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  1. Article ; Online: Hebbian Learning on Small Data Enables Experimental Discovery of High

    Dennis, Joseph M / Zubarev, Dmitry Yu

    The journal of physical chemistry. A

    2021  Volume 125, Issue 31, Page(s) 6829–6835

    Abstract: We report a study combining computational design and experimental evaluation of polyimides with high glass transition temperatures: ...

    Abstract We report a study combining computational design and experimental evaluation of polyimides with high glass transition temperatures:
    Language English
    Publishing date 2021-07-30
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.1c02959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Primary Non Hodgkin’s Lymphoma of the Lacrimal Sac-A Noteworthy Watery Eye

    PAVITHRA THANIGAIVEL / LEENA DENNIS JOSEPH / VASUGI ARUMUGAM / SANJEEV MOHANTY

    Journal of Clinical and Diagnostic Research, Vol 15, Iss 9, Pp ED04-ED

    2021  Volume 06

    Abstract: Lacrimal sac tumours are rare tumours in ophthalmology but may have serious complications when misdiagnosed. Lacrimal sac tumours can be either epithelial or non epithelial tumours. Epithelial tumours account for 60-94% of tumours. Pseudostratified ... ...

    Abstract Lacrimal sac tumours are rare tumours in ophthalmology but may have serious complications when misdiagnosed. Lacrimal sac tumours can be either epithelial or non epithelial tumours. Epithelial tumours account for 60-94% of tumours. Pseudostratified ciliated columnar epithelium lines the lacrimal sac. Squamous cell carcinoma, transitional cell carcinoma, mucoepidermoid carcinoma, oncocytic adenocarcinoma, adenoid cystic carcinoma and metastasis are the commonly occurring epithelial tumours. Inverted papilloma is a locally aggressive tumour. Non epithelial tumours (25%) are rarer than the epithelial tumours. Lymphoproliferative, melanocytic, and mesenchymal tumours are the non epithelial tumours, among which the lymphoproliferative tumours constitute 2-8%. Very rarely Non Hodgkin’s lymphoma can occur as a primary in the lacrimal sac. Melanoma can occur as a primary from the melanocytes of the lining in the lacrimal sac or as a secondary from the conjuctival melanoma. Kaposi sarcoma and rhabdomyosarcoma are the mesenchymal tumours. Here is a case of Non Hodgkin’s Lymphoma (NHL) occurring in the lacrimal sac in an 80-year-old male. The patient came with the chief complaint of swelling around the right eye since two months. On radiological examination, Computed Tomography (CT) revealed a homogenous solid mass in the right medial canthus, causing bony erosions of the orbit and extending into the nasolacrimal canal. An incisional biopsy of the mass was consistent with the diagnosis of Non Hodgkin’s lymphoma which was further confirmed by immunohistochemistry. This unusual presentation and histopathological features are described.
    Keywords immunohistochemistry ; lymphoproliferative lesion ; non epithelial tumour ; orbit ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The false alarm

    Sanjivanee Ingole / V. Pavithra / Sandhya Sundaram / Leena Dennis Joseph / Syed Altaf Hussain / Bhawna Dev

    The Egyptian Journal of Radiology and Nuclear Medicine, Vol 53, Iss 1, Pp 1-

    Rosai–Dorfman disease of breast: case report

    2022  Volume 6

    Abstract: Abstract Introduction Rosai–Dorfman disease is a rare disorder caused by benign proliferation of histiocytes and thus also called sinus histiocytosis with massive lymphadenopathy. It is typically known to involve lymph nodes but can also affect extra ... ...

    Abstract Abstract Introduction Rosai–Dorfman disease is a rare disorder caused by benign proliferation of histiocytes and thus also called sinus histiocytosis with massive lymphadenopathy. It is typically known to involve lymph nodes but can also affect extra nodal sites with breast involvement being extremely rare. This disease is known to mimic malignancy clinically and on imaging. The final verdict is through histopathological evaluation. Case presentation We present a case of a 21-year-old female who presented with a palpable suspicious lump in right breast. Ultrasound, mammogram and MRI breast were done followed by fine needle aspiration, which showed lymphocytes and occasional histiocytes, which is suggestive of a lymphoid process. Surgical excision was done due to high suspicion of low-grade angiosarcoma in spite of a negative cytology. Diagnosis of Rosai–Dorfman disease was concluded after histopathological evaluation and was further confirmed by immunohistochemical staining by immunohistochemical markers S-100 and CD68. Conclusion Rosai–Dorfman disease can present as low-grade angiosarcoma clinically as well as on imaging. There is a need for high level of suspicion to rule out benign mimics of malignancy to avoid radical surgery. Final diagnosis is by histopathology along with immunohistochemical staining.
    Keywords Rosai–Dorfman disease ; Sinus histiocytosis ; Breast ; Benign mimic of malignancy ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 610
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book: Writing, publishing, and reading local gazetteers in imperial China, 1100 - 1700

