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  1. Book ; Thesis: Transcriptomal profiling of mTNF reverse signalling

    Derer, Stefanie

    2009  

    Author's details vorgelegt von Stefanie Derer
    Subject code 616.3
    Language English
    Size 128 S., Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 2009
    HBZ-ID HT016476499
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 D 747 order for loan Magazin

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  2. Book ; Online ; Thesis: Zirkadiane Rhythmen hedonischen Appetits in Leptin-defizienten ob/ob-Mäusen

    Heinen, Keno Ole [Verfasser] / Oster, Henrik [Akademischer Betreuer] / Mittag, Jens [Akademischer Betreuer] / Derer, Stefanie [Akademischer Betreuer]

    2023  

    Author's details Keno Ole Heinen ; Akademische Betreuer: Henrik Oster, Jens Mittag, Stefanie Derer
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Zentrale Hochschulbibliothek Lübeck
    Publishing place Lübeck
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article ; Online: The intestinal complement system in inflammatory bowel disease: Shaping intestinal barrier function.

    Sina, Christian / Kemper, Claudia / Derer, Stefanie

    Seminars in immunology

    2018  Volume 37, Page(s) 66–73

    Abstract: The complement system is part of innate sensor and effector systems such as the Toll-like receptors (TLRs). It recognizes and quickly systemically and/or locally respond to microbial-associated molecular patterns (MAMPs) with a tailored defense reaction. ...

    Abstract The complement system is part of innate sensor and effector systems such as the Toll-like receptors (TLRs). It recognizes and quickly systemically and/or locally respond to microbial-associated molecular patterns (MAMPs) with a tailored defense reaction. MAMP recognition by intestinal epithelial cells (IECs) and appropriate immune responses are of major importance for the maintenance of intestinal barrier function. Enterocytes highly express various complement components that are suggested to be pivotal for proper IEC function. Appropriate activation of the intestinal complement system seems to play an important role in the resolution of chronic intestinal inflammation, while over-activation and/or dysregulation may worsen intestinal inflammation. Mice deficient for single complement components suffer from enhanced intestinal inflammation mimicking the phenotype of patients with chronic inflammatory bowel disease (IBD) such as Crohn's disease (CD) or ulcerative colitis (UC). However, the mechanisms leading to complement expression in IECs seem to differ markedly between UC and CD patients. Hence, how IECs, intestinal bacteria and epithelial cell expressed complement components interact in the course of IBD still remains to be mostly elucidated to define potential unique patterns contributing to the distinct subtypes of intestinal inflammation observed in CD and UC.
    MeSH term(s) Animals ; Complement Activation ; Complement System Proteins/genetics ; Complement System Proteins/metabolism ; Disease Models, Animal ; Humans ; Immunity, Innate ; Inflammatory Bowel Diseases/immunology ; Intestinal Mucosa/physiology ; Mice ; Mice, Knockout ; Pathogen-Associated Molecular Pattern Molecules/immunology ; Receptors, Pattern Recognition/metabolism
    Chemical Substances Pathogen-Associated Molecular Pattern Molecules ; Receptors, Pattern Recognition ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2018-02-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2018.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: The AT1 Receptor Blocker Telmisartan Reduces Intestinal Mucus Thickness in Obese Mice.

    Nickel, Laura / Sünderhauf, Annika / Rawish, Elias / Stölting, Ines / Derer, Stefanie / Thorns, Christoph / Matschl, Urte / Othman, Alaa / Sina, Christian / Raasch, Walter

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 815353

    Abstract: The angiotensin II (type 1) ( ... ...

    Abstract The angiotensin II (type 1) (AT
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.815353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Seasonal Clock Changes Are Underappreciated Health Risks-Also in IBD?

    Föh, Bandik / Schröder, Torsten / Oster, Henrik / Derer, Stefanie / Sina, Christian

    Frontiers in medicine

    2019  Volume 6, Page(s) 103

    Abstract: Today, daylight saving time is observed in nearly 80 countries around the world, including the European Union, the USA, Canada, and Russia. The benefits of daylight saving time in energy management have been questioned since it was first introduced ... ...

