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  1. Article ; Online: Psychosocial Implications of COVID-19 on Head and Neck Cancer.

    Dermody, Sarah M / Shuman, Andrew G

    Current oncology (Toronto, Ont.)

    2022  Volume 29, Issue 2, Page(s) 1062–1068

    Abstract: The COVID-19 pandemic has fundamentally changed healthcare access, delivery, and treatment paradigms throughout oncology. Patients with head and neck cancer comprise an especially vulnerable population due to the nature of their disease and the ... ...

    Abstract The COVID-19 pandemic has fundamentally changed healthcare access, delivery, and treatment paradigms throughout oncology. Patients with head and neck cancer comprise an especially vulnerable population due to the nature of their disease and the transmission mechanism of the SARS-CoV-2 virus. The consequences of triage decisions and delays in care have serious psychosocial implications for patients. The development of structured psychosocial support programs, coupled with clear and consistent communication from treating physicians, can help mitigate perceptions of abandonment and distress that may accompany delays in care. As the unpredictability of the pandemic's course continues to burden both providers and patients, we must be proactive in addressing the psychosocial implications of these delays in care.
    MeSH term(s) COVID-19 ; Head and Neck Neoplasms/therapy ; Humans ; Medical Oncology ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol29020090
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  2. Article ; Online: Defining Critical Portions of Surgery.

    Dermody, Sarah M / Shuman, Andrew G

    Annals of surgery

    2022  Volume 276, Issue 2, Page(s) 213–214

    Language English
    Publishing date 2022-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000005484
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  3. Article ; Online: Considerations for Optimal Grafting in Rhinoplasty.

    Dermody, Sarah M / Lindsay, Robin W / Justicz, Natalie

    Facial plastic surgery : FPS

    2023  Volume 39, Issue 6, Page(s) 625–629

    Abstract: A wide variety of grafting materials and techniques can be used to create functional and aesthetic changes in rhinoplasty. Choosing the optimal grafting approach is critical to achieving an optimal patient outcome. We present a review of autografts, ... ...

    Abstract A wide variety of grafting materials and techniques can be used to create functional and aesthetic changes in rhinoplasty. Choosing the optimal grafting approach is critical to achieving an optimal patient outcome. We present a review of autografts, allografts, and alloplasts used in primary and revision rhinoplasty and discuss factors that impact graft choice. Autologous grafts serve as the pillar for grafting material in rhinoplasty given their reliable long-term outcomes, low rates of infection, resorption, and extrusion, and ability to provide structural scaffolding as well as contour. Cadaveric allografts can be utilized as a source of grafting material in certain clinical scenarios including revision rhinoplasty and have been shown to be equally safe and effective as autologous grafts while avoiding donor-site morbidity. Alloplasts can prove useful in rhinoplasty in cases of iatrogenic nasal deformities or revision cases. Careful consideration of clinical scenario, patient factors, and outcome goals is necessary to choose the appropriate grafting approach to address functional and cosmetic outcomes.
    MeSH term(s) Humans ; Rhinoplasty/adverse effects ; Rhinoplasty/methods ; Esthetics, Dental ; Transplantation, Autologous/methods ; Autografts ; Reoperation/methods ; Retrospective Studies
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 630090-x
    ISSN 1098-8793 ; 0736-6825
    ISSN (online) 1098-8793
    ISSN 0736-6825
    DOI 10.1055/a-2116-4566
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  4. Article ; Online: Reducing Risks of Graft Failure for Composite Skin-Cartilage Grafts.

    Yamasaki, Alisa / Dermody, Sarah M / Moyer, Jeffrey S

    Facial plastic surgery clinics of North America

    2023  Volume 31, Issue 2, Page(s) 289–296

    Abstract: Facial skin defects pose unique challenges for the reconstructive surgeon. Aesthetically complex areas involving a free margin-such as the ear, eyelid, columella, columella-lobule interface, soft tissue triangle, alar rim, and internal nasal lining-are ... ...

    Abstract Facial skin defects pose unique challenges for the reconstructive surgeon. Aesthetically complex areas involving a free margin-such as the ear, eyelid, columella, columella-lobule interface, soft tissue triangle, alar rim, and internal nasal lining-are particularly demanding, as secondary soft tissue contracture in these locations can lead to a very poor cosmetic outcome. In these cases, composite grafts offer an ideal combination of soft tissue coverage and structural rigidity, all accomplished in a single-stage surgery. Composite grafts are often underused in facial reconstructive surgery due to the tenuous blood supply and high reported rates of graft failure.
    MeSH term(s) Humans ; Skin Transplantation ; Nose/surgery ; Cartilage/transplantation ; Nose Neoplasms/surgery ; Nasal Septum/surgery ; Face/surgery ; Rhinoplasty/adverse effects
    Language English
    Publishing date 2023-02-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1315178-2
    ISSN 1558-1926 ; 1064-7406
    ISSN (online) 1558-1926
    ISSN 1064-7406
    DOI 10.1016/j.fsc.2023.01.007
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  5. Article ; Online: Implications of Research Biopsies in Clinical Trials.

