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  1. Article ; Online: Feasibility of Automated Gonioscopy Imaging in Clinical Practice.

    Barbour-Hastie, Catriona / Deol, Sundeep S / Peroni, Andrea / Gillan, Stewart / Trucco, Emanuele / Tatham, Andrew J

    Journal of glaucoma

    2022  Volume 32, Issue 3, Page(s) 159–164

    Abstract: Prcis: Automated gonioscopy provided good-quality images of the anterior chamber angle. There was a short learning curve for operators, and the examination was well tolerated by patients. Patients expressed a preference for automated gonioscopy compared ...

    Abstract Prcis: Automated gonioscopy provided good-quality images of the anterior chamber angle. There was a short learning curve for operators, and the examination was well tolerated by patients. Patients expressed a preference for automated gonioscopy compared with traditional gonioscopy.
    Purpose: The purpose of this study was to assess the feasibility of using a desktop automated gonioscopy camera in glaucoma clinics by examining patient tolerability, ease of use, and image quality and comparing patient preference compared with traditional gonioscopy.
    Patients and methods: A prospective study was conducted in a university hospital clinic. Traditional gonioscopy was performed followed by imaging of the iridocorneal angle (ICA) using the Nidek GS-1 camera by 2 glaucoma specialists. Participants were asked to rate the comfort of automated gonioscopy and which method they preferred. The clinicians graded the ease of acquisition for each patient, and the image quality was reviewed by a grader.
    Results: Forty-three eyes of 25 participants were included. Sixty-eight percent of participants viewed automated gonioscopy as "extremely comfortable," and the remainder reported it "comfortable". Forty percent preferred automated gonioscopy compared with traditional gonioscopy, while 52% were equivocal. Clinicians scored 32% of participants as "somewhat difficult" to the image. In 46% of eyes, good-quality photographs were obtained for 360 degrees of the ICA. Only 1 eye had no parts of the ICA clearly visible. Seventy-four percent of eyes had at least half of the ICA clearly visible in all 4 quadrants.
    Conclusion: Automated gonioscopy provided good-quality images of the ICA for most patients. It was often not possible to image the entire 360 degrees at the first attempt, but the examination was comfortable for patients, and only 8% preferred traditional gonioscopy to the automated photographic examination.
    MeSH term(s) Humans ; Feasibility Studies ; Gonioscopy ; Prospective Studies ; Intraocular Pressure ; Photography ; Glaucoma/diagnosis
    Language English
    Publishing date 2022-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 913494-3
    ISSN 1536-481X ; 1057-0829
    ISSN (online) 1536-481X
    ISSN 1057-0829
    DOI 10.1097/IJG.0000000000002162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A case and literature review of orbital microcystic adnexal carcinoma.

    Brent, Alexander J / Deol, Sundeep S / Vaidhyanath, Ram / Saldanha, Gerald / Sampath, Raghavan

    Orbit (Amsterdam, Netherlands)

    2018  Volume 37, Issue 6, Page(s) 472–475

    Abstract: Microcystic adnexal carcinoma (MAC) is a very rare and locally aggressive sweat gland tumour. MAC has been well reported presenting as a periocular cutaneous lesion, rarely with subsequent direct orbital invasion and only once as a primary orbital lesion. ...

    Abstract Microcystic adnexal carcinoma (MAC) is a very rare and locally aggressive sweat gland tumour. MAC has been well reported presenting as a periocular cutaneous lesion, rarely with subsequent direct orbital invasion and only once as a primary orbital lesion. Local recurrence is frequent after primary surgical excision and the role of adjuvant radiotherapy is ill-defined. We describe a case of orbital MAC treated successfully with radiotherapy after incomplete margin clearance post exenteration surgery and review the associated literature.
    MeSH term(s) Adult ; Combined Modality Therapy ; Humans ; Magnetic Resonance Imaging ; Male ; Ophthalmologic Surgical Procedures ; Orbital Neoplasms/diagnostic imaging ; Orbital Neoplasms/pathology ; Orbital Neoplasms/therapy ; Radiotherapy ; Sweat Gland Neoplasms/diagnostic imaging ; Sweat Gland Neoplasms/pathology ; Sweat Gland Neoplasms/therapy ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-02-20
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 603157-2
    ISSN 1744-5108 ; 0167-6830
    ISSN (online) 1744-5108
    ISSN 0167-6830
    DOI 10.1080/01676830.2018.1440607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Feasibility and clinical utility of handheld fundus cameras for retinal imaging.

