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  1. Article ; Online: Avoiding Checkmate-Playing Chess With Cancer.

    Desai, Aakash

    JAMA oncology

    2022  Volume 8, Issue 12, Page(s) 1740

    MeSH term(s) Humans ; Neoplasms
    Language English
    Publishing date 2022-09-23
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2022.4422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Machine Learning for Economics Research

    Desai, Ajit

    When What and How?

    2023  

    Abstract: This article provides a curated review of selected papers published in prominent economics journals that use machine learning (ML) tools for research and policy analysis. The review focuses on three key questions: (1) when ML is used in economics, (2) ... ...

    Abstract This article provides a curated review of selected papers published in prominent economics journals that use machine learning (ML) tools for research and policy analysis. The review focuses on three key questions: (1) when ML is used in economics, (2) what ML models are commonly preferred, and (3) how they are used for economic applications. The review highlights that ML is particularly used to process nontraditional and unstructured data, capture strong nonlinearity, and improve prediction accuracy. Deep learning models are suitable for nontraditional data, whereas ensemble learning models are preferred for traditional datasets. While traditional econometric models may suffice for analyzing low-complexity data, the increasing complexity of economic data due to rapid digitalization and the growing literature suggests that ML is becoming an essential addition to the econometrician's toolbox.
    Keywords Economics - General Economics ; Computer Science - Artificial Intelligence ; Computer Science - Machine Learning ; Statistics - Applications
    Subject code 006
    Publishing date 2023-03-31
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: The Histopathological Spectrum of Scrotal Lesions in a Tertiary Care Hospital: A Cross-Sectional Study.

    Desai, Apara / Wilkinson, Anne

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52767

    Abstract: Background: The incidence and clinical presentation of testicular and paratesticular lesions are variable. A preoperative diagnosis is often difficult with only a clinical examination. The diagnosis of testicular lesions is mainly based on histological ... ...

    Abstract Background: The incidence and clinical presentation of testicular and paratesticular lesions are variable. A preoperative diagnosis is often difficult with only a clinical examination. The diagnosis of testicular lesions is mainly based on histological investigation, despite advances in imaging and tumor marker testing. This study aimed to document the histopathological spectrum of scrotal lesions, including testicular and paratesticular lesions.
    Aim: The study aimed to research the histopathological spectrum of scrotal lesions.
    Settings and design: This was a cross-sectional study conducted at NKP Salve Institute of Medical Sciences & Research Centre and Lata Mangeshkar Hospital, a tertiary care hospital in Nagpur, India.
    Materials and methods: Following the institutional ethics committee's approval, a two-year cross-sectional study was carried out in the tertiary care hospital. Seventy operated scrotal specimens sent for histopathological examination were included in the study. The clinical details and investigations of the patients, as well as the gross and histopathological findings of all the specimens, were studied carefully.
    Statistical analysis: The clinical details and gross and histopathological findings were noted in a proforma, entered in a Microsoft Excel sheet (Microsoft Corp., Redmond, WA), and verified. The data were presented in a tabular form using tablets, pie charts, and bar diagrams. The collected data were analyzed and presented in percentages and frequencies.
    Results: The present study evaluated the histopathological spectrum of scrotal lesions in 70 operated scrotal masses. The mean age of the participants in the study was 46.55 ± 18.69 years, with the youngest patient at four years and the oldest being 88 years of age. Sixty-six (80%) of the 70 cases were of non-neoplastic lesions, while 14 (20%) were of neoplastic lesions. Testicular atrophy (16 cases) was the most common non-neoplastic lesion. The most frequent neoplastic lesion in the present study was a seminoma (seven cases).
    Conclusion: This study strongly recommends routine histopathological examination of all scrotal specimens for the detection of various testicular and paratesticular lesions, as well as neoplasms. Histopathology not only provides a tissue diagnosis in scrotal disorders, but it also adds to understanding etiopathogenesis and can aid in the development of future treatment options.
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Searching for clinical trials in oncology: finding a path through the maze.

    Desai, A / Feldman, J / Subbiah, V

    Annals of oncology : official journal of the European Society for Medical Oncology

    2023  Volume 34, Issue 9, Page(s) 732–733

    MeSH term(s) Humans ; Medical Oncology ; Clinical Trials as Topic
    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Editorial
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1016/j.annonc.2023.06.004
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    Zs.A 2862: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Twentieth-Century Lessons for a Modern Coronavirus Pandemic.

    Desai, Angel

    JAMA

    2020  Volume 323, Issue 21, Page(s) 2118–2119

    MeSH term(s) Betacoronavirus ; COVID-19 ; Cities/epidemiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Disclosure ; History, 20th Century ; Humans ; Influenza, Human/epidemiology ; Influenza, Human/history ; Influenza, Human/prevention & control ; Influenza, Human/transmission ; National Health Programs/history ; Newspapers as Topic/history ; Pandemics ; Personal Protective Equipment/history ; Personal Protective Equipment/standards ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Quarantine/history ; Recurrence ; SARS-CoV-2 ; United States/epidemiology ; Xenophobia/history
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Historical Article ; Interview ; News
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.4165
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  6. Article: Strategies to overcome resistance to ALK inhibitors in non-small cell lung cancer: a narrative review.

