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  1. Article ; Online: Description of Hepatitis B Virus Genotypes in Selected Groups of Subjects from Paraguay and Brazil

    María Teresa Maidana Giret / Maria Angélica Camargo Suarez / Raquel Valdovinos / Gloria Orué / Denise S. Rodrigues / Maria Eugenia F. Canciane / Celso F. H. Granato

    American Journal of Infectious Diseases, Vol 4, Iss 4, Pp 220-

    2008  Volume 223

    Abstract: Hepatitis B virus genotyping was conducted among 11560 healthy blood donors and haemodialysis patients in Brazil and Paraguay. Genotypes A, D and F were found in Brazil and genotypes D and F in Paraguay. This is the first report showing HBV genotype ... ...

    Abstract Hepatitis B virus genotyping was conducted among 11560 healthy blood donors and haemodialysis patients in Brazil and Paraguay. Genotypes A, D and F were found in Brazil and genotypes D and F in Paraguay. This is the first report showing HBV genotype diversity in individuals in Paraguay.
    Keywords </keyword><keyword>Hepatitis B virus ; genotypes ; Paraguay ; Infectious and parasitic diseases ; RC109-216 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2008-01-01T00:00:00Z
    Publisher Science Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.

    John T Loffredo / Thomas C Friedrich / Enrique J León / Jason J Stephany / Denise S Rodrigues / Sean P Spencer / Alex T Bean / Dominic R Beal / Benjamin J Burwitz / Richard A Rudersdorf / Lyle T Wallace / Shari M Piaskowski / Gemma E May / John Sidney / Emma Gostick / Nancy A Wilson / David A Price / Esper G Kallas / Helen Piontkivska /
    Austin L Hughes / Alessandro Sette / David I Watkins

    PLoS ONE, Vol 2, Iss 11, p e

    2007  Volume 1152

    Abstract: BACKGROUND:It is generally accepted that CD8+ T cell responses play an important role in control of immunodeficiency virus replication. The association of HLA-B27 and -B57 with control of viremia supports this conclusion. However, specific correlates of ... ...

    Abstract BACKGROUND:It is generally accepted that CD8+ T cell responses play an important role in control of immunodeficiency virus replication. The association of HLA-B27 and -B57 with control of viremia supports this conclusion. However, specific correlates of viral control in individuals expressing these alleles have been difficult to define. We recently reported that transient in vivo CD8+ cell depletion in simian immunodeficiency virus (SIV)-infected elite controller (EC) macaques resulted in a brief period of viral recrudescence. SIV replication was rapidly controlled with the reappearance of CD8+ cells, implicating that these cells actively suppress viral replication in ECs. METHODS AND FINDINGS:Here we show that three ECs in that study made at least seven robust CD8+ T cell responses directed against novel epitopes in Vif, Rev, and Nef restricted by the MHC class I molecule Mamu-B*08. Two of these Mamu-B*08-positive animals subsequently lost control of SIV replication. Their breakthrough virus harbored substitutions in multiple Mamu-B*08-restricted epitopes. Indeed, we found evidence for selection pressure mediated by Mamu-B*08-restricted CD8+ T cells in all of the newly identified epitopes in a cohort of chronically infected macaques. CONCLUSIONS:Together, our data suggest that Mamu-B*08-restricted CD8+ T cell responses effectively control replication of pathogenic SIV(mac)239. All seven regions encoding Mamu-B*08-restricted CD8+ T cell epitopes also exhibit amino acid replacements typically seen only in the presence of Mamu-B*08, suggesting that the variation we observe is indeed selected by CD8+ T cell responses. SIV(mac)239 infection of Indian rhesus macaques expressing Mamu-B*08 may therefore provide an animal model for understanding CD8+ T cell-mediated control of HIV replication in humans.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2007-11-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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