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  1. Article ; Online: COVID-19 Vaccination and Serological Profile of a Brazilian University Population

    Marina dos Santos Barreto / Beatriz Soares da Silva / Ronaldy Santana Santos / Deise Maria Rego Rodrigues Silva / Eloia Emanuelly Dias Silva / Pedro Henrique Macedo Moura / Jessiane Bispo de Souza / Lucas Alves da Mota Santana / Dennyson Leandro M. Fonseca / Igor Salerno Filgueiras / Adriana Gibara Guimarães / Otavio Cabral-Marques / Lena F. Schimke / Lysandro Pinto Borges

    Life, Vol 13, Iss 1925, p

    2023  Volume 1925

    Abstract: Background: COVID-19 led to the suspension academic activities worldwide, affecting millions of students and staff. Methods: In this study, we evaluated the presence of IgM and IgG anti-SARS-CoV-2 antibodies in an academic population during the return to ...

    Abstract Background: COVID-19 led to the suspension academic activities worldwide, affecting millions of students and staff. Methods: In this study, we evaluated the presence of IgM and IgG anti-SARS-CoV-2 antibodies in an academic population during the return to classes after a one-year suspension. The study took place over five months at a Brazilian university and included 942 participants. Results: We found that most participants had reactive IgG and non-reactive IgM. All received at least one dose, and 940 received two or more doses, of different COVID-19 vaccines. We obtained a higher average of memory antibodies (IgG) in participants who received the CoronaVac/ChAdOx1 combination. IgG was consistently distributed for each vaccine group, but individuals who completed the vaccination schedule had higher levels. There were no differences between antibodies and gender, presence of symptoms, and previous COVID-19 infection, but older participants (>53 years) and contacts of infected individuals had higher IgM levels. Conclusion: This study makes significant contributions to the assessment of antibodies in the academic environment, allowing us to infer that most participants had memory immunity and low indications of recent infection when returning to face-to-face classes, as well as demonstrating the need to monitor immunity and update vaccinations.
    Keywords COVID-19 ; antibodies ; universities ; academic population ; vaccines ; Brazil ; Science ; Q
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Corrigendum to “Cross-sectional analysis of students and school workers reveals a high number of asymptomatic SARS-CoV-2 infections during school reopening in Brazilian cities” [Heliyon 8 (11) (November 2022) Article e11368]

    Lysandro P. Borges / Adriana G. Guimarães / Dennyson Leandro M. Fonseca / Paula P. Freire / Íkaro D.C. Barreto / Daniela R.V. Souza / Ricardo Q. Gurgel / Aline S.A. Lopes / José Melquiades de Rezende Neto / Kezia A. dos Santos / Igor L.S. Matos / Grazielly B. da Invenção / Brenda M. Oliveira / Aryanne A. Santos / Daniele Almeida Soares / Pamela C. de Jesus / Cliomar A. dos Santos / Marco A.O. Goes / Desirée Rodrigues Plaça /
    Igor Salerno Filgueiras / Alexandre H.C. Marques / Gabriela Crispim Baiocchi / William CabralMiranda / Gustavo Cabral de Miranda / Niels Olsen Saraiva Camara / Vera Lúcia Garcia Calich / Rodrigo Nalio Ramos / Helder I. Nakaya / Vanderson Rocha / Lasse M. Giil / Hans D. Ochs / Lena F. Schimke / Mércia S.F. de Souza / Luis E. Cuevas / Aline F. Martins / Otavio Cabral-Marques

    Heliyon, Vol 9, Iss 3, Pp e14398- (2023)

    2023  

    Keywords Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response

    Ranieri Coelho Salgado / Dennyson Leandro M. Fonseca / Alexandre H. C. Marques / Sarah Maria da Silva Napoleao / Tábata Takahashi França / Karen Tiemi Akashi / Caroline Aliane de Souza Prado / Gabriela Crispim Baiocchi / Desirée Rodrigues Plaça / Gabriel Jansen-Marques / Igor Salerno Filgueiras / Roberta De Vito / Paula Paccielli Freire / Gustavo Cabral de Miranda / Niels Olsen Saraiva Camara / Vera Lúcia Garcia Calich / Hans D. Ochs / Lena F. Schimke / Igor Jurisica /
    Antonio Condino-Neto / Otavio Cabral-Marques

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 17

    Abstract: Abstract Fungal infections represent a major global health problem affecting over a billion people that kills more than 1.5 million annually. In this study, we employed an integrative approach to reveal the landscape of the human immune responses to ... ...

    Abstract Abstract Fungal infections represent a major global health problem affecting over a billion people that kills more than 1.5 million annually. In this study, we employed an integrative approach to reveal the landscape of the human immune responses to Candida spp. through meta-analysis of microarray, bulk, and single-cell RNA sequencing (scRNA-seq) data for the blood transcriptome. We identified across these different studies a consistent interconnected network interplay of signaling molecules involved in both Toll-like receptor (TLR) and interferon (IFN) signaling cascades that is activated in response to different Candida species (C. albicans, C. auris, C. glabrata, C. parapsilosis, and C. tropicalis). Among these molecules are several types I IFN, indicating an overlap with antiviral immune responses. scRNA-seq data confirmed that genes commonly identified by the three transcriptomic methods show cell type-specific expression patterns in various innate and adaptive immune cells. These findings shed new light on the anti-Candida immune response, providing putative molecular pathways for therapeutic intervention.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Cross-sectional analysis of students and school workers reveals a high number of asymptomatic SARS-CoV-2 infections during school reopening in Brazilian cities

