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  1. Article ; Online: Why are we not optimising healthcare?

    Handley, Thomas / Denning, Max / Melcher, Marc L

    BMJ leader

    2023  

    Language English
    Publishing date 2023-01-26
    Publishing country England
    Document type Journal Article
    ISSN 2398-631X
    ISSN (online) 2398-631X
    DOI 10.1136/leader-2022-000674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Trainees and Reserve Service: maximising opportunities and avoiding pitfalls: a surgical perspective.

    Whitaker, John / Denning, M / Malik, N S / Cordell, R F / Macmillan, A / Bowley, D

    BMJ military health

    2019  Volume 167, Issue 1, Page(s) 5–7

    MeSH term(s) Clinical Competence/standards ; Humans ; Personnel Staffing and Scheduling/standards ; Personnel Staffing and Scheduling/trends ; Surgeons/education ; Surgeons/standards ; Surgeons/trends ; Training Support/methods ; United Kingdom
    Language English
    Publishing date 2019-10-03
    Publishing country England
    Document type Editorial
    ZDB-ID 3011686-7
    ISSN 2633-3775 ; 2633-3767
    ISSN (online) 2633-3775
    ISSN 2633-3767
    DOI 10.1136/jramc-2019-001324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: HealthCall: Smartphone Enhancement of Brief Interventions to Improve HIV Medication Adherence Among Patients in HIV Care.

    Knox, Justin / Aharonovich, Efrat / Zingman, Barry S / Stohl, Malka / Walsh, Claire / Elliott, Jennifer C / Fink, David S / Durant, Sean / Menchaca, Raquel / Sharma, Anjali / Denning, Maggie / Hasin, Deborah

    AIDS and behavior

    2024  

    Abstract: Heavy drinking among people living with HIV (PLWH) reduces ART adherence and worsens health outcomes. Lengthy interventions are not feasible in most HIV care settings, and patients infrequently follow referrals to outside treatment. Utilizing visual and ... ...

    Abstract Heavy drinking among people living with HIV (PLWH) reduces ART adherence and worsens health outcomes. Lengthy interventions are not feasible in most HIV care settings, and patients infrequently follow referrals to outside treatment. Utilizing visual and video features of smartphone technology, we developed HealthCall as an electronic means of increasing patient involvement in a brief intervention to reduce drinking and improve ART adherence. The objective of the current study is to evaluate the efficacy of HealthCall to improve ART adherence among PLWH who drink heavily when paired with two brief interventions: the National Institute on Alcoholism and Alcohol Abuse (NIAAA) Clinician's Guide (CG) or Motivational Interviewing (MI). Therefore, we conducted a 1:1:1 randomized trial among 114 participants with alcohol dependence at a large urban HIV clinic. Participants were randomized to one of three groups: (1) CG only (n = 37), (2) CG and HealthCall (n = 38), or (3) MI and HealthCall (n = 39). Baseline interventions targeting drinking reduction and ART adherence were ~ 25 min, with brief (10-15 min) booster sessions at 30 and 60 days. The outcome was ART adherence assessed using unannounced phone pill-count method (possible adherence scores: 0-100%) at 30-day, 60-day, 3, 6, and 12 months. Analyses were conducted using generalized linear mixed models with pre-planned contrasts. Of the 114 enrolled patients, 58% were male, 75% identified as Black/African American, 28% were Hispanic, and 62% had less than a high school education. The mean age was 47.5 years (standard deviation [SD]  10 years) and the mean number of years since they were diagnosed with HIV was 18.6 (SD 7.6). Participants assigned to HealthCall to extend the CG had increased levels of ART adherence at 60-day and 6-month follow-up (compared to CG only), although there was no statistically significant difference by 12-month follow-up. Participants who were assigned to HealthCall to extend the MI never had statistically significant higher levels of ART adherence. These results suggest that the use of a smartphone app can be used to initially extend the reach of a brief drinking intervention to improve ART adherence over a short period of time; however, sustained long-term improvements in ART adherence after intervention activity ends remains a challenge.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-024-04289-z
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  4. Article ; Online: The Association of Psychological Well-Being with Disablement Processes in a National Sample.

    Mishra, Aura Ankita / Friedman, Elliot M / Christ, Sharon L / Denning, Madison

    Applied psychology. Health and well-being

    2019  Volume 11, Issue 2, Page(s) 262–285

    Abstract: Objective: Objectives were to explore subgroups of individuals with differential disability trajectories and evaluate the protective effects of psychological well-being (i.e. hedonic and eudaimonic) in the presence of multiple disease conditions (or ... ...