    Dennis, Joseph

    (Harvard East Asian monographs ; 379)

    2015  

    Author's details Joseph Dennis
    Series title Harvard East Asian monographs ; 379
    Keywords Gazetteers/History ; China
    Language English
    Size XV, 390 S., Ill., Kt.
    Publisher Harvard Univ. Press
    Publishing place Cambridge, Mass. u.a.
    Document type Book
    Note Includes bibliographical references and index
    ISBN 9780674504295 ; 0674504291
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article ; Online: The Quest for the Ideal Base: Rational Design of a Nickel Precatalyst Enables Mild, Homogeneous C-N Cross-Coupling.

    Liu, Richard Y / Dennis, Joseph M / Buchwald, Stephen L

    Journal of the American Chemical Society

    2020  Volume 142, Issue 9, Page(s) 4500–4507

    Abstract: Palladium-catalyzed amination reactions using soluble organic bases have provided a solution to the many issues associated with heterogeneous reaction conditions. Still, homogeneous C-N cross-coupling approaches cannot yet employ bases as weak and ... ...

    Abstract Palladium-catalyzed amination reactions using soluble organic bases have provided a solution to the many issues associated with heterogeneous reaction conditions. Still, homogeneous C-N cross-coupling approaches cannot yet employ bases as weak and economical as trialkylamines. Furthermore, organic base-mediated methods have not been developed for Ni(0/II) catalysis, despite some advantages of such systems over those employing Pd-based catalysts. We designed a new air-stable and easily prepared Ni(II) precatalyst bearing an electron-deficient bidentate phosphine ligand that enables the cross-coupling of aryl triflates with aryl amines using triethylamine (TEA) as base. The method is tolerant of sterically congested coupling partners, as well as those bearing base- and nucleophile-sensitive functional groups. With the aid of density functional theory (DFT) calculations, we determined that the electron-deficient auxiliary ligands decrease both the p
    MeSH term(s) Aniline Compounds/chemical synthesis ; Aniline Compounds/chemistry ; Catalysis ; Coordination Complexes/chemistry ; Indoles/chemical synthesis ; Indoles/chemistry ; Ligands ; Mesylates/chemistry ; Nickel/chemistry ; Phosphines/chemistry
    Chemical Substances Aniline Compounds ; Coordination Complexes ; Indoles ; Ligands ; Mesylates ; Phosphines ; Nickel (7OV03QG267)
    Language English
    Publishing date 2020-02-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.0c00286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Utility of immunohistochemical expression of E-cadherin in colorectal carcinoma

    Sharmilla Devi Rajkumar / Barathi Gunabooshanam / Leena Dennis Joseph / Lawrence D’Cruze

    Gastroenterology Review, Vol 17, Iss 1, Pp 59-

    2021  Volume 66

    Keywords colorectal cancer ; e-cadherin ; immunohistochemistry ; prognosis ; Medicine ; R
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Nutrient and arsenic biogeochemistry of Sargassum in the western Atlantic.

    McGillicuddy, Dennis Joseph / Morton, Peter Lynn / Brewton, Rachel Aileen / Hu, Chuanmin / Kelly, Thomas Bryce / Solow, Andrew Robert / Lapointe, Brian Edward

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6205

    Abstract: The oceanographic ecology of pelagic Sargassum, and the means by which these floating macroalgae thrive in the nutrient-poor waters of the open ocean, have been studied for decades. Beginning in 2011, the Great Atlantic Sargassum Belt (GASB) emerged, ... ...

    Abstract The oceanographic ecology of pelagic Sargassum, and the means by which these floating macroalgae thrive in the nutrient-poor waters of the open ocean, have been studied for decades. Beginning in 2011, the Great Atlantic Sargassum Belt (GASB) emerged, with Sargassum proliferating in the tropical Atlantic and Caribbean where it had not previously been abundant. Here we show that the nutritional status of Sargassum in the GASB is distinct, with higher nitrogen and phosphorus content than populations residing in its Sargasso Sea habitat. Moreover, we find that variations in arsenic content of Sargassum reflect phosphorus limitation, following a hyperbolic relationship predicted from Michaelis-Menten nutrient uptake kinetics. Although the sources of nutrients fueling the GASB are not yet clear, our results suggest that nitrogen and phosphorus content of Sargassum, together with its isotopic composition, can be used to identify those sources, whether they be atmospheric, oceanic, or riverine in origin.
    MeSH term(s) Sargassum ; Arsenic ; Nitrogen ; Nutrients ; Phosphorus ; Atlantic Ocean
    Chemical Substances Arsenic (N712M78A8G) ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W)
    Language English
    Publishing date 2023-10-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-41904-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Doubly Threaded Slide-Ring Polycatenane Networks.