    Desai, Aakash / Lovly, Christine M

    Translational lung cancer research

    2023  Volume 12, Issue 3, Page(s) 615–628

    Abstract: Background and objective: Anaplastic lymphoma kinase (ALK) rearrangements are detected in 3-7% of advanced non-small cell lung cancer (NSCLC). There are currently 5 U.S Food and Drug Administration (FDA)-approved ALK tyrosine kinase inhibitors (TKIs) ... ...

    Abstract Background and objective: Anaplastic lymphoma kinase (ALK) rearrangements are detected in 3-7% of advanced non-small cell lung cancer (NSCLC). There are currently 5 U.S Food and Drug Administration (FDA)-approved ALK tyrosine kinase inhibitors (TKIs) for the treatment of patients with ALK-positive lung cancer in the advanced/metastatic disease setting. Despite these advances, most patients with ALK-positive lung cancer who are treated with ALK TKI therapy ultimately experience disease progression due to various mechanisms of drug resistance. In this review, we discuss strategies to address acquired therapeutic resistance to ALK inhibition, novel agents and combinatorial strategies in development for both on and off-target resistance, and some emerging approaches to prolong response to ALK inhibitors.
    Methods: We performed a search of peer-reviewed literature in the English language, conference abstracts, and trial registrations from the MEDLINE (Ovid), Embase (Elsevier), and CENTRAL (Cochrane Library) databases and major international oncology meetings up to August 2022. We then screened for studies describing interventions to overcome ALK resistance based on review of each title and abstract.
    Key content and findings: For patients with oligo-progression, treatment may include maintaining the same systemic treatment beyond progression while adding local therapies to progressing lesions. Strategies to combat ALK TKI resistance mediated by on-target resistance mechanisms include 4
    Conclusions: Strategies to overcome resistance to currently available ALK inhibitors are urgently needed. Given the variety of resistance mechanisms, tailormade approaches are required for disease control.
    Language English
    Publishing date 2023-03-20
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-22-708
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  7. Article ; Online: Challenges in the implementation of ultrasensitive liquid biopsy approaches in precision oncology.

    Desai, Aakash / Lovly, Christine M

    Journal for immunotherapy of cancer

    2023  Volume 11, Issue 6

    MeSH term(s) Humans ; Neoplasms/diagnosis ; Neoplasms/pathology ; Precision Medicine ; Liquid Biopsy ; Medical Oncology
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2023-006793
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  8. Article ; Online: Bacillary layer detachment as an inflammatory biomarker in toxoplasmosis retinochoroiditis: serial evolution on optical coherence tomography.

    Desai, Arjun / Tyagi, Mudit

    BMJ case reports

    2023  Volume 16, Issue 12

    Abstract: We describe the clinical course and serial evolution of bacillary layer detachment (BALAD) on optical coherence tomography (OCT) in toxoplasmosis retinochoroiditis and its importance as an inflammatory biomarker. Colour fundus photography and swept- ... ...

    Abstract We describe the clinical course and serial evolution of bacillary layer detachment (BALAD) on optical coherence tomography (OCT) in toxoplasmosis retinochoroiditis and its importance as an inflammatory biomarker. Colour fundus photography and swept-source OCT of the BALAD were done at the time of presentation and subsequently at 1 week, 2 weeks, 4 weeks and at 11 weeks. Treatment involved oral trimethoprim (160 mg) + sulphamethoxazole (800 mg) two times per day, started at presentation for 2 months. Oral prednisolone was started after 1 week at a dose of 50 mg a day and tapered weekly over the next 5 weeks. The BALAD initially increased after starting treatment with trimethoprim-sulphamethoxazole and regressed within 1 week after initiation of oral prednisolone. Best corrected visual acuity improved to 20/40 from 20/160 at presentation (Snellen equivalent). This suggests that BALAD is an indicator of an acute inflammatory event and the accumulated fluid is secondary to retinal and choroidal inflammation.
    MeSH term(s) Humans ; Bacillus ; Tomography, Optical Coherence/methods ; Retina ; Toxoplasmosis, Ocular/diagnostic imaging ; Toxoplasmosis, Ocular/drug therapy ; Firmicutes ; Prednisolone/therapeutic use ; Retinal Detachment
    Chemical Substances Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-256629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hear Me Out: Mitigating Cisplatin-Induced Ototoxicity.

    Desai, Aakash / Das, Devika

    JCO oncology practice

    2023  Volume 19, Issue 5, Page(s) 284–285

    MeSH term(s) Humans ; Cisplatin/adverse effects ; Ototoxicity/etiology ; Antineoplastic Agents/adverse effects
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Antineoplastic Agents
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.23.00120
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    Zs.A 7198: Show issues Location:
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  10. Article ; Online: Direct-to-Patient Clinical Trials: One Small Step or a Giant Leap?

    Desai, Aakash / Subbiah, Vivek

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2023  Volume 29, Issue 13, Page(s) 2339–2341

    Abstract: Genome driven precision oncology has transformed the landscape of multiple cancers. However, access barriers exist. A recent study exemplified a direct-to-patient outreach program via social media through the implementation of a global program that ... ...

    Abstract Genome driven precision oncology has transformed the landscape of multiple cancers. However, access barriers exist. A recent study exemplified a direct-to-patient outreach program via social media through the implementation of a global program that offered free tumor genomic testing with a focus on rare cancers. See related article by Doe-Tetteh et al., p. 2445.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Precision Medicine ; Genomics ; Medical Oncology
    Language English
    Publishing date 2023-01-28
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-23-0746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4223: Show issues Location:
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