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Article: Biogenic Synthesis, Characterization, and Photocatalytic Evaluation of Pristine and Graphene-Loaded Zn

Pachiyappan, Jayakaran / Nirmala, Gnanasundaram / Sivamani, Selvaraju / Govindasamy, Rajakumar / Thiruvengadam, Muthu / Derkho, Marina / Burkov, Pavel / Popovich, Aleksey / Gribkova, Vera

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 16

Abstract: Algal biomass synthesised nanocomposites have a higher surface area and reusability advantages. This study aimed to synthesise and characterise ZnMgO and silica-supported graphene with ZnMgO (G-ZnMgO) nanocomposites ... ...

Abstract	Algal biomass synthesised nanocomposites have a higher surface area and reusability advantages. This study aimed to synthesise and characterise ZnMgO and silica-supported graphene with ZnMgO (G-ZnMgO) nanocomposites from
Language	English
Publishing date	2022-08-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12162809
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Application of CRISPR-Cas9 genome editing technology in various fields: A review.

Ansori, Arif Nm / Antonius, Yulanda / Susilo, Raden Jk / Hayaza, Suhailah / Kharisma, Viol D / Parikesit, Arli A / Zainul, Rahadian / Jakhmola, Vikash / Saklani, Taru / Rebezov, Maksim / Ullah, Md Emdad / Maksimiuk, Nikolai / Derkho, Marina / Burkov, Pavel

Narra J

2023 Volume 3, Issue 2, Page(s) e184

Abstract: CRISPR-Cas9 has emerged as a revolutionary tool that enables precise and efficient modifications of the genetic material. This review provides a comprehensive overview of CRISPR-Cas9 technology and its applications in genome editing. We begin by ... ...

Abstract	CRISPR-Cas9 has emerged as a revolutionary tool that enables precise and efficient modifications of the genetic material. This review provides a comprehensive overview of CRISPR-Cas9 technology and its applications in genome editing. We begin by describing the fundamental principles of CRISPR-Cas9 technology, explaining how the system utilizes a single guide RNA (sgRNA) to direct the Cas9 nuclease to specific DNA sequences in the genome, resulting in targeted double-stranded breaks. In this review, we provide in-depth explorations of CRISPR-Cas9 technology and its applications in agriculture, medicine, environmental sciences, fisheries, nanotechnology, bioinformatics, and biotechnology. We also highlight its potential, ongoing research, and the ethical considerations and controversies surrounding its use. This review might contribute to the understanding of CRISPR-Cas9 technology and its implications in various fields, paving the way for future developments and responsible applications of this transformative technology.
Language	English
Publishing date	2023-08-27
Publishing country	Indonesia
Document type	Journal Article ; Review
ISSN	2807-2618
ISSN (online)	2807-2618
DOI	10.52225/narra.v3i2.184
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Article: Bioactive Components and Health Potential of Endophytic Micro-Fungal Diversity in Medicinal Plants.

Muthukrishnan, Sundaram / Prakathi, Paranivasakam / Sivakumar, Thangavel / Thiruvengadam, Muthu / Jayaprakash, Bindhu / Baskar, Venkidasamy / Rebezov, Maksim / Derkho, Marina / Zengin, Gokhan / Shariati, Mohammad Ali

Antibiotics (Basel, Switzerland)

2022 Volume 11, Issue 11

Abstract: The endophytic fungi that reside inside medicinal plants have the potential to produce various pharmaco-potential bioactive compounds. The endophytic ... ...

Abstract	The endophytic fungi that reside inside medicinal plants have the potential to produce various pharmaco-potential bioactive compounds. The endophytic fungi
Language	English
Publishing date	2022-11-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics11111533
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Article: Comprehensive review on naringenin and naringin polyphenols as a potent anticancer agent

Rauf, Abdur / Shariati, Mohammad Ali / Imran, Muhammad / Bashir, Kashif / Khan, Shahid Ali / Mitra, Saikat / Emran, Talha Bin / Badalova, Kamala / Uddin, Md. Sahab / Mubarak, Mohammad S. / Aljohani, Abdullah S. M. / Alhumaydhi, Fahad A. / Derkho, Marina / Korpayev, Serdar / Zengin, Gokhan

Environmental science and pollution research. 2022 May, v. 29, no. 21

2022

Abstract: Though the incidence of several cancers in Western societies is regulated wisely, some cancers such as breast, lung, and colorectal cancer are currently rising in many low- and middle-income countries due to increased risk factors triggered by societal ... ...