    Dermody, Sarah M / Shuman, Andrew G

    The oncologist

    2021  Volume 26, Issue 12, Page(s) 994–996

    MeSH term(s) Biopsy ; Humans ; Medical Oncology
    Language English
    Publishing date 2021-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1002/onco.13948
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  6. Article: Considerations for Optimal Grafting in Rhinoplasty

    Dermody, Sarah M. / Lindsay, Robin W. / Justicz, Natalie

    Facial Plastic Surgery

    (Functional Rhinoplasty)

    2023  Volume 39, Issue 06, Page(s) 625–629

    Abstract: A wide variety of grafting materials and techniques can be used to create functional and aesthetic changes in rhinoplasty. Choosing the optimal grafting approach is critical to achieving an optimal patient outcome. We present a review of autografts, ... ...

    Series title Functional Rhinoplasty
    Abstract A wide variety of grafting materials and techniques can be used to create functional and aesthetic changes in rhinoplasty. Choosing the optimal grafting approach is critical to achieving an optimal patient outcome. We present a review of autografts, allografts, and alloplasts used in primary and revision rhinoplasty and discuss factors that impact graft choice. Autologous grafts serve as the pillar for grafting material in rhinoplasty given their reliable long-term outcomes, low rates of infection, resorption, and extrusion, and ability to provide structural scaffolding as well as contour. Cadaveric allografts can be utilized as a source of grafting material in certain clinical scenarios including revision rhinoplasty and have been shown to be equally safe and effective as autologous grafts while avoiding donor-site morbidity. Alloplasts can prove useful in rhinoplasty in cases of iatrogenic nasal deformities or revision cases. Careful consideration of clinical scenario, patient factors, and outcome goals is necessary to choose the appropriate grafting approach to address functional and cosmetic outcomes.
    Keywords rhinoplasty ; grafting ; autograft ; costal cartilage ; allograft
    Language English
    Publishing date 2023-06-22
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 630090-x
    ISSN 1098-8793 ; 0736-6825
    ISSN (online) 1098-8793
    ISSN 0736-6825
    DOI 10.1055/a-2116-4566
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  7. Article ; Online: Lymph node level ratio as a predictor of survival in oral cavity squamous cell carcinoma.

    Dermody, Sarah M / McMichael, Brennan M / Bellile, Emily / Marchiano, Emily J / Chinn, Steven B

    Oral oncology

    2023  Volume 146, Page(s) 106572

    Abstract: Objective: To evaluate whether nodal yields and ratios based on level serves as prognostic indicators in patients with oral cavity squamous cell carcinoma undergoing neck dissection.: Materials and methods: A retrospective analysis of 342 patients ... ...

    Abstract Objective: To evaluate whether nodal yields and ratios based on level serves as prognostic indicators in patients with oral cavity squamous cell carcinoma undergoing neck dissection.
    Materials and methods: A retrospective analysis of 342 patients with oral cavity squamous cell carcinoma treated surgically between 1998 and 2017 were included.Demographics and clinicopathologic data were collated. Disease specific survival and overall survival were analyzed via Kaplan-Meier method and log-rank test as well as univariable and multivariable Cox models.
    Results: Total nodal yield is associated with improved overall and disease specific survival (p < 0.01). Total positive nodal yield (p < 0.01), positive nodal ratio per level (p < 0.001), and identification of <4 lymph nodes/level (p < 0.001) are associated with worse disease specific survival and overall survival. A ratio of at least 4 lymph nodes/level dissected yields the maximal hazard ratio on for both disease specific and overall survival optimizes the Kaplan-Meier split between survival groups. After controlling for sex, age, margin status, disease stage, extranodal extension, perineural invasion, and lymphovascular invasion as fixed covariates in the Cox models, a nodal level ratio of 4 lymph nodes/level provides hazard ratio (95% CI) of 3.59 (1.69, 7.60); p < 0.0006) for disease free survival and 2.90 (1.54, 5.46; p < 0.001) for overall survival.
    Conclusion: Nodal level ratio of < 4 lymph nodes/level is associated with worse disease specific and overall survival in oral cavity squamous cell carcinoma. This level-specific metric may prove useful qualitatively and in predicting survival in oral cavity cancer with broader utility to address variations in levels of neck dissection performed.
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck/pathology ; Retrospective Studies ; Carcinoma, Squamous Cell/pathology ; Mouth Neoplasms/pathology ; Lymph Nodes/pathology ; Neck Dissection ; Prognosis ; Head and Neck Neoplasms/pathology ; Neoplasm Staging
    Language English
    Publishing date 2023-09-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2023.106572
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  8. Article ; Online: A Multispecialty Critical Airway Simulation Course for Medical Students.

