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  1. Article ; Online: Extraskeletal Ewing's sarcoma of supraglottis: A rare case report.

    Poojari, Mayadevi / Madabhavi, Irappa / Desai, Sharad

    Oral oncology

    2024  Volume 152, Page(s) 106789

    Abstract: Ewing's Sarcoma family of tumors is a group of small round tumor cells. Ewing's sarcoma majority occurs in bone, accounts about 10 % of primary bone tumors. Extraskeletal Ewing's sarcoma (ESS) is unusual and commonly seen in trunk, paravertebral, and ... ...

    Abstract Ewing's Sarcoma family of tumors is a group of small round tumor cells. Ewing's sarcoma majority occurs in bone, accounts about 10 % of primary bone tumors. Extraskeletal Ewing's sarcoma (ESS) is unusual and commonly seen in trunk, paravertebral, and chest wall region. It is rarely seen in head and neck region, accounting to 2-3 %. In head and neck region, ESS is seen in nasal or oral cavities, sinuses. EES originating in the larynx is very rare. Here, we report a 22 years old female having the complaints of change in voice and noisy breathing who was diagnosed as a case of EES of supraglottis. As the disease progressed during the time of diagnosis, she had to undergo emergency tracheostomy. The disease was inoperable so she received neoadjuvant chemotherapy followed by radiation followed by adjuvant chemotherapy. At present she is symptomatically better. The aim of this report is to put forward the rare site of Ewing's Sarcoma and highlighting the early diagnosis in suspected case with IHC, providing effective multimodality treatment.
    MeSH term(s) Humans ; Sarcoma, Ewing/therapy ; Sarcoma, Ewing/diagnosis ; Sarcoma, Ewing/pathology ; Female ; Young Adult ; Laryngeal Neoplasms/therapy ; Laryngeal Neoplasms/diagnosis ; Laryngeal Neoplasms/pathology
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2024.106789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4869: Show issues Location:
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  2. Article: The Building of a Cancer Center for the Rural Folk.

    Desai, Sharad / Desai, Shivani

    Indian journal of surgical oncology

    2022  Volume 13, Issue Suppl 1, Page(s) 104–105

    Abstract: The requirement of rural folk differs from the requirements of the well-off urbanites. In developing nations, the onus of their healthcare falls upon the doctors practicing in the periphery. Since public awareness and support are minimal, income has to ... ...

    Abstract The requirement of rural folk differs from the requirements of the well-off urbanites. In developing nations, the onus of their healthcare falls upon the doctors practicing in the periphery. Since public awareness and support are minimal, income has to be generated from the poor folk. Hard work and simple living by the caretakers are the cornerstones to divert all profits for further growth of the hospital. Cancer therapy does not always require big investments. Scientific healthcare can be provided to the poor by doctors with good knowledge, hard work, and good skills.
    Language English
    Publishing date 2022-05-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-022-01555-1
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  3. Article ; Online: Malignant recurrent orbital solitary fibrous tumor.

    Pol, Jaydeep N / Patil, Dipti B / Desai, Sharad S / Calcuttawala, Adnan B

    Indian journal of pathology & microbiology

    2023  Volume 66, Issue 4, Page(s) 819–822

    Abstract: Solitary fibrous tumor (SFT) is a rare mesenchymal tumor of fibroblastic origin commonly occurring in pleura. It can occur at many extrapleural sites but is rare in orbit. Most cases are benign and recurrence is not unusual in the head and neck and orbit ...

    Abstract Solitary fibrous tumor (SFT) is a rare mesenchymal tumor of fibroblastic origin commonly occurring in pleura. It can occur at many extrapleural sites but is rare in orbit. Most cases are benign and recurrence is not unusual in the head and neck and orbit and is usually due to incomplete surgical excision. However, malignant transformation (MT) in orbital SFT is extremely unusual. We present a case of orbital SFT in adult male who developed recurrence with MT eight years after initial surgical excision. He underwent left orbital exenteration. The recurrent tumor revealed features of malignancy with areas exhibiting morphology typical of SFT. The immunochemistry confirmed the diagnosis of SFT with MT. The patient was given adjuvant radiation and was disease free for the last 18 months. Identification of malignancy in orbital SFT is important for the patient to receive appropriate postoperative treatment, as seen in the present case.
    MeSH term(s) Adult ; Humans ; Male ; Orbital Neoplasms/diagnosis ; Orbital Neoplasms/surgery ; Orbital Neoplasms/pathology ; Neoplasm Recurrence, Local/surgery ; Solitary Fibrous Tumors/diagnosis ; Solitary Fibrous Tumors/surgery ; Solitary Fibrous Tumors/pathology ; Hemangiopericytoma ; Fibrosarcoma
    Language English
    Publishing date 2023-12-12
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/ijpm.ijpm_713_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 862: Show issues Location:
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  4. Article: IASO COVID-19 Guidelines (Updated on 9th April 2020).