    Abstract Today, daylight saving time is observed in nearly 80 countries around the world, including the European Union, the USA, Canada, and Russia. The benefits of daylight saving time in energy management have been questioned since it was first introduced during World War I and the latest research has led to varying results. Meanwhile, adverse effects of seasonal time shifts on human biology have been postulated and the European Union is planning to abandon the biannual clock change completely. Medical studies have revealed a correlation of seasonal time shifts with increased incidences of several diseases including stroke, myocardial infarction, and unipolar depressive episodes. Moreover, studies in mice have provided convincing evidence, that circadian rhythm disruption may be involved in the pathogenesis of inflammatory bowel diseases, mainly by disturbing the intestinal barrier integrity. Here, we present previously unpublished data from a large German cohort indicating a correlation of seasonal clock changes and medical leaves due to ulcerative colitis and Crohn's disease. Furthermore, we discuss the health risks of clock changes and the current attempts on reforming daylight saving time from a medical perspective.
    Language English
    Publishing date 2019-05-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2019.00103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Purification and Functional Characterization of the Chloroform/Methanol-Soluble Protein 3 (CM3) From

    Thiel, Anna-Lena / Ragab, Mohab / Wagner, Anika E / Divanovic, Senad / Derer, Stefanie / Sina, Christian

    Frontiers in nutrition

    2020  Volume 7, Page(s) 607937

    Abstract: Non-celiac wheat sensitivity (NCWS) has been proposed to be an independent disease entity that is characterized by intestinal (e.g., abdominal pain, flatulence) and extra-intestinal symptoms (e.g., headache, fatigue), which are propagated following the ... ...

    Abstract Non-celiac wheat sensitivity (NCWS) has been proposed to be an independent disease entity that is characterized by intestinal (e.g., abdominal pain, flatulence) and extra-intestinal symptoms (e.g., headache, fatigue), which are propagated following the ingestion of wheat products. Increased activity of amylase trypsin inhibitors (ATIs) in modern wheat is suggested to be major trigger of NCWS, while underlying mechanisms still remain elusive. Here, we aimed to generate and functionally characterize the most abundant ATI in modern wheat, chloroform/methanol-soluble protein 3 (CM3),
    Language English
    Publishing date 2020-12-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2020.607937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice

    Sünderhauf, Annika / Pagel, René / Künstner, Axel / Wagner, Anika E / Rupp, Jan / Ibrahim, Saleh M / Derer, Stefanie / Sina, Christian

    Nutrients. 2020 Apr. 17, v. 12, no. 4

    2020  

    Abstract: Non-caloric artificial sweeteners are frequently discussed as components of the “Western diet”, negatively modulating intestinal homeostasis. Since the artificial sweetener saccharin is known to depict bacteriostatic and microbiome-modulating properties, ...

    Abstract Non-caloric artificial sweeteners are frequently discussed as components of the “Western diet”, negatively modulating intestinal homeostasis. Since the artificial sweetener saccharin is known to depict bacteriostatic and microbiome-modulating properties, we hypothesized oral saccharin intake to influence intestinal inflammation and aimed at delineating its effect on acute and chronic colitis activity in mice. In vitro, different bacterial strains were grown in the presence or absence of saccharin. Mice were supplemented with saccharin before or after induction of acute or chronic colitis using dextran sodium sulfate (DSS) and the extent of colitis was assessed. Ex vivo, intestinal inflammation, fecal bacterial load and composition were studied by immunohistochemistry analyses, quantitative PCR, 16 S RNA PCR or next generation sequencing in samples collected from analyzed mice. In vitro, saccharin inhibited bacterial growth in a species-dependent manner. In vivo, oral saccharin intake reduced fecal bacterial load and altered microbiome composition, while the intestinal barrier was not obviously affected. Of note, DSS-induced colitis activity was significantly improved in mice after therapeutic or prophylactic treatment with saccharin. Together, this study demonstrates that oral saccharin intake decreases intestinal bacteria count and hence encompasses the capacity to reduce acute and chronic colitis activity in mice.
    Keywords RNA ; Western diets ; antibacterial properties ; bacterial growth ; colitis ; high-throughput nucleotide sequencing ; homeostasis ; immunohistochemistry ; inflammation ; intestinal microorganisms ; intestines ; mice ; microbial load ; microbiome ; nutrients ; quantitative polymerase chain reaction ; saccharin ; sampling ; strains ; therapeutics
    Language English
    Dates of publication 2020-0417
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12041122
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Heterozygous

    Raschdorf, Annika / Sünderhauf, Annika / Skibbe, Kerstin / Ghebrehiwet, Berhane / Peerschke, Ellinor I / Sina, Christian / Derer, Stefanie

    Frontiers in oncology

    2021  Volume 10, Page(s) 631592

    Abstract: Rapid proliferation of cancer cells is enabled by favoring aerobic glycolysis over mitochondrial oxidative phosphorylation (OXPHOS). P32 ( ...

    Abstract Rapid proliferation of cancer cells is enabled by favoring aerobic glycolysis over mitochondrial oxidative phosphorylation (OXPHOS). P32 (
    Language English
    Publishing date 2021-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.631592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Crohn's Disease Patients in Remission Display an Enhanced Intestinal IgM⁺ B Cell Count in Concert with a Strong Activation of the Intestinal Complement System.

