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  1. AU="Deniz Kantar"
  2. AU="Stucky, Cheryl L"
  3. AU="Higashino, Kosaku"
  4. AU="Johnston, Sara C"
  5. AU=Fisayo Temitope
  6. AU="Buret, Laetitia"
  7. AU=Guirao Antonio
  8. AU="Tang, Anthony"
  9. AU="Garnelo, Luiza"
  10. AU=Sakanari J A AU=Sakanari J A
  11. AU="Ni, Fuchuan"
  12. AU="Anithachristy S Arumanayagam"
  13. AU="Melman, Dick"

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  1. Artikel ; Online: Carnosic Acid Ameliorates Indomethacin-Induced Gastric Ulceration in Rats by Alleviating Oxidative Stress and Inflammation

    Betul Danisman / Betul Cicek / Serkan Yildirim / Ismail Bolat / Deniz Kantar / Kirill S. Golokhvast / Dragana Nikitovic / Aristidis Tsatsakis / Ali Taghizadehghalehjoughi

    Biomedicines, Vol 11, Iss 829, p

    2023  Band 829

    Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and indomethacin (IND) are the most commonly prescribed for inflammation or pain. However, widespread use causes several adverse effects, such as gastric ulcers, upper gastric system bleeding, ...

    Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and indomethacin (IND) are the most commonly prescribed for inflammation or pain. However, widespread use causes several adverse effects, such as gastric ulcers, upper gastric system bleeding, and erosions. Carnosic acid (CA) is an important natural antioxidant found in rosemary (Rosmarinus essentials) and exhibits a protective effect by suppressing oxidative stress and inflammation. This study aimed to investigate the impact of CA on IND-induced gastric ulceration. Wistar male rats received CA (100 mg/kg) or esomeprazole (ESP) (20 mg/kg, standard drug) by oral gavage for 14 days, after that gastric ulceration was induced by oral administration of 100 mg/kg IND. CA pretreatment attenuated both gross morphological lesions and histopathological alterations. CA strongly reduced IND-induced oxidative stress, verified by a decrease in MDA ( p < 0.001) and TOS levels ( p < 0.05). Furthermore, an IND-dependent increase in CAT ( p < 0.001) and GPx ( p < 0.01) activities, as well as a reduction in GSH levels ( p < 0.01), were ameliorated by CA pretreatment. CA also attenuated inflammatory damage by suppressing IL-1β ( p < 0.01), IL-6 ( p < 0.01), and TNFα ( p < 0.001) production and increasing Nrf2/HO-1 ( p < 0.05) expressions. In conclusion, CA shows a gastroprotective effect by reducing oxidative stress and attenuating inflammation.
    Schlagwörter indomethacin ; gastric ulcer ; carnosic acid ; inflammation ; oxidative stress ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The developmental effects of extremely low frequency electric fields on visual and somatosensory evoked potentials in adult rats.

    Gok, Deniz Kantar / Akpinar, Deniz / Hidisoglu, Enis / Ozen, Sukru / Agar, Aysel / Yargicoglu, Piraye

    Electromagnetic biology and medicine

    2016  Band 35, Heft 1, Seite(n) 65–74

    Abstract: The purpose of our study was to investigate the developmental effects of extremely low frequency electric fields (ELF-EFs) on visual evoked potentials (VEPs) and somatosensory-evoked potentials (SEPs) and to examine the relationship between lipid ... ...