    Das, Susmit / Kuht, Helen J / De Silva, Ian / Deol, Sundeep S / Osman, Lina / Burns, Joyce / Sarvananthan, Nagini / Sarodia, Usman / Kapoor, Bharat / Islam, Tahir / Sampath, Raghavan / Poyser, Alicia / Konidaris, Vasileios / Anzidei, Rossella / Proudlock, Frank A / Thomas, Mervyn G

    Eye (London, England)

    2022  Volume 37, Issue 2, Page(s) 274–279

    Abstract: Background/objectives: Handheld fundus cameras are portable and cheaper alternatives to table-top counterparts. To date there have been no studies comparing feasibility and clinical utility of handheld fundus cameras to table-top devices. We compare the ...

    Abstract Background/objectives: Handheld fundus cameras are portable and cheaper alternatives to table-top counterparts. To date there have been no studies comparing feasibility and clinical utility of handheld fundus cameras to table-top devices. We compare the feasibility and clinical utility of four handheld fundus cameras/retinal imaging devices (Remidio NMFOP, Volk Pictor Plus, Volk iNview, oDocs visoScope) to a table-top camera (Zeiss Visucam
    Subjects/methods: Healthy participants (n = 10, mean age ± SD = 21.0 ± 0.9 years) underwent fundus photography with five devices to assess success/failure rates of image acquisition. Participants with optic disc abnormalities (n = 8, mean age ± SD = 26.8 ± 15.9) and macular abnormalities (n = 10, mean age ± SD = 71.6 ± 15.4) underwent imaging with the top three scoring fundus cameras. Images were randomised and subsequently validated by ophthalmologists masked to the diagnoses and devices used.
    Results: Image acquisition success rates (100%) were achieved in non-mydriatic and mydriatic settings for Zeiss, Remidio and Pictor, compared with lower success rates for iNview and oDocs. Image quality and gradeability were significantly higher for Zeiss, Remidio and Pictor (p < 0.0001) compared to iNview and oDocs. For cup:disc ratio estimates, similar levels of bias were seen for Zeiss (-0.09 ± SD:0.15), Remidio (-0.07 ± SD:0.14) and Pictor (-0.05 ± SD:0.16). Diagnostic sensitivities were highest for Zeiss (84.9%; 95% CI, 78.2-91.5%) followed by Pictor (78.1%; 95% CI, 66.6-89.5%) and Remidio (77.5%; 95% CI, 65.9-89.0%).
    Conclusions: Remidio and Pictor achieve comparable results to the Zeiss table-top camera. Both devices achieved similar scores in feasibility, image quality, image gradeability and diagnostic sensitivity. This suggests that these devices potentially offer a more cost-effective alternative in certain clinical scenarios.
    MeSH term(s) Humans ; Feasibility Studies ; Retina/diagnostic imaging ; Fluorescein Angiography ; Diagnostic Techniques, Ophthalmological ; Photography/methods ; Fundus Oculi
    Language English
    Publishing date 2022-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-021-01926-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: Feasibility and clinical utility of handheld fundus cameras for retinal imaging.

    Das, Susmit / Kuht, Helen J / De Silva, Ian / Deol, Sundeep S / Osman, Lina / Burns, Joyce / Sarvananthan, Nagini / Sarodia, Usman / Kapoor, Bharat / Islam, Tahir / Sampath, Raghavan / Poyser, Alicia / Konidaris, Vasileios / Anzidei, Rossella / Proudlock, Frank A / Thomas, Mervyn G

    Eye (London, England)

    2022  Volume 37, Issue 2, Page(s) 380–381

    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Published Erratum
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-022-02041-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impact of COVID-19 pandemic and lockdown on retinal detachments.

    Poyser, Alicia / Deol, Sundeep S / Osman, Lina / Sivagnanasithiyar, Tharsica / Kuht, Helen J / Manrique, Roslyn / Okafor, Linda O / Sharpe, David / Savant, Vijay / Sarodia, Usman / Sarvananthan, Nagini / Chaudhuri, Ray / Banerjee, Somnath / Burns, Joyce / Thomas, Mervyn G

    Eye (London, England)

    2020  Volume 35, Issue 8, Page(s) 2322–2323

    MeSH term(s) COVID-19 ; Communicable Disease Control ; Humans ; Pandemics ; Retinal Detachment/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-18
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-020-01137-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Impact of COVID-19 pandemic and lockdown on eye emergencies.

