC 2.7.11.18) ; Myosin Light Chains ; Tjp1 protein, mouse ; Neuroprotective Agents
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205692
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Article ; Online: Carotid intramural hematoma after ultrasound-guided fine-needle aspiration biopsy.

Qin, Xiaojuan / Deng, Yao

Asian journal of surgery

2022 Volume 46, Issue 6, Page(s) 2542–2543

MeSH term(s)	Humans ; Biopsy, Fine-Needle/adverse effects ; Image-Guided Biopsy/adverse effects ; Ultrasonography ; Ultrasonography, Interventional ; Hematoma/diagnostic imaging ; Hematoma/etiology
Language	English
Publishing date	2022-12-31
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.12.101
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Article ; Online: A rare case of a neonate with fallot-type absent pulmonary valve and occlusion of the left main bronchus.

Mu, Chunjie / Zhao, Minzhang / Ma, Runwei / Li, Xiang / Liu, Min / Deng, Yao

Journal of cardiothoracic surgery

2024 Volume 19, Issue 1, Page(s) 61

Abstract: Fallot-type absent pulmonary valve is a rare and complex congenital heart disease. Repair surgery for this condition during the neonatal period has a mortality rate of over 50%. We reported a neonate with Fallot-type absent pulmonary valve and occlusion ... ...

Abstract	Fallot-type absent pulmonary valve is a rare and complex congenital heart disease. Repair surgery for this condition during the neonatal period has a mortality rate of over 50%. We reported a neonate with Fallot-type absent pulmonary valve and occlusion of the left main bronchus. The patient's pulmonary artery had unusual anatomy of a type that has not previously been reported. This case report outlines a successful treatment strategy for patients with complex congenital heart disease and airway occlusion during the neonatal period and the effect of these unusual anatomical conditions on postoperative outcomes.
MeSH term(s)	Infant, Newborn ; Humans ; Pulmonary Valve/surgery ; Tetralogy of Fallot/surgery ; Pulmonary Atresia ; Pulmonary Artery/surgery ; Bronchi
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-024-02534-z
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Article ; Online: Targeting BRD4 with PROTAC degrader ameliorates LPS-induced acute lung injury by inhibiting M1 alveolar macrophage polarization.

Li, Difei / Deng, Yao / Wen, Guanxi / Wang, Lingwei / Shi, Xing / Chen, Shanze / Chen, Rongchang

International immunopharmacology

2024 Volume 132, Page(s) 111991

Abstract: Objectives: Acute lung injury (ALI) is a highly inflammatory condition with the involvement of M1 alveolar macrophages (AMs) polarization, eventually leading to the development of non-cardiogenic edema in alveolar and interstitial regions, accompanied ... ...

Abstract	Objectives: Acute lung injury (ALI) is a highly inflammatory condition with the involvement of M1 alveolar macrophages (AMs) polarization, eventually leading to the development of non-cardiogenic edema in alveolar and interstitial regions, accompanied by persistent hypoxemia. Given the significant mortality rate associated with ALI, it is imperative to investigate the underlying mechanisms of this condition so as to identify potential therapeutic targets. The therapeutic effects of the inhibition of bromodomain containing protein 4 (BRD4), an epigenetic reader, has been proven with high efficacy in ameliorating various inflammatory diseases through mediating immune cell activation. However, little is known about the therapeutic potential of BRD4 degradation in acute lung injury. Methods: This study aimed to assess the protective efficacy of ARV-825, a novel BRD4-targeted proteolysis targeting chimera (PROTAC), against ALI through histopathological examination in lung tissues and biochemical analysis in bronchoalveolar lavage fluid (BALF). Additionally, the underlying mechanism by which BRD4 regulated M1 AMs was elucidated by using CUT & Tag assay. Results: In this study, we found the upregulation of BRD4 in a lipopolysaccharide (LPS)-induced ALI model. Furthermore, we observed that intraperitoneal administration of ARV-825, significantly alleviated LPS-induced pulmonary pathological changes and inflammatory responses. These effects were accompanied by the suppression of M1 AMs. In addition, our findings revealed that the administration of ARV-825 effectively suppressed M1 AMs by inhibiting the expression of IRF7, a crucial transcriptional factor involved in M1 macrophages. Conclusion: Our study suggested that targeting BRD4 using ARV-825 is a potential therapeutic approach for ALI.
Language	English
Publishing date	2024-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111991
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Article ; Online: Association of the LPA gene polymorphisms with coronary artery disease risk in the Xinjiang population of China: A case-control study.

