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Article ; Online: Serum Levels of Copper and Zinc and Survival in Breast Cancer Patients.

Szwiec, Marek / Marciniak, Wojciech / Derkacz, Róża / Huzarski, Tomasz / Gronwald, Jacek / Cybulski, Cezary / Dębniak, Tadeusz / Jakubowska, Anna / Lener, Marcin R / Falco, Michał / Kładny, Józef / Baszuk, Piotr / Kotsopoulos, Joanne / Narod, Steven A / Lubiński, Jan

Nutrients

2024 Volume 16, Issue 7

Abstract: There is emerging interest in the relationship between several serum micronutrients and the prognosis of patients with breast cancer. The relationship between serum zinc and copper levels and breast cancer prognosis is unclear. In our study, we included ... ...

Abstract	There is emerging interest in the relationship between several serum micronutrients and the prognosis of patients with breast cancer. The relationship between serum zinc and copper levels and breast cancer prognosis is unclear. In our study, we included 583 patients with breast cancer diagnosed between 2008 and 2015 in the region of Szczecin, Poland. In a blood sample obtained before treatment, serum zinc and copper levels were quantified by mass spectroscopy. Each patient was assigned to one of four categories (quartiles) based on the distribution of the elements in the entire cohort. Patients were followed from diagnosis to death over a mean of 10.0 years. The 10-year overall survival was 58.3% for women in the highest and 82.1% for those in the lowest quartile of serum copper/zinc ratio (
MeSH term(s)	Humans ; Female ; Breast Neoplasms ; Copper ; Zinc ; Breast ; Mass Spectrometry
Chemical Substances	Copper (789U1901C5) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16071000
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Article ; Online: Blood Cadmium Level Is a Marker of Cancer Risk in Men.

Derkacz, Róża / Marciniak, Wojciech / Baszuk, Piotr / Wysokińska, Monika / Chrzanowska, Natalia / Lener, Marcin / Huzarski, Tomasz / Gronwald, Jacek / Dębniak, Tadeusz / Cybulski, Cezary / Jakubowska, Anna / Scott, Rodney J / Lubiński, Jan

Nutrients

2024 Volume 16, Issue 9

Abstract: Cadmium (Cd) is a known carcinogen, but its impact on cancer risk at lower concentrations is poorly understood. Previous studies on Cd and cancer risk in men show inconsistent results, prompting further investigation. A prospective cohort study involving ...

Abstract	Cadmium (Cd) is a known carcinogen, but its impact on cancer risk at lower concentrations is poorly understood. Previous studies on Cd and cancer risk in men show inconsistent results, prompting further investigation. A prospective cohort study involving 2956 men was conducted. Blood Cd levels were measured, and participants were followed for 78 months to assess cancer incidence. Men with high blood Cd levels (>0.71 µg/L) had a significantly increased risk of cancer compared to those with low levels (<0.19 µg/L) (HR 3.42,
MeSH term(s)	Humans ; Male ; Cadmium/blood ; Middle Aged ; Neoplasms/blood ; Neoplasms/epidemiology ; Prospective Studies ; Risk Factors ; Adult ; Incidence ; Aged ; Biomarkers/blood ; Smoking/adverse effects ; Smoking/blood
Chemical Substances	Cadmium (00BH33GNGH) ; Biomarkers
Language	English
Publishing date	2024-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16091309
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Article ; Online: Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients.

Pietrzak, Sandra / Marciniak, Wojciech / Derkacz, Róża / Matuszczak, Milena / Kiljańczyk, Adam / Baszuk, Piotr / Bryśkiewicz, Marta / Sikorski, Andrzej / Gronwald, Jacek / Słojewski, Marcin / Cybulski, Cezary / Gołąb, Adam / Huzarski, Tomasz / Dębniak, Tadeusz / Lener, Marcin R / Jakubowska, Anna / Kluz, Tomasz / Scott, Rodney J / Lubiński, Jan

Nutrients

2024 Volume 16, Issue 4

Abstract: The most prevalent type of cancer among males is prostate cancer. Survival is considered quite good, but it can be further improved when risk factors are optimized. One of these factors is micronutrients, including Se and Zn. To our knowledge, the ... ...

