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  1. Article ; Online: An integrative review protocol on interventions to improve users' ability to identify trustworthy online health information.

    Hind Mohamed / Jon Salsberg / Dervla Kelly

    PLoS ONE, Vol 18, Iss 4, p e

    2023  Volume 0284028

    Abstract: Background The epidemiological transition phenomena drive the attention to focus the scope on health literacy as it has an impact on patients' health outcomes and quality of life. Aim This paper aims to explore the implemented interventions for improving ...

    Abstract Background The epidemiological transition phenomena drive the attention to focus the scope on health literacy as it has an impact on patients' health outcomes and quality of life. Aim This paper aims to explore the implemented interventions for improving users' ability to identify trustworthy online health information. Methodology A comprehensive search of the literature will be conducted on the following electronic bibliographic databases: Ovid Medline, Embase, Cochrane database, Academic search complete and APA psycinfo. Further, manual search of eligible studies reference lists will be carried out to identify other eligible studies. The search strategy will include a combination of three key blocks of terms, namely: (adult OR adults) Or (patient OR patients) OR (layperson OR laypersons) OR (caregiver OR caregivers), (Intervention OR Interventions) OR Educational programs OR (health literacy And curriculum) OR Community outreach OR Interactive workshops OR (Online portal OR Patient Portals), and information seeking behavior OR consumer health information OR online information OR social media OR access to information. The results of these categories will then be combined using the AND connector. Two independent reviewers will screen and assess data quality. Disagreements will be resolved by consensus. Due to the anticipated methodological pluralism of the potentially eligible studies, a narrative synthesis of the findings on interventions aimed at improving users' ability to identify trustworthy online information will be provided according to the pre-identified thematic areas. Furthermore, a narrative synthesis of the reported barriers and facilitators for applying these interventions by end users. Expected results and impact Given that the focus of our review findings is on understanding the breadth and depth of the global research into interventions to improve users' ability to identify trustworthy online health information. The findings will be of great value to inform future innovative approaches to ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 302
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: An integrative review protocol on interventions to improve users’ ability to identify trustworthy online health information

    Hind Mohamed / Jon Salsberg / Dervla Kelly

    PLoS ONE, Vol 18, Iss

    2023  Volume 4

    Abstract: Background The epidemiological transition phenomena drive the attention to focus the scope on health literacy as it has an impact on patients’ health outcomes and quality of life. Aim This paper aims to explore the implemented interventions for improving ...

    Abstract Background The epidemiological transition phenomena drive the attention to focus the scope on health literacy as it has an impact on patients’ health outcomes and quality of life. Aim This paper aims to explore the implemented interventions for improving users’ ability to identify trustworthy online health information. Methodology A comprehensive search of the literature will be conducted on the following electronic bibliographic databases: Ovid Medline, Embase, Cochrane database, Academic search complete and APA psycinfo. Further, manual search of eligible studies reference lists will be carried out to identify other eligible studies. The search strategy will include a combination of three key blocks of terms, namely: (adult OR adults) Or (patient OR patients) OR (layperson OR laypersons) OR (caregiver OR caregivers), (Intervention OR Interventions) OR Educational programs OR (health literacy And curriculum) OR Community outreach OR Interactive workshops OR (Online portal OR Patient Portals), and information seeking behavior OR consumer health information OR online information OR social media OR access to information. The results of these categories will then be combined using the AND connector. Two independent reviewers will screen and assess data quality. Disagreements will be resolved by consensus. Due to the anticipated methodological pluralism of the potentially eligible studies, a narrative synthesis of the findings on interventions aimed at improving users’ ability to identify trustworthy online information will be provided according to the pre-identified thematic areas. Furthermore, a narrative synthesis of the reported barriers and facilitators for applying these interventions by end users. Expected results and impact Given that the focus of our review findings is on understanding the breadth and depth of the global research into interventions to improve users’ ability to identify trustworthy online health information. The findings will be of great value to inform future innovative approaches to ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 302
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Toxicities and outcomes of neoadjuvant treatment in elderly patients with locally advanced rectal cancer

    Dervla Kelly / Ruba Ahmed Hamed / Greg Korpanty

    BMJ Open, Vol 12, Iss

    a scoping review protocol

    2022  Volume 5

    Keywords Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Mapping health, social and health system issues and applying a social accountability inventory to a problem based learning medical curriculum

    Dervla Kelly / Sarah Hyde / Mohamed Elhassan Abdalla

    Medical Education Online, Vol 27, Iss

    2022  Volume 1

    Abstract: Social accountability is a powerful concept. It is applied to medical education to encourage future doctors to take action to address health inequalities and overlooked health needs of disadvantaged populations. Problem-based learning (PBL) provides an ... ...