    Poyser, Alicia / Deol, Sundeep S / Osman, Lina / Kuht, Helen J / Sivagnanasithiyar, Tharsica / Manrique, Roslyn / Okafor, Linda O / DeSilva, Ian / Sharpe, David / Savant, Vijay / Sarodia, Usman / Sarvananthan, Nagini / Chaudhuri, Ray / Banerjee, Somnath / Burns, Joyce / Thomas, Mervyn G

    European journal of ophthalmology

    2020  Volume 31, Issue 6, Page(s) 2894–2900

    Abstract: Background: To characterise and compare ocular pathologies presenting to an emergency eye department (EED) during the COVID-19 pandemic in 2020 against an equivalent period in 2019.: Methods: Electronic patient records of 852 patients in 2020 and ... ...

    Abstract Background: To characterise and compare ocular pathologies presenting to an emergency eye department (EED) during the COVID-19 pandemic in 2020 against an equivalent period in 2019.
    Methods: Electronic patient records of 852 patients in 2020 and 1818 patients in 2019, attending the EED at a tertiary eye centre (University Hospitals of Leicester, UK) were analysed. Data was extracted over a 31-day period during: (study period 1 (SP1)) COVID-19 pandemic lockdown in UK (24th March 2020-23rd April 2020) and (study period 2 (SP2)) the equivalent 2019 period (24th March 2019-23rd April 2019).
    Results: A 53% reduction in EED attendance was noted during lockdown. The top three pathologies accounting for >30% of the caseload were trauma-related, keratitis and uveitis in SP1 in comparison to conjunctivitis, trauma-related and blepharitis in SP2. The overall number of retinal tears and retinal detachments (RD) were lower in SP1, the proportion of macula-off RD's (84.6%) was significantly (
    Conclusion: COVID-19 pandemic related lockdown has had a significant impact on the range of presenting conditions to the EED. Measures to stop spread of COVID-19 such as awareness of hand hygiene practices, social distancing measures and school closures could have an indirect role in reducing spread of infective conjunctivitis. The higher proportion of macula-off RD and lower number of retinal tears raises possibility of delayed presentation in these cases. Going forward, we anticipate additional pressures on EED and other subspecialty services due to complications and associated morbidity from delayed presentations.
    MeSH term(s) COVID-19 ; Communicable Disease Control ; Emergencies ; Humans ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-11-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/1120672120974944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Impact of COVID-19 pandemic and lockdown on retinal detachments

    Poyser, Alicia / Deol, Sundeep S / Osman, Lina / Sivagnanasithiyar, Tharsica / Kuht, Helen J / Manrique, Roslyn / Okafor, Linda O / Sharpe, David / Savant, Vijay / Sarodia, Usman / Sarvananthan, Nagini / Chaudhuri, Ray / Banerjee, Somnath / Burns, Joyce / Thomas, Mervyn G
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #723120
    Database COVID19

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  8. Article ; Online: Impact of COVID-19 pandemic and lockdown on retinal detachments

    Poyser, Alicia / Deol, Sundeep S. / Osman, Lina / Sivagnanasithiyar, Tharsica / Kuht, Helen J. / Manrique, Roslyn / Okafor, Linda O. / Sharpe, David / Savant, Vijay / Sarodia, Usman / Sarvananthan, Nagini / Chaudhuri, Ray / Banerjee, Somnath / Burns, Joyce / Thomas, Mervyn G.

    Eye ; ISSN 0950-222X 1476-5454

    2020  

    Keywords Ophthalmology ; General Arts and Humanities ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1038/s41433-020-01137-x
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Molecular dynamics simulations of GlpF in a micelle vs in a bilayer: conformational dynamics of a membrane protein as a function of environment.

    Patargias, George / Bond, Peter J / Deol, Sundeep S / Sansom, Mark S P

    The journal of physical chemistry. B

    2006  Volume 109, Issue 1, Page(s) 575–582

    Abstract: Octyl glucoside (OG) is a detergent widely employed in structural and functional studies of membrane proteins. To better understand the nature of protein-OG interactions, molecular dynamics simulations (duration 10 ns) have been used to explore an alpha- ... ...