    Abstract The purpose of our study was to investigate the developmental effects of extremely low frequency electric fields (ELF-EFs) on visual evoked potentials (VEPs) and somatosensory-evoked potentials (SEPs) and to examine the relationship between lipid peroxidation and changes of these potentials. In this context, thiobarbituric acid reactive substances (TBARS) levels were determined as an indicator of lipid peroxidation. Wistar albino female rats were divided into four groups; Control (C), gestational (prenatal) exposure (Pr), gestational+ postnatal exposure (PP) and postnatal exposure (Po) groups. Pregnant rats of Pr and PP groups were exposed to 50 Hz electric field (EF) (12 kV/m; 1 h/day), while those of C and Po groups were placed in an inactive system during pregnancy. Following parturition, rats of PP and Po groups were exposed to ELF-EFs whereas rats of C and Pr groups were kept under the same experimental conditions without being exposed to any EF during 68 days. On postnatal day 90, rats were prepared for VEP and SEP recordings. The latencies of VEP components in all experimental groups were significantly prolonged versus C group. For SEPs, all components of PP group, P2, N2 components of Pr group and P1, P2, N2 components of Po group were delayed versus C group. As brain TBARS levels were significantly increased in Pr and Po groups, retina TBARS levels were significantly elevated in all experimental groups versus C group. In conclusion, alterations seen in evoked potentials, at least partly, could be explained by lipid peroxidation in the retina and brain.
    Mesh-Begriff(e) Animals ; Electricity ; Evoked Potentials, Somatosensory ; Evoked Potentials, Visual ; Female ; Lipid Peroxidation ; Pregnancy ; Rats ; Rats, Wistar ; Thiobarbituric Acid Reactive Substances/metabolism
    Chemische Substanzen Thiobarbituric Acid Reactive Substances
    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2026727-7
    ISSN 1536-8386 ; 1061-9526
    ISSN (online) 1536-8386
    ISSN 1061-9526
    DOI 10.3109/15368378.2014.987923
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Effects of pre- and postnatal exposure to extremely low-frequency electric fields on mismatch negativity component of the auditory event-related potentials: Relation to oxidative stress.

    Akpınar, Deniz / Gok, Deniz Kantar / Hidisoglu, Enis / Aslan, Mutay / Ozen, Sukru / Agar, Aysel / Yargicoglu, Piraye

    Electromagnetic biology and medicine

    2016  Band 35, Heft 3, Seite(n) 245–259

    Abstract: In our previous study, the developmental effects of extremely low-frequency electric fields (ELF-EF) on visual and somatosensory evoked potentials in adult rats were studied. There is no study so far examining the effects of 50 Hz electric field (EF) on ... ...

    Abstract In our previous study, the developmental effects of extremely low-frequency electric fields (ELF-EF) on visual and somatosensory evoked potentials in adult rats were studied. There is no study so far examining the effects of 50 Hz electric field (EF) on mismatch negativity (MMN) recordings after exposure of rats during development. Therefore, our present study aimed to investigate MMN and oxidative brain damage in rats exposed to EF (12 kV/m, 1 h/day). Rats were divided into four groups, namely control (C), prenatal (Pr), postnatal (Po), and prenatal+postnatal (PP). Pregnant rats of Pr and PP groups were exposed to EF during pregnancy. Following birth, rats of PP and Po groups were exposed to EF for three months. After exposure to EF, MMN was recorded by electrodes positioned stereotaxically to the surface of the dura, and then brain tissues were removed for histological and biochemical analyses. The MMN amplitude was higher to deviant tones than to standard tones. It was decreased in all experimental groups compared with the C group. 4-Hydroxy-2-nonenal (4-HNE) levels were significantly increased in the Po group with respect to the C group, whereas they were significantly decreased in the PP group compared with Pr and Po groups. Protein carbonyl levels were significantly decreased in the PP group compared with C, Pr, and Po groups. EF decreased MMN amplitudes were possibly induced by lipid peroxidation.
    Mesh-Begriff(e) Aldehydes/metabolism ; Animals ; Apoptosis ; Brain/metabolism ; Brain/pathology ; Brain/physiopathology ; Electricity/adverse effects ; Evoked Potentials, Auditory ; Female ; Male ; Oxidative Stress ; Pregnancy ; Prenatal Exposure Delayed Effects/metabolism ; Prenatal Exposure Delayed Effects/pathology ; Prenatal Exposure Delayed Effects/physiopathology ; Rats ; Rats, Wistar
    Chemische Substanzen Aldehydes ; 4-hydroxy-2-nonenal (K1CVM13F96)
    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2026727-7
    ISSN 1536-8386 ; 1061-9526
    ISSN (online) 1536-8386
    ISSN 1061-9526
    DOI 10.3109/15368378.2015.1076727
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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