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  1. Article ; Online: In silico genomic surveillance by CoVerage predicts and characterizes SARS-CoV-2 Variants of Interest

    Norwood, K. / Deng, Z.-L. / Reimering, S. / Robertson, G. / Foroughmand-Araabi, M.-H. / Goliaei, S. / Hölzer, M. / McHardy, A. C.

    bioRxiv

    Abstract: Rapidly evolving viral pathogens such as SARS-CoV-2 continuously accumulate amino acid changes, some of which affect transmissibility, virulence or improve the virus9 ability to escape host immunity. Since the beginning of the pandemic and establishment ... ...

    Abstract Rapidly evolving viral pathogens such as SARS-CoV-2 continuously accumulate amino acid changes, some of which affect transmissibility, virulence or improve the virus9 ability to escape host immunity. Since the beginning of the pandemic and establishment of SARS-CoV-2 as a human pathogen, multiple lineages with concerning phenotypic alterations, so called Variants of Concern (VOCs), have emerged and risen to predominance. To optimize public health management and to ensure the continued efficacy of vaccines, the early detection of such variants of interest is essential. Therefore, large-scale viral genomic surveillance programs have been initiated worldwide, with data being deposited in public repositories in a timely manner. However, technologies for their continuous interpretation are currently lacking. Here, we describe the CoVerage system (www.sarscoverage.org) for viral genomic surveillance, which continuously predicts and characterizes novel and emerging potential Variants of Interest (pVOIs) together with their antigenic and evolutionary alterations. Using the establishment of Omicron and its current sublineages as an example, we demonstrate how CoVerage can be used to quickly identify and characterize such variants. CoVerage can facilitate the timely identification and assessment of future SARS-CoV-2 Variants of Concern.
    Keywords covid19
    Language English
    Publishing date 2024-03-08
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2024.03.07.583829
    Database COVID19

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  2. Article ; Online: Enterococcus faecalis

    Ma, R Y / Deng, Z L / Du, Q Y / Dai, M Q / Luo, Y Y / Liang, Y E / Dai, X Z / Guo, S M / Zhao, W H

    Journal of dental research

    2024  , Page(s) 220345241230867

    Abstract: Enterococcus ... ...

    Abstract Enterococcus faecalis
    Language English
    Publishing date 2024-04-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345241230867
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  3. Article: [Cimetidine in the treatment of recurrent acute intermittent porphyria: a case report].

    Xie, Y Y / Deng, Z L / Zhang, S

    Zhonghua nei ke za zhi

    2016  Volume 55, Issue 8, Page(s) 640–642

    Language Chinese
    Publishing date 2016-08-01
    Publishing country China
    Document type Journal Article
    ZDB-ID 754223-9
    ISSN 0578-1426
    ISSN 0578-1426
    DOI 10.3760/cma.j.issn.0578-1426.2016.08.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Clinical analysis of reoperation for secondary hyperparathyroidism].

    Hua, Z / Zhang, L / Li, C / Deng, Z L / Yao, L

    Zhonghua wai ke za zhi [Chinese journal of surgery

    2018  Volume 56, Issue 6, Page(s) 442–446

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; China ; Female ; Humans ; Hyperparathyroidism, Secondary/surgery ; Male ; Middle Aged ; Parathyroid Glands/surgery ; Parathyroid Hormone ; Parathyroidectomy ; Recurrence ; Reoperation
    Chemical Substances Parathyroid Hormone
    Language Chinese
    Publishing date 2018-05-24
    Publishing country China
    Document type Journal Article
    ZDB-ID 604573-x
    ISSN 0529-5815
    ISSN 0529-5815
    DOI 10.3760/cma.j.issn.0529-5815.2018.06.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Haploflow: Strain-resolved

    Fritz, A / Bremges, A / Deng, Z-L / Lesker, T-R / Götting, J / Ganzenmüller, T / Sczyrba, A / Dilthey, A / Klawonn, F / McHardy, A C

    bioRxiv : the preprint server for biology

    2021  

    Abstract: In viral infections often multiple related viral strains are present, due to coinfection or within-host evolution. We describe Haploflow, a de Bruijn graph-based assembler ... ...

