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  1. Article: Effect of nationwide reimbursement of real-time continuous glucose monitoring on HbA1c, hypoglycemia and quality of life in a pediatric type 1 diabetes population: The RESCUE-pediatrics study.

    De Ridder, Francesca / Charleer, Sara / Jacobs, Seppe / Bolsens, Nancy / Ledeganck, Kristien J / Van Aken, Sara / Vanbesien, Jesse / Gies, Inge / Casteels, Kristina / Massa, Guy / Lysy, Philippe A / Logghe, Karl / Lebrethon, Marie-Christine / Depoorter, Sylvia / Gillard, Pieter / De Block, Christophe / den Brinker, Marieke

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 991633

    Abstract: Objective: Real-time continuous glucose monitoring (RT-CGM) can improve metabolic control and quality of life (QoL), but long-term real-world data in children with type 1 diabetes (T1D) are scarce. Over a period of 24 months, we assessed the impact of ... ...

    Abstract Objective: Real-time continuous glucose monitoring (RT-CGM) can improve metabolic control and quality of life (QoL), but long-term real-world data in children with type 1 diabetes (T1D) are scarce. Over a period of 24 months, we assessed the impact of RT-CGM reimbursement on glycemic control and QoL in children/adolescents with T1D treated with insulin pumps.
    Research design and methods: We conducted a multicenter prospective observational study. Primary endpoint was the change in HbA1c. Secondary endpoints included change in time in hypoglycemia, QoL, hospitalizations for hypoglycemia and/or ketoacidosis and absenteeism (school for children, work for parents).
    Results: Between December 2014 and February 2019, 75 children/adolescents were followed for 12 (
    Conclusion: RT-CGM in pump-treated children/adolescents with T1D showed a temporary improvement in HbA1c in participants with a baseline HbA1c ≥ 7.5%, without increasing time in hypoglycemia. QoL was not affected. Importantly, RT-CGM reduced the need for assistance by ambulance due to hypoglycemia and reduced work absenteeism for parents after 24 months.
    Clinical trial registration: [ClinicalTrials.gov], identifier [NCT02601729].
    Language English
    Publishing date 2022-10-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.991633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Parental stress, anxiety and trait mindfulness: associations with parent-child mealtime interactions in children with type 1 diabetes.

    Van Gampelaere, Cynthia / Luyckx, Koen / Goethals, Eveline R / van der Straaten, Saskia / Laridaen, Jolien / Casteels, Kristina / Vanbesien, Jesse / Depoorter, Sylvia / Klink, Daniel / Cools, Martine / Goubert, Liesbet

    Journal of behavioral medicine

    2020  Volume 43, Issue 3, Page(s) 448–459

    Abstract: Introduction This study examined how maternal and paternal stress, anxiety, and trait mindfulness, and child glycemic control are related to real-life parent-child interactions in families confronted with type 1 diabetes (T1D). Methods Parents reported ... ...

    Abstract Introduction This study examined how maternal and paternal stress, anxiety, and trait mindfulness, and child glycemic control are related to real-life parent-child interactions in families confronted with type 1 diabetes (T1D). Methods Parents reported on trait mindfulness, illness-related parenting stress, general stress, and state anxiety. Parent-child mealtime interactions were videotaped and scored in 33 families (31 mothers and 20 fathers) of children with T1D (5-12y., mean HbA1c = 7.22%). Results Parental stress and anxiety were related to more maladaptive and less adaptive parent-child interactions. For mothers, mindfulness was related to less observed discomfort of the child during injection. For fathers, more emotional involvement was related to better child glycemic control. Discussion Results indicate that parental stress and anxiety may be risk factors for maladaptive parent-child interactions.
    MeSH term(s) Adult ; Anxiety/psychology ; Anxiety Disorders ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 1/psychology ; Fathers ; Female ; Humans ; Male ; Meals ; Mindfulness ; Mothers/psychology ; Parent-Child Relations ; Parenting/psychology ; Parents/psychology
    Language English
    Publishing date 2020-03-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 441827-x
    ISSN 1573-3521 ; 0160-7715
    ISSN (online) 1573-3521
    ISSN 0160-7715
    DOI 10.1007/s10865-020-00144-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1448: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Families with pediatric type 1 diabetes: A comparison with the general population on child well-being, parental distress, and parenting behavior.

    Van Gampelaere, Cynthia / Luyckx, Koen / van der Straaten, Saskia / Laridaen, Jolien / Goethals, Eveline R / Casteels, Kristina / Vanbesien, Jesse / den Brinker, Marieke / Depoorter, Sylvia / Klink, Daniel / Cools, Martine / Goubert, Liesbet

    Pediatric diabetes

    2019  Volume 21, Issue 2, Page(s) 395–408

    Abstract: Aims: The aim of this study was to compare families with a child (2-12 years) with type 1 diabetes (T1D) to families which are not confronted with chronic illness, with regard to children's well-being, parental distress, and parenting behavior. In ... ...