Abstract	Though the incidence of several cancers in Western societies is regulated wisely, some cancers such as breast, lung, and colorectal cancer are currently rising in many low- and middle-income countries due to increased risk factors triggered by societal and development problems. Surgery, chemotherapy, hormone, radiation, and targeted therapies are examples of traditional cancer treatment approaches. However, multiple short- and long-term adverse effects may also significantly affect patient prognosis depending on treatment-associated clinical factors. More and more research has been carried out to find new therapeutic agents in natural products, among which the bioactive compounds derived from plants have been increasingly studied. Naringin and naringenin are abundantly found in citrus fruits, such as oranges and grapefruits. A variety of cell signaling pathways mediates their anti-carcinogenic properties. Naringin and naringenin were also documented to overcome multidrug resistance, one of the major challenges to clinical practice due to multiple defense mechanisms in cancer. The effective parameters underlying the anticancer effects of naringenin and naringin include GSK3β inactivation, suppression of the gene and protein activation of NF-kB and COX-2, JAK2/STAT3 downregulation, downregulation of intracellular adhesion molecules-1, upregulation of Notch1 and tyrocite-specific genes, and activation of p38/MAPK and caspase-3. Thus, this review outlines the potential of naringin and naringenin in managing different types of cancers.
Keywords	Citrus ; adhesion ; antineoplastic agents ; breasts ; cancer therapy ; caspase-3 ; colorectal neoplasms ; drug therapy ; genes ; lungs ; multiple drug resistance ; naringenin ; naringin ; patients ; pollution ; polyphenols ; prognosis ; research ; transcription factor NF-kappa B
Language	English
Dates of publication	2022-05
Size	p. 31025-31041.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-18754-6
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Article ; Online: Evaluation of the anti-diarrheal effects of the whole plant extracts of

Muhammad, Naveed / Ullah, Sana / Rauf, Abdur / Atif, Muhammad / Patel, Seema / Israr, Muhammad / Akbar, Sajid / Shehzad, Omer / Saeed, Muhammad / Bawazeer, Saud / Uddin, Md Sahab / Derkho, Marina / Shariati, Mohammad Ali / Mubarak, Mohammad S

Toxicology reports

2021 Volume 8, Page(s) 395–404

Abstract: Background: Cuscuta reflexa: Methods: The antidiarrheal effect of : Results: In addition to cisplatin-induced diarrhea, all paradigms tested gave significant results (: Conclusions: Taken all together, results from this study reveal that the ... ...

Abstract	Background: Cuscuta reflexa Methods: The antidiarrheal effect of Results: In addition to cisplatin-induced diarrhea, all paradigms tested gave significant results ( Conclusions: Taken all together, results from this study reveal that the juice, aqueous, and methanol extract of
Language	English
Publishing date	2021-02-23
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2805786-7
ISSN	2214-7500 ; 2214-7500
ISSN (online)	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2021.02.013
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Article: Preclinical and Clinical Antioxidant Effects of Natural Compounds against Oxidative Stress-Induced Epigenetic Instability in Tumor Cells.

Bouyahya, Abdelhakim / El Menyiy, Naoual / Oumeslakht, Loubna / El Allam, Aicha / Balahbib, Abdelaali / Rauf, Abdur / Muhammad, Naveed / Kuznetsova, Elena / Derkho, Marina / Thiruvengadam, Muthu / Shariati, Mohammad Ali / El Omari, Nasreddine

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 10

Abstract: ROS (reactive oxygen species) are produced via the noncomplete reduction in molecular oxygen in the mitochondria of higher organisms. The produced ROS are placed in various cell compartments, such as the mitochondria, cytoplasm, and endoplasmic reticulum. ...