    Preisker, Sophie / Brethack, Ann-Kathrin / Bokemeyer, Arne / Bettenworth, Dominik / Sina, Christian / Derer, Stefanie

    Cells

    2019  Volume 8, Issue 1

    Abstract: Inflammatory bowel disease (IBD) is an umbrella term that comprises Crohn's disease (CD) and ulcerative colitis (UC). Both entities are characterized by a disturbed mucosal immune response and an imbalance of intestinal microbiota composition. The ... ...

    Abstract Inflammatory bowel disease (IBD) is an umbrella term that comprises Crohn's disease (CD) and ulcerative colitis (UC). Both entities are characterized by a disturbed mucosal immune response and an imbalance of intestinal microbiota composition. The complement system (C) plays a critical role in the detection, and clearance of bacteria and dysregulation of single complement components has been linked to IBD. Here, we asked if the C contributes to distinct subtypes of inflammation observed in CD and UC. We performed systematical expression analyses of the intestinal C in IBD patients and controls. Immunohistochemistry or immunoblot experiments were performed to verify qPCR data. Activity of the three activation pathways of C was studied in sera samples. In CD patients a strong upregulation of the C was observed enabling the definition of unique expression patterns being associated either with remission or active disease. These data were reflected by an enhanced C activation in sera and fecal samples. An excessive mucosal presence of immunoglobulin M (IgM) and CR2/CD21 positive B cells in concert with decreased fecal IgA level was identified in CD patients in remission. These findings point to an exacerbated induction of the intestinal C that may potentially be involved in the etiology of CD.
    MeSH term(s) B-Lymphocytes/immunology ; Complement Activation/immunology ; Complement System Proteins/immunology ; Crohn Disease/blood ; Crohn Disease/immunology ; Crohn Disease/pathology ; Feces ; Female ; Humans ; Immunoglobulin M/metabolism ; Immunologic Memory ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Intestines/immunology ; Lymphocyte Count ; Male ; Models, Immunological ; Remission Induction ; Up-Regulation
    Chemical Substances Immunoglobulin M ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2019-01-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells8010078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice.

    Sünderhauf, Annika / Pagel, René / Künstner, Axel / Wagner, Anika E / Rupp, Jan / Ibrahim, Saleh M / Derer, Stefanie / Sina, Christian

    Nutrients

    2020  Volume 12, Issue 4

    Abstract: Non-caloric artificial sweeteners are frequently discussed as components of the "Western diet", negatively modulating intestinal homeostasis. Since the artificial sweetener saccharin is known to depict bacteriostatic and microbiome-modulating properties, ...

    Abstract Non-caloric artificial sweeteners are frequently discussed as components of the "Western diet", negatively modulating intestinal homeostasis. Since the artificial sweetener saccharin is known to depict bacteriostatic and microbiome-modulating properties, we hypothesized oral saccharin intake to influence intestinal inflammation and aimed at delineating its effect on acute and chronic colitis activity in mice. In vitro, different bacterial strains were grown in the presence or absence of saccharin. Mice were supplemented with saccharin before or after induction of acute or chronic colitis using dextran sodium sulfate (DSS) and the extent of colitis was assessed. Ex vivo, intestinal inflammation, fecal bacterial load and composition were studied by immunohistochemistry analyses, quantitative PCR, 16 S RNA PCR or next generation sequencing in samples collected from analyzed mice. In vitro, saccharin inhibited bacterial growth in a species-dependent manner. In vivo, oral saccharin intake reduced fecal bacterial load and altered microbiome composition, while the intestinal barrier was not obviously affected. Of note, DSS-induced colitis activity was significantly improved in mice after therapeutic or prophylactic treatment with saccharin. Together, this study demonstrates that oral saccharin intake decreases intestinal bacteria count and hence encompasses the capacity to reduce acute and chronic colitis activity in mice.
    MeSH term(s) Acute Disease ; Administration, Oral ; Animals ; Bacillus cereus/drug effects ; Chronic Disease ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/microbiology ; Dextran Sulfate ; Dietary Supplements ; Disease Models, Animal ; Drug Resistance, Bacterial ; Inflammation ; Intestinal Mucosa/microbiology ; Klebsiella pneumoniae/drug effects ; Male ; Mice, Inbred C57BL ; Pseudomonas aeruginosa/drug effects ; Saccharin/administration & dosage ; Saccharin/pharmacology ; Staphylococcus aureus/drug effects
    Chemical Substances Dextran Sulfate (9042-14-2) ; Saccharin (FST467XS7D)
    Language English
    Publishing date 2020-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12041122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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