    Hart, Laura F / Lenart, William R / Hertzog, Jerald E / Oh, Jongwon / Turner, Wilson R / Dennis, Joseph M / Rowan, Stuart J

    Journal of the American Chemical Society

    2023  Volume 145, Issue 22, Page(s) 12315–12323

    Abstract: Crosslinking in polymer networks leads to intrinsic structural inhomogeneities that result in brittle materials. Replacing fixed covalent crosslinks with mobile ones in mechanically interlocked polymers (MIPs), such as in slide-ring networks (SRNs) in ... ...

    Abstract Crosslinking in polymer networks leads to intrinsic structural inhomogeneities that result in brittle materials. Replacing fixed covalent crosslinks with mobile ones in mechanically interlocked polymers (MIPs), such as in slide-ring networks (SRNs) in which interlocked crosslinks are formed when polymer chains are threaded through crosslinked rings, can lead to tougher, more robust networks. An alternative class of MIPs is the polycatenane network (PCN), in which the covalent crosslinks are replaced with interlocked rings that introduce the unusual catenane's mobility elements (elongation, rotation, and twisting) as connections between polymer chains. A slide-ring polycatenane network (SR-PCN), with doubly threaded rings embedded as crosslinks in a covalent network, combines the mobility features of both the SRNs and PCNs, where the catenated ring crosslinks can slide along the polymer backbone between the two limits of network bonding (covalent and interlocked). This work explores using a metal ion-templated doubly threaded pseudo[3]rotaxane (P3R) crosslinker, combined with a covalent crosslinker and a chain extender, to access such networks. A catalyst-free nitrile-oxide/alkyne cycloaddition polymerization was used to vary the ratio of P3R and covalent crosslinker to yield a series of SR-PCNs that vary in the amount of interlocked crosslinking units. Studies on their mechanical properties show that metal ions fix the rings in the network, leading to similar behavior as the covalent PEG gels. Removal of the metal ion frees the rings resulting in a high-frequency transition attributed to the additional relaxation of polymer chains through the catenated rings while also increasing the rate of poroelastic draining at longer timescales.
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c02837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Accessing pluripotent materials through tempering of dynamic covalent polymer networks.

    Boynton, Nicholas R / Dennis, Joseph M / Dolinski, Neil D / Lindberg, Charlie A / Kotula, Anthony P / Grocke, Garrett L / Vivod, Stephanie L / Lenhart, Joseph L / Patel, Shrayesh N / Rowan, Stuart J

    Science (New York, N.Y.)

    2024  Volume 383, Issue 6682, Page(s) 545–551

    Abstract: Pluripotency, which is defined as a system not fixed as to its developmental potentialities, is typically associated with biology and stem cells. Inspired by this concept, we report synthetic polymers that act as a single "pluripotent" feedstock and can ... ...

    Abstract Pluripotency, which is defined as a system not fixed as to its developmental potentialities, is typically associated with biology and stem cells. Inspired by this concept, we report synthetic polymers that act as a single "pluripotent" feedstock and can be differentiated into a range of materials that exhibit different mechanical properties, from hard and brittle to soft and extensible. To achieve this, we have exploited dynamic covalent networks that contain labile, dynamic thia-Michael bonds, whose extent of bonding can be thermally modulated and retained through tempering, akin to the process used in metallurgy. In addition, we show that the shape memory behavior of these materials can be tailored through tempering and that these materials can be patterned to spatially control mechanical properties.
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adi5009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Asymptomatic Solitary Mastocytoma with Negative Darier’s Sign

    Azra Fathima / Krishnakanth Muralidhar / Mahalakshmi Veeraraghavan / R Madhu / Leena Dennis Joseph / Murugan Sundaram

    Journal of Clinical and Diagnostic Research, Vol 14, Iss 5, Pp WD01-WD

    2020  Volume 03

    Abstract: Mastocytosis is a heterogenous group of disorders characterised by clonal proliferation of mast cells accumulating in single or multiple organs in children or adults. Skin is the most common organ involved in children. It usually presents as a nodule or ... ...

    Abstract Mastocytosis is a heterogenous group of disorders characterised by clonal proliferation of mast cells accumulating in single or multiple organs in children or adults. Skin is the most common organ involved in children. It usually presents as a nodule or plaque, yellow to tan-brown in colour remaining asymptomatic or may become red and itchy on rubbing indicating Darier’s sign positivity which helps in clinical diagnosis of mastocytosis. This case is of a three-month-old baby who presented with solitary asymptomatic noduloplaque with negative Darier’s sign which was clinically suspected to be mastocytosis and was confirmed by histopathology and immunohistochemistry.
    Keywords good prognosis ; noduloplaque ; non-itchy ; paediatric mastocytosis ; Medicine ; R
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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