    Lysandro P. Borges / Adriana G. Guimarães / Dennyson Leandro M. Fonseca / Paula P. Freire / Íkaro D.C. Barreto / Daniela R.V. Souza / Ricardo Q. Gurgel / Aline S.A. Lopes / José Melquiades de Rezende Neto / Kezia A. dos Santos / Igor L.S. Matos / Grazielly B. da Invenção / Brenda M. Oliveira / Aryanne A. Santos / Daniele Almeida Soares / Pamela C. de Jesus / Cliomar A. dos Santos / Marco A.O. Goes / Desirée Rodrigues Plaça /
    Igor Salerno Filgueiras / Alexandre H.C. Marques / Gabriela Crispim Baiocchi / William Cabral-Miranda / Gustavo Cabral de Miranda / Niels Olsen Saraiva Camara / Vera Lúcia Garcia Calich / Rodrigo Nalio Ramos / Helder I. Nakaya / Vanderson Rocha / Lasse M. Giil / Hans D. Ochs / Lena F. Schimke / Mércia S.F. de Souza / Luis E. Cuevas / Aline F. Martins / Otavio Cabral-Marques

    Heliyon, Vol 8, Iss 11, Pp e11368- (2022)

    2022  

    Abstract: Brazil experienced one of the most prolonged periods of school closures, and reopening could have exposed students to high rates of SARS-CoV-2 infection. However, the infection status of students and school workers at the time of the reopening of schools ...

    Abstract Brazil experienced one of the most prolonged periods of school closures, and reopening could have exposed students to high rates of SARS-CoV-2 infection. However, the infection status of students and school workers at the time of the reopening of schools located in Brazilian cities is unknown. Here we evaluated viral carriage by RT-PCR and seroprevalence of anti-SARS-CoV-2 antibodies (IgM and IgG) by immunochromatography in 2259 individuals (1139 students and 1120 school workers) from 28 schools in 28 Brazilian cities. We collected the samples within 30 days after public schools reopened and before the start of vaccination campaigns. Most students (n = 421) and school workers (n = 446) had active (qRT-PCR + IgM− IgG− or qRT-PCR + IgM + IgG−/+) SARS-CoV-2 infection. Regression analysis indicated a strong association between the infection status of students and school workers. Furthermore, while 45% (n = 515) of the students and 37% (n = 415) of the school workers were neither antigen nor antibody positive in laboratory tests, 16% of the participants (169 students and 193 school workers) were oligosymptomatic, including those reinfected. These individuals presented mild symptoms such as headache, sore throat, and cough. Notably, most of the individuals were asymptomatic (83.9%). These results indicate that many SARS-CoV-2 infections in Brazilian cities during school reopening were asymptomatic. Thus, our study highlights the need to promote a coordinated public health effort to guarantee a safe educational environment while avoiding exacerbating pre-existent social inequalities in Brazil, reducing social, mental, and economic losses for students, school workers, and their families.
    Keywords Asymptomatic SARS-CoV-2 infection ; Anti-SARS-CoV-2 antibodies ; Seroprevalence ; School reopening ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 370
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States

    Lena F. Schimke / Alexandre H. C. Marques / Gabriela Crispim Baiocchi / Caroline Aliane de Souza Prado / Dennyson Leandro M. Fonseca / Paula Paccielli Freire / Desirée Rodrigues Plaça / Igor Salerno Filgueiras / Ranieri Coelho Salgado / Gabriel Jansen-Marques / Antonio Edson Rocha Oliveira / Jean Pierre Schatzmann Peron / Gustavo Cabral-Miranda / José Alexandre Marzagão Barbuto / Niels Olsen Saraiva Camara / Vera Lúcia Garcia Calich / Hans D. Ochs / Antonio Condino-Neto / Katherine A. Overmyer /
    Joshua J. Coon / Joseph Balnis / Ariel Jaitovich / Jonas Schulte-Schrepping / Thomas Ulas / Joachim L. Schultze / Helder I. Nakaya / Igor Jurisica / Otávio Cabral-Marques

    Cells, Vol 11, Iss 847, p

    2022  Volume 847

    Abstract: Severe COVID-19 patients present a clinical and laboratory overlap with other hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH). However, the underlying mechanisms of these conditions remain to be explored. Here, we ... ...

    Abstract Severe COVID-19 patients present a clinical and laboratory overlap with other hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH). However, the underlying mechanisms of these conditions remain to be explored. Here, we investigated the transcriptome of 1596 individuals, including patients with COVID-19 in comparison to healthy controls, other acute inflammatory states (HLH, multisystem inflammatory syndrome in children [MIS-C], Kawasaki disease [KD]), and different respiratory infections (seasonal coronavirus, influenza, bacterial pneumonia). We observed that COVID-19 and HLH share immunological pathways (cytokine/chemokine signaling and neutrophil-mediated immune responses), including gene signatures that stratify COVID-19 patients admitted to the intensive care unit (ICU) and COVID-19_nonICU patients. Of note, among the common differentially expressed genes (DEG), there is a cluster of neutrophil-associated genes that reflects a generalized hyperinflammatory state since it is also dysregulated in patients with KD and bacterial pneumonia. These genes are dysregulated at the protein level across several COVID-19 studies and form an interconnected network with differentially expressed plasma proteins that point to neutrophil hyperactivation in COVID-19 patients admitted to the intensive care unit. scRNAseq analysis indicated that these genes are specifically upregulated across different leukocyte populations, including lymphocyte subsets and immature neutrophils. Artificial intelligence modeling confirmed the strong association of these genes with COVID-19 severity. Thus, our work indicates putative therapeutic pathways for intervention.
    Keywords COVID-19 ; neutrophil activation ; acute inflammatory states ; transcriptome profile ; integrative analysis of omics data ; systems biology ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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