    Abstract Aims: The aim of this study was to compare families with a child (2-12 years) with type 1 diabetes (T1D) to families which are not confronted with chronic illness, with regard to children's well-being, parental distress, and parenting behavior. In addition, differences were explored between families whose child has optimal vs suboptimal glycemic control.
    Methods: Mothers, fathers, and children of 105 families with pediatric T1D completed questionnaires assessing child well-being, parental distress, and parenting. The control group consisted of 414 families without chronic illness.
    Results: With regard to child well-being, children with T1D had more adjustment difficulties (as reported by mothers) and lower quality of life (QoL) (as reported by mothers and fathers), whereas children themselves (8-12 years) reported higher QoL compared to controls. In terms of parental distress, mothers, but not fathers, of children with T1D reported more stress, anxiety symptoms, and depressive symptoms than controls. With regard to parenting behavior, parent reports revealed less protectiveness in fathers and less autonomy support and responsiveness in both parents as compared to controls. No differences were found in parent-reported psychological control between parents of children with and without T1D, but children with T1D perceived lowered parental psychological control. Lastly, secondary analyses indicated that especially families with suboptimal child glycemic control showed more maternal distress and worse child well-being (according to parents).
    Conclusions: Families confronted with pediatric T1D differ from families without chronic illness: childhood T1D impacts parental perceptions of child well-being and differentially affects mothers' and fathers' distress levels and behaviors.
    MeSH term(s) Adult ; Case-Control Studies ; Child ; Child Health ; Child, Preschool ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/psychology ; Fathers/psychology ; Female ; Glycemic Control/psychology ; Humans ; Male ; Middle Aged ; Mothers/psychology ; Parenting ; Psychological Distress
    Language English
    Publishing date 2019-11-17
    Publishing country Denmark
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1502504-4
    ISSN 1399-5448 ; 1745-1426 ; 1399-543X
    ISSN (online) 1399-5448
    ISSN 1745-1426 ; 1399-543X
    DOI 10.1111/pedi.12942
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5422: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Effectiveness and safety of the tri-iodothyronine analogue Triac in children and adults with MCT8 deficiency: an international, single-arm, open-label, phase 2 trial.

    Groeneweg, Stefan / Peeters, Robin P / Moran, Carla / Stoupa, Athanasia / Auriol, Françoise / Tonduti, Davide / Dica, Alice / Paone, Laura / Rozenkova, Klara / Malikova, Jana / van der Walt, Adri / de Coo, Irenaeus F M / McGowan, Anne / Lyons, Greta / Aarsen, Femke K / Barca, Diana / van Beynum, Ingrid M / van der Knoop, Marieke M / Jansen, Jurgen /
    Manshande, Martien / Lunsing, Roelineke J / Nowak, Stan / den Uil, Corstiaan A / Zillikens, M Carola / Visser, Frank E / Vrijmoeth, Paul / de Wit, Marie Claire Y / Wolf, Nicole I / Zandstra, Angelique / Ambegaonkar, Gautam / Singh, Yogen / de Rijke, Yolanda B / Medici, Marco / Bertini, Enrico S / Depoorter, Sylvia / Lebl, Jan / Cappa, Marco / De Meirleir, Linda / Krude, Heiko / Craiu, Dana / Zibordi, Federica / Oliver Petit, Isabelle / Polak, Michel / Chatterjee, Krishna / Visser, Theo J / Visser, W Edward

    The lancet. Diabetes & endocrinology

    2019  Volume 7, Issue 9, Page(s) 695–706

    Abstract: Background: Deficiency of the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) causes severe intellectual and motor disability and high serum tri-iodothyronine (T: Methods: In this investigator-initiated, multicentre, open-label, ... ...

    Abstract Background: Deficiency of the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) causes severe intellectual and motor disability and high serum tri-iodothyronine (T
    Methods: In this investigator-initiated, multicentre, open-label, single-arm, phase 2, pragmatic trial, we investigated the effectiveness and safety of oral Triac in male paediatric and adult patients with MCT8 deficiency in eight countries in Europe and one site in South Africa. Triac was administered in a predefined escalating dose schedule-after the initial dose of once-daily 350 μg Triac, the daily dose was increased progressively in 350 μg increments, with the goal of attaining serum total T
    Findings: Between Oct 15, 2014, and June 1, 2017, we screened 50 patients, all of whom were eligible. Of these patients, four (8%) patients decided not to participate because of travel commitments. 46 (92%) patients were therefore enrolled in the trial to receive Triac (median age 7·1 years [range 0·8-66·8]). 45 (98%) participants received Triac and had at least one follow-up measurement of thyroid function and thus were included in the analyses of the primary endpoints. Of these 45 patients, five did not complete the trial (two patients withdrew [travel burden, severe pre-existing comorbidity], one was lost to follow-up, one developed of Graves disease, and one died of sepsis). Patients required a mean dose of 38.3 μg/kg of bodyweight (range 6·4-84·3) to attain T
    Interpretation: Key features of peripheral thyrotoxicosis were alleviated in paediatric and adult patients with MCT8 deficiency who were treated with Triac. Triac seems a reasonable treatment strategy to ameliorate the consequences of untreated peripheral thyrotoxicosis in patients with MCT8 deficiency.
    Funding: Dutch Scientific Organization, Sherman Foundation, NeMO Foundation, Wellcome Trust, UK National Institute for Health Research Cambridge Biomedical Centre, Toulouse University Hospital, and Una Vita Rara ONLUS.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Europe ; Follow-Up Studies ; Guidelines as Topic ; Humans ; Infant ; Male ; Membrane Transport Proteins/administration & dosage ; Membrane Transport Proteins/pharmacology ; Mental Retardation, X-Linked/drug therapy ; Mental Retardation, X-Linked/physiopathology ; Muscle Hypotonia/drug therapy ; Muscle Hypotonia/physiopathology ; Muscular Atrophy/drug therapy ; Muscular Atrophy/physiopathology ; Patient Safety ; South Africa ; Triiodothyronine/administration & dosage ; Triiodothyronine/analogs & derivatives ; Triiodothyronine/pharmacology ; Young Adult
    Chemical Substances Membrane Transport Proteins ; Triiodothyronine (06LU7C9H1V) ; 3,3',5-triiodothyroacetic acid (29OQ9EU4R1)
    Language English
    Publishing date 2019-07-31
    Publishing country England
    Document type Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(19)30155-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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