Article: ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid-β copathology.
Alzheimer's & dementia (Amsterdam, Netherlands)
2019 Volume 11, Page(s) 277–280
Abstract: Introduction: Apolipoprotein E (ApoE) is the most important genetic risk factor for Alzheimer's disease (AD), with ApoE4 thought to enhance and accelerate amyloid-β (Aβ) pathology. ApoE4 has recently been described to increase neurodegeneration in a ... ...
| Abstract | Introduction: Apolipoprotein E (ApoE) is the most important genetic risk factor for Alzheimer's disease (AD), with ApoE4 thought to enhance and accelerate amyloid-β (Aβ) pathology. ApoE4 has recently been described to increase neurodegeneration in a mouse model of frontotemporal dementia (FTD), Methods: We analyzed 704 patients with FTD, including a genetically and neuropathologically confirmed subset, and 452 healthy elderly controls. We compared ApoE4 genotype frequency and age at onset in tau+ or TDP43+ FTD patients with or without Aβ copathology. Results: The ApoE4 genotype lowered age at onset in patients with FTD and tau pathology, particularly once accounting for confounding effects of Aβ pathology. Discussion: We conclude that ApoE4 accelerates neurodegeneration in FTD patients with |
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| Language | English |
| Publishing date | 2019-03-19 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2832898-X |
| ISSN | 2352-8729 |
| ISSN | 2352-8729 |
| DOI | 10.1016/j.dadm.2019.01.010 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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