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  1. AU="Denness, Helene"
  2. AU="Zaidi, Emna"
  3. AU=Lando-King Elizabeth
  4. AU="Roodnat, Joke I"
  5. AU="Yu, Runjie"
  6. AU="Balaso Mohite, Sachin"
  7. AU="Gendelman, Howard E."
  8. AU="Mundkinajeddu, Deepak"
  9. AU="Abel Monteagudo-Mendoza"
  10. AU="Herskind, C"
  11. AU="Dąbrowski, M."
  12. AU="Uttam Kumar Roy"
  13. AU="Sawyer, Sarah L"
  14. AU="Maiti, Siddhartha"
  15. AU="Conley, Kenda"
  16. AU="Huang, Hsu Chih"
  17. AU="Dumont, Elise"
  18. AU="Christopher D. Pascoe"
  19. AU="Imura, Satoshi"
  20. AU="Sutherland, Kate D"
  21. AU="Xiao Jian"
  22. AU="Littler, Dene R." AU="Littler, Dene R."
  23. AU="Yoo, Byeongjun"

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  1. Artikel ; Online: Influenza vaccination for immunocompromised patients: summary of a systematic review and meta-analysis.

    Beck, Charles R / McKenzie, Bruce C / Hashim, Ahmed B / Harris, Rebecca C / Zanuzdana, Arina / Agboado, Gabriel / Orton, Elizabeth / Béchard-Evans, Laura / Morgan, Gemma / Stevenson, Charlotte / Weston, Rachel / Mukaigawara, Mitsuru / Enstone, Joanne / Augustine, Glenda / Butt, Mobasher / Kim, Sophie / Puleston, Richard / Dabke, Girija / Howard, Robert /
    O'Boyle, Julie / O'Brien, Mary / Ahyow, Lauren / Denness, Helene / Farmer, Siobhan / Figureroa, Jose / Fisher, Paul / Greaves, Felix / Haroon, Munib / Haroon, Sophie / Hird, Caroline / Isba, Rachel / Ishola, David A / Kerac, Marko / Parish, Vivienne / Roberts, Jonathan / Rosser, Julia / Theaker, Sarah / Wallace, Dean / Wigglesworth, Neil / Lingard, Liz / Vinogradova, Yana / Horiuchi, Hiroshi / Peñalver, Javier / Nguyen-Van-Tam, Jonathan S

    Influenza and other respiratory viruses

    2013  Band 7 Suppl 2, Seite(n) 72–75

    Abstract: Vaccination of immunocompromised patients is recommended in many national guidelines to protect against severe or complicated influenza infection. However, due to uncertainties over the evidence base, implementation is frequently patchy and dependent on ... ...

    Abstract Vaccination of immunocompromised patients is recommended in many national guidelines to protect against severe or complicated influenza infection. However, due to uncertainties over the evidence base, implementation is frequently patchy and dependent on individual clinical discretion. We conducted a systematic review and meta-analysis to assess the evidence for influenza vaccination in this patient group. Healthcare databases and grey literature were searched and screened for eligibility. Data extraction and assessments of risk of bias were undertaken in duplicate, and results were synthesised narratively and using meta-analysis where possible. Our data show that whilst the serological response following vaccination of immunocompromised patients is less vigorous than in healthy controls, clinical protection is still meaningful, with only mild variation in adverse events between aetiological groups. Although we encountered significant clinical and statistical heterogeneity in many of our meta-analyses, we advocate that immunocompromised patients should be targeted for influenza vaccination.
    Mesh-Begriff(e) Antibodies, Viral/blood ; Humans ; Immunocompromised Host ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/immunology ; Influenza, Human/prevention & control ; Vaccination/methods
    Chemische Substanzen Antibodies, Viral ; Influenza Vaccines
    Sprache Englisch
    Erscheinungsdatum 2013-09-30
    Erscheinungsland England
    Dokumenttyp Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2274538-5
    ISSN 1750-2659 ; 1750-2640
    ISSN (online) 1750-2659
    ISSN 1750-2640
    DOI 10.1111/irv.12084
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Influenza vaccination for immunocompromised patients: systematic review and meta-analysis from a public health policy perspective.

