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  1. Article ; Online: Efficient ocular delivery of siRNA

    Cao, Xiaowen / Wang, Changrong / Deng, Zhennv / Zhong, Yiming / Chen, Hao

    International journal of pharmaceutics: X

    2023  Volume 5, Page(s) 100183

    Abstract: Corneal neovascularization (CoNV)-induced blindness is an enduring and challenging condition with limited management options. Small interfering RNA (siRNA) is a promising strategy for preventing CoNV. This study reported a new strategy using siVEGFA to ... ...

    Abstract Corneal neovascularization (CoNV)-induced blindness is an enduring and challenging condition with limited management options. Small interfering RNA (siRNA) is a promising strategy for preventing CoNV. This study reported a new strategy using siVEGFA to silence vascular endothelial growth factor A (VEGFA) for CoNV treatment. To improve the efficacy of siVEGFA delivery, a pH-sensitive polycationic mPEG
    Language English
    Publishing date 2023-04-29
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-1567
    ISSN (online) 2590-1567
    DOI 10.1016/j.ijpx.2023.100183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention.

    Chen, Siqi / Qin, Chen / Fang, Qiuna / Duo, Lan / Wang, Mengting / Deng, Zhennv / Chen, Hao / Lin, Quankui

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 930540

    Abstract: Posterior capsular opacification (PCO), the highest incidence complication after cataract surgery, is mainly due to the attachment, proliferation, and migration of the residual lens epithelial cells (LECs). Although the drug-eluting IOLs have been proved ...

    Abstract Posterior capsular opacification (PCO), the highest incidence complication after cataract surgery, is mainly due to the attachment, proliferation, and migration of the residual lens epithelial cells (LECs). Although the drug-eluting IOLs have been proved to be an effective way to prevent PCO incidence, its preparations are time consuming and require tedious preparation steps. Herein, the thermoreversible agarose is adopted to prepare drug-eluting IOL. Such functional coating can be obtained easily by simple immersion in the antiproliferative drug containing hot agarose and taken out for cooling, which not only does not affect the optical property but also can effectively decrease the PCO incidence after intraocular implantation. As a result, the proposed agarose coating provides a rapid and economical alternative of drug-eluting IOL fabrication for PCO prevention.
    Language English
    Publishing date 2022-08-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.930540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Drug-free contact lens based on quaternized chitosan and tannic acid for bacterial keratitis therapy and corneal repair

    Jiao, Zehui / Huo, Qiuyi / Lin, Xuanyu / Chu, Xiaoying / Deng, Zhennv / Guo, Hanwen / Peng, Yaou / Lu, Si / Zhou, Xianjing / Wang, Xinping / Wang, Bailiang

    Carbohydrate polymers. 2022 June 15, v. 286

    2022  

    Abstract: Bacterial keratitis (BK) and related inflammatory diseases causes irreversible damage to the corneal tissue. In this study, a novel polyacrylamide semi-interpenetrating network hydrogel including quaternized chitosan and tannic acid (PAM-QCS-TA) were ... ...

    Abstract Bacterial keratitis (BK) and related inflammatory diseases causes irreversible damage to the corneal tissue. In this study, a novel polyacrylamide semi-interpenetrating network hydrogel including quaternized chitosan and tannic acid (PAM-QCS-TA) were used to construct a novel antibacterial and antioxidant contact lens. The obtained hydrogels showed high water content (>85%), swelling resistance, light transmittance (>90%) and adjustable mechanical property. Both quantitative and qualitative antibacterial experiments against Staphylococcus aureus and Escherichia coli (E. coli) indicated excellent sterilization function especially against E. coli (almost 100%). Due to the presence of tannin acid, it showed obvious antioxidant properties, which relieved oxidative stress and protect cells from reactive oxygen species-induced cytotoxicity. Animal experiments also indicated the shortened treatment time of BK (only 3 days) as well as the protection of eye tissue structure. Therefore, such drug-free antibacterial and antioxidant contact lens avoiding the development of drug resistance is a potential candidate in ocular infectious and inflammatory diseases treatment.
    Keywords Escherichia coli ; Staphylococcus aureus ; animals ; antioxidants ; chitosan ; cornea ; cytotoxicity ; drug development ; drug resistance ; hydrogels ; keratitis ; mechanical properties ; oxidative stress ; oxygen ; polyacrylamide ; tannins ; therapeutics ; transmittance ; water content
    Language English
    Dates of publication 2022-0615
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2022.119314
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Drug-free contact lens based on quaternized chitosan and tannic acid for bacterial keratitis therapy and corneal repair.

    Jiao, Zehui / Huo, Qiuyi / Lin, Xuanyu / Chu, Xiaoying / Deng, Zhennv / Guo, Hanwen / Peng, Yaou / Lu, Si / Zhou, Xianjing / Wang, Xinping / Wang, Bailiang

    Carbohydrate polymers

    2022  Volume 286, Page(s) 119314

    Abstract: Bacterial keratitis (BK) and related inflammatory diseases causes irreversible damage to the corneal tissue. In this study, a novel polyacrylamide semi-interpenetrating network hydrogel including quaternized chitosan and tannic acid (PAM-QCS-TA) were ... ...

    Abstract Bacterial keratitis (BK) and related inflammatory diseases causes irreversible damage to the corneal tissue. In this study, a novel polyacrylamide semi-interpenetrating network hydrogel including quaternized chitosan and tannic acid (PAM-QCS-TA) were used to construct a novel antibacterial and antioxidant contact lens. The obtained hydrogels showed high water content (>85%), swelling resistance, light transmittance (>90%) and adjustable mechanical property. Both quantitative and qualitative antibacterial experiments against Staphylococcus aureus and Escherichia coli (E. coli) indicated excellent sterilization function especially against E. coli (almost 100%). Due to the presence of tannin acid, it showed obvious antioxidant properties, which relieved oxidative stress and protect cells from reactive oxygen species-induced cytotoxicity. Animal experiments also indicated the shortened treatment time of BK (only 3 days) as well as the protection of eye tissue structure. Therefore, such drug-free antibacterial and antioxidant contact lens avoiding the development of drug resistance is a potential candidate in ocular infectious and inflammatory diseases treatment.
    MeSH term(s) Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Chitosan/chemistry ; Contact Lenses ; Escherichia coli ; Hydrogels/chemistry ; Keratitis/drug therapy ; Tannins/pharmacology ; Tannins/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Hydrogels ; Tannins ; Chitosan (9012-76-4)
    Language English
    Publishing date 2022-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2022.119314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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