    Dermody, Sarah M / Masciello, Maria / Malekzadeh, Sonya

    The Laryngoscope

    2020  Volume 131, Issue 7, Page(s) 1482–1486

    Abstract: Objectives: To develop a novel multispecialty simulation-based course that teaches both technical and nontechnical skills in the management of adult and pediatric critical airways to graduating medical students and 2) to encourage a collaborative, ... ...

    Abstract Objectives: To develop a novel multispecialty simulation-based course that teaches both technical and nontechnical skills in the management of adult and pediatric critical airways to graduating medical students and 2) to encourage a collaborative, multispecialty approach to the management of a difficult airway amongst fourth-year medical students who have enrolled in otolaryngology, anesthesia, and emergency medicine residency programs.
    Methods: Fourth-year medical student who had matched into otolaryngology, anesthesia, and emergency medicine participated in an intensive half-day course consisting of a series of hands-on skills stations with increasing complexity, followed by simulated complex patient scenarios designed for shared management of airway emergencies. Participants completed questionnaires prior to and immediately after the course. Fischer's exact test was utilized to compare data between the precourse and postcourse surveys. Free-text responses were qualitatively assessed to inform course development.
    Results: Thirty-four medical students were enrolled (6 otolaryngology, 15 anesthesia, 13 emergency medicine), and 30 students completed both surveys. Fisher's exact test demonstrated improved confidence (P < .05) for every skill. More than 85% of participants strongly agreed or agreed that the intervention was useful in developing their knowledge, technical skills, and self-confidence and in improving clinical performance prior to residency.
    Conclusions: This critical airway course introduces a multispecialty simulation-based course designed to impart graduating medical students with the necessary knowledge, skills, and behaviors for critical airway management while fostering interprofessional collaboration. Our course was successful in improving confidence and was perceived as useful in developing knowledge, technical skills, self-confidence, and clinical performance prior to residency.
    Level of evidence: NA Laryngoscope, 131:1482-1486, 2021.
    MeSH term(s) Adult ; Airway Management/methods ; Anesthesiology/education ; Child ; Clinical Competence/statistics & numerical data ; Critical Care/methods ; Curriculum ; Education, Medical/methods ; Emergency Medicine/education ; Humans ; Internship and Residency/statistics & numerical data ; Interprofessional Education/methods ; Otolaryngology/education ; Simulation Training/methods ; Students, Medical/statistics & numerical data ; Surveys and Questionnaires/statistics & numerical data
    Language English
    Publishing date 2020-11-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.29264
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  9. Article: Trans-Renal Cell-Free Tumor DNA for Urine-Based Liquid Biopsy of Cancer.

    Dermody, Sarah M / Bhambhani, Chandan / Swiecicki, Paul L / Brenner, J Chad / Tewari, Muneesh

    Frontiers in genetics

    2022  Volume 13, Page(s) 879108

    Abstract: Cancer biomarkers are a promising tool for cancer detection, personalization of therapy, and monitoring of treatment response or recurrence. "Liquid biopsy" commonly refers to minimally invasive or non-invasive sampling of a bodily fluid (i.e., blood, ... ...

    Abstract Cancer biomarkers are a promising tool for cancer detection, personalization of therapy, and monitoring of treatment response or recurrence. "Liquid biopsy" commonly refers to minimally invasive or non-invasive sampling of a bodily fluid (i.e., blood, urine, saliva) for detection of cancer biomarkers such as circulating tumor cells or cell-free tumor DNA (ctDNA). These methods offer a means to collect frequent tumor assessments without needing surgical biopsies. Despite much progress with blood-based liquid biopsy approaches, there are limitations-including the limited amount of blood that can be drawn from a person and challenges with collecting blood samples at frequent intervals to capture ctDNA biomarker kinetics. These limitations are important because ctDNA is present at extremely low levels in plasma and there is evidence that measuring ctDNA biomarker kinetics over time can be useful for clinical prediction. Additionally, blood-based assays require access to trained phlebotomists and often a trip to a healthcare facility. In contrast, urine is a body fluid that can be self-collected from a patient's home, at frequent intervals, and mailed to a laboratory for analysis. Multiple reports indicate that fragments of ctDNA pass from the bloodstream through the kidney's glomerular filtration system into the urine, where they are known as trans-renal ctDNA (TR-ctDNA). Accumulating studies indicate that the limitations of blood based ctDNA approaches for cancer can be overcome by measuring TR-ctDNA. Here, we review current knowledge about TR-ctDNA in urine as a cancer biomarker approach, and discuss its clinical potential and open questions in this research field.
    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.879108
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  10. Article ; Conference proceedings: Sinonasal Mucosal Melanoma Response to Immunotherapy: Surgical Resection of Necrosis

    Dermody, Sarah M. / Fischer, Ilana P. / McLean, Scott A.

    Journal of Neurological Surgery Part B: Skull Base

    2022  Volume 83, Issue S 01

    Event/congress 31st Annual Meeting North American Skull Base Society, Online, 2022-02-18
    Language English
    Publishing date 2022-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0042-1743939
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