    Abstract In viral infections often multiple related viral strains are present, due to coinfection or within-host evolution. We describe Haploflow, a de Bruijn graph-based assembler for
    Language English
    Publishing date 2021-01-26
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2021.01.25.428049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: MicroRNA-155 facilitates skeletal muscle regeneration by balancing pro- and anti-inflammatory macrophages.

    Nie, M / Liu, J / Yang, Q / Seok, H Y / Hu, X / Deng, Z-L / Wang, D-Z

    Cell death & disease

    2016  Volume 7, Issue 6, Page(s) e2261

    Abstract: Skeletal muscle has remarkable regeneration capacity and regenerates in response to injury. Muscle regeneration largely relies on muscle stem cells called satellite cells. Satellite cells normally remain quiescent, but in response to injury or exercise ... ...

    Abstract Skeletal muscle has remarkable regeneration capacity and regenerates in response to injury. Muscle regeneration largely relies on muscle stem cells called satellite cells. Satellite cells normally remain quiescent, but in response to injury or exercise they become activated and proliferate, migrate, differentiate, and fuse to form multinucleate myofibers. Interestingly, the inflammatory process following injury and the activation of the myogenic program are highly coordinated, with myeloid cells having a central role in modulating satellite cell activation and regeneration. Here, we show that genetic deletion of microRNA-155 (miR-155) in mice substantially delays muscle regeneration. Surprisingly, miR-155 does not appear to directly regulate the proliferation or differentiation of satellite cells. Instead, miR-155 is highly expressed in myeloid cells, is essential for appropriate activation of myeloid cells, and regulates the balance between pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages during skeletal muscle regeneration. Mechanistically, we found that miR-155 suppresses SOCS1, a negative regulator of the JAK-STAT signaling pathway, during the initial inflammatory response upon muscle injury. Our findings thus reveal a novel role of miR-155 in regulating initial immune responses during muscle regeneration and provide a novel miRNA target for improving muscle regeneration in degenerative muscle diseases.
    MeSH term(s) Animals ; Cell Differentiation/genetics ; Cytokines/metabolism ; Inflammation/genetics ; Inflammation/pathology ; Janus Kinases/metabolism ; Macrophages/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; MicroRNAs/metabolism ; Models, Biological ; Muscle, Skeletal/injuries ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Myoblasts/metabolism ; Phenotype ; Regeneration ; STAT Transcription Factors/metabolism ; Satellite Cells, Skeletal Muscle/metabolism ; Suppressor of Cytokine Signaling 1 Protein/metabolism
    Chemical Substances Cytokines ; MicroRNAs ; Mirn155 microRNA, mouse ; STAT Transcription Factors ; Socs1 protein, mouse ; Suppressor of Cytokine Signaling 1 Protein ; Janus Kinases (EC 2.7.10.2)
    Language English
    Publishing date 2016-06-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/cddis.2016.165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Penicilliosis marneffei].

    Deng, Z L

    Zhonghua bing li xue za zhi = Chinese journal of pathology

    1987  Volume 16, Issue 4, Page(s) 306–8, 46

    MeSH term(s) Animals ; China ; Disease Reservoirs ; Lung Diseases, Fungal/epidemiology ; Lung Diseases, Fungal/microbiology ; Lung Diseases, Fungal/pathology ; Mycoses/epidemiology ; Mycoses/microbiology ; Mycoses/pathology ; Penicillium/isolation & purification ; Rodentia/microbiology
    Language Chinese
    Publishing date 1987-12
    Publishing country China
    Document type Journal Article
    ZDB-ID 784533-9
    ISSN 0529-5807
    ISSN 0529-5807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: High efficacy and safety of low-dose CD19-directed CAR-T cell therapy in 51 refractory or relapsed B acute lymphoblastic leukemia patients.