    Beck, Charles R / McKenzie, Bruce C / Hashim, Ahmed B / Harris, Rebecca C / Zanuzdana, Arina / Agboado, Gabriel / Orton, Elizabeth / Béchard-Evans, Laura / Morgan, Gemma / Stevenson, Charlotte / Weston, Rachel / Mukaigawara, Mitsuru / Enstone, Joanne / Augustine, Glenda / Butt, Mobasher / Kim, Sophie / Puleston, Richard / Dabke, Girija / Howard, Robert /
    O'Boyle, Julie / O'Brien, Mary / Ahyow, Lauren / Denness, Helene / Farmer, Siobhan / Figureroa, Jose / Fisher, Paul / Greaves, Felix / Haroon, Munib / Haroon, Sophie / Hird, Caroline / Isba, Rachel / Ishola, David A / Kerac, Marko / Parish, Vivienne / Roberts, Jonathan / Rosser, Julia / Theaker, Sarah / Wallace, Dean / Wigglesworth, Neil / Lingard, Liz / Vinogradova, Yana / Horiuchi, Hiroshi / Peñalver, Javier / Nguyen-Van-Tam, Jonathan S

    PloS one

    2011  Band 6, Heft 12, Seite(n) e29249

    Abstract: Background: Immunocompromised patients are vulnerable to severe or complicated influenza infection. Vaccination is widely recommended for this group. This systematic review and meta-analysis assesses influenza vaccination for immunocompromised patients ... ...

    Abstract Background: Immunocompromised patients are vulnerable to severe or complicated influenza infection. Vaccination is widely recommended for this group. This systematic review and meta-analysis assesses influenza vaccination for immunocompromised patients in terms of preventing influenza-like illness and laboratory confirmed influenza, serological response and adverse events.
    Methodology/principal findings: Electronic databases and grey literature were searched and records were screened against eligibility criteria. Data extraction and risk of bias assessments were performed in duplicate. Results were synthesised narratively and meta-analyses were conducted where feasible. Heterogeneity was assessed using I(2) and publication bias was assessed using Begg's funnel plot and Egger's regression test. Many of the 209 eligible studies included an unclear or high risk of bias. Meta-analyses showed a significant effect of preventing influenza-like illness (odds ratio [OR]=0.23; 95% confidence interval [CI]=0.16-0.34; p<0.001) and laboratory confirmed influenza infection (OR=0.15; 95% CI=0.03-0.63; p=0.01) through vaccinating immunocompromised patie nts compared to placebo or unvaccinated controls. We found no difference in the odds of influenza-like illness compared to vaccinated immunocompetent controls. The pooled odds of seroconversion were lower in vaccinated patients compared to immunocompetent controls for seasonal influenza A(H1N1), A(H3N2) and B. A similar trend was identified for seroprotection. Meta-analyses of seroconversion showed higher odds in vaccinated patients compared to placebo or unvaccinated controls, although this reached significance for influenza B only. Publication bias was not detected and narrative synthesis supported our findings. No consistent evidence of safety concerns was identified.
    Conclusions/significance: Infection prevention and control strategies should recommend vaccinating immunocompromised patients. Potential for bias and confounding and the presence of heterogeneity mean the evidence reviewed is generally weak, although the directions of effects are consistent. Areas for further research are identified.
    Mesh-Begriff(e) Health Policy ; Humans ; Immunocompromised Host ; Influenza Vaccines/adverse effects ; Influenza Vaccines/immunology ; Influenza Vaccines/therapeutic use ; Placebos ; Public Health
    Chemische Substanzen Influenza Vaccines ; Placebos
    Sprache Englisch
    Erscheinungsdatum 2011-12-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0029249
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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