Abstract	ROS (reactive oxygen species) are produced via the noncomplete reduction in molecular oxygen in the mitochondria of higher organisms. The produced ROS are placed in various cell compartments, such as the mitochondria, cytoplasm, and endoplasmic reticulum. In general, there is an equilibrium between the synthesis of ROS and their reduction by the natural antioxidant defense system, called the redox system. Therefore, when this balance is upset, the excess ROS production can affect different macromolecules, such as proteins, lipids, nucleic acids, and sugars, which can lead to an electronic imbalance than oxidation of these macromolecules. Recently, it has also been shown that ROS produced at the cellular level can affect different signaling pathways that participate in the stimulation of transcription factors linked to cell proliferation and, consequently, to the carcinogenesis process. Indeed, ROS can activate the pathway of tyrosine kinase, MAP kinase, IKK, NF-KB, phosphoinositol 3 phosphate, and hypoxia-inducible factor (HIF). The activation of these signaling pathways directly contributes to the accelerated proliferation process and, as a result, the appearance of cancer. In addition, the use of antioxidants, especially natural ones, is now a major issue in the approach to cancer prevention. Some natural molecules, especially phytochemicals isolated from medicinal plants, have now shown interesting preclinical and clinical results.
Language	English
Publishing date	2021-09-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10101553
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Article ; Online: Sedative-hypnotic effect and in silico study of dinaphthodiospyrols isolated from Diospyros lotus Linn.

Al-Awthan, Yahya S / Rauf, Abdur / Rashid, Umer / Bawazeer, Sami / Naz, Saima / Bahattab, Omar / Bawazeer, Saud / Muhammad, Naveed / Waggas, Dania Saad / Batiha, Gaber El-Saber / Shariati, Mohammad Ali / Derkho, Marina / Suleria, Hafiz Ansar Rasul

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2021 Volume 140, Page(s) 111745

Abstract: Traditionally, Diospyros lotus Linn is used for insomnia and other associated disorders. Insomnia is a worldwide disorder with different etiology which is treated with different synthetic medicine associated with addiction. Natural products are generally ...

Abstract	Traditionally, Diospyros lotus Linn is used for insomnia and other associated disorders. Insomnia is a worldwide disorder with different etiology which is treated with different synthetic medicine associated with addiction. Natural products are generally devoid of such addition with good efficacy. Current research was conducted to evaluate the sedative and hypnotic effects of dimeric naphthoquinones such as dinaphthodiospyrol A (1), dinaphthodiospyrol B (2), dinaphthodiospyrol C (3), dinaphthodiospyrol D (4), dinaphthodiospyrol E (5) and dinaphthodiospyrol F (6) isolated from the chloroform fractions of D. lotus. The sedative and hypnotic effects at the dose of 5 and 10 mg/kg (each compound) were assessed through open field and phenobarbital induced sleep test, respectively. In the case of open field test the administration of tested compounds significantly hindered the movement of animals, while in case of hypnotic effect the tested samples significantly improved the onset and duration of sleep as compared to control. The overall effects were in a dose dependent manner. The compounds were also assessed for acute toxicity, but no toxicity was observed. In this regard, our research triumphantly announced the strong chemical base for the folkloric values of the plant with their fringe benefits and implemented a platform for further aspects of mechanistic and clinical studies. A possible mechanism of in vivo inhibition was studied by using docking simulations on GABA receptors. Binding orientations and types of interactions revealed that a possible mechanism behind these pharmacological actions might be interaction with GABA receptors.
MeSH term(s)	Animals ; Diospyros ; Female ; Hypnotics and Sedatives/pharmacology ; Hypnotics and Sedatives/toxicity ; Male ; Mice ; Molecular Docking Simulation ; Naphthoquinones/pharmacology ; Naphthoquinones/toxicity ; Plant Roots ; Receptors, GABA/metabolism ; Sleep/drug effects
Chemical Substances	Hypnotics and Sedatives ; Naphthoquinones ; Receptors, GABA
Language	English
Publishing date	2021-05-19
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2021.111745
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Article ; Online: Prognostic significance of programmed death-1 and programmed death ligand-1 proteins in breast cancer.

