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Article: Comparative Evaluation of DFDBA versus PRF with DFDBA in Treatment of Grade-II Furcation Defects - A Clinical Trial.

Desai, Kinjal N / Thakkar, Rohit R / Patel, Jalpa / Gupta, Ekta / Trivedi, Namrata / Sampat, Dipali

Journal of pharmacy & bioallied sciences

2024 Volume 16, Issue Suppl 1, Page(s) S794–S796

Abstract: Background: In order to determine whether a method is more successful for treating a grade-II furcation deficiency, this randomized trial will compare demineralized freeze-dried bone allograft (DFDBA) to platelet-rich fibrin with DFDBA.: Materials and ...

Abstract	Background: In order to determine whether a method is more successful for treating a grade-II furcation deficiency, this randomized trial will compare demineralized freeze-dried bone allograft (DFDBA) to platelet-rich fibrin with DFDBA. Materials and methods: Twenty systematically healthy patients between the ages of 30 and 60 with a grade-II furcation were evaluated pre and postoperatively for changes in the modified plaque index, probing depth, relative vertical and horizontal clinical attachment level, gingival marginal level, and radiographic bone defect. Results: The test group significantly outperformed the control group on all clinical and radiological measures. Conclusion: The experimental group improved at both clinical attachment levels and had a higher decrease in probing depth than the control group did.
Language	English
Publishing date	2024-02-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.jpbs_1016_23
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Article: Safety and Efficacy of Sildenafil for Group 2 Pulmonary Hypertension in Left Heart Failure.

Desai, Kinjal / Di Lorenzo, Michael / Zuckerman, Warren A / Emeruwa, Ezinne / Krishnan, Usha S

Children (Basel, Switzerland)

2023 Volume 10, Issue 2

Abstract: Pulmonary hypertension (PH) is a multifactorial, progressive disease with poor outcomes. Group 2 PH is defined by pulmonary vascular disease with elevated pulmonary capillary wedge pressure including both left-sided obstructive lesions and diastolic ... ...

Abstract	Pulmonary hypertension (PH) is a multifactorial, progressive disease with poor outcomes. Group 2 PH is defined by pulmonary vascular disease with elevated pulmonary capillary wedge pressure including both left-sided obstructive lesions and diastolic heart failure (HF). Sildenafil was historically discouraged in this population as pulmonary vasodilation can lead to pulmonary edema. However, evidence suggests that sildenafil can help to treat the precapillary component of PH. This is a single center, retrospective pilot study of pediatric PH patients with left-sided HF who were treated with sildenafil for ≥ 4 weeks. HF patients without mechanical support (HF group) and HF patients with a left ventricular assist device (HF-VAD) were analyzed. The exploratory analysis described the safety and side effects of the drug. Echocardiographic parameters were compared before and after sildenafil treatment in a paired analysis. The changes in medical therapy during treatment, mechanical support, and mortality was reported; 19/22 patients tolerated sildenafil. Pulmonary edema in two patients resolved upon discontinuation of sildenafil. In the HF group, both the right atrial volume and right ventricular diastolic area decreased, and the tricuspid regurgitation (TR) S/D ratio decreased after therapy (
Language	English
Publishing date	2023-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10020270
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Thesis ; Online: Characterizing the impact of single nucleotide variation in breast cancer

Desai, Kinjal

2016

Abstract: Genome sequencing technology has enabled the identification of genetic variants that are linked with cancer phenotypes, whether these are somatically acquired mutations or common inherited single nucleotide polymorphisms (SNPs). Whereas coding variants ... ...

