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  1. Article ; Online: Editorial.

    Denis, Noble

    Progress in biophysics and molecular biology

    2018  Volume 136, Page(s) 1–2

    MeSH term(s) Evolution, Molecular ; Viruses
    Language English
    Publishing date 2018-03-12
    Publishing country England
    Document type Editorial
    ZDB-ID 209302-9
    ISSN 1873-1732 ; 0079-6107
    ISSN (online) 1873-1732
    ISSN 0079-6107
    DOI 10.1016/j.pbiomolbio.2018.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Why integration?

    Denis Noble

    Integrative Medicine Research, Vol 1, Iss 1, Pp 2-

    2012  Volume 4

    Abstract: The recent growth of the systems approach to biology provides a better conceptual framework within which to interpret holistic approaches to medicine. The reason is that systems biology respects the way in which the whole constrains the parts to behave ... ...

    Abstract The recent growth of the systems approach to biology provides a better conceptual framework within which to interpret holistic approaches to medicine. The reason is that systems biology respects the way in which the whole constrains the parts to behave in ways that are different from what they would do in isolation. Holistic treatments depend on the same insight and can therefore be successful in practice where reductionist approaches would fail.
    Keywords holistic biology ; integrative medicine ; systems biology ; sasang constitutional medicine ; Miscellaneous systems and treatments ; RZ409.7-999
    Language English
    Publishing date 2012-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Was the Watchmaker Blind? Or Was She One-Eyed?

    Raymond Noble / Denis Noble

    Biology, Vol 6, Iss 4, p

    2017  Volume 47

    Abstract: The question whether evolution is blind is usually presented as a choice between no goals at all (‘the blind watchmaker’) and long-term goals which would be external to the organism, for example in the form of special creation or intelligent design. The ... ...

    Abstract The question whether evolution is blind is usually presented as a choice between no goals at all (‘the blind watchmaker’) and long-term goals which would be external to the organism, for example in the form of special creation or intelligent design. The arguments either way do not address the question whether there are short-term goals within rather than external to organisms. Organisms and their interacting populations have evolved mechanisms by which they can harness blind stochasticity and so generate rapid functional responses to environmental challenges. They can achieve this by re-organising their genomes and/or their regulatory networks. Epigenetic as well as DNA changes are involved. Evolution may have no foresight, but it is at least partially directed by organisms themselves and by the populations of which they form part. Similar arguments support partial direction in the evolution of behavior.
    Keywords blind chance ; harnessing stochasticity ; hypermutation ; evolutionary hold mechanisms ; adaptability driver ; internal and external goals ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Could there Be a Synthesis between Western and Oriental Medicine, and with Sasang Constitutional Medicine in Particular?

    Denis Noble

    Evidence-Based Complementary and Alternative Medicine, Vol 6, Iss S1, Pp 5-

    2009  Volume 10

    Abstract: Attitudes towards oriental medicine are changing for two major reasons. The first is that many patients, even in the West, are choosing to use its practitioners and methods. The second is that the rise of Systems Biology may offer a better basis for ... ...

    Abstract Attitudes towards oriental medicine are changing for two major reasons. The first is that many patients, even in the West, are choosing to use its practitioners and methods. The second is that the rise of Systems Biology may offer a better basis for dialogue, and even for synthesis, between the oriental and Western traditions. However, a lot of work is needed to clear the way for such dialogue and synthesis. Much of this work should be devoted to clarifying the meanings of the terms used, and the framework of theory and practice within which oriental methods operate. But it is also necessary for Systems Biology itself to mature as a discipline, particularly at the higher levels of biological organization since it is at these levels that oriental medicine derives its ideas and practice. Higher level Systems Biology could be a basis for interpretation of the Korean version of oriental medicine: Sasang constitutional medicine since it seeks patient specific analysis and treatment, and the mathematical methods of systems biology could be used to analyze the central concept of balance in Sasang.
    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2009-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Data bias

    Teppo Felin / Jan Koenderink / Joachim I. Krueger / Denis Noble / George F. R. Ellis

    Genome Biology, Vol 22, Iss 1, Pp 1-

    2021  Volume 4

    Keywords Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Origins of Systems Biology in William Harvey’s Masterpiece on the Movement of the Heart and the Blood in Animals

    Charles Auffray / Denis Noble

    International Journal of Molecular Sciences, Vol 10, Iss 4, Pp 1658-

    2009  Volume 1669

    Abstract: In this article we continue our exploration of the historical roots of systems biology by considering the work of William Harvey. Central arguments in his work on the movement of the heart and the circulation of the blood can be shown to presage the ... ...