    Abstract Objective: Objectives were to explore subgroups of individuals with differential disability trajectories and evaluate the protective effects of psychological well-being (i.e. hedonic and eudaimonic) in the presence of multiple disease conditions (or multimorbidity) and sociodemographic disadvantages.
    Methods: Data come from the prospective longitudinal cohort study the Midlife Development in the United States (n = 3,904). Three waves of data spanning a 20-year period were used to identify subgroups with different disability trajectories. Subgroup membership was then modelled as a function of psychological well-being assessed at wave 1 of the study using multinomial logistic regression.
    Results: Three unique groups were identified: a normative group with initially low and slowly increasing levels of disability; a group with high levels of disability that was stable over time; and a group with moderate initial levels of disability that increased over time. Hedonic well-being at wave 1 was associated with membership in the risk groups relative to the normative group.
    Conclusion: Individuals may follow one of three disability pathways mostly as a function of multimorbidity. However, hedonic well-being was associated with having an advantageous disability trajectory regardless of multimorbidity status. Cultivating psychological well-being may improve disability outcomes in aging individuals.
    MeSH term(s) Adult ; Aged ; Disabled Persons/psychology ; Female ; Health Status ; Humans ; Longitudinal Studies ; Male ; Mental Health ; Middle Aged ; Prospective Studies ; United States ; Young Adult
    Language English
    Publishing date 2019-02-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2483053-7
    ISSN 1758-0854 ; 1758-0846
    ISSN (online) 1758-0854
    ISSN 1758-0846
    DOI 10.1111/aphw.12152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Emergency cricothyroidotomy following tracheobronchial stenting.

    Cavinato, Simon Robert / Denning, Mike / Madden, Brendan P

    BMJ case reports

    2017  Volume 2017

    Abstract: A man aged 51 years was referred for tracheobronchial stenting after a poorly differentiated oesophageal carcinoma had progressed to cause stridor. Bronchoscopy revealed a left vocal cord palsy and tumour infiltration into the trachea. A tracheobronchial ...

    Abstract A man aged 51 years was referred for tracheobronchial stenting after a poorly differentiated oesophageal carcinoma had progressed to cause stridor. Bronchoscopy revealed a left vocal cord palsy and tumour infiltration into the trachea. A tracheobronchial stent was placed, and after distal migration was endoscopically resited. Returning from theatre, the patient developed severe upper airway obstruction that progressed to cause CO
    MeSH term(s) Airway Obstruction/etiology ; Airway Obstruction/surgery ; Bronchi ; Emergencies ; Esophageal Neoplasms/complications ; Humans ; Male ; Middle Aged ; Respiratory Sounds/etiology ; Self Expandable Metallic Stents/adverse effects ; Trachea
    Language English
    Publishing date 2017-02-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2016-218948
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  6. Article: The Modified Crescenteric Anterior Intercostal Perforator Flap.

    Denning, Max / Hayes, Philippa / Tsang, Fiona / Leff, Daniel / Thiruchelvam, Paul / Hadjiminas, Dimitri

    Plastic and reconstructive surgery. Global open

    2020  Volume 8, Issue 5, Page(s) e2785

    Abstract: Lower pole breast cancers are challenging to manage because conventional wide local excision may produce a "bird's beak" deformity. In an era of oncoplastic surgery, techniques that balance oncological results with cosmetic outcomes such as local flaps ... ...

    Abstract Lower pole breast cancers are challenging to manage because conventional wide local excision may produce a "bird's beak" deformity. In an era of oncoplastic surgery, techniques that balance oncological results with cosmetic outcomes such as local flaps have extended the role of breast-conserving surgery. Local flaps are particularly useful for partial breast reconstruction due to the relative simplicity of the surgical procedure and reduced morbidity. Intercostal artery perforator flaps have a shorter duration of surgery than free flaps and do not require microsurgical anastomoses. Anterior intercostal artery perforator (AICAP) flaps provide excellent cosmesis, yet traditional crescenteric harvest yields limited volume for reconstruction. We describe a modification to an established reconstructive technique for lower pole breast defects. The technique is based on 3 extensions of tissue, providing a larger volume of tissue replacement compared with traditional AICAP flaps. The technique is particularly suitable for small- and medium-sized non-ptotic breasts, with lower pole tumors. The modified crescenteric AICAP technique can be used to increase the available tissue when performing lower pole reconstructions.
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000002785
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    Zs.A 7091: Show issues Location:
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  7. Article: Assessing trauma care systems in low-income and middle-income countries: a systematic review and evidence synthesis mapping the Three Delays framework to injury health system assessments.