Abstract	Genome sequencing technology has enabled the identification of genetic variants that are linked with cancer phenotypes, whether these are somatically acquired mutations or common inherited single nucleotide polymorphisms (SNPs). Whereas coding variants have been reported to disrupt protein function to promote cancer, most variants map to noncoding regions, with no known function. Recently, much effort has gone into annotating the human noncoding genome, enabling the characterization of the functional basis of noncoding SNPs. As an example of functional impact, breast cancer (BrCa) risk-associated SNPs can alter transcription factor binding at distal enhancers. Identifying the targets of risk SNPs remains a challenge. One reason for this is the complex three-dimensional structure of the genome. Local chromatin openness correlates with chromatin activity, and sites of chromatin that are open concurrently across multiple cell types indicates a functional relationship between them. We mapped BrCa risk-associated SNPs to regions of open chromatin to predict the most likely functional risk SNPs. Then, we predicted their targets by identifying the gene promoters whose openness correlated with these risk regions. Further, we validated a gene which is a novel therapeutic target and relevant in breast cancer biology. In addition to SNPs, noncoding somatic mutations are also predicted to play a role in cancer. In 2012, driver mutations were reported in the telomerase gene promoter, hinting at the relevance of mutations in regulatory elements. This is particularly true when considering oncogenes whose elevated expression in certain cancers is not attributable to coding mutations or copy number amplification. We reveal the enrichment and functional nature of somatic mutations mapping to enhancers that regulate the estrogen receptor gene, which is known to drive over two-thirds of breast cancer. Attributing function to noncoding SNPs and mutations associated with cancer risk and progression is a growing necessity in this era of whole-genome cancer biology. This thesis demonstrates a methodology to identify the functional consequence and gene targets of significantly mutated or risk variant-bearing enhancer sets to narrow the gap between known and unknown risk factors in BrCa.
Keywords	Molecular biology\|Genetics
Subject code	616
Language	ENG
Publishing date	2016-01-01 00:00:01.0
Publisher	Dartmouth College
Publishing country	us
Document type	Thesis ; Online
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Article ; Online: Physiologic diagnosis of congenital heart disease in cyanotic neonates.

Desai, Kinjal / Rabinowitz, Edon J / Epstein, Shilpi

Current opinion in pediatrics

2019 Volume 31, Issue 2, Page(s) 274–283

Abstract: Purpose of review: We aim to improve diagnosis of congenital heart disease (CHD) with cyanosis by physiology for general practitioners to reduce time to appropriate treatment.: Recent findings: New implementation of the critical congenital heart ... ...

Abstract	Purpose of review: We aim to improve diagnosis of congenital heart disease (CHD) with cyanosis by physiology for general practitioners to reduce time to appropriate treatment. Recent findings: New implementation of the critical congenital heart disease (CCHD) pulse oximetry screen has improved rate of diagnosis of CHD in recent years. However, many infants with cyanotic heart lesions often decompensate before screening in the newborn nursery, or have lesions that are not amenable to pulse oximetry screening and that present later in the emergency room. Recent literature has shown preoperative acidosis because of delayed diagnosis of cyanotic CHD worsens outcomes postoperatively. Wide availability of prostaglandin therapy and catheter procedures help to preoperatively stabilize critical cardiac patients. With a firm grasp of the underlying physiology of neonatal cyanotic CHD, practitioners can appropriately implement these therapies more judiciously. This early recognition will subsequently improve overall outcomes. Summary: Physiologic diagnosis of CHD with cyanosis by general practitioners will allow initiation of appropriate management more quickly and effectively. This may avoid progressive clinical decompensation and acidosis until cardiology consultation and potential intervention are available.
MeSH term(s)	Cyanosis/complications ; Cyanosis/etiology ; Delayed Diagnosis ; Heart Defects, Congenital/diagnosis ; Humans ; Infant ; Infant, Newborn ; Neonatal Screening ; Oximetry
Language	English
Publishing date	2019-02-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1049374-8
ISSN	1531-698X ; 1040-8703
ISSN (online)	1531-698X
ISSN	1040-8703
DOI	10.1097/MOP.0000000000000742
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Article: Delayed methimazole-induced agranulocytosis in a 6-year old patient with Graves' disease.

Puthenpura, Vidya / Desai, Kinjal / Bauer, Andrew / Marshall, Ian

International journal of pediatric endocrinology

2016 Volume 2016, Issue 1, Page(s) 16

Abstract: Background: Agranulocytosis is regarded as a rare side effect of methimazole (MMI) therapy that occurs in a dose dependent manner and that usually develops within the first 3-6 months of treatment. Although delayed development beyond this timeline has ... ...

