LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Your last searches

  1. AU="Denic, Milica"
  2. AU="Pértega-Díaz, Sonia"
  3. AU=Passos Maria do Carmo Friche
  4. AU=Lumb Bridget M
  5. AU="Drabo, Emmanuel F"
  6. AU="Raux, M"
  7. AU="Kubba, Haytham"
  8. AU="Hence, Deanna"
  9. AU="Swiger, James"
  10. AU="Loftus Jr, E. V."
  11. AU="Pozzi Mucelli, Roberto"
  12. AU="Subedi, Prajan"
  13. AU=Xiao Xizhu
  14. AU="Franzén, Anna"
  15. AU=Klonoff David C
  16. AU="DeCobelli, Francesco"
  17. AU="Zhang, KaiDong"

Search results

Result 1 - 9 of total 9

Search options

  1. Article ; Online: Recursive Numeral Systems Optimize the Trade-off Between Lexicon Size and Average Morphosyntactic Complexity.

    Denić, Milica / Szymanik, Jakub

    Cognitive science

    2024  Volume 48, Issue 3, Page(s) e13424

    Abstract: Human languages vary in terms of which meanings they lexicalize, but this variation is constrained. It has been argued that languages are under two competing pressures: the pressure to be simple (e.g., to have a small lexicon) and to allow for ... ...

    Abstract Human languages vary in terms of which meanings they lexicalize, but this variation is constrained. It has been argued that languages are under two competing pressures: the pressure to be simple (e.g., to have a small lexicon) and to allow for informative (i.e., precise) communication, and that which meanings get lexicalized may be explained by languages finding a good way to trade off between these two pressures. However, in certain semantic domains, languages can reach very high levels of informativeness even if they lexicalize very few meanings in that domain. This is due to productive morphosyntax and compositional semantics, which may allow for construction of meanings which are not lexicalized. Consider the semantic domain of natural numbers: many languages lexicalize few natural number meanings as monomorphemic expressions, but can precisely convey very many natural number meanings using morphosyntactically complex numerals. In such semantic domains, lexicon size is not in direct competition with informativeness. What explains which meanings are lexicalized in such semantic domains? We will propose that in such cases, languages need to solve a different kind of trade-off problem: the trade-off between the pressure to lexicalize as few meanings as possible (i.e, to minimize lexicon size) and the pressure to produce as morphosyntactically simple utterances as possible (i.e, to minimize average morphosyntactic complexity of utterances). To support this claim, we will present a case study of 128 natural languages' numeral systems, and show computationally that they achieve a near-optimal trade-off between lexicon size and average morphosyntactic complexity of numerals. This study in conjunction with previous work on communicative efficiency suggests that languages' lexicons are shaped by a trade-off between not two but three pressures: be simple, be informative, and minimize average morphosyntactic complexity of utterances.
    MeSH term(s) Humans ; Language ; Semantics ; Communication
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2002940-8
    ISSN 1551-6709 ; 0364-0213
    ISSN (online) 1551-6709
    ISSN 0364-0213
    DOI 10.1111/cogs.13424
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Indefinite Pronouns Optimize the Simplicity/Informativeness Trade-Off.

    Denić, Milica / Steinert-Threlkeld, Shane / Szymanik, Jakub

    Cognitive science

    2022  Volume 46, Issue 5, Page(s) e13142

    Abstract: The vocabulary of human languages has been argued to support efficient communication by optimizing the trade-off between simplicity and informativeness. The argument has been originally based on cross-linguistic analyses of vocabulary in semantic domains ...

    Abstract The vocabulary of human languages has been argued to support efficient communication by optimizing the trade-off between simplicity and informativeness. The argument has been originally based on cross-linguistic analyses of vocabulary in semantic domains of content words, such as kinship, color, and number terms. The present work applies this analysis to a category of function words: indefinite pronouns (e.g., someone, anyone, no one). We build on previous work to establish the meaning space and featural make-up for indefinite pronouns, and show that indefinite pronoun systems across languages optimize the simplicity/informativeness trade-off. This demonstrates that pressures for efficient communication shape both content and function word categories. In doing so, our work aligns with several concurrent studies exploring the simplicity/informativeness trade-off in functional vocabulary. Importantly, we further argue that the trade-off may explain some of the universal properties of indefinite pronouns, thus reducing the explanatory load for linguistic theories.
    MeSH term(s) Communication ; Humans ; Language ; Linguistics ; Semantics ; Vocabulary
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2002940-8
    ISSN 1551-6709 ; 0364-0213
    ISSN (online) 1551-6709
    ISSN 0364-0213
    DOI 10.1111/cogs.13142
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: The influence of polarity items on inferential judgments.

