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Article: 3D Printing in alloy design to improve biocompatibility in metallic implants.

Mitra, Indranath / Bose, Susmita / Dernell, William S / Dasgupta, Nairanjana / Eckstrand, Chrissy / Herrick, Jim / Yaszemski, Michael J / Goodman, Stuart B / Bandyopadhyay, Amit

Materials today (Kidlington, England)

2021 Volume 45, Page(s) 20–34

Abstract: 3D Printing (3DP) or additive manufacturing (AM) enables parts with complex shapes, design flexibility, and customization opportunities for defect specific patient-matched implants. 3DP or AM also offers a design platform that can be used to innovate ... ...

Abstract	3D Printing (3DP) or additive manufacturing (AM) enables parts with complex shapes, design flexibility, and customization opportunities for defect specific patient-matched implants. 3DP or AM also offers a design platform that can be used to innovate novel alloys for application-specific compositional modifications. In medical applications, the biological response from a host tissue depends on a biomaterial's structural and compositional properties in the physiological environment. Application of 3DP can pave the way towards manufacturing innovative metallic implants, combining structural variations at different length scales and tailored compositions designed for specific biological responses. This study shows how 3DP can be used to design metallic alloys for orthopedic and dental applications with improved biocompatibility using
Language	English
Publishing date	2021-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2083513-9
ISSN	1873-4103 ; 1369-7021
ISSN (online)	1873-4103
ISSN	1369-7021
DOI	10.1016/j.mattod.2020.11.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Initial wound management.

Dernell, William S

The Veterinary clinics of North America. Small animal practice

2006 Volume 36, Issue 4, Page(s) 713–738

Abstract: A wounded patient can be presented to the veterinary surgeon under a number of circumstances. The wound could result from external trauma,such as vehicle trauma or an animal fight, or it could have been created by surgical intervention, such as the ... ...

Abstract	A wounded patient can be presented to the veterinary surgeon under a number of circumstances. The wound could result from external trauma,such as vehicle trauma or an animal fight, or it could have been created by surgical intervention, such as the removal of a mass. A wound could also be secondary to a failed initial attempt at wound closure. No matter what the cause, initial wound management often follows similar pathways. A successful wound closure and healing outcome is often dependent on adherence to basic principles of wound assessment, appropriate care, and reassessment. This article covers the approach to and specific options for the initial stages of wound management.
MeSH term(s)	Animals ; Debridement/veterinary ; Drainage/veterinary ; Patient Care Management ; Suture Techniques/veterinary ; Veterinary Medicine/methods ; Wound Healing ; Wounds and Injuries/surgery ; Wounds and Injuries/therapy ; Wounds and Injuries/veterinary
Language	English
Publishing date	2006-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	757662-6
ISSN	1878-1306 ; 0195-5616
ISSN (online)	1878-1306
ISSN	0195-5616
DOI	10.1016/j.cvsm.2006.04.003
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Article: Additively manufactured calcium phosphate reinforced CoCrMo alloy: Bio-tribological and biocompatibility evaluation for load-bearing implants.

Bandyopadhyay, Amit / Shivaram, Anish / Isik, Murat / Avila, Jose D / Dernell, William S / Bose, Susmita

Additive manufacturing

2019 Volume 28, Page(s) 312–324

Abstract: Cobalt-chromium-molybdenum (CoCrMo) alloys are widely used in load-bearing implants; specifically, in hip, knee, and spinal applications due to their excellent wear resistance. However, due ... ...

Abstract	Cobalt-chromium-molybdenum (CoCrMo) alloys are widely used in load-bearing implants; specifically, in hip, knee, and spinal applications due to their excellent wear resistance. However, due to
Language	English
Publishing date	2019-05-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2777285-8
ISSN	2214-8604
ISSN	2214-8604
DOI	10.1016/j.addma.2019.04.020
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Article ; Online: Dysregulated microRNA clusters in response to retinoic acid and CYP26B1 inhibitor induced testicular function in dogs.

Kasimanickam, Vanmathy R / Kasimanickam, Ramanathan K / Dernell, William S

PloS one

2014 Volume 9, Issue 6, Page(s) e99433

Abstract: Spermatogenesis is a multistep synchronized process. Diploid spermatogonia differentiate into haploid spermatozoa following mitosis, meiosis and spermiogenesis. Division and differentiation of male germ cells is achieved through the sequential expression ...