    Abstract Octyl glucoside (OG) is a detergent widely employed in structural and functional studies of membrane proteins. To better understand the nature of protein-OG interactions, molecular dynamics simulations (duration 10 ns) have been used to explore an alpha-helical membrane protein, GlpF, in OG micelles and in DMPC bilayers. Greater conformational drift of the extramembraneous protein loops, from the initial X-ray structure, is seen for the GlpF-OG simulations than for the GlpF-DMPC simulation. The mobility of the transmembrane alpha-helices is approximately 1.3x higher in the GlpF-OG than the GlpF-DMPC simulations. The detergent is seen to form an irregular torus around the protein. The presence of the protein leads to a small perturbation in the behavior of the alkyl chains in the OG micelle, namely an approximately 15% increase in the trans-gauche(-)-gauche(+) transition time. Aromatic side chains (Trp, Tyr) and basic side chains (Arg, Lys) play an important role in both protein-detergent (OG) and protein-lipid (DMPC) interactions.
    MeSH term(s) Aquaporins/chemistry ; Computer Simulation ; Escherichia coli Proteins/chemistry ; Glucosides/chemistry ; Lipid Bilayers/chemistry ; Membrane Proteins/chemistry ; Micelles ; Models, Molecular ; Protein Conformation ; Protein Structure, Secondary ; Structure-Activity Relationship ; Time Factors
    Chemical Substances Aquaporins ; Escherichia coli Proteins ; Glucosides ; Lipid Bilayers ; Membrane Proteins ; Micelles ; GlpF protein, E coli (122463-91-6) ; octyl-beta-D-glucoside (29836-26-8)
    Language English
    Publishing date 2006-07-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-6106
    ISSN 1520-6106
    DOI 10.1021/jp046727h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Modeling and simulations of a bacterial outer membrane protein: OprF from Pseudomonas aeruginosa.

    Khalid, Syma / Bond, Peter J / Deol, Sundeep S / Sansom, Mark S P

    Proteins

    2006  Volume 63, Issue 1, Page(s) 6–15

    Abstract: OprF is a major outer membrane protein from Pseudomonas aeruginosa, a homolog of OmpA from Escherichia coli. The N-terminal domains of both proteins have been demonstrated to form low conductance channels in lipid bilayers. Homology models, consisting of ...

    Abstract OprF is a major outer membrane protein from Pseudomonas aeruginosa, a homolog of OmpA from Escherichia coli. The N-terminal domains of both proteins have been demonstrated to form low conductance channels in lipid bilayers. Homology models, consisting of an eight-stranded beta-barrel, of the N-terminal domain OprF have been constructed based on the crystal structure of the corresponding domain from E. coli OmpA. OprF homology models have been evaluated via a set (6 x 10 ns) of simulations of the beta-barrel embedded within a solvated dimyristoyl-phosphatidylcholine (DMPC) bilayer. The conformational stability of the models is similar to that of the crystal structure of OmpA in comparable simulations. There is a degree of water penetration into the pore-like center of the OprF barrel. The presence of an acidic/basic (E8/K121) side-chain interaction within the OprF barrel may form a "gate" able to close/open a central pore. Lipid-protein interactions within the simulations were analyzed and revealed that aromatic side-chains (Trp, Tyr) of OprF interact with lipid headgroups. Overall, the behavior of the OprF model in simulations supports the suggestion that this molecule is comparable to OmpA. The simulations help to explain the mechanism of formation of low conductance pores within the outer membrane.
    MeSH term(s) Bacteria/metabolism ; Bacterial Outer Membrane Proteins/chemistry ; Biophysical Phenomena ; Biophysics ; Cell Membrane/metabolism ; Computational Biology/methods ; Computer Simulation ; Crystallography, X-Ray ; Dimyristoylphosphatidylcholine/chemistry ; Escherichia coli/metabolism ; Ions ; Lipid Bilayers/chemistry ; Lipids/chemistry ; Models, Biological ; Models, Molecular ; Molecular Conformation ; Porins/chemistry ; Porins/physiology ; Protein Binding ; Protein Conformation ; Protein Structure, Tertiary ; Proteomics/methods ; Pseudomonas aeruginosa/metabolism ; Water/chemistry
    Chemical Substances Bacterial Outer Membrane Proteins ; Ions ; Lipid Bilayers ; Lipids ; Porins ; Water (059QF0KO0R) ; Dimyristoylphosphatidylcholine (U86ZGC74V5)
    Language English
    Publishing date 2006-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 806683-8
    ISSN 1097-0134 ; 0887-3585
    ISSN (online) 1097-0134
    ISSN 0887-3585
    DOI 10.1002/prot.20845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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