Tahir, Imtiaz Mahmood / Rauf, Abdur / Mehboob, Huma / Sadaf, Samia / Alam, Muhammad Shaiful / Kalsoom, Fadia / Bouyahya, Abdelhakim / El Allam, Aicha / El Omari, Nasreddine / Bakrim, Saad / Akram, Muhammad / Raza, Syed Kashif / Emran, Talha Bin / Mabkhot, Yahia N / Zengin, Gokhan / Derkho, Marina / Natalya, Suray / Shariati, Mohammad Ali

Human antibodies

2022 Volume 30, Issue 3, Page(s) 131–150

Abstract: In numerous studies related to tumor prognosis, programmed death-ligand 1 (PD-L1) has been identified as a biomarker. This work aimed to determine the prognostic importance of PD-L1 in breast cancer. We searched electronic databases such as PubMed, ... ...

Abstract	In numerous studies related to tumor prognosis, programmed death-ligand 1 (PD-L1) has been identified as a biomarker. This work aimed to determine the prognostic importance of PD-L1 in breast cancer. We searched electronic databases such as PubMed, Google scholar, home pages of publishing groups, medical, clinical, and pharmaceutical sciences journals, as well as other relevant sources to discover the importance of PD-1 and PD-L1 expression in breast cancer therapies and also recurrence. The keywords used in this search were autoimmunity, programmed cell death, PD-L1 or PD-1, and breast cancer. Our inclusion criteria included studies showing the synergy between the expression of PD-L1 and PD-1 in primary breast cancers as prognostic markers and this research was limited to humans only. We included review articles, original research, letters to the editor, case reports, and short communications in our study, published in English. We focused our work on PD-L1 mRNA expression in breast cancer cell lines. PD-L1 expression has been decisively demonstrated to be a high-risk factor for breast cancer with a bad prognosis.
MeSH term(s)	B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Biomarkers, Tumor/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Humans ; Prognosis ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/metabolism
Chemical Substances	B7-H1 Antigen ; Biomarkers, Tumor ; CD274 protein, human ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2022-08-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1383468-x
ISSN	1875-869X ; 1093-2607
ISSN (online)	1875-869X
ISSN	1093-2607
DOI	10.3233/HAB-220001
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Article ; Online: Comprehensive review on naringenin and naringin polyphenols as a potent anticancer agent.

Rauf, Abdur / Shariati, Mohammad Ali / Imran, Muhammad / Bashir, Kashif / Khan, Shahid Ali / Mitra, Saikat / Emran, Talha Bin / Badalova, Kamala / Uddin, Md Sahab / Mubarak, Mohammad S / Aljohani, Abdullah S M / Alhumaydhi, Fahad A / Derkho, Marina / Korpayev, Serdar / Zengin, Gokhan

Environmental science and pollution research international

2022 Volume 29, Issue 21, Page(s) 31025–31041

Abstract	Though the incidence of several cancers in Western societies is regulated wisely, some cancers such as breast, lung, and colorectal cancer are currently rising in many low- and middle-income countries due to increased risk factors triggered by societal and development problems. Surgery, chemotherapy, hormone, radiation, and targeted therapies are examples of traditional cancer treatment approaches. However, multiple short- and long-term adverse effects may also significantly affect patient prognosis depending on treatment-associated clinical factors. More and more research has been carried out to find new therapeutic agents in natural products, among which the bioactive compounds derived from plants have been increasingly studied. Naringin and naringenin are abundantly found in citrus fruits, such as oranges and grapefruits. A variety of cell signaling pathways mediates their anti-carcinogenic properties. Naringin and naringenin were also documented to overcome multidrug resistance, one of the major challenges to clinical practice due to multiple defense mechanisms in cancer. The effective parameters underlying the anticancer effects of naringenin and naringin include GSK3β inactivation, suppression of the gene and protein activation of NF-kB and COX-2, JAK2/STAT3 downregulation, downregulation of intracellular adhesion molecules-1, upregulation of Notch1 and tyrocite-specific genes, and activation of p38/MAPK and caspase-3. Thus, this review outlines the potential of naringin and naringenin in managing different types of cancers.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Citrus ; Flavanones/pharmacology ; Humans ; Neoplasms ; Polyphenols
Chemical Substances	Antineoplastic Agents ; Flavanones ; Polyphenols ; naringenin (HN5425SBF2) ; naringin (N7TD9J649B)
Language	English
Publishing date	2022-02-04
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-18754-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluation of the anti-diarrheal effects of the whole plant extracts of Cuscuta reflexa Roxb in pigeons

