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  1. Article ; Online: The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome

    Denis Miyashiro / Bruno de Castro e Souza / Marina Passos Torrealba / Kelly Cristina Gomes Manfrere / Maria Notomi Sato / José Antonio Sanches

    International Journal of Molecular Sciences, Vol 23, Iss 936, p

    2022  Volume 936

    Abstract: Sézary syndrome is an aggressive leukemic variant of cutaneous T-cell lymphomas, characterized by erythroderma, lymphadenopathy, and peripheral blood involvement by CD4+ malignant T-cells. The pathogenesis of Sézary syndrome is not fully understood. ... ...

    Abstract Sézary syndrome is an aggressive leukemic variant of cutaneous T-cell lymphomas, characterized by erythroderma, lymphadenopathy, and peripheral blood involvement by CD4+ malignant T-cells. The pathogenesis of Sézary syndrome is not fully understood. However, the course of the disease is strongly influenced by the tumor microenvironment, which is altered by a combination of cytokines, chemokines, and growth factors. The crosstalk between malignant and reactive cells affects the immunologic response against tumor cells causing immune dysregulation. This review focuses on the interaction of malignant Sézary cells and the tumor microenvironment.
    Keywords Sézary syndrome ; cutaneous T-cell lymphoma ; tumor microenvironment ; cytokines ; chemokines ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Clinicopathological analysis of acral melanoma in a single center

    Bruno de Castro e Souza / Diego Henrique Morais Silva / Denis Miyashiro / Priscila Kakizaki / Neusa Yuriko Sakai Valente

    Revista da Associação Médica Brasileira, Vol 66, Iss 10, Pp 1391-

    a study of 45 cases

    2020  Volume 1395

    Abstract: SUMMARY OBJECTIVE: The relationship between the clinicopathological and sociodemographics characteristics of acral melanomas diagnosed at the Hospital do Servidor Público Estadual de São Paulo was analyzed and traced between 1997 and 2016. METHODS: An ... ...

    Abstract SUMMARY OBJECTIVE: The relationship between the clinicopathological and sociodemographics characteristics of acral melanomas diagnosed at the Hospital do Servidor Público Estadual de São Paulo was analyzed and traced between 1997 and 2016. METHODS: An observational, descriptive, and retrospective study of patients diagnosed with acral melanoma was performed at Hospital do Servidor Público Estadual de São Paulo. Sociodemographic and clinicopathological characteristics were collected and analyzed. RESULTS: Forty-five patients with acral melanomas were found during the evaluation period. Thirty-one were females, and 14 were males (68.89% and 31.3%, respectively). Most of the cases were invasive (88.37%), and the predominant histological subtype was the acral lentiginous (91.11%). The plantar region was the most prevalent (64.44%). The median Breslow index was 3 mm, and there was a tendency towards greater severity in male patients. CONCLUSIONS: Acral site melanomas are detected diagnosed when they reach more advanced stages, which leads to a worse prognosis for patients. Late detection assumes even greater importance in highly mixed and black populations, such as the Brazilian population.
    Keywords Melanoma/epidemiology ; Melanoma/pathology ; Skin neoplasms ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Imbalanced IL-1B and IL-18 Expression in Sézary Syndrome

    Kelly Cristina Gomes Manfrere / Marina Passos Torrealba / Frederico Moraes Ferreira / Emanuella Sarmento Alho de Sousa / Denis Miyashiro / Franciane Mouradian Emidio Teixeira / Ricardo Wesley Alberca Custódio / Helder I. Nakaya / Yasmin Alefe Leuzzi Ramos / Mirian Nacagami Sotto / Anders Woetmann / Niels Ødum / Alberto José da Silva Duarte / José Antonio Sanches / Maria Notomi Sato

    International Journal of Molecular Sciences, Vol 24, Iss 4674, p

    2023  Volume 4674

    Abstract: Sézary syndrome (SS) is a rare and aggressive type of cutaneous T-cell lymphoma, with an abnormal inflammatory response in affected skin. The cytokines IL-1B and IL-18, as key signaling molecules in the immune system, are produced in an inactive form and ...

    Abstract Sézary syndrome (SS) is a rare and aggressive type of cutaneous T-cell lymphoma, with an abnormal inflammatory response in affected skin. The cytokines IL-1B and IL-18, as key signaling molecules in the immune system, are produced in an inactive form and cleave to the active form by inflammasomes. In this study, we assessed the skin, serum, peripheral mononuclear blood cell (PBMC) and lymph-node samples of SS patients and control groups (healthy donors (HDs) and idiopathic erythroderma (IE) nodes) to investigate the inflammatory markers IL-1B and IL-18 at the protein and transcript expression levels, as potential markers of inflammasome activation. Our findings showed increased IL-1B and decreased IL-18 protein expression in the epidermis of SS patients; however, in the dermis layer, we detected increased IL-18 protein expression. In the lymph nodes of SS patients at advanced stages of the disease (N2/N3), we also detected an enhancement of IL-18 and a downregulation of IL-1B at the protein level. Moreover, the transcriptomic analysis of the SS and IE nodes confirmed the decreased expression of IL1B and NLRP3 , whereas the pathway analysis indicated a further downregulation of IL1B -associated genes. Overall, the present findings showed compartmentalized expressions of IL-1B and IL-18 and provided the first evidence of their imbalance in patients with Sézary syndrome.
    Keywords Sézary syndrome ; lymph nodes ; inflammasome ; IL-1B ; IL-18 ; erythroderma skin ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Increasing awareness of human T-lymphotropic virus type-1 infection

    Marzia Puccioni-Sohler / Maria Fernanda Rios Grassi / Bernardo Galvão-Castro / Adele Caterino / Anna Bárbara de Freitas Carneiro Proietti / Ana Carolina Paulo Vicente / Ana Verena Galvão-Castro / Antonio Carlos Vallinoto / Arthur Paiva / Augusto Penalva / Carolina Rosadas / Denis Miyashiro / Edel Figueiredo Barbosa / Edgar Marcelino de Carvalho / Everton da Silva Batista / Jerusa Smid / Jorge Casseb / Jose Vidal / Maisa Silva Sousa /
    Maria Graça de Castro Viana / Michele de Souza Bastos / Monique Lírio / Ney Boa-Sorte / Orlando C. Ferreira Jr / Osvaldo Takayanagui / Patrícia Moura / Regina Rocco / Rodrigo Guimaraes Cunha / Simone Kashima Haddad / Tatiane Assone / Thessika Hialla Almeida Araújo

    Revista da Sociedade Brasileira de Medicina Tropical, Vol

    a serious, invisible, and neglected health problem in Brazil

    2019  Volume 52

    Keywords Arctic medicine. Tropical medicine ; RC955-962
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher Sociedade Brasileira de Medicina Tropical (SBMT)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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