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Article: [Analysis of genetic polymorphisms and a novel tri-allelic cloning sequence for the D13S317 locus among an ethnic Han Chinese population].

Gao, Suqing / He, Liumei / Li, Zhen / Zhang, Yinming / Deng, Zhihui

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

2024 Volume 41, Issue 1, Page(s) 42–46

Abstract: Objective: To study the genetic polymorphisms of short-tandem repeats (STR) for the D13S317 locus among an ethnic Han Chinese population and verify a novel tri-allelic pattern identified for the locus.: Methods: A total of 378 paternity test cases ... ...

Abstract	Objective: To study the genetic polymorphisms of short-tandem repeats (STR) for the D13S317 locus among an ethnic Han Chinese population and verify a novel tri-allelic pattern identified for the locus. Methods: A total of 378 paternity test cases from Guangdong Forensic Authentication Institute from October 17, 2017 to December 28, 2017 were selected as the study subjects. A GlobalFiler Results: Six alleles were detected for the D13S317 locus, with the characteristic distribution frequencies being 8 (29.1%), 9 (13.1%), 10 (15.21%), 11 (24.21%), 12 (13.89%) and 13 (3.44%), respectively. In one of the families, the D13S317 locus of the proband was suspected to harbor a triband allele (8, 9, 10). A re-test has confirmed the result of initial test. Molecular cloning and sequencing analysis of the D13S317 locus in the proband and his daughter has failed to find allelic variants in the primer-binding region and flanking sequence, which has confirmed the novel tri-allelic pattern for the locus. Conclusion: A novel type 2 tri-allelic pattern (8, 9, 10) at the D13S317 locus has been identified among the ethnic Han Chinese population. The pattern has not been transmitted to the female offspring, and has been included in the international STRBase database for the first time.
MeSH term(s)	Humans ; Alleles ; China ; Cloning, Molecular ; Gene Frequency ; Genetics, Population ; Microsatellite Repeats ; Polymorphism, Genetic ; East Asian People/genetics
Language	Chinese
Publishing date	2024-01-03
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1003-9406
ISSN	1003-9406
DOI	10.3760/cma.j.cn511374-20221101-00742
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Article ; Online: A Ship Detection Model Based on Dynamic Convolution and an Adaptive Fusion Network for Complex Maritime Conditions.

Li, Zhisheng / Deng, Zhihui / Hao, Kun / Zhao, Xiaofang / Jin, Zhigang

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 3

Abstract: Ship detection is vital for maritime safety and vessel monitoring, but challenges like false and missed detections persist, particularly in complex backgrounds, multiple scales, and adverse weather conditions. This paper presents YOLO-Vessel, a ship ... ...

Abstract	Ship detection is vital for maritime safety and vessel monitoring, but challenges like false and missed detections persist, particularly in complex backgrounds, multiple scales, and adverse weather conditions. This paper presents YOLO-Vessel, a ship detection model built upon YOLOv7, which incorporates several innovations to improve its performance. First, we devised a novel backbone network structure called Efficient Layer Aggregation Networks and Omni-Dimensional Dynamic Convolution (ELAN-ODConv). This architecture effectively addresses the complex background interference commonly encountered in maritime ship images, thereby improving the model's feature extraction capabilities. Additionally, we introduce the space-to-depth structure in the head network, which can solve the problem of small ship targets in images that are difficult to detect. Furthermore, we introduced ASFFPredict, a predictive network structure addressing scale variation among ship types, bolstering multiscale ship target detection. Experimental results demonstrate YOLO-Vessel's effectiveness, achieving a 78.3% mean average precision (mAP), surpassing YOLOv7 by 2.3% and Faster R-CNN by 11.6%. It maintains real-time detection at 8.0 ms/frame, meeting real-time ship detection needs. Evaluation in adverse weather conditions confirms YOLO-Vessel's superiority in ship detection, offering a robust solution to maritime challenges and enhancing marine safety and vessel monitoring.
Language	English
Publishing date	2024-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24030859
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Article ; Online: The novel KIR3DL3*117 allele identified by sequencing-based typing in a Chinese Han individual.