    Abstract In this article we continue our exploration of the historical roots of systems biology by considering the work of William Harvey. Central arguments in his work on the movement of the heart and the circulation of the blood can be shown to presage the concepts and methods of integrative systems biology. These include: (a) the analysis of the level of biological organization at which a function (e.g. cardiac rhythm) can be said to occur; (b) the use of quantitative mathematical modelling to generate testable hypotheses and deduce a fundamental physiological principle (the circulation of the blood) and (c) the iterative submission of his predictions to an experimental test. This article is the result of a tri-lingual study: as Harvey’s masterpiece was published in Latin in 1628, we have checked the original edition and compared it with and between the English and French translations, some of which are given as notes to inform the reader of differences in interpretation.
    Keywords William Harvey ; heart rhythm ; circulation of the blood ; mathematical deduction: experimental verification ; systems biology ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2009-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Investigation of the Cellular Pharmacological Mechanism and Clinical Evidence of the Multi-Herbal Antiarrhythmic Chinese Medicine Xin Su Ning

    Yu-ling Ma / Rou-Mu Hu / Xinchun Yang / Taiyi Wang / Penelope J. Noble / Robert Wilkins / Clive Ellory / Carolyn Carr / Denis Noble / Jiefu Yang / Weixing Lu / Junhua Zhang / Hongde Hu / Xiaomei Guo / Min Chen / Yang Wu / Meng Wei / Jingyuan Mao / Xiaochang Ma /
    Ling Qin / Huanlin Wu / Feng Lu / Ying Cao / Sheng Gao / Wanli Gu

    Frontiers in Pharmacology, Vol

    2020  Volume 11

    Abstract: Xin Su Ning (XSN), a China patented and certified multi-herbal medicine, has been available in China since 2005 for treating cardiac ventricular arrhythmia including arrhythmia induced by ischemic heart diseases and viral myocarditis, without adverse ... ...

    Abstract Xin Su Ning (XSN), a China patented and certified multi-herbal medicine, has been available in China since 2005 for treating cardiac ventricular arrhythmia including arrhythmia induced by ischemic heart diseases and viral myocarditis, without adverse reactions being reported. It is vitally important to discover pharmacologically how XSN as a multicomponent medicine exerts its clinical efficacy, and whether the therapeutic effect of XSN can be verified by standard clinical trial studies. In this paper we report our discoveries in a cellular electrophysiological study and in a three-armed, randomized, double-blind, placebo-controlled, parallel-group, multicenter trial. Conventional electrophysiological techniques were used to study the cellular antiarrhythmic mechanism of XSN. Data was then modeled with computational simulation of human action potential (AP) of the cardiac ventricular myocytes. The clinical trial was conducted with a total of 861 eligible participants randomly assigned in a ratio of 2:2:1 to receive XSN, mexiletine, or the placebo for 4 weeks. The primary and secondary endpoint was the change of premature ventricular contraction (PVC) counts and PVC-related symptoms, respectively. This trial was registered in the Chinese Clinical Trial Register Center (ChiCTR-TRC-14004180). We found that XSN prolonged AP duration of the ventricular myocytes in a dose-dependent, reversible manner and blocked potassium channels. Patients in XSN group exhibited significant total effective responses in the reduction of PVCs compared to those in the placebo group (65.85% vs. 27.27%, P < 0.0001). No severe adverse effects attributable to XSN were observed. In conclusion, XSN is an effective multicomponent antiarrhythmic medicine to treat PVC without adverse effect in patients, which is convincingly supported by its class I & III pharmacological antiarrhythmic mechanism of blocking hERG potassium channels and hNaV1.5 sodium channel reported in our earlier publication and prolongs AP duration both in ventricular ...
    Keywords Xin Su Ning ; traditional Chinese medicine ; multicomponent antiarrhythmic medicine ; cellular electrophysiology ; premature ventricular contraction ; Therapeutics. Pharmacology ; RM1-950
    Subject code 610
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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