    Desai, Sharad / Gupta, Arnab

    Indian journal of surgical oncology

    2020  Volume 11, Issue 2, Page(s) 171–174

    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country India
    Document type Case Reports
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-020-01081-y
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  5. Article: Carcinosarcoma: A rare case report of a recurrent mass in the neck region.

    Hormuzdi, Dinshaw / Desai, Sharad / Bommanavar, Sushma / Patil, Dipti

    Journal of oral and maxillofacial pathology : JOMFP

    2020  Volume 24, Issue 2, Page(s) 327–331

    Abstract: Carcinosarcoma, a biphasic malignant mixed tumor, is an extremely rare neoplasm with >1% incidence. This aggressive malignancy is characterized by the presence of two components admixed with each other, i.e., the epithelial component and the mesenchymal ... ...

    Abstract Carcinosarcoma, a biphasic malignant mixed tumor, is an extremely rare neoplasm with >1% incidence. This aggressive malignancy is characterized by the presence of two components admixed with each other, i.e., the epithelial component and the mesenchymal component arising from a monoclonal/multiclonal origin or
    Language English
    Publishing date 2020-09-09
    Publishing country India
    Document type Case Reports
    ZDB-ID 2390999-7
    ISSN 1998-393X ; 0973-029X
    ISSN (online) 1998-393X
    ISSN 0973-029X
    DOI 10.4103/jomfp.JOMFP_120_20
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  6. Article ; Online: IASO COVID-19 Guidelines (Updated on 9th April 2020)

    Desai, Sharad / Gupta, Arnab

    Indian Journal of Surgical Oncology

    2020  Volume 11, Issue 2, Page(s) 171–174

    Keywords Surgery ; Oncology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-020-01081-y
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  8. Article: Free Gastric Flap for Oral Reconstruction-a Feasibility Study in Oral Defects.

    Komanduri, Suneel Kaushik / Hormuzdi, Dinshaw / Desai, Sharad Shankar / Patil, Dipti Babasaheb / Khivasara, Jayesh Shirishkumar / Kulkarni, Sanika G S / Desai, Shivani Sharad

    Indian journal of surgical oncology

    2021  Volume 12, Issue 1, Page(s) 172–176

    Abstract: Background: Free flap transfer is a standard practice in reconstruction of oral defects. Fasciocutaneous flaps are commonly used for reconstruction of soft tissue defects. Replacement of oral mucosa with skin often causes discomfort, foreign body ... ...

    Abstract Background: Free flap transfer is a standard practice in reconstruction of oral defects. Fasciocutaneous flaps are commonly used for reconstruction of soft tissue defects. Replacement of oral mucosa with skin often causes discomfort, foreign body sensation, dysgeusia, problems with skin hair and morbidity at the donor site. Morbidity at the donor site may interfere with physical activity among manual labourers.
    Materials and methods: We prospectively analysed nine cases of oral cavity defects reconstructed with free gastro-omental flap over 4 months from March to July 2019. A free gastric flap based on right and left gastric artery and vascular arcade was harvested from the body of stomach. Feasibility, technical aspects, advantages and disadvantages of the flap are reviewed.
    Results: Flap survival was 100%. No re-exploration for salvage was required. Flap was monitored for viability by colour change and capillary refill. All the nine cases healed well. One patient required readmission for bleeding from the raw area exposed at the margins of the flap. Patient satisfaction and quality of life was satisfactory. Long pedicle length, rich submucosal vascular network, dual pedicles available for anastomosis, like to like mucosal tissue replacement and low donor site morbidity make it a reliable option in the armamentarium of oral reconstruction.
    Conclusion: Free gastro-omental flap is a feasible and reliable tissue available for reconstruction of oral soft tissue defects.
    Language English
    Publishing date 2021-01-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-020-01276-3
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  9. Article ; Online: Consensus guidelines for the management of HR-positive HER2/neu negative early breast cancer in India, SAARC region and other LMIC by DELPHI survey method.

    Parikh, Purvish / Babu, Govind / Singh, Randeep / Krishna, Vamshi / Bhatt, Amit / Bansal, Indu / Rajappa, Senthil / Sahoo, Tarini Prasad / Aggarwal, Shyam / Bapna, Ajay / Biswas, Ghanshyam / Somashekhar, S P / Bajpai, Jyoti / Maniar, Vashishtha / Desai, Sharad / Raja, T / Rath, Goura Kishor

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 714

    Abstract: Background: Precise prognostication is the key to optimum and effective treatment planning for early-stage hormone receptor (HR) positive, HER2/neu negative breast cancer patients. Differences in the breast cancer incidence and tumor anatomical features ...