Abstract	The most prevalent type of cancer among males is prostate cancer. Survival is considered quite good, but it can be further improved when risk factors are optimized. One of these factors is micronutrients, including Se and Zn. To our knowledge, the interaction between Se and Zn and prostate cancer remains undescribed. This study aimed to investigate the optimal levels of selenium (Se) and zinc (Zn) and their impact on the survival of individuals diagnosed with prostate cancer. A total of 338 prostate cancer patients were enrolled in this study, which was conducted in Poland between 2009 and 2015. Mass spectrometry, which uses inductively coupled plasma mass, was used to assess serum element levels before treatment. The study participants were categorized into quartiles (QI-QIV) based on the distributions of Se and Zn levels observed among surviving participants. Cox regression was used to assess the association between serum Se and Zn levels and the survival of prostate cancer patients. Our results reveal the effect of combined Se and Zn levels on survival in prostate cancer patients (SeQI-ZnQI vs. SeQIV-ZnQIV; HR = 20.9). These results need further research to establish Se/Zn norms for different populations.
MeSH term(s)	Male ; Humans ; Selenium ; Zinc ; Prostatic Neoplasms ; Micronutrients/analysis ; Mass Spectrometry/methods ; Copper
Chemical Substances	Selenium (H6241UJ22B) ; Zinc (J41CSQ7QDS) ; Micronutrients ; Copper (789U1901C5)
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16040527
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Article ; Online: Serum Essential Elements and Survival after Cancer Diagnosis.

Lubiński, Jan / Lener, Marcin R / Marciniak, Wojciech / Pietrzak, Sandra / Derkacz, Róża / Cybulski, Cezary / Gronwald, Jacek / Dębniak, Tadeusz / Jakubowska, Anna / Huzarski, Tomasz / Matuszczak, Milena / Pullella, Katherine / Sun, Ping / Narod, Steven A

Nutrients

2023 Volume 15, Issue 11

Abstract: In a prospective study, we measured the associations between three serum elements (Se, Zn and Cu) and the prognosis of 1475 patients with four different types of cancer (breast, prostate, lung and larynx) from University Hospitals in Szczecin, Poland. ... ...

Abstract	In a prospective study, we measured the associations between three serum elements (Se, Zn and Cu) and the prognosis of 1475 patients with four different types of cancer (breast, prostate, lung and larynx) from University Hospitals in Szczecin, Poland. The elements were measured in serum taken after diagnosis and prior to treatment. Patients were followed from the date of diagnosis until death from any cause or until the last follow-up date (mean years of follow-up: 6.0-9.8 years, according to site). Kaplan-Meier curves were constructed for all cancers combined and for each cancer separately. Age-adjusted hazard ratios (HRs) were estimated using Cox regression. The outcome was all-cause mortality. A Se level in the highest quartile was also associated with a reduced mortality (HR = 0.66; 95%CI 0.49-0.88;
MeSH term(s)	Male ; Humans ; Copper ; Prospective Studies ; Selenium ; Zinc ; Prognosis ; Trace Elements ; Neoplasms/diagnosis
Chemical Substances	Copper (789U1901C5) ; Selenium (H6241UJ22B) ; Zinc (J41CSQ7QDS) ; Trace Elements
Language	English
Publishing date	2023-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15112611
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Article ; Online: Survival of Laryngeal Cancer Patients Depending on Zinc Serum Level and Oxidative Stress Genotypes.

Lubiński, Jakub / Jaworowska, Ewa / Derkacz, Róża / Marciniak, Wojciech / Białkowska, Katarzyna / Baszuk, Piotr / Scott, Rodney J / Lubiński, Jan A

Biomolecules

2021 Volume 11, Issue 6

Abstract: Stress contributes to various aspects of malignancy and could influence survival in laryngeal cancer patients. Among antioxidant mechanisms, zinc and the antioxidant enzymes superoxide dismutase 2, catalase and glutathione peroxidase 1 play a major role. ...

Abstract	Stress contributes to various aspects of malignancy and could influence survival in laryngeal cancer patients. Among antioxidant mechanisms, zinc and the antioxidant enzymes superoxide dismutase 2, catalase and glutathione peroxidase 1 play a major role. The aim of this study was a prospective evaluation of the survival of patients with laryngeal cancer in relation to serum levels of zinc in combination with functional genotype differences of three key antioxidant enzymes. The study group consisted of 300 patients treated surgically for laryngeal cancer. Serum zinc levels and common polymorphisms in
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Disease-Free Survival ; Female ; Genotype ; Humans ; Laryngeal Neoplasms/blood ; Laryngeal Neoplasms/genetics ; Laryngeal Neoplasms/mortality ; Male ; Middle Aged ; Neoplasm Proteins/blood ; Neoplasm Proteins/genetics ; Oxidative Stress ; Survival Rate ; Zinc/blood
Chemical Substances	Neoplasm Proteins ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2021-06-10
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom11060865
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Article: Serum Iron Level and 10-Year Survival after Melanoma.