    Denić, Milica / Homer, Vincent / Rothschild, Daniel / Chemla, Emmanuel

    Cognition

    2021  Volume 215, Page(s) 104791

    Abstract: Polarity items are linguistic expressions such as any, at all, some, which are acceptable in some linguistic environments but not others. Crucially, whether a polarity item is acceptable in a given environment is argued to depend on the inferences (in ... ...

    Abstract Polarity items are linguistic expressions such as any, at all, some, which are acceptable in some linguistic environments but not others. Crucially, whether a polarity item is acceptable in a given environment is argued to depend on the inferences (in the reasoning sense) that this environment allows. We show that the inferential judgments reported for a given environment are modified in the presence of polarity items. Hence, there is a two-way influence between linguistic and reasoning abilities: the linguistic acceptability of polarity items is dependent on reasoning facts and, conversely, reasoning judgments can be altered by the mere addition of seemingly innocuous polarity items.
    MeSH term(s) Humans ; Judgment ; Problem Solving
    Language English
    Publishing date 2021-07-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1499940-7
    ISSN 1873-7838 ; 0010-0277
    ISSN (online) 1873-7838
    ISSN 0010-0277
    DOI 10.1016/j.cognition.2021.104791
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Review: Pathogenesis of Helicobacter pylori infection.

    Denic, Milica / Touati, Eliette / De Reuse, Hilde

    Helicobacter

    2020  Volume 25 Suppl 1, Page(s) e12736

    Abstract: The original strategies developed by Helicobacter pylori to persistently colonise its host and to deregulate its cellular functions make this bacterium an outstanding model to study host-pathogen interaction and the mechanisms responsible for bacterial- ... ...

    Abstract The original strategies developed by Helicobacter pylori to persistently colonise its host and to deregulate its cellular functions make this bacterium an outstanding model to study host-pathogen interaction and the mechanisms responsible for bacterial-induced carcinogenesis. During the last year, significant results were obtained on the role of bacterial factors essential for gastric colonisation such as spiral shape maintenance, orientation through chemotaxis and the formation of bacteria clonal population islands inside the gastric glands. Particularities of the H pylori cell surface, a structure important for immune escape, were demonstrated. New insights in the bacterial stress response revealed the importance of DNA methylation-mediated regulation. Further findings were reported on H pylori components that mediate natural transformation and mechanisms of bacterial DNA horizontal transfer which maintain a high level of H pylori genetic variability. Within-host evolution was found to be niche-specific and probably associated with physiological differences between the antral and oxyntic gastric mucosa. In addition, with the progress of CryoEM, high-resolution structures of the major virulence factors, VacA and CagT4SS, were obtained. The use of gastric organoid models fostered research revealing, preferential accumulation of bacteria at the site of injury during infection. Several studies further characterised the role of CagA in the oncogenic properties of H pylori, identifying the activation of novel CagA-dependent pathways, leading to the promotion of genetic instabilities, epithelial-to-mesenchymal transition and finally carcinogenesis. Recent studies also highlight that microRNA-mediated regulation and epigenetic modifications, through DNA methylation, are key events in the H pylori-induced tumorigenesis process.
    MeSH term(s) Antigens, Bacterial/metabolism ; Bacterial Proteins/metabolism ; Gastric Mucosa/microbiology ; Gene Expression Regulation, Bacterial ; Helicobacter Infections/pathology ; Helicobacter pylori ; Host-Pathogen Interactions ; Humans ; Virulence Factors/metabolism
    Chemical Substances Antigens, Bacterial ; Bacterial Proteins ; VacA protein, Helicobacter pylori ; Virulence Factors ; cagA protein, Helicobacter pylori
    Language English
    Publishing date 2020-09-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1330665-0
    ISSN 1523-5378 ; 1083-4389
    ISSN (online) 1523-5378
    ISSN 1083-4389
    DOI 10.1111/hel.12736
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: The SlyD metallochaperone targets iron-sulfur biogenesis pathways and the TCA cycle.

