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  1. Article: Investigating the Use of Pharmacogenetic and Pharmacometabolomic Markers to Predict Haloperidol Efficacy and Safety Rates.

    Skryabin, Valentin Yurievich / Zastrozhin, Mikhail Sergeevich / Parkhomenko, Aleksandra Aleksandrovna / Pankratenko, Ekaterina Petrovna / Pozdnyakov, Sergei Aleksandrovich / Denisenko, Natalia Pavlovna / Akmalova, Kristina Anatolyevna / Bryun, Evgeny Alekseevich / Sychev, Dmitry Alekseevich

    Hospital pharmacy

    2023  Volume 58, Issue 4, Page(s) 363–367

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1468893-1
    ISSN 0018-5787
    ISSN 0018-5787
    DOI 10.1177/00185787231155842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1758: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 21: Show issues

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  2. Article ; Online: Influence of ABCB1, CYP3A5 and CYP3A4 gene polymorphisms on prothrombin time and the residual equilibrium concentration of rivaroxaban in patients with non-valvular atrial fibrillation in real clinical practice.

    Sychev, Dmitry Alekseevitch / Sokolov, Aleksey Vladimirovich / Reshetko, Olga Vilorovna / Fisenko, Vladimir Petrovich / Sychev, Igor Nikolaevich / Grishina, Elena Anatolievna / Bochkov, Pavel Olegovich / Shevchenko, Roman Vladimirovich / Abdullaev, Sherzod Pardaboevich / Denisenko, Natalia Pavlovna / Ivashchenko, Dmitry Vladimirovich / Sozaeva, Zhannet Alimovna / Kachanova, Anastasia Alekseevna

    Pharmacogenetics and genomics

    2022  Volume 32, Issue 9, Page(s) 301–307

    Abstract: Objective: The study of ABCB1 and CYP3A4/3A5 gene polymorphism genes is promising in terms of their influence on prothrombin time variability, the residual equilibrium concentration of direct oral anticoagulants (DOACs) in patients with atrial ... ...

    Abstract Objective: The study of ABCB1 and CYP3A4/3A5 gene polymorphism genes is promising in terms of their influence on prothrombin time variability, the residual equilibrium concentration of direct oral anticoagulants (DOACs) in patients with atrial fibrillation and the development of new personalized approaches to anticoagulation therapy in these patients. The aim of the study is to evaluate the effect of ABCB1 (rs1045642) C>T; ABCB1 (rs4148738) C>T and CYP3A5 (rs776746) A>G, CYP3A4*22(rs35599367) C>T gene polymorphisms on prothrombin time level and residual equilibrium concentration of rivaroxaban in patients with atrial fibrillation.
    Methods: In total 86 patients (42 men and 44 female), aged 67.24 ± 1.01 years with atrial fibrillation were enrolled in the study. HPLC mass spectrometry analysis was used to determine rivaroxaban residual equilibrium concentration. Prothrombin time data were obtained from patient records.
    Results: The residual equilibrium concentration of rivaroxaban in patients with ABCB1 rs4148738 CT genotype is significantly higher than in patients with ABCB1 rs4148738 CC (P  = 0.039). The analysis of the combination of genotypes did not find a statistically significant role of combinations of alleles of several polymorphic markers in increasing the risk of hemorrhagic complications when taking rivaroxaban.
    Conclusion: Patients with ABCB1 rs4148738 CT genotype have a statistically significantly higher residual equilibrium concentration of rivaroxaban in blood than patients with ABCB1 rs4148738 CC genotype, which should be considered when assessing the risk of hemorrhagic complications and risk of drug-drug interactions. Further studies of the effect of rivaroxaban pharmacogenetics on the safety profile and efficacy of therapy are needed.
    MeSH term(s) Female ; Humans ; Male ; ATP Binding Cassette Transporter, Subfamily B/genetics ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/genetics ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Genotype ; Polymorphism, Genetic ; Prothrombin Time ; Rivaroxaban/adverse effects ; Aged
    Chemical Substances ABCB1 protein, human ; ATP Binding Cassette Transporter, Subfamily B ; CYP3A4 protein, human (EC 1.14.14.55) ; CYP3A5 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Rivaroxaban (9NDF7JZ4M3)
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175826-8
    ISSN 1744-6880 ; 0960-314X ; 1744-6872
    ISSN (online) 1744-6880
    ISSN 0960-314X ; 1744-6872
    DOI 10.1097/FPC.0000000000000483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: The impact of

    Sychev, Dmitriy Alekseevich / Levanov, Alexander Nikolaevich / Shelekhova, Tatiana Vladimirovna / Bochkov, Pavel Olegovich / Denisenko, Natalia Pavlovna / Ryzhikova, Kristina Anatolyevna / Mirzaev, Karin Badavievich / Grishina, Elena Anatolyevna / Gavrilov, Mikhail Alekseevich / Ramenskaya, Galina Vladislavovna / Kozlov, Aleksei Vladimirovich / Bogoslovsky, Tanya

    Pharmacogenomics and personalized medicine

    2018  Volume 11, Page(s) 127–137

    Abstract: Background: Non-vitamin K oral anticoagulants (NOACs) are commonly used for prophylaxis of venous thromboembolism (VTE) in orthopedic patients. Despite known safety and high potency of NOACs, potential interactions of NOACs with genetic polymorphisms ... ...

    Abstract Background: Non-vitamin K oral anticoagulants (NOACs) are commonly used for prophylaxis of venous thromboembolism (VTE) in orthopedic patients. Despite known safety and high potency of NOACs, potential interactions of NOACs with genetic polymorphisms are poorly understood. Dabigatran etexilate is one of the most commonly prescribed direct thrombin inhibitors for the prevention of VTE. The objectives of this study were to assess the effect of
    Patients and methods: A total of 60 patients, aged 37-81 years, who underwent surgery for knee replacement have been included in the study. VTE prophylaxis was conducted via administration of dabigatran etexilate 220 mg once daily. Genotyping for carrier state of polymorphic variants such as rs1045642 and rs4148738 of the
    Results: Our study revealed that TT genotype of rs1045642 polymorphism of the
    Conclusion: Our findings indicate that the polymorphisms of
    Language English
    Publishing date 2018-07-25
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2508173-1
    ISSN 1178-7066
    ISSN 1178-7066
    DOI 10.2147/PGPM.S169277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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