Yu, Qiong / Yang, Zhichao / Chen, Hao / Deng, Zhihui

HLA

2023 Volume 102, Issue 3, Page(s) 397–398

Abstract: The novel KIR3DL3*117 allele differs from the closest allele KIR3DL3*01002 by two mutations in exon 3. ...

Abstract	The novel KIR3DL3117 allele differs from the closest allele KIR3DL301002 by two mutations in exon 3.
MeSH term(s)	Humans ; Alleles ; East Asian People/genetics ; Exons/genetics ; Mutation ; Receptors, KIR/genetics
Chemical Substances	KIR3DL3 protein, human ; Receptors, KIR
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.15092
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Article ; Online: Identification of the novel KIR3DL3*118 allele in a Chinese Han individual.

Zhen, Jianxin / Yang, Zhichao / Chen, Hao / Deng, Zhihui

HLA

2023 Volume 102, Issue 3, Page(s) 399–400

Abstract: The novel KIR3DL3*118 allele differs from the closest allele KIR3DL3*01002 by a single missense mutation at CDS nt502 A > G in exon 4. ...

Abstract	The novel KIR3DL3118 allele differs from the closest allele KIR3DL301002 by a single missense mutation at CDS nt502 A > G in exon 4.
MeSH term(s)	Humans ; Alleles ; Base Sequence ; East Asian People/genetics ; Mutation, Missense ; Receptors, KIR/genetics
Chemical Substances	KIR3DL3 protein, human ; Receptors, KIR
Language	English
Publishing date	2023-05-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.15090
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Article ; Online: Characterization of the novel KIR3DL3*116 allele identified in a Chinese Han individual.

Yang, Zhichao / Chen, Hao / Deng, Zhihui

HLA

2023 Volume 102, Issue 3, Page(s) 395–397

Abstract: The novel KIR3DL3*116 allele differs from the closest allele KIR3DL3*00902 by a single missense mutation. ...

Abstract	The novel KIR3DL3116 allele differs from the closest allele KIR3DL300902 by a single missense mutation.
MeSH term(s)	Humans ; Alleles ; Base Sequence ; East Asian People/genetics ; Receptors, KIR/genetics ; Sequence Analysis, DNA ; Mutation, Missense
Chemical Substances	KIR3DL3 protein, human ; Receptors, KIR
Language	English
Publishing date	2023-05-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.15094
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Article ; Online: The novel KIR2DL4*00108 allele identified by sequencing-based typing in a Chinese Han individual.

Chen, Hao / Yang, Zhichao / Deng, Zhihui

HLA

2022 Volume 101, Issue 3, Page(s) 315–316

Abstract: The novel KIR2DL4*00108 allele differs from the closest allele KIR2DL4*00102 by a single synonymous mutation. ...

Abstract	The novel KIR2DL400108 allele differs from the closest allele KIR2DL400102 by a single synonymous mutation.
MeSH term(s)	Humans ; Alleles ; Base Sequence ; East Asian People ; Ethnicity/genetics ; Exons/genetics ; Receptors, KIR2DL4/genetics
Chemical Substances	KIR2DL4 protein, human ; Receptors, KIR2DL4
Language	English
Publishing date	2022-10-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.14854
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Article: [Association of molecular genetic polymorphism of KIR-HLA systems with acute leukemia in Southern Chinese Han].

Zhen, Jianxin / Yang, Zhichao / Deng, Zhihui

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

2022 Volume 39, Issue 5, Page(s) 499–504

Abstract: Objective: To investigate the association of molecular genetic polymorphism of KIR-HLA systems with acute lymphoblastic leukemia (ALL) and acute myelocytic leukemia (AML) in southern Chinese Han.: Methods: A total number of 323 cases of adult ALL ... ...

