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Article ; Online: PI-RADS and Likert scales for structured reporting in multiparametric MR imaging of the prostate.

Desai, Shivang / Costa, Daniel N

2021 Volume 95, Issue 1131, Page(s) 20210758

Abstract: Multiparametric MRI (mpMRI) plays a critical role in the detection, staging and risk stratification of prostate cancer (PCa). There are two widely accepted structured reporting systems used for interpretation of mpMRI of the prostate - PI-RADS v2.1 and ... ...

Abstract	Multiparametric MRI (mpMRI) plays a critical role in the detection, staging and risk stratification of prostate cancer (PCa). There are two widely accepted structured reporting systems used for interpretation of mpMRI of the prostate - PI-RADS v2.1 and Likert. Both these systems demonstrate good diagnostic performance with high cancer detection rates however have key conceptual differences. In this commentary, the authors highlight the individual strengths and areas of potential improvement as well as emphasize the need for continued clinical validation for these interpreting and reporting systems.
MeSH term(s)	Humans ; Image Interpretation, Computer-Assisted ; Male ; Multiparametric Magnetic Resonance Imaging/methods ; Neoplasm Staging ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Radiology Information Systems ; Reproducibility of Results ; Risk Assessment
Language	English
Publishing date	2021-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20210758
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Article ; Online: Association of apolipoprotein B and apolipoprotein A1 levels with social determinants of health and coronary artery disease mortality in the United Kingdom Biobank - is there a need for consideration?

Füller, David / Liu, Chang / Desai, Shivang R / Vatsa, Nishant / Sun, Yan V / Quyyumi, Arshed A

Coronary artery disease

2024

Abstract: Background: A higher prevalence of cardiovascular risk factors has previously been shown to be associated with adverse social determinants of health (SDoH) and to explain some of their impact on cardiovascular risk. Whether there is a relationship ... ...

Abstract	Background: A higher prevalence of cardiovascular risk factors has previously been shown to be associated with adverse social determinants of health (SDoH) and to explain some of their impact on cardiovascular risk. Whether there is a relationship between lipid parameters, specifically apolipoprotein B (apoB), apolipoprotein A1 (apoA1), their ratio (apoB/apoA1), and SDoH, and whether coronary artery disease (CAD) mortality risk associated with circulating apoB and apoA1 is modified by SDoH was unclear. Methods: We investigated associations of apoA1, apoB, and apoB/apoA1 with the level of education and household income and their joint impact on CAD mortality in participants of the UK Biobank (UKB) with and without prevalent CAD at enrollment. Hazard ratios for CAD mortality were estimated after adjusting for SDoH and clinical covariates. Results: In 292 804 participants without established CAD, apoB, and the apoB/apoA1 ratio were inversely associated with level of education and household income, whereas apoA1 was positively associated with household income. Adjustment for education level and household income coupled with the number of people living in the household did not attenuate the association between the apolipoprotein levels and incident CAD mortality rates. In a cohort of 13 826 participants with prevalent CAD, apoA1 levels were inversely associated with level of education. Higher apoB levels were only associated with greater CAD mortality risk after adjustment for risk factors. Risk estimation for CAD death through circulating apoA1 levels requires accounting for significant differences by sex. Conclusion: Circulating lipid parameters are associated with SDoH in individuals without CAD. CAD mortality risk estimation through apoA1 and apoB levels does not require accounting for SDoH.
Language	English
Publishing date	2024-05-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1047268-x
ISSN	1473-5830 ; 0954-6928
ISSN (online)	1473-5830
ISSN	0954-6928
DOI	10.1097/MCA.0000000000001380
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Article ; Online: Polyurethane-functionalized starch nanocrystals as anti-tuberculosis drug carrier.

Desai, Shivang K / Mondal, Dhananjoy / Bera, Smritilekha

Scientific reports

2021 Volume 11, Issue 1, Page(s) 8331

Abstract: Studies related to loading ability and delivery of clinically used first-line anti-tuberculosis drugs (ATDs) such as isoniazid, rifampicin, pyrazinamide and streptomycin on the surface of starch-derived bulk and nanopolyurethanes (SBPUs and SNPUs) as ... ...

Abstract	Studies related to loading ability and delivery of clinically used first-line anti-tuberculosis drugs (ATDs) such as isoniazid, rifampicin, pyrazinamide and streptomycin on the surface of starch-derived bulk and nanopolyurethanes (SBPUs and SNPUs) as drug delivery systems (DDS) have been focused to minimise or remove the drug-associated adverse effects. The efficiencies of nanopolyurethanes obtained from the differently substituted cyclic aliphatic and aromatic isocyanates have been studied for drug loading and release purposes. Different advanced instrumental techniques analysed the structural and morphological properties, thermal stability and crystallinity of the starch nanopolyurethans. Average particle sizes ranging from 27.35-42.38 nm to 126.89-218.60 nm for starch nanopolyurethans, SNPU3i and SNPU4i, respectively, were determined by high-resolution transmission electron microscopy. Similarly, the loading efficiency of ATDs to the surfaces of SNPUs and SBPUs was observed in the range of 60-97% while ATDs-loaded SNPUs showed a sustainable release profile for all ATDs except for streptomycin. However, most SBPUs provided burst-release for all the above-mentioned ATDs in pH-dependent studies. The anti-tuberculosis assay against the Mycobacterium tuberculosis H37Rv strain revealed that streptomycin-loaded SNPU4i and isoniazid-loaded SNPU7i are approximately 42 and 7 times more active than the native streptomycin and isoniazid, respectively.
MeSH term(s)	Antitubercular Agents/administration & dosage ; Antitubercular Agents/adverse effects ; Antitubercular Agents/pharmacology ; Drug Carriers/chemistry ; Drug Delivery Systems ; Drug Liberation ; Drug Resistance, Bacterial ; Drug Stability ; Hydrogen-Ion Concentration ; Isoniazid/administration & dosage ; Isoniazid/pharmacology ; Mycobacterium tuberculosis/drug effects ; Nanoparticles/chemistry ; Particle Size ; Polyurethanes/chemistry ; Starch/chemistry ; Streptomycin/administration & dosage ; Streptomycin/pharmacology
Chemical Substances	Antitubercular Agents ; Drug Carriers ; Polyurethanes ; Starch (9005-25-8) ; Isoniazid (V83O1VOZ8L) ; Streptomycin (Y45QSO73OB)
Language	English
Publishing date	2021-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-86767-1
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Article: First-line anti-tubercutilosis drugs-loaded starch nanocrystals for combating the threat of M. tuberculosis H37Rv strain