Liu, Yi-Wen / Dong, Chun-Lan / Jiang, Xue / Liu, Deng-Yao

Medicine

2023 Volume 102, Issue 48, Page(s) e36181

Abstract: Lipoprotein(a) is a well-known independent risk factor for coronary artery disease (CAD) and primarily determined by variation in the LPA gene coding for the apolipoprotein(a) moiety. Our study purpose was to evaluate the association between the human ... ...

Abstract	Lipoprotein(a) is a well-known independent risk factor for coronary artery disease (CAD) and primarily determined by variation in the LPA gene coding for the apolipoprotein(a) moiety. Our study purpose was to evaluate the association between the human LPA gene polymorphisms and CAD in Han and Uyghur populations in Xinjiang, China. A case-control study was conducted with 831 Han people (392 CAD patients and 439 control subjects) and 829 Uygur people (513 CAD patients and 316 control subjects). All participants were genotyped for the same 3 single nucleotide polymorphisms (rs1801693, rs6923877, and rs9364559) of the LPA gene by a Real-time PCR instrument. In CAD patients, the levels of lipoprotein(a) were significantly higher in the Han population with the C/C genotype at the rs1801693 (P = .018) and the A/A genotype at the rs9364559 (P = .029) than in the Uyghur population. The polymorphisms rs1801693, rs6923877, and rs9364559 were found to be associated with CAD in the Han population. For men, the distribution of rs1801693 in genotypes, alleles and recessive model (CC vs CT + TT) showed a significant difference (all P < .05), and the difference in recessive model was retained after adjustment for covariates (odds ratio [OR]: 0.557, 95% confidence interval [CI]: 0.355-0.874, P = .011). But the distribution of rs6923877 in genotypes and dominant model (GG vs AG + AA) showed a significant difference (both P < .05) in both men and women, and the difference was kept in dominant model after adjustment (OR: 1.473, 95% CI:1.009-2.148, P = .045). For women, a significant difference was found in the distribution of rs9364559 in the alleles and dominant model (AA vs AG + GG) (for alleles: P = .021, for dominant model: P = .025, OR: 0.560, 95% CI:0.350-0.898, P = .016) after adjustment. Polymorphisms rs1801693, rs6923877, and rs9364559 of the LPA gene are associated with CAD in the Han population in Xinjiang Uygur Autonomous Region of China.
MeSH term(s)	Female ; Humans ; Male ; Case-Control Studies ; China/epidemiology ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/genetics ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Lipoprotein(a)/genetics ; Polymorphism, Single Nucleotide
Chemical Substances	Lipoprotein(a) ; LPA protein, human
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000036181
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Article: The Effects of the Temperature and Termination(-O) on the Friction and Adhesion Properties of MXenes Using Molecular Dynamics Simulation.

Deng, Yao / Chen, Yu / Liu, Hanxu / Yan, Xin

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 5

Abstract: Two-dimensional transition metal carbides and nitrides (MXenes) are widely applied in the fields of electrochemistry, energy storage, electromagnetism, etc., due to their extremely excellent properties, including mechanical performance, thermal stability, ...