Muhammad, Naveed / Ullah, Sana / Rauf, Abdur / Atif, Muhammad / Patel, Seema / Israr, Muhammad / Akbar, Sajid / Shehzad, Omer / Saeed, Muhammad / Bawazeer, Saud / Uddin, Md. Sahab / Derkho, Marina / Shariati, Mohammad Ali / Mubarak, Mohammad S

Toxicology reports. 2021, v. 8

2021

Abstract: Cuscuta reflexa (dodder) belonging to the family Convolvulaceae has many ethno-medicinal uses such as antidiarrheal and antiemetic. This plant has been employed to treat diarrhea, where the antidiarrheal use of this plant is well established in different ...

Abstract	Cuscuta reflexa (dodder) belonging to the family Convolvulaceae has many ethno-medicinal uses such as antidiarrheal and antiemetic. This plant has been employed to treat diarrhea, where the antidiarrheal use of this plant is well established in different communities around the world without scientific bases. In addition, the antibacterial, anthelmintic, anticholinergic, and antihistaminic effects of this parasitic vine are partly responsible for the folkloric antidiarrheal use of this plant. In the present study, the antidiarrheal activity of C. reflexa was evaluated in pigeons (Columba livia) using the juice (JCR), aqueous (CRAE), and methanol (CRME) extracts.The antidiarrheal effect of C. reflexa was evaluated using different reported research models, with few modifications. In pigeons, diarrhea was induced by administration of castor oil (6 mL/kg, PO), ampicillin (250 mg/kg, IP), magnesium sulfate (2 gm/kg, PO), and cisplatin (6 mg/kg, IV). In these experiments, loperamide (2 mg/kg, IM) was used as a positive control, whereas JCR (1 mL/kg (1%) and 1 mL/kg (2%), CRAE (50, 100 and 200 mg/kg) and CRME (50, 100 and 200 mg/kg) were administered intramuscularly at different doses into each pigeon in the test groups.In addition to cisplatin-induced diarrhea, all paradigms tested gave significant results (P < 0.01). The JCR, at different doses, exhibited a significant (p < 0.01) a dose-dependent antidiarrheal effect on both the frequency and the onset of diarrhea. Similarly, CRAE and CRME, at doses of 100 and 200 mg/kg, showed considerable (p < 0.001) inhibition against the onset and frequency of diarrhea. On the other hand, JCR, CRAE, and CRME exerted significant effects (p < 0.001) on the percentage inhibition (PI) of diarrhea and gastrointestinal charcoal transit in a dose-dependent manner. In this respect, the maximum PI (p < 0.01) of JCR, CRAE, and CRME in different experimental paradigms was 43.13, 49.14, and 55.99 %, respectively.Taken all together, results from this study reveal that the juice, aqueous, and methanol extract of C. reflexa exhibit significant anti-motility and anti-secretory potential. These findings may explain the medicinal use of C. reflexa in folk medicine as an antidiarrheal medicinal plant.
Keywords	Columba livia ; Cuscuta reflexa ; ampicillin ; anthelmintics ; antidiarrheal effect ; antiemetics ; castor oil ; charcoal ; cisplatin ; diarrhea ; dose response ; gastrointestinal system ; juices ; magnesium sulfate ; medicinal plants ; methanol ; pigeons ; toxicology ; traditional medicine ; vines
Language	English
Size	p. 395-404.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light
ZDB-ID	2805786-7
ISSN	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2021.02.013
Database	NAL-Catalogue (AGRICOLA)

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