Rowińska, Karolina / Baszuk, Piotr / Rogoża-Janiszewska, Emilia / Deptuła, Jakub / Marciniak, Wojciech / Derkacz, Róża / Lener, Marcin / Cybulski, Cezary / Kiedrowicz, Magdalena / Boer, Magdalena / Marchlewicz, Mariola / Dębniak, Tadeusz / Lubiński, Jan

Biomedicines

2022 Volume 10, Issue 12

Abstract: The malignant melanoma of the skin is a very aggressive tumor. The determination of prognostic biomarkers is important for the early detection of recurrence, and for the enrollment of the patients into different treatment regimens. An evaluation of a ... ...

Abstract	The malignant melanoma of the skin is a very aggressive tumor. The determination of prognostic biomarkers is important for the early detection of recurrence, and for the enrollment of the patients into different treatment regimens. An evaluation of a cohort of 375 Polish MM cases revealed that a low serum iron concentration (i.e., below 893.05 µg/L) was associated with increased mortality. The study group was followed up from the date of melanoma diagnosis until death or 2020. Patients were assigned to one of four categories in accordance with increasing iron level (I-IV quarters). Patients with a low iron level of below 893.05 µg/L (I quarter) had a significantly lower survival rate when compared to the subgroup with the highest iron level, above 1348.63 µg/L (IV quarter; HR = 4.12;
Language	English
Publishing date	2022-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10123018
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Article: Risk of Second Primary Thyroid Cancer in Women with Breast Cancer.

Cieszyńska, Monika / Kluźniak, Wojciech / Wokołorczyk, Dominika / Cybulski, Cezary / Huzarski, Tomasz / Gronwald, Jacek / Falco, Michał / Dębniak, Tadeusz / Jakubowska, Anna / Derkacz, Róża / Marciniak, Wojciech / Lener, Marcin / Woronko, Karolina / Mocarz, Dominika / Baszuk, Piotr / Bryśkiewicz, Marta / Narod, Steven A / Lubiński, Jan

Cancers

2022 Volume 14, Issue 4

Abstract: The goal of this study was to estimate the risk of thyroid cancer following breast cancer and to identify therapeutic and genetic risk factors for the development of thyroid cancer after breast cancer. We followed 10,832 breast cancer patients for a mean ...

Abstract	The goal of this study was to estimate the risk of thyroid cancer following breast cancer and to identify therapeutic and genetic risk factors for the development of thyroid cancer after breast cancer. We followed 10,832 breast cancer patients for a mean of 14 years for new cases of thyroid cancer. All women were genotyped for three Polish founder mutations in BRCA1 (C61G, 4153delA, 5382insC) and four mutations in CHEK2 (1100delC, IVS2 + 1G/A, del5395, I157T). Information was collected on chemotherapy, radiotherapy, hormonal therapies, and oophorectomy. Of the 10,832 women, 53 (0.49%) developed a second primary thyroid cancer. Based on Polish population statistics, the expected number was 12.4 (SIR = 4.3). The ten-year risk of developing thyroid cancer was higher in women who carried a CHEK2 mutation (1.5%) than in women who carried no mutation (0.9%). The age-adjusted hazard ratio for developing thyroid cancer was 1.89 (0.46-7.79;
Language	English
Publishing date	2022-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14040957
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Article: Blood Copper Levels and the Occurrence of Colorectal Cancer in Poland.

Baszuk, Piotr / Marciniak, Wojciech / Derkacz, Róża / Jakubowska, Anna / Cybulski, Cezary / Gronwald, Jacek / Dębniak, Tadeusz / Huzarski, Tomasz / Białkowska, Katarzyna / Pietrzak, Sandra / Muszyńska, Magdalena / Kładny, Józef / Narod, Steven A / Lubiński, Jan / Lener, Marcin R

Biomedicines

2021 Volume 9, Issue 11

Abstract: There is a need for sensitive and specific biomarkers for the early detection of colorectal cancer. In this retrospective study, we assessed whether a high blood copper level was associated with the presence of colorectal cancer. The blood copper level ... ...