Abstract	Two-dimensional transition metal carbides and nitrides (MXenes) are widely applied in the fields of electrochemistry, energy storage, electromagnetism, etc., due to their extremely excellent properties, including mechanical performance, thermal stability, photothermal conversion and abundant surface properties. Usually, the surfaces of the MXenes are terminated by -OH, -F, -O or other functional groups and these functional groups of MXenes are related surface properties and reported to affect the mechanical properties of MXenes. Thus, understanding the effects of surface terminal groups on the properties of MXenes is crucial for device fabrication as well as composite synthesis using MXenes. In this paper, using molecular dynamics (MD) simulation, we study the adhesion and friction properties of Ti
Language	English
Publishing date	2022-02-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12050798
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Article ; Online: Recurrent extrarenal nonanastomotic pseudoaneurysm of renal transplantion after endovascular repair.

Deng, Yao / Yu, Cheng / Wang, Zhendi / Xie, Mingxing

Asian journal of surgery

2022 Volume 45, Issue 10, Page(s) 1879–1880

MeSH term(s)	Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation ; Endovascular Procedures ; Humans ; Stents
Language	English
Publishing date	2022-04-14
Publishing country	China
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.03.121
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Article ; Online: Geographic variation in maternal investment and trade-offs between egg size and clutch size in an endemic toad of the Qinghai-Tibet Plateau.

Yu, Tong Lei / Deng, Yao Hui

Scientific reports

2020 Volume 10, Issue 1, Page(s) 6838

Abstract: Life history theory predicts that animals often produce fewer offspring of larger size and indicate a stronger trade-off between the number and size of offspring to cope with increasing environmental stress. In order to evaluate this prediction, we ... ...

Abstract	Life history theory predicts that animals often produce fewer offspring of larger size and indicate a stronger trade-off between the number and size of offspring to cope with increasing environmental stress. In order to evaluate this prediction, we tested the life history characteristics of Bufo minshanicus at eight different altitudes on the eastern Tibetan Plateau, China. Our results revealed a positive correlation between female SVL and clutch size or egg size, revealing that larger females produce more and larger eggs. However, high-altitude toads seem to favor more offspring and smaller egg sizes when removing the effect of female SVL, which is counter to theoretical predictions. In addition, there was an overall significantly negative relationship between egg size and clutch size, indicative of a trade-off between egg size and fecundity. Therefore, we suggest that higher fecundity, rather than larger egg size, is a more effective reproductive strategy for this species of anuran living at high-altitude environments.
MeSH term(s)	Animals ; Anura/anatomy & histology ; Anura/physiology ; Clutch Size/physiology ; Female ; Fertility/physiology ; Tibet ; Zygote/cytology ; Zygote/physiology
Language	English
Publishing date	2020-04-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-63635-y
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Article: P3b Amplitude and Latency in Tic Disorders: A Meta-Analysis.

Yang, Yue / Yang, Hua / Deng, Yao / Yu, Tao / Luo, Rong

Brain sciences

2022 Volume 12, Issue 12

Abstract: P3b is an event-related potential (ERP) that may be abnormal in patients with tic disorders (TD), but evidence has been inconsistent. Given the possible association between P3b and TD and the need for biomarkers for TD, the primary objective of this meta- ...

Abstract	P3b is an event-related potential (ERP) that may be abnormal in patients with tic disorders (TD), but evidence has been inconsistent. Given the possible association between P3b and TD and the need for biomarkers for TD, the primary objective of this meta-analysis was to characterize P3b in patients with TD in comparison to healthy controls (HCs). Methods: By searching PubMed, Embase, Web of Science, SCOPUS, Medline, and Google Scholar, we identified studies that compared P3b between TD patients and HCs. The amplitude and latency of P3b were then analyzed. Subgroup analyses were conducted to investigate the influence of different experimental factors on P3b indices. Result: Overall, 19 articles involving 388 cases and 414 controls were evaluated. There were no significant abnormalities in P3b amplitude and latency in TD patients. The P3b amplitude of the TD patients was significantly decreased during the oddball task, and the P3b amplitude of the adult TD patients was also significantly decreased. Conclusion: TD patients may have an abnormal P3b compared to HCs under specified conditions.
Language	English
Publishing date	2022-12-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci12121712
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