Abstract	Spermatogenesis is a multistep synchronized process. Diploid spermatogonia differentiate into haploid spermatozoa following mitosis, meiosis and spermiogenesis. Division and differentiation of male germ cells is achieved through the sequential expression of several genes. Numerous mRNAs in the differentiating germ cells undergo post-transcriptional and translational regulation. MiRNAs are powerful negative regulators of mRNA transcription, stability, and translation and recognize their mRNA targets through base-pairing. Retinoic acid (RA) signaling is essential for spermatogenesis and testicular function. Testicular RA level is critical for RA signal transduction. This study investigated the miRNAs modulation in an RA- induced testicular environment following the administration of all-trans RA (2 µM) and CYP26B1- inhibitor (1 µM) compared to control. Eighty four canine mature miRNAs were analyzed and their expression signatures were distinguished using real-time PCR based array technology. Of the miRNAs analyzed, miRNA families such as miR-200 (cfa-miR-200a, cfa-miR-200b and cfa-miR-200c), Mirlet-7 (cfa-let-7a, cfa-let-7b, cfa-let-7c, cfa-let-7g and cfa-let-7f), miR-125 (cfa-miR-125a and cfa-miR-125b), miR-146 (cfa-miR-146a and cfa-miR-146b), miR-34 (cfa-miR-34a, cfa-miR-34b and cfa-miR-34c), miR-23 (cfa-miR-23a and cfa-miR-23b), cfa-miR-184, cfa-miR-214 and cfa-miR-141 were significantly up-regulated with testicular RA intervention via administration of CYP26B1 inhibitor and all-trans-RA and species of miRNA such as cfa-miR-19a, cfa-miR-29b, cfa-miR-29c, cfa-miR-101 and cfa-miR-137 were significantly down-regulated. This study explored information regarding chromosome distribution, human orthologous sequences and the interaction of target genes of miRNA families significantly distinguished in this study using prediction algorithms. This study importantly identified dysregulated miRNA species resulting from RA-induced spermatogenesis. The present contribution serves as a useful resource for further elucidation of the regulatory role of individual miRNA in RA synchronized canine spermatogenesis.
MeSH term(s)	Animals ; Benzothiazoles/pharmacology ; Cluster Analysis ; Cytochrome P-450 Enzyme Inhibitors/pharmacology ; Cytochrome P-450 Enzyme System/metabolism ; Dogs ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Gene Regulatory Networks ; Male ; MicroRNAs/genetics ; Multigene Family ; Retinoic Acid 4-Hydroxylase ; Testis/drug effects ; Testis/metabolism ; Transcriptome ; Tretinoin/pharmacology ; Triazoles/pharmacology
Chemical Substances	Benzothiazoles ; Cytochrome P-450 Enzyme Inhibitors ; MicroRNAs ; Triazoles ; Tretinoin (5688UTC01R) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Retinoic Acid 4-Hydroxylase (EC 1.14.14.1) ; R 115866 (XKD9N5CJ6W)
Language	English
Publishing date	2014-06-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0099433
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Article: Effects of MgO and SiO2 on Plasma-Sprayed Hydroxyapatite Coating: An in Vivo Study in Rat Distal Femoral Defects

Ke, Dongxu / Robertson Samuel F / Dernell William S / Bandyopadhyay Amit / Bose Susmita

ACS Applied Materials & Interfaces. 2017 Aug. 09, v. 9, no. 31

2017

Abstract: Plasma-sprayed hydroxyapatite (HA)-coated titanium implants have been widely used in orthopedic applications due to their inheritance of an excellent mechanical property from titanium and great osteoconductivity from HA. However, the lack of ... ...