Abstract	Background: Agranulocytosis is regarded as a rare side effect of methimazole (MMI) therapy that occurs in a dose dependent manner and that usually develops within the first 3-6 months of treatment. Although delayed development beyond this timeline has been documented in adults, very few children have been reported with this presentation. Case presentation: We present a 6-year old patient who developed agranulocytosis 18 months after the start of MMI therapy. Conclusions: This is an unusual case of a 6-year old patient who developed this serious side effect on stable MMI therapy well beyond the typical timeline. Our review of the literature revealed that there really is inconclusive data on the incidence, time, and dose-dependency of MMI-induced agranulocytosis in the pediatric Graves' disease population.
Language	English
Publishing date	2016-09-06
Publishing country	England
Document type	Case Reports
ZDB-ID	2528691-2
ISSN	1687-9856 ; 1687-9848
ISSN (online)	1687-9856
ISSN	1687-9848
DOI	10.1186/s13633-016-0034-6
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Article: A Fatal Fungal Infection:

Nielsen, Marisa C / Peterson, Joshua M / Shine, Billie / Hornak, J Patrik / Esechie, Aimalohi / Bhatt, Sandeep / Desai, Kinjal / Dabi, Alok / Felicella, Michelle M / Ren, Ping

Open forum infectious diseases

2022 Volume 9, Issue 7, Page(s) ofac236

Abstract: Cryptococcus ... ...

Abstract	Cryptococcus gattii
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofac236
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Article ; Online: Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2

Selvadurai, Hayden J / Luis, Erika / Desai, Kinjal / Lan, Xiaoyang / Vladoiu, Maria C / Whitley, Owen / Galvin, Ciaran / Vanner, Robert J / Lee, Lilian / Whetstone, Heather / Kushida, Michelle / Nowakowski, Tomasz / Diamandis, Phedias / Hawkins, Cynthia / Bader, Gary / Kriegstein, Arnold / Taylor, Michael D / Dirks, Peter B

Cell reports

2020 Volume 31, Issue 2, Page(s) 107511

Abstract: Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with ... ...

Abstract	Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with Sox2
MeSH term(s)	Animals ; Cell Lineage/genetics ; Cells, Cultured ; Cerebellar Neoplasms/pathology ; Cerebellum/embryology ; Female ; Hedgehog Proteins/metabolism ; Humans ; Male ; Medulloblastoma/etiology ; Medulloblastoma/metabolism ; Mice, Knockout ; Mice, Transgenic ; Neoplasm Recurrence, Local/pathology ; Neural Stem Cells/metabolism ; Neurogenesis ; Neurons/metabolism ; SOXB1 Transcription Factors/metabolism ; SOXB1 Transcription Factors/physiology ; Signal Transduction/physiology ; Single-Cell Analysis/methods
Chemical Substances	Hedgehog Proteins ; SOX2 protein, human ; SOXB1 Transcription Factors
Language	English
Publishing date	2020-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2020.03.075
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Article ; Online: Publisher Correction: ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters.

Bailey, Swneke D / Zhang, Xiaoyang / Desai, Kinjal / Aid, Malika / Corradin, Olivia / Cowper-Sal Lari, Richard / Akhtar-Zaidi, Batool / Scacheri, Peter C / Haibe-Kains, Benjamin / Lupien, Mathieu

Nature communications

2018 Volume 9, Page(s) 16194

Abstract: This corrects the article DOI: 10.1038/ncomms7186. ...

Abstract	This corrects the article DOI: 10.1038/ncomms7186.
Language	English
Publishing date	2018-04-10
Publishing country	England
Document type	Journal Article ; Published Erratum
ISSN	2041-1723
ISSN (online)	2041-1723
DOI	10.1038/ncomms16194
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Article ; Online: Examining the Utility of Coronary Artery Lack of Tapering and Perivascular Brightness in Incomplete Kawasaki Disease.

Rabinowitz, Edon J / Rubin, Lorry G / Desai, Kinjal / Hayes, Denise A / Tugertimur, Aykut / Kwon, Elena N / Dhanantwari, Preeta / Misra, Nilanjana / Stoffels, Guillaume / Blaufox, Andrew D / Mitchell, Elizabeth

Pediatric cardiology

2018 Volume 40, Issue 1, Page(s) 147–153

Abstract: Background: In 2017, the AHA published revised guidelines for the diagnosis of Kawasaki disease (KD). In the absence of compelling data supporting or refuting the utility of lack of tapering (LT) and perivascular brightness (PB), expert panel consensus ... ...