    Denic, Milica / Turlin, Evelyne / Zamble, Deborah B / Betton, Jean-Michel / Vinella, Daniel / De Reuse, Hilde

    mBio

    2023  Volume 14, Issue 5, Page(s) e0096723

    Abstract: Importance: Correct folding of proteins represents a crucial step for their functions. Among the chaperones that control protein folding, the ubiquitous PPIases catalyze ... ...

    Abstract Importance: Correct folding of proteins represents a crucial step for their functions. Among the chaperones that control protein folding, the ubiquitous PPIases catalyze the
    MeSH term(s) Peptidylprolyl Isomerase/genetics ; Escherichia coli ; Metallochaperones/chemistry ; Metallochaperones/metabolism ; Iron ; Protein Folding ; Escherichia coli Proteins/metabolism
    Chemical Substances Peptidylprolyl Isomerase (EC 5.2.1.8) ; Metallochaperones ; Iron (E1UOL152H7) ; Escherichia coli Proteins ; SlyD protein, E coli
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00967-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: The σB signalling activation pathway in the enteropathogen Clostridioides difficile

    Kint, Nicolas / Alves Feliciano, Carolina / Hamiot, Audrey / Denic, Milica / Dupuy, Bruno / Martin‐Verstraete, Isabelle

    Environmental microbiology. 2019 Aug., v. 21, no. 8

    2019  

    Abstract: Clostridium difficile is the main cause of antibiotic‐associated diarrhoea. Inside the gut, C. difficile must adapt to the stresses it copes with, by inducing protection, detoxification and repair systems that belong to the general stress response ... ...

    Abstract Clostridium difficile is the main cause of antibiotic‐associated diarrhoea. Inside the gut, C. difficile must adapt to the stresses it copes with, by inducing protection, detoxification and repair systems that belong to the general stress response involving σᴮ. Following stresses, σᴮ activation requires a PP2C phosphatase to dephosphorylate the anti‐anti‐sigma factor RsbV that allows its interaction with the anti‐sigma factor RsbW and the release of σᴮ. In this work, we studied the signalling pathway responsible for the activation of σᴮ in C. difficile. Contrary to other firmicutes, the expression of sigB in C. difficile is constitutive and not autoregulated. We confirmed the partner switching mechanism that involved RsbV, RsbW and σᴮ. We also showed that CD2685, renamed RsbZ, and its phosphatase activity are required for RsbV dephosphorylation triggering σᴮ activation. While CD0007 and CD0008, whose genes belong to the sigB operon, are not involved in σᴮ activity, depletion of the essential iron–sulphur flavoprotein, CD2684, whose gene forms an operon with rsbZ, prevents σᴮ activation. Finally, we observed that σᴮ is heterogeneously active in a subpopulation of C. difficile cells from the exponential phase, likely leading to a ‘bet‐hedging’ strategy allowing a better chance for the cells to survive adverse conditions.
    Keywords Clostridium difficile ; dephosphorylation ; diarrhea ; digestive system ; enteropathogens ; enzyme activity ; enzymes ; flavoproteins ; operon ; signal transduction ; stress response
    Language English
    Dates of publication 2019-08
    Size p. 2852-2870.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.14642
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  7. Article ; Online: A novel mode of control of nickel uptake by a multifunctional metallochaperone.

    Denic, Milica / Turlin, Evelyne / Michel, Valérie / Fischer, Frédéric / Khorasani-Motlagh, Mozhgan / Zamble, Deborah / Vinella, Daniel / de Reuse, Hilde

    PLoS pathogens

    2021  Volume 17, Issue 1, Page(s) e1009193

    Abstract: Cellular metal homeostasis is a critical process for all organisms, requiring tight regulation. In the major pathogen Helicobacter pylori, the acquisition of nickel is an essential virulence determinant as this metal is a cofactor for the acid-resistance ...