Abstract	There is a need for sensitive and specific biomarkers for the early detection of colorectal cancer. In this retrospective study, we assessed whether a high blood copper level was associated with the presence of colorectal cancer. The blood copper level was measured among 187 colorectal cancer patients and 187 matched controls. Cases and controls were matched for sex, smoking status (yes/no) and year of birth. Among the cases, the mean blood copper level was 1031 µg/L (range 657 µg/L to 2043 µg/L) and among the controls, the mean blood copper level was 864 µg/L (range 589 µg/L to 1433 µg/L). The odds ratio for colorectal cancer for those in the highest quartile of copper level (versus the lowest) was 12.7 (95% CI: 4.98-32.3;
Language	English
Publishing date	2021-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9111628
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Article: Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women.

Baszuk, Piotr / Stadnik, Paulina / Marciniak, Wojciech / Derkacz, Róża / Jakubowska, Anna / Cybulski, Cezary / Huzarski, Tomasz / Gronwald, Jacek / Dębniak, Tadeusz / Białkowska, Katarzyna / Pietrzak, Sandra / Kładny, Józef / Scott, Rodney J / Lubiński, Jan / Lener, Marcin R

Biomedicines

2021 Volume 9, Issue 9

Abstract: In following study we examined whether blood arsenic (As) levels combined with specific polymorphisms ... ...

Abstract	In following study we examined whether blood arsenic (As) levels combined with specific polymorphisms in
Language	English
Publishing date	2021-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9091105
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Article ; Online: Blood Lead Level as Marker of Increased Risk of Ovarian Cancer in BRCA1 Carriers.

Kiljańczyk, Adam / Matuszczak, Milena / Marciniak, Wojciech / Derkacz, Róża / Stempa, Klaudia / Baszuk, Piotr / Bryśkiewicz, Marta / Lubiński, Krzysztof / Cybulski, Cezary / Dębniak, Tadeusz / Gronwald, Jacek / Huzarski, Tomasz / Lener, Marcin R / Jakubowska, Anna / Szwiec, Marek / Stawicka-Niełacna, Małgorzata / Godlewski, Dariusz / Prusaczyk, Artur / Jasiewicz, Andrzej /

Kluz, Tomasz / Tomiczek-Szwiec, Joanna / Kilar-Kobierzycka, Ewa / Siołek, Monika / Wiśniowski, Rafał / Posmyk, Renata / Jarkiewicz-Tretyn, Joanna / Sun, Ping / Scott, Rodney J / Narod, Steven A / Lubiński, Jan

Nutrients

2024 Volume 16, Issue 9

Abstract: BRCA1 mutations substantially elevate the risks of breast and ovarian cancer. Various modifiers, including environmental factors, can influence cancer risk. Lead, a known carcinogen, has been associated with various cancers, but its impact on BRCA1 ... ...

Abstract	BRCA1 mutations substantially elevate the risks of breast and ovarian cancer. Various modifiers, including environmental factors, can influence cancer risk. Lead, a known carcinogen, has been associated with various cancers, but its impact on BRCA1 carriers remains unexplored. A cohort of 989 BRCA1 mutation carriers underwent genetic testing at the Pomeranian Medical University, Poland. Blood lead levels were measured using inductively coupled plasma mass spectrometry. Each subject was assigned to a category based on their tertile of blood lead. Cox regression analysis was used to assess cancer risk associations. Elevated blood lead levels (>13.6 μg/L) were associated with an increased risk of ovarian cancer (univariable: HR = 3.33; 95% CI: 1.23-9.00;
MeSH term(s)	Humans ; Female ; Ovarian Neoplasms/blood ; Ovarian Neoplasms/genetics ; Lead/blood ; Adult ; Middle Aged ; BRCA1 Protein/genetics ; Risk Factors ; Poland ; Heterozygote ; Mutation ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Genetic Predisposition to Disease ; Aged ; Proportional Hazards Models
Chemical Substances	Lead (2P299V784P) ; BRCA1 Protein ; BRCA1 protein, human ; Biomarkers, Tumor
Language	English
Publishing date	2024-04-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16091370
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