Abstract	Objective: To investigate the association of molecular genetic polymorphism of KIR-HLA systems with acute lymphoblastic leukemia (ALL) and acute myelocytic leukemia (AML) in southern Chinese Han. Methods: A total number of 323 cases of adult ALL patients, 350 adult AML, and 745 random healthy controls were tested by KIR PCR-SSP and HLA-A, -B, -C sequence-based typing (PCR-SBT) methods. The molecular genetic polymorphisms of KIR genes and KIR gene profiles, classⅠ HLA ligands, and KIR receptor +HLA ligand combinations were compared between patient and healthy control groups. Results: A total number of 32 and 33 different kinds of KIR profiles were identified in the ALL and AML patient groups. Compared with the observed frequencies of KIR profiles in healthy controls, the observed frequencies of KIR profile AA1 were significantly lower in both the ALL and AML groups (ALL group: 45.79% vs. 55.30%, Pc=0.004; AML group: 48.27% vs. 55.30%, Pc=0.030). In the ALL group, the observed frequencies of 2DL2 gene and 2DL2+HLA-C1 combination, 2DS2 gene and 2DS2+HLA-C1 combination were significantly higher than those in healthy controls (P<0.05), whereas the frequencies of 2DL3 gene, HLA-A3/A11 ligand and 3DL2+HLA-A3/A11 combination were significantly lower than those in healthy controls. However, no significant differences remained after Bonferroni correction (Pc>0.05). In AML group, the observed frequencies of both 2DS1 and 2DL5 genes were significantly higher than that in healthy controls, whereas the frequencies of HLA-C2 ligand and 2DL1+HLA-C2 combination were significantly lower than that in healthy controls(P<0.05). However, no significant difference existed after Bonferroni correction (Pc>0.05). Conclusion: This study revealed some potential susceptibility or protective factors related to acute leukemia in southern Chinese Han, especially the protective factor KIR profile AA1, which might provide new clues and theoretical basis for the pathogenesis of acute leukemia and individualized immunotherapy.
MeSH term(s)	Adult ; China ; Gene Frequency ; Genotype ; HLA-A3 Antigen/genetics ; Humans ; Leukemia, Myeloid, Acute/genetics ; Ligands ; Polymorphism, Genetic ; Receptors, KIR/genetics
Chemical Substances	HLA-A3 Antigen ; Ligands ; Receptors, KIR
Language	Chinese
Publishing date	2022-05-22
Publishing country	China
Document type	Journal Article
ISSN	1003-9406
ISSN	1003-9406
DOI	10.3760.cma.j.cn511374-20211201-00954
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exploration of the Visual Function after the Implantation of Continuous Visual Range Human Cocrystal Micromonocular Vision in Both Eyes of the Patient.

Cai, Fangrong / Wang, Xiaoli / Deng, Zhihui / Bai, Lina

publication RETRACTED

Journal of healthcare engineering

2022 Volume 2022, Page(s) 6000977

Abstract: Eye diseases such as myopia, hyperopia, astigmatism, and cataract are have affected most people at home and abroad for many years. With the development of science and technology, people who wear glasses are now younger, and they are on the rise over time. ...

Abstract	Eye diseases such as myopia, hyperopia, astigmatism, and cataract are have affected most people at home and abroad for many years. With the development of science and technology, people who wear glasses are now younger, and they are on the rise over time. This paper is to explore the visual function after the implantation of continuous visual range human cocrystal micromonocular vision in both eyes of the patient. On this basis, the latest visual sensor technology is used to conduct clinical research on the operation, a case-control study is performed on the patient's eyes, followed by intraocular lens insertion surgery, one eye is hemitrope and the other eye has a certain degree of intraocular lens inserted, and it is recorded within a period of time after the operation. According to the analysis of the experimental results, the patient's naked eye and corrected distance vision is (t = 2.102, P = 0.049), middle distance vision (t = 1.403, P = 0.200), and near vision (t = 1.463, P = 0.216). After the operation, the ratio of patients taking off glasses 91.8%. After the continuous visual range intraocular lens micromonocular vision design, it can well correct the patient's near and far vision of the naked eye of both eyes.
MeSH term(s)	Astigmatism/surgery ; Case-Control Studies ; Humans ; Lens Implantation, Intraocular ; Lenses, Intraocular ; Myopia/surgery ; Visual Acuity
Language	English
Publishing date	2022-03-07
Publishing country	England
Document type	Journal Article ; Retracted Publication
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2022/6000977
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification of the novel HLA-B*46:01:33 allele by next generation sequencing in a Chinese individual.