    Abstract Cellular metal homeostasis is a critical process for all organisms, requiring tight regulation. In the major pathogen Helicobacter pylori, the acquisition of nickel is an essential virulence determinant as this metal is a cofactor for the acid-resistance enzyme, urease. Nickel uptake relies on the NixA permease and the NiuBDE ABC transporter. Till now, bacterial metal transporters were reported to be controlled at their transcriptional level. Here we uncovered post-translational regulation of the essential Niu transporter in H. pylori. Indeed, we demonstrate that SlyD, a protein combining peptidyl-prolyl isomerase (PPIase), chaperone, and metal-binding properties, is required for the activity of the Niu transporter. Using two-hybrid assays, we found that SlyD directly interacts with the NiuD permease subunit and identified a motif critical for this contact. Mutants of the different SlyD functional domains were constructed and used to perform in vitro PPIase activity assays and four different in vivo tests measuring nickel intracellular accumulation or transport in H. pylori. In vitro, SlyD PPIase activity is down-regulated by nickel, independently of its C-terminal region reported to bind metals. In vivo, a role of SlyD PPIase function was only revealed upon exposure to high nickel concentrations. Most importantly, the IF chaperone domain of SlyD was shown to be mandatory for Niu activation under all in vivo conditions. These data suggest that SlyD is required for the active functional conformation of the Niu permease and regulates its activity through a novel mechanism implying direct protein interaction, thereby acting as a gatekeeper of nickel uptake. Finally, in agreement with a central role of SlyD, this protein is essential for the colonization of the mouse model by H. pylori.
    MeSH term(s) Animals ; Bacterial Proteins/metabolism ; Helicobacter Infections/metabolism ; Helicobacter Infections/microbiology ; Helicobacter pylori/metabolism ; Metallochaperones/metabolism ; Mice ; Nickel/metabolism ; Peptidylprolyl Isomerase/metabolism ; Urease/metabolism
    Chemical Substances Bacterial Proteins ; Metallochaperones ; Nickel (7OV03QG267) ; Urease (EC 3.5.1.5) ; Peptidylprolyl Isomerase (EC 5.2.1.8)
    Language English
    Publishing date 2021-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1009193
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: The σ

    Kint, Nicolas / Alves Feliciano, Carolina / Hamiot, Audrey / Denic, Milica / Dupuy, Bruno / Martin-Verstraete, Isabelle

    Environmental microbiology

    2019  Volume 21, Issue 8, Page(s) 2852–2870

    Abstract: Clostridium difficile is the main cause of antibiotic-associated diarrhoea. Inside the gut, C. difficile must adapt to the stresses it copes with, by inducing protection, detoxification and repair systems that belong to the general stress response ... ...

    Abstract Clostridium difficile is the main cause of antibiotic-associated diarrhoea. Inside the gut, C. difficile must adapt to the stresses it copes with, by inducing protection, detoxification and repair systems that belong to the general stress response involving σ
    MeSH term(s) Bacillus subtilis/genetics ; Bacterial Proteins/metabolism ; Clostridium difficile/genetics ; Clostridium difficile/metabolism ; Gene Expression Regulation, Bacterial ; Operon ; Phosphoprotein Phosphatases/metabolism ; Sigma Factor/metabolism ; Signal Transduction
    Chemical Substances Bacterial Proteins ; Sigma Factor ; Phosphoprotein Phosphatases (EC 3.1.3.16)
    Language English
    Publishing date 2019-05-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.14642
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases.

    Knez, Damijan / Diez-Iriepa, Daniel / Chioua, Mourad / Gottinger, Andrea / Denic, Milica / Chantegreil, Fabien / Nachon, Florian / Brazzolotto, Xavier / Skrzypczak-Wiercioch, Anna / Meden, Anže / Pišlar, Anja / Kos, Janko / Žakelj, Simon / Stojan, Jure / Sałat, Kinga / Serrano, Julia / Fernández, Ana Patricia / Sánchez-García, Aitana / Martínez-Murillo, Ricardo /
    Binda, Claudia / López-Muñoz, Francisco / Gobec, Stanislav / Marco-Contelles, José

    Acta pharmaceutica Sinica. B

    2023  Volume 13, Issue 5, Page(s) 2152–2175

    Abstract: We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase-hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We ... ...

    Abstract We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase-hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN
    Language English
    Publishing date 2023-01-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-3835
    ISSN 2211-3835
    DOI 10.1016/j.apsb.2023.01.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top