    Abstract Background: Precise prognostication is the key to optimum and effective treatment planning for early-stage hormone receptor (HR) positive, HER2/neu negative breast cancer patients. Differences in the breast cancer incidence and tumor anatomical features at diagnosis, pharmacogenomics data between Western and Indian women along with the vast diversity in the economic status and differences in insurance policies of these regions; suggest recommendations put forward for Western women might not be applicable to Indian/Asian women. Opinions from oncologists through a voting survey on various prognostic factors/tools to be considered for planning adjuvant therapy are consolidated in this report for the benefit of oncologists of the sub-continent, SAARC and Asia's LMIC (low and middle-income countries).
    Methods: A three-phase DELPHI survey was conducted to collect opinions on prognostic factors considered for planning adjuvant therapy in early-stage HR+/HER2/neu negative breast cancer patients. A panel of 25 oncologists with expertise in breast cancer participated in the survey conducted in 2021. The experts provided opinions as 'agree' or disagree' or 'not sure' in phases-1 and 2 which were conducted virtually; in the final phase-3, all the panel experts met in person and concluded the survey.
    Results: Opinions on 41 statements related to prognostic factors/tools and their implications in planning adjuvant endocrine/chemotherapy were collected. All the statements were supported by the latest data from the clinical trials (prospective/retrospective). The statements with opinions of consensus less than 66% were disseminated in phase-2, and later in phase-3 with supporting literature. In phase-3, all the opinions from panelists were consolidated and guidelines were framed.
    Conclusions: This consensus guideline will assist oncologists of India, SAARC and LMIC countries in informed clinical decision-making on adjuvant treatment in early HR+/HER2/neu negative breast cancer patients.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/epidemiology ; Breast Neoplasms/genetics ; Breast Neoplasms/therapy ; Triple Negative Breast Neoplasms ; Prospective Studies ; Developing Countries ; Retrospective Studies ; Surveys and Questionnaires ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/therapeutic use
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-11121-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Antiosteoporotic effect of Hemidesmus indicus Linn. on ovariectomised rats.

    Desai, Sharad / Babaria, Parth / Nakarani, Madhavi / Shah, Kunal / Paranjape, Archana

    Journal of ethnopharmacology

    2017  Volume 199, Page(s) 1–8

    Abstract: Pharmacological relevance: Root of Hemidesmus indicus (L). R. Br., an herbal drug of India is traditionally used to prevent or treat female hormonal disturbance related disorders and assuaging symptoms of menopausal conditions.: Aim of the study: ... ...

    Abstract Pharmacological relevance: Root of Hemidesmus indicus (L). R. Br., an herbal drug of India is traditionally used to prevent or treat female hormonal disturbance related disorders and assuaging symptoms of menopausal conditions.
    Aim of the study: Lack of scientific data for potential use in bone loss, the present study was undertaken to investigate the effects of ethanol extract of Hemidesmus indicus root for osteoporosis in ovariectomised rats.
    Materials and methods: Thirty wistar female rats were randomly divided into five groups. One group was sham operated and other four groups were undergone dorsal ovariectomy (OVX). After four weeks of post-operative recovery, three OVX groups, viz. Group1, Group2 and Group3 were treated for ninety days with standard raloxifene (RLX) 1mg/kg/day, Hemidesmus indicus root extract (HIRE) 100mg/kg/day and HIRE 200mg/kg/day respectively. Sham and OVX control groups were fed with equal 1% vehicle volume. Serum and urine biochemistry (alkaline phosphatase, tartrate resistant acid phosphatase, triglyceride, total cholesterol, calcium, phosphorous and hydroxyproline), weight of body, uterus and vagina, femur parameters, three point bending of tibia and fourth lumbar vertebra compression were examined. Furthermore, bone architecture and uterine hypertrophy were examined by histopathological studies.
    Results: Application of HIRE has increased bone strength and restored bone turnover markers such as alkaline phosphatase, tartrate resistant acid phosphatase and hydroxyproline moreover, improved femur parameters indicated mineralized bones, similar to the results observed with raloxifene treatment. Histopathology studies showed fibrocartilaginous proliferation of trabecular bone and absence of uterine hypertrophy.
    Conclusion: The results strongly suggest that HIRE prevents bone loss in OVX induced osteoporosis without estrogen like side effects. It might be a potential remedy like raloxifene for postmenopausal or estrogen deficiency caused osteoporosis.
    MeSH term(s) Animals ; Bone Density/drug effects ; Bone Density/physiology ; Female ; Hemidesmus ; Humans ; Osteoporosis, Postmenopausal/drug therapy ; Osteoporosis, Postmenopausal/etiology ; Osteoporosis, Postmenopausal/pathology ; Ovariectomy/adverse effects ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Roots ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Treatment Outcome
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2017-01-21
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2017.01.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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