    Pan, J / Yang, J F / Deng, B P / Zhao, X J / Zhang, X / Lin, Y H / Wu, Y N / Deng, Z L / Zhang, Y L / Liu, S H / Wu, T / Lu, P H / Lu, D P / Chang, A H / Tong, C R

    Leukemia

    2017  

    Abstract: Refractory or relapsed B lymphoblastic leukemia (B-ALL) patients have a dismal outcome with current therapy. We treated 42 primary refractory/hematological relapsed (R/R) and 9 refractory minimal residual disease by flow cytometry (FCM- ... ...

    Abstract Refractory or relapsed B lymphoblastic leukemia (B-ALL) patients have a dismal outcome with current therapy. We treated 42 primary refractory/hematological relapsed (R/R) and 9 refractory minimal residual disease by flow cytometry (FCM-MRD
    Language English
    Publishing date 2017-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/leu.2017.145
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  9. Article: Progressive disseminated penicilliosis caused by Penicillium marneffei. Report of eight cases and differentiation of the causative organism from Histoplasma capsulatum.

    Deng, Z L / Connor, D H

    American journal of clinical pathology

    1985  Volume 84, Issue 3, Page(s) 323–327

    Abstract: Eight patients with fatal penicilliosis caused by Penicillium marneffei are reported. All were natives of southern rural Guangxi, and none had a predisposing illness or evidence of altered immunity. The distinctive features of P. marneffei include ... ...

    Abstract Eight patients with fatal penicilliosis caused by Penicillium marneffei are reported. All were natives of southern rural Guangxi, and none had a predisposing illness or evidence of altered immunity. The distinctive features of P. marneffei include proliferation of yeast-like cells within histiocytes, followed by the development of focal necrosis and, eventually, large abscesses. Outside the histiocytes, the fungi elongate, become slightly curved, and form septa. In vitro, P. marneffei produces a red pigment which diffuses into the culture medium. The differentiation between P. marneffei and Histoplasma capsulatum is described, and possible reservoirs for P. marneffei are discussed.
    MeSH term(s) Adolescent ; Adult ; Child ; Female ; Histiocytes/microbiology ; Histiocytes/pathology ; Histoplasmosis/microbiology ; Humans ; Intestines/microbiology ; Liver/microbiology ; Lung/microbiology ; Lymph Nodes/microbiology ; Male ; Mycoses/microbiology ; Palatine Tonsil/microbiology ; Penicillium/isolation & purification ; Skin/microbiology
    Language English
    Publishing date 1985-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/84.3.323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Human penicilliosis marneffei and its relation to the bamboo rat (Rhizomys pruinosus).

    Deng, Z L / Yun, M / Ajello, L

    Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology

    1986  Volume 24, Issue 5, Page(s) 383–389

    Abstract: Fourteen cases of penicilliosis marneffei occurred in persons in the Guangxi region of the People's Republic of China; the first known case of that disease had been found in Vietnamese bamboo rats (Rhizomys sinensis). A survey of the wild rats in this ... ...

    Abstract Fourteen cases of penicilliosis marneffei occurred in persons in the Guangxi region of the People's Republic of China; the first known case of that disease had been found in Vietnamese bamboo rats (Rhizomys sinensis). A survey of the wild rats in this region was initiated to determine if any of these animals were infected by Penicillium marneffei. Although R. sinensis rats live in the study area, they are relatively rare. The only rats captured were another species of bamboo rat (R. pruinosus). Of the 19 rats captured, 18 yielded cultures of P. marneffei from one or more of their internal organs. The implications of this finding in respect to the epidemiology of penicilliosis marneffei are discussed.
    MeSH term(s) Animals ; China ; Humans ; Mice ; Microscopy, Electron ; Microscopy, Electron, Scanning ; Muridae ; Mycoses/epidemiology ; Mycoses/microbiology ; Mycoses/veterinary ; Penicillium/isolation & purification ; Penicillium/ultrastructure ; Rodent Diseases/epidemiology ; Rodent Diseases/microbiology
    Language English
    Publishing date 1986-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 632745-x
    ISSN 0268-1218
    ISSN 0268-1218
    DOI 10.1080/02681218680000581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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