    Abstract Social accountability is a powerful concept. It is applied to medical education to encourage future doctors to take action to address health inequalities and overlooked health needs of disadvantaged populations. Problem-based learning (PBL) provides an ideal setting to teach medical students about these topics. The objective of this study is to explore how well the components of social accountability are covered in a pre-clinical PBL medical curriculum and to determine the usefulness of an adapted validated social accountability framework. We identified Irish health needs and social issues through a literature review. The retrieved documents were aligned to four values (relevance, equity, cost-effectiveness and quality) from a validated social accountability inventory, to generate a map of social accountability values present in the Irish health system and population. We then used the adapted validated social accountability inventory to evaluate the content of the PBL medical curriculum at an Irish medical school. We identified 45 documents, which upon analysis lead to the identification of health and social issues related to social accountability. 66 pre-clinical PBL cases included demographic, health and psychosocial issues similar to the local population. Analysing along the four social accountability values, the PBL cases demonstrated room for improvement in the equity and relevance domains. Topics for expansion are Traveller health, LGBTI health, alcohol use, climate change and more. Medical educators can use the paper as an example of how to apply this methodology to evaluate PBL cases. Adapting and applying a validated framework is a useful pedagogical exercise to understand established societal values related to social accountability to inform a medical curriculum. We identified opportunities to improve the PBL cases to depict emerging global and social issues.
    Keywords social accountability ; medical education ; problem-based learning ; curriculum mapping ; content analysis ; Special aspects of education ; LC8-6691 ; Medicine (General) ; R5-920
    Subject code 300
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Management of psychotropic medications in adults with intellectual disability

    Ashley Costello / Cian Hehir / Drona Sharma / Owen Doody / Dervla Kelly

    HRB Open Research, Vol

    a scoping review protocol [version 1; peer review: 1 approved, 2 approved with reservations]

    2021  Volume 4

    Abstract: Introduction: Psychotropic medications are commonly prescribed among adults with intellectual disability (ID), often in the absence of a psychiatric diagnosis. As such, there is great disparity between the estimated prevalence of mental illness and the ... ...

    Abstract Introduction: Psychotropic medications are commonly prescribed among adults with intellectual disability (ID), often in the absence of a psychiatric diagnosis. As such, there is great disparity between the estimated prevalence of mental illness and the rates of psychotropic medication use amongst people with ID. ‘Off-label’ use of these medications may account for much of this discrepancy, in particular their use in the management of challenging behaviour. This has come under scrutiny due to the myriad of side effects and the deficiency of high-quality data supporting their use for this indication. Understanding the causes and justifications for such disparity is essential in discerning the efficacy of current prescription practice. Objective: To explore the existing evidence base regarding the prescription and management of psychotropic medications in adults with ID. The aim will be achieved through identifying the psychotropic medications commonly prescribed, the underlying rationale(s) for their prescription and the evidence available that demonstrates their appropriateness and effectiveness. Additionally, the paper will seek to evaluate the availability of any existing guidance that informs the management of these medications, and the evidence and outcomes of psychotropic medication dose reduction and/or cessation interventions. Inclusion criteria: This review will consider studies that focus on the use of psychotropic medications amongst patients with ID. Methods: Research studies (qualitative, quantitative and mixed design) and Grey Literature (English) will be included. The search will be conducted without time restrictions. Databases will include: Ovid MEDLINE, Embase, CINAHL, JBI Evidence Synthesis, Cochrane Central Register of Controlled Trials, Cochrane Databased of Systematic Reviews, PsycINFO and Scopus. A three-step search strategy will be followed, with results screened by two independent reviewers. Data will be extracted independently by two reviewers using a data extraction tool with results ...
    Keywords Medicine ; R
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Measuring medical graduate behavioral intention for administering on-site care to road traffic accident victims

    Neeti Rustagi / Abhishek Jaiswal / Dervla Kelly / Naveen Dutt / Arvind Sinha / Pankaja Raghav

    Indian Journal of Public Health, Vol 65, Iss 1, Pp 39-

    Development and validation of a questionnaire

    2021  Volume 44

    Abstract: Background: Prehospital trauma care skills are often taught and assessed in undergraduate medical curricula but the intention to voluntarily offer these skills in out of hospital or primary care settings is poorly understood. Objectives: The objective is ...