Zou, Hong-Yan / Zhong, Yan-Ping / Deng, Zhi-Hui

HLA

2022 Volume 101, Issue 2, Page(s) 166–167

Abstract: B*46:01:33 differs from B*46:01:01:01 by one nucleotide change at nucleotide 105 in exon 2 from C to T. ...

Abstract	B46:01:33 differs from B46:01:01:01 by one nucleotide change at nucleotide 105 in exon 2 from C to T.
MeSH term(s)	Humans ; Alleles ; East Asian People ; High-Throughput Nucleotide Sequencing ; HLA-B Antigens/genetics
Chemical Substances	HLA-B Antigens
Language	English
Publishing date	2022-11-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.14873
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Article ; Online: Effects of theaflavin-3, 3'-digallate on high-fat diet-induced liver injury in mice and its mechanism

ZHANG Gan / FU Hongjuan / ZOU Yixin / DENG Zhihui / CHANG Hui

Di-san junyi daxue xuebao, Vol 44, Iss 2, Pp 147-

2022 Volume 154

Abstract: Objective To investigate the protective effects of dietary intervention with theaflavin-3, 3'-digallate (TFDG) on liver injury induced by high-fat diet (HFD) in mice and its underlying mechanism. Methods Forty C57BL/6 mice were randomly and equally ... ...

Abstract	Objective To investigate the protective effects of dietary intervention with theaflavin-3, 3'-digallate (TFDG) on liver injury induced by high-fat diet (HFD) in mice and its underlying mechanism. Methods Forty C57BL/6 mice were randomly and equally divided into normal control (NC), model control (MC) and TFDG administration (TF5 and TF10) groups. The mice of the NC group were fed with normal diet, and those of the other 3 groups were given HFD. Then the TF5 and TF10 groups were intragastrically given 5 mg/kg and 10 mg/kg TFDG respectively, while the NC and MC groups were treated with normal saline. After 12 weeks of intervention, the liver index, serum ALT and AST levels were detected, and the pathological changes of liver tissues were observed in the mice. The contents of inflammatory factors and the expression levels of related proteins in liver tissue were determined by ELISA and Western blotting respectively, and the mRNA level of miR-233 was measured by qRT-PCR. Results HFD significantly increased the liver index as well as serum ALT and AST levels, while these changes were effectively reversed by TFDG administration (P < 0.05). Pathological observation displayed that TFDG intervention reduced the formation of lipid droplets in liver tissue, and lipid content detection also suggested that TFDG remarkably declined the levels of triglyceride (TG) and total cholesterol (TC) in liver tissue (P < 0.05). ELISA indicated that the levels of IL-1β, IL-6 and TNF-α were elevated notably in the liver of HFD-fed mice, and Western blotting confirmed higher protein levels of NLRP3, caspase-1 and IL-1β, whereas TFDG inhibited the inflammatory response of liver (P < 0.05) and the activation of NLRP3/IL-1β pathway (P < 0.05). In addition, TFDG intervention greatly up-regulated the expression of miR-223 in the hepatocytes under high-fat condition. After oligonucleotide inhibitor blocked the effect of TFDG on miR-223 expression, its inhibitory effect on inflammatory response was weakened as well (P < 0.05). ...
Keywords	theaflavin ; non-alcoholic fatty liver disease ; inflammatory response ; microrna ; Medicine (General) ; R5-920
Subject code	610
Language	Chinese
Publishing date	2022-01-01T00:00:00Z
Publisher	Editorial Office of Journal of Third Military Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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