Abstract	Plasma-sprayed hydroxyapatite (HA)-coated titanium implants have been widely used in orthopedic applications due to their inheritance of an excellent mechanical property from titanium and great osteoconductivity from HA. However, the lack of osteoinductivity limits their further applications. In this study, 1 wt % MgO and 0.5 wt % SiOâ were mixed with HA for making plasma-sprayed coatings on titanium implants. Plasma-sprayed HA- and MgO/SiOââHA-coated titanium implants showed adhesive bond strengths of 25.73 Â± 1.92 and 23.44 Â± 2.89 MPa, respectively. The presence of MgO and SiOâ significantly increased the osteogenesis, osseointegration, and bone mineralization of HA-coated titanium implants by the evaluation of their histomorphology after 6, 10, and 14 weeks of implantation in rat distal femoral defects. Implant pushout tests also showed a shear modulus of 149.83 Â± 3.69 MPa for MgO/SiOââHA-coated implants after 14 weeks of implantation, compared to 52.68 Â± 10.41 MPa for uncoated implants and 83.92 Â± 3.68 MPa for pure HA-coated implants; These are differences in the shear modulus of 96% and 56.4%, respectively. This study assesses for the first time the quality of the boneâimplant interface of induction plasma-sprayed MgO and SiOâ binary-doped HA coatings on load-bearing implants compared to bare titanium and pure HA coatings in a quantitative manner. Relating the osseointegration and interface shear modulus to the quality of implant fixation is critical to the advancement and implementation of HA-coated orthopedic implants.
Keywords	bone mineralization ; coatings ; hydroxyapatite ; magnesium oxide ; mechanical properties ; modulus of elasticity ; orthopedics ; prostheses ; rats ; silica ; titanium
Language	English
Dates of publication	2017-0809
Size	p. 25731-25737.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021%2Facsami.7b05574
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Article ; Online: Effects of MgO and SiO

Ke, Dongxu / Robertson, Samuel F / Dernell, William S / Bandyopadhyay, Amit / Bose, Susmita

ACS applied materials & interfaces

2017 Volume 9, Issue 31, Page(s) 25731–25737

Abstract	Plasma-sprayed hydroxyapatite (HA)-coated titanium implants have been widely used in orthopedic applications due to their inheritance of an excellent mechanical property from titanium and great osteoconductivity from HA. However, the lack of osteoinductivity limits their further applications. In this study, 1 wt % MgO and 0.5 wt % SiO
MeSH term(s)	Animals ; Coated Materials, Biocompatible ; Durapatite/chemistry ; Magnesium Oxide ; Osseointegration ; Prostheses and Implants ; Rats ; Silicon Dioxide ; Titanium
Chemical Substances	Coated Materials, Biocompatible ; Magnesium Oxide (3A3U0GI71G) ; Silicon Dioxide (7631-86-9) ; Durapatite (91D9GV0Z28) ; Titanium (D1JT611TNE)
Language	English
Publishing date	2017-07-28
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.7b05574
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Article ; Online: SrO- and MgO-doped microwave sintered 3D printed tricalcium phosphate scaffolds: mechanical properties and in vivo osteogenesis in a rabbit model.

Tarafder, Solaiman / Dernell, William S / Bandyopadhyay, Amit / Bose, Susmita

Journal of biomedical materials research. Part B, Applied biomaterials

2014 Volume 103, Issue 3, Page(s) 679–690

Abstract: The presence of interconnected macro pores allows guided tissue regeneration in tissue engineering scaffolds. However, highly porous scaffolds suffer from having poor mechanical strength. Previously, we showed that microwave sintering could successfully ... ...

Abstract	The presence of interconnected macro pores allows guided tissue regeneration in tissue engineering scaffolds. However, highly porous scaffolds suffer from having poor mechanical strength. Previously, we showed that microwave sintering could successfully be used to improve mechanical strength of macro porous tricalcium phosphate (TCP) scaffolds. This study reports the presence of SrO and MgO as dopants in TCP scaffolds improves mechanical and in vivo biological performance. We have used direct three dimensional printing (3DP) technology for scaffold fabrication. These 3DP scaffolds possessed multiscale porosity, that is, 3D interconnected designed macro pores along with intrinsic micro pores. A significant increase in mechanical strength, between 37 and 41%, was achieved due to SrO and MgO doping in TCP as compared with pure TCP. Maximum compressive strengths of 9.38 ± 1.86 MPa and 12.01 ± 1.56 MPa were achieved by conventional and microwave sintering, respectively, for SrO-MgO-doped 3DP scaffolds with 500 μm designed pores. Histomorphological and histomorphometric analysis revealed a significantly higher osteoid, bone and haversian canal formation induced by the presence of SrO and MgO dopants in 3DP TCP as compared with pure TCP scaffolds when tested in rabbit femoral condyle defect model. Increased osteon and thus enhanced network of blood vessel formation, and osteocalcin expression were observed in the doped TCP scaffolds. Our results show that these 3DP SrO-MgO-doped TCP scaffolds have the potential for early wound healing through accelerated osteogenesis and vasculogenesis.
MeSH term(s)	Animals ; Biomechanical Phenomena ; Bone Regeneration/drug effects ; Bone Substitutes ; Calcium Phosphates/chemistry ; Calcium Phosphates/pharmacology ; Compressive Strength ; Femur/physiology ; Femur/surgery ; Magnesium Oxide/chemistry ; Materials Testing ; Mesenchymal Stem Cells/cytology ; Microwaves ; Osteocalcin/biosynthesis ; Osteogenesis/drug effects ; Oxides/chemistry ; Porosity ; Printing, Three-Dimensional ; Rabbits ; Strontium/chemistry ; Tissue Scaffolds
Chemical Substances	Bone Substitutes ; Calcium Phosphates ; Oxides ; Osteocalcin (104982-03-8) ; Magnesium Oxide (3A3U0GI71G) ; tricalcium phosphate (K4C08XP666) ; Strontium (YZS2RPE8LE)
Language	English
Publishing date	2014-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.33239
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Article ; Online: Preparation of canine and feline cadavers for surgical laboratories.

Mathews, Kyle G / Riley, Kristen / Lascelles, B D X / Dernell, William S

Veterinary surgery : VS

2010 Volume 39, Issue 2, Page(s) 224–225

MeSH term(s)	Animals ; Cadaver ; Cats/surgery ; Dogs/surgery ; Embalming/methods ; Surgery, Veterinary/education ; Surgery, Veterinary/methods
Language	English
Publishing date	2010-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491071-8
ISSN	1532-950X ; 0161-3499
ISSN (online)	1532-950X
ISSN	0161-3499
DOI	10.1111/j.1532-950X.2009.00586.x
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Article: Preparation of Canine and Feline Cadavers for Surgical Laboratories

MATHEWS, KYLE G / RILEY, KRISTEN / LASCELLES, B.D.X / DERNELL, WILLIAM S

Veterinary surgery. 2010 Feb., v. 39, no. 2

2010

Keywords	cats ; dogs ; veterinary medicine ; veterinary education ; methodology
Language	English
Dates of publication	2010-02
Size	p. 224-225.
Publisher	Blackwell Publishing Inc
Publishing place	Malden, USA
Document type	Article
ZDB-ID	1491071-8
ISSN	1532-950X ; 0161-3499
ISSN (online)	1532-950X
ISSN	0161-3499
DOI	10.1111/j.1532-950X.2009.00586.x
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Article ; Online: Partial foot amputation in 11 dogs.

Liptak, Julius M / Dernell, William S / Rizzo, Scott A / Withrow, Stephen J

Journal of the American Animal Hospital Association

2005 Volume 41, Issue 1, Page(s) 47–55

Abstract: Eleven dogs with malignant tumors of the digits and feet were treated with partial foot amputation. Partial foot amputation involved amputation of one or both central weight-bearing digits. Lameness occurred in all dogs but resolved in eight dogs at a ... ...

Abstract	Eleven dogs with malignant tumors of the digits and feet were treated with partial foot amputation. Partial foot amputation involved amputation of one or both central weight-bearing digits. Lameness occurred in all dogs but resolved in eight dogs at a median of 37 days postoperatively. In the remaining three dogs, lameness improved but did not resolve. Tumor control was excellent, with no evidence of local recurrence in 10 dogs. One dog underwent limb amputation. Based on these results, partial foot amputation may be recommended in the management of malignant tumors of the canine foot in which more than one digit must be amputated to achieve adequate surgical margins.
MeSH term(s)	Amputation/methods ; Amputation/veterinary ; Animals ; Dog Diseases/surgery ; Dogs ; Female ; Foot Diseases/surgery ; Foot Diseases/veterinary ; Lameness, Animal ; Male ; Neoplasms/surgery ; Neoplasms/veterinary ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2005-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	410383-x
ISSN	1547-3317 ; 1062-8266 ; 0587-2871
ISSN (online)	1547-3317
ISSN	1062-8266 ; 0587-2871
DOI	10.5326/0410047
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