    Whitaker, John / O'Donohoe, Nollaig / Denning, Max / Poenaru, Dan / Guadagno, Elena / Leather, Andrew J M / Davies, Justine I

    BMJ global health

    2021  Volume 6, Issue 5

    Abstract: Background: The large burden of injuries falls disproportionately on low/middle-income countries (LMICs). Health system interventions improve outcomes in high-income countries. Assessing LMIC trauma systems supports their improvement. Evaluating systems ...

    Abstract Background: The large burden of injuries falls disproportionately on low/middle-income countries (LMICs). Health system interventions improve outcomes in high-income countries. Assessing LMIC trauma systems supports their improvement. Evaluating systems using a Three Delays framework, considering barriers to seeking (Delay 1), reaching (Delay 2) and receiving care (Delay 3), has aided maternal health gains. Rapid assessments allow timely appraisal within resource and logistically constrained settings. We systematically reviewed existing literature on the assessment of LMIC trauma systems, applying the Three Delays framework and rapid assessment principles.
    Methods: We conducted a systematic review and narrative synthesis of articles assessing LMIC trauma systems. We searched seven databases and grey literature for studies and reports published until October 2018. Inclusion criteria were an injury care focus and assessment of at least one defined system aspect. We mapped each study to the Three Delays framework and judged its suitability for rapid assessment.
    Results: Of 14 677 articles identified, 111 studies and 8 documents were included. Sub-Saharan Africa was the most commonly included region (44.1%). Delay 3, either alone or in combination, was most commonly assessed (79.3%) followed by Delay 2 (46.8%) and Delay 1 (10.8%). Facility assessment was the most common method of assessment (36.0%). Only 2.7% of studies assessed all Three Delays. We judged 62.6% of study methodologies potentially suitable for rapid assessment.
    Conclusions: Whole health system injury research is needed as facility capacity assessments dominate. Future studies should consider novel or combined methods to study Delays 1 and 2, alongside care processes and outcomes.
    MeSH term(s) Africa South of the Sahara ; Developing Countries ; Emergency Medical Services ; Humans ; Income ; Poverty
    Language English
    Publishing date 2021-05-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ISSN 2059-7908
    ISSN 2059-7908
    DOI 10.1136/bmjgh-2020-004324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Life and death signaling in epidermis: following a planned cell death pathway involving a trail that does not lead to skin cancer.

    Nickoloff, B J / Denning, M

    The Journal of investigative dermatology

    2001  Volume 117, Issue 1, Page(s) 1–2

    MeSH term(s) Apoptosis/physiology ; Epidermis/cytology ; Humans ; Signal Transduction/physiology ; Skin Neoplasms/pathology
    Language English
    Publishing date 2001-06-07
    Publishing country United States
    Document type Journal Article ; Review ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1046/j.1523-1747.2001.117001001.x
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  9. Article: Sensing and killing bacteria in skin: innate immune defense system: good and bad news.

    Nickoloff, B J / Denning, M

    The Journal of investigative dermatology

    2001  Volume 117, Issue 1, Page(s) 2, 170

    MeSH term(s) Humans ; Immunity, Innate/immunology ; Skin/immunology ; Staphylococcal Skin Infections/immunology ; Staphylococcus aureus
    Language English
    Publishing date 2001-07
    Publishing country United States
    Document type Comment ; Journal Article ; Review
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1046/j.1523-1747.2001.117001001.x
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  10. Article: C1q does not complement the removal of apoptotic keratinocytes in vivo.

    Nickoloff, B J / Denning, M

    The Journal of investigative dermatology

    2001  Volume 117, Issue 1, Page(s) 170

    MeSH term(s) Animals ; Apoptosis/immunology ; Complement C1q/immunology ; Keratinocytes/cytology ; Keratinocytes/immunology ; Phagocytosis/immunology
    Chemical Substances Complement C1q (80295-33-6)
    Language English
    Publishing date 2001-07
    Publishing country United States
    Document type Comment ; Journal Article ; Review
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1046/j.1523-1747.2001.117001001.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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