Abstract	Background: In 2017, the AHA published revised guidelines for the diagnosis of Kawasaki disease (KD). In the absence of compelling data supporting or refuting the utility of lack of tapering (LT) and perivascular brightness (PB), expert panel consensus removed LT and PB from consideration. We hypothesize that LT and PB are unreliable, subjective findings, non-specific to KD, which can be seen in systemic febrile illnesses without KD and in normal controls. Methods: We performed a single-center retrospective study from 1/2008 to 12/2016. De-identified coronary artery (CA) echocardiographic clips from patients 0-10 years old were interpreted blindly by six pediatric cardiologists. Subjects were grouped as follows: (1) healthy: afebrile with benign murmur, (2) KD: IVIG treatment, 4-5 clinical criteria at presentation, (3) incomplete KD (iKD): IVIG, 1-3 clinical criteria, (4) Febrile: ≥3 days of fever, no IVIG, KD not suspected. The presence or absence of LT and PB was recorded. Inter-rater and intra-rater reliabilities were analyzed using intra-class correlation coefficient, Fleiss' Kappa and Cohen's Kappa coefficients. Results: We interpreted 117 echocardiograms from healthy (27), KD (30), iKD (32), and febrile (28) subjects. Analysis showed moderate agreement in CA z score measurements. LT and PB were observed by most readers in control groups. LT exhibited fair inter-reader agreement (reliability coefficient 0.36) and PB slight inter-reader agreement (reliability coefficient 0.13). Intra-rater reliability was inconsistent for both parameters. Conclusions: LT and PB are subjective, poorly reproducible features that can be seen in febrile patients without KD and in healthy children.
MeSH term(s)	Case-Control Studies ; Child ; Child, Preschool ; Coronary Vessels/diagnostic imaging ; Echocardiography ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Mucocutaneous Lymph Node Syndrome/classification ; Mucocutaneous Lymph Node Syndrome/diagnostic imaging ; Reproducibility of Results ; Retrospective Studies
Language	English
Publishing date	2018-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-018-1971-z
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Article ; Online: Neonates With Complex Cardiac Malformation and Congenital Diaphragmatic Hernia Born to SARS-CoV-2 Positive Women-A Single Center Experience.

World journal for pediatric & congenital heart surgery

2020 Volume 11, Issue 6, Page(s) 697–703

Abstract: Background: Our understanding of the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on pregnancies and perinatal outcomes is limited. The clinical course of neonates born to women who acquired coronavirus disease 2019 (COVID-19) ... ...

Abstract	Background: Our understanding of the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on pregnancies and perinatal outcomes is limited. The clinical course of neonates born to women who acquired coronavirus disease 2019 (COVID-19) during their pregnancy has been previously described. However, the course of neonates born with complex congenital malformations during the COVID-19 pandemic is not known. Methods: We report a case series of seven neonates with congenital heart and lung malformations born to women who tested positive for SARS-CoV-2 during their pregnancy at a single academic medical center in New York City. Results: Six infants had congenital heart disease and one was diagnosed with congenital diaphragmatic hernia. In all seven infants, the clinical course was as expected for the congenital lesion. None of the seven exhibited symptoms generally associated with COVID-19. None of the infants in our case series tested positive by nasopharyngeal test for SARS-CoV-2 at 24 hours of life and at multiple points during their hospital course. Conclusions: In this case series, maternal infection with SARS-CoV-2 during pregnancy did not result in adverse outcomes in neonates with complex heart or lung malformations. Neither vertical nor horizontal transmission of SARS-CoV-2 was noted.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/transmission ; Female ; Heart Defects, Congenital ; Hernias, Diaphragmatic, Congenital ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Male ; Pandemics ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Prenatal Diagnosis ; SARS-CoV-2/isolation & purification ; Trisomy 13 Syndrome
Keywords	covid19
Language	English
Publishing date	2020-08-27
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2550261-X
ISSN	2150-136X ; 2150-1351
ISSN (online)	2150-136X
ISSN	2150-1351
DOI	10.1177/2150135120950256
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