Desai, Shivang K / Mondal, Dhananjoy / Bera, Smritilekha

Carbohydrate research. 2020 Sept., v. 495

2020

Abstract: Nanoparticles-based drug delivery is at the forefront in the field of pharmaceutical and medicinal research to eradicate or alleviate the associated impediments, such as prolonged treatment time, high doses, toxicity and resistance problem of anti- ... ...

Abstract	Nanoparticles-based drug delivery is at the forefront in the field of pharmaceutical and medicinal research to eradicate or alleviate the associated impediments, such as prolonged treatment time, high doses, toxicity and resistance problem of anti-tuberculosis drugs for the treatment of age-old tuberculosis disease. Herein, the first-line anti-tuberculosis drugs were loaded into the biodegradable starch nanocrystals and native starch to improve the therapeutic profile addressing the existing issues related to conventional drugs. The loading performance of anti-tuberculosis drugs with starch nanocrystals and native starch was found in the range of 65–95%. According to the release study, the native starch was not appropriate, however, the starch nanocrystals demonstrated sustained release drug delivery for isoniazid and pyrazinamide ranging from 50 to 93% for 24 h; the burst release for streptomycin was reported at pH 2 in 6.5 h while only 14% rifampicin was released at pH 8 buffer. An anti-mycobacterium analysis of strain H37Rv showed that minimum inhibition concentration of starch nanocrystals loaded with isoniazid and pyrazinamide (0.033 μg/mL and 1.25 μg/mL, respectively) were more effective than the parent isoniazid (0.2 μg/mL) and pyrazinamide (25.0 μg/mL) at pH 5.5.
Keywords	Mycobacterium tuberculosis ; biodegradability ; isoniazid ; minimum inhibitory concentration ; nanocrystals ; pH ; research ; rifampicin ; starch ; streptomycin ; therapeutics ; toxicity ; tuberculosis
Language	English
Dates of publication	2020-09
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1435-7
ISSN	1873-426X ; 0008-6215
ISSN (online)	1873-426X
ISSN	0008-6215
DOI	10.1016/j.carres.2020.108070
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: In vitro

Frenster, Joshua D / Desai, Shivang / Placantonakis, Dimitris G

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

2020 Volume 37, Issue 2, Page(s) 20–26

Abstract: The concept of thermal therapy toward the treatment of brain tumors has gained traction in recent years. Traditionally, thermal therapy has been subdivided into hyperthermia, with mild elevation of temperature in treated tissue above the physiologic ... ...

Abstract	The concept of thermal therapy toward the treatment of brain tumors has gained traction in recent years. Traditionally, thermal therapy has been subdivided into hyperthermia, with mild elevation of temperature in treated tissue above the physiologic baseline; and thermal ablation, where even higher temperatures are achieved. The recent surge in interest has been driven by the use of novel thermal ablation technologies, including laser interstitial thermal therapy (LITT), that are implemented in brain tumor treatment. Here, we review previous scientific literature on the biologic effects of thermal therapy on brain tumors, with an emphasis on glioblastoma (GBM), an aggressive brain malignancy. In addition, we present
MeSH term(s)	Brain Neoplasms/surgery ; Cell Death ; Glioblastoma/surgery ; Humans ; Hyperthermia, Induced ; Laser Therapy ; Lasers ; Magnetic Resonance Imaging ; Temperature ; Tumor Cells, Cultured
Language	English
Publishing date	2020-07-29
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632526-9
ISSN	1464-5157 ; 0265-6736
ISSN (online)	1464-5157
ISSN	0265-6736
DOI	10.1080/02656736.2020.1774082
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Article ; Online: Periprosthetic proximal femoral fractures in cemented and uncemented stems according to Vancouver classification: observation of a new fracture pattern.

Karam, James / Campbell, Paul / Desai, Shivang / Hunter, Michael

Journal of orthopaedic surgery and research

2020 Volume 15, Issue 1, Page(s) 100

Abstract: Background: Periprosthetic fractures are increasingly encountered in hip arthroplasty. The Vancouver classification system is widely used. Little knowledge exists regarding the association of the Vancouver classification with either cemented or ... ...

Abstract	Background: Periprosthetic fractures are increasingly encountered in hip arthroplasty. The Vancouver classification system is widely used. Little knowledge exists regarding the association of the Vancouver classification with either cemented or uncemented stems. The aim was to analyse a series of fractures and determine associations. Methods: A series of consecutive patients over 8 years was identified including only post-operative fractures of primary hip arthroplasties. Baseline and radiographic characteristics were recorded including the type of stem fixation (cemented or uncemented) and Vancouver classification. Statistical analysis was performed to determine the association of the Vancouver classification between cemented and uncemented stems. Results: A total of 172 patients were identified (84 cemented stems, 88 uncemented stems). There were 30 Vancouver A fractures (12 cemented vs.18 uncemented, p > 0.