    Abstract Background: Prehospital trauma care skills are often taught and assessed in undergraduate medical curricula but the intention to voluntarily offer these skills in out of hospital or primary care settings is poorly understood. Objectives: The objective is to develop and validate a questionnaire measuring behavioral intention among medical graduates for administering on-site care to road accident victims. Methods: A cross-sectional study was conducted from September 2018 to February 2019, among medical graduates of an academic institution in Jodhpur, Rajasthan. Items for “Measure of Intention to help road accident victim (MIHRAV) instrument” were framed as per the constructs of theory of planned behavior. A total of 150 candidates undergoing internship were approached for informed consent and a link for online questionnaire was shared. Statistical Analysis: Exploratory factor analysis (EFA) and tests for convergent, discriminant, and predictive validity was done using IBM SPSS version 23.0 for psychometric validation of scale. Results: Original version of MIHRAV included 29 items which were reduced to 18 items. EFA identified five factors which explained 72% of cumulative variance with high Cronbach's α (0.920). Discriminant validity showed adequate correlations ranging from 0.283 to 0.541. Predictive validity demonstrated that model was significantly able to predict “behavioural intention to help” (F (4128) = 24.139, P = 0.0001) and explained 43% of variance. Conclusion: The findings reveal that developed instrument “MIHRAV” is a reliable and valid scale for predicting behavioral intention among medical graduates for administering onsite care to road accident victims.
    Keywords “intention ; ” “road traffic accidents ; ” “scale development” ; “theory of planned behaviour ; ” “validation” ; Public aspects of medicine ; RA1-1270
    Subject code 380
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Exploration of GP perspectives on deprescribing antidepressants

    Liam Glynn / Peter Hayes / Dervla Kelly / Justin Graffi / Maria Noonan / Philip Green

    BMJ Open, Vol 11, Iss

    a qualitative study

    2021  Volume 4

    Abstract: Objective Our aim was to explore general practitioners’ (GPs) perceptions and experiences of discontinuing antidepressants.Study design A qualitative study using semistructured interviews was undertaken between July 2019 and March 2020. The interviews ... ...

    Abstract Objective Our aim was to explore general practitioners’ (GPs) perceptions and experiences of discontinuing antidepressants.Study design A qualitative study using semistructured interviews was undertaken between July 2019 and March 2020. The interviews were transcribed and analysed using a thematic analysis framework.Setting GPs affiliated with a university education and research network for general practice in Ireland.Participants A purposive sample of GPs (n=10).Results Five themes emerged: shared decision-making; personalised therapy; medication-tapering toolkit; health service factors and concerns around tapering. GPs described being less likely to engage in deprescribing for patients with long-term and/or recurrent depression, older patients and those with comorbidities due to fear of relapse. Access to evidence-based psychological therapies, guidelines, information on rates of relapse, patient leaflets on discontinuing antidepressants and reminder prompts on GP-prescribing software were suggested to optimise appropriate antidepressant discontinuation. There was some suggestion that patients may use antidepressants for longer when talk therapy is not available or taken up.Conclusions GPs are largely confident in their role of managing mild-to-moderate depression and deprescribing antidepressants. This study provides an insight into factors that influence GPs’ decisions to deprescribe antidepressants. More information on rates of relapse after discontinuation would be helpful to inform decision-making.
    Keywords Medicine ; R
    Subject code 150
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Gut Microbiota, Fusobacteria, and Colorectal Cancer

    Dervla Kelly / Liying Yang / Zhiheng Pei

    Diseases, Vol 6, Iss 4, p

    2018  Volume 109

    Abstract: The gut microbiota has emerged as an environmental contributor to colorectal cancer (CRC) in both animal models and human studies. It is now generally accepted that bacteria are ubiquitous colonizers of all exposed human body surfaces, including the ... ...

    Abstract The gut microbiota has emerged as an environmental contributor to colorectal cancer (CRC) in both animal models and human studies. It is now generally accepted that bacteria are ubiquitous colonizers of all exposed human body surfaces, including the entire alimentary tract (5). Recently, the concept that a normal bacterial microbiota is essential for the development of inflammation-induced carcinoma has emerged from studies of well-known colonic bacterial microbiota. This review explores the evidence for a role of fusobacteria, an anaerobic gram-negative bacterium that has repeatedly been detected at colorectal tumor sites in higher abundance than surrounding histologically normal tissue. Mechanistic studies provide insight on the interplay between fusobacteria, other gut microbiota, barrier functions, and host responses. Studies have shown that fusobacteria activate host inflammatory responses designed to protect against pathogens that promote tumor growth. We discuss how future research identifying the pathophysiology underlying fusobacteria colon colonization during colorectal cancer may lead to new therapeutic targets for cancer. Furthermore, disease-protective strategies suppressing tumor development by targeting the local tumor environment via bacteria represent another exciting avenue for researchers and are highlighted in this review.
    Keywords fusobacteria ; colorectal cancer ; carcinogenesis ; microbiome ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Household medication safety practices during the COVID-19 pandemic

    Carly Wheeler / Tamasine C Grimes / Sara Garfield / Dervla Kelly / Joan Cahill / Sam Cromie

    BMJ Open, Vol 10, Iss

    a descriptive qualitative study protocol

    2020  Volume 11

    Abstract: Introduction Those who are staying at home and reducing contact with other people during the COVID-19 pandemic are likely to be at greater risk of medication-related problems than the general population. This study aims to explore household medication ... ...

    Abstract Introduction Those who are staying at home and reducing contact with other people during the COVID-19 pandemic are likely to be at greater risk of medication-related problems than the general population. This study aims to explore household medication practices by and for this population, identify practices that benefit or jeopardise medication safety and develop best practice guidance about household medication safety practices during a pandemic, grounded in individual experiences.Methods and analysis This is a descriptive qualitative study using semistructured interviews, by telephone or video call. People who have been advised to ‘cocoon’/‘shield’ and/or are aged 70 years or over and using at least one long-term medication, or their caregivers, will be eligible for inclusion. We will recruit 100 patient/carer participants: 50 from the UK and 50 from Ireland. Recruitment will be supported by our patient and public involvement (PPI) partners, personal networks and social media. Individual participant consent will be sought, and interviews audio/video recorded and/or detailed notes made. A constructivist interpretivist approach to data analysis will involve use of the constant comparative method to organise the data, along with inductive analysis. From this, we will iteratively develop best practice guidance about household medication safety practices during a pandemic from the patient’s/carer’s perspective.Ethics and dissemination This study has Trinity College Dublin, University of Limerick and University College London ethics approvals. We plan to disseminate our findings via presentations at relevant patient/public, professional, academic and scientific meetings, and for publication in peer-reviewed journals. We will create a list of helpful strategies that participants have reported and share this with participants, PPI partners and on social media.
    Keywords Medicine ; R
    Subject code 020
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Health Care Utilisation by Bullying Victims

    Catherine Hayes / Dervla Kelly / Cristina Taut / Elizabeth Nixon / Lina Zgaga / James Williams / Thomas O’Dowd / Udo Reulbach

    Healthcare, Vol 6, Iss 1, p

    A Cross-Sectional Study of A 9-Year-Old Cohort in Ireland

    2018  Volume 19

    Abstract: Children frequently refrain from disclosing being bullied. Early identification of bullying by healthcare professionals in children may prevent adverse health consequences. The aim of our study was to determine whether Health Care Utilisation (HCU) is ... ...

    Abstract Children frequently refrain from disclosing being bullied. Early identification of bullying by healthcare professionals in children may prevent adverse health consequences. The aim of our study was to determine whether Health Care Utilisation (HCU) is higher in 9-year-olds who report being bullied and factors influencing type of HCU. The study consists of cross-sectional surveys of Child Cohort of Irish National Longitudinal Study of Children (Wave 1), 8,568 9-year-olds, and their carers. Being bullied was assessed by a self-reported questionnaire completed by children at home. HCU outcomes consisted of the following: visits to GP, Mental Health Practitioner (MHP), Emergency Department (ED), and nights in hospital by parent interview. Bivariate logistic regression and gender-stratified Poisson models were used to determine association. Victimisation by bullying independently increased visits to GP (OR 1.13, 95% confidence interval (CI): 1.03 to 1.25; p = 0.02), MHP (OR 1.31, 95% CI: 1.05 to 1.63; p = 0.02), though not ED visits (OR 0.99, 95% CI: 0.87 to 1.13; p = 0.8) or nights in hospital (OR 1.07 95% CI: 0.97 to 1.18; p = 0.2), adjusting for underlying chronic condition(s) and socio-demographic confounders. Victimised girls made higher GP visits (RR 1.14, 95% CI: 1.06 to 1.23; p < 0.001) and spent more nights in hospital (RR 1.10, 95% CI: 1.04 to 1.15; p < 0.001). Victimised boys were more likely to contact MHPs (RR 1.21, 95% CI: 1.02 to 1.44; p = 0.03). 9-year-old bullied subjects were more likely to utilise primary care services than non-bullied 9-year-olds. Different HCU patterns were observed according to gender and gender differences in the presentation of victimisation. Our findings may lead to the development of clinical practice guidelines for early detection and appropriate management of bullied children.
    Keywords bullying ; gender ; primary health care ; general practice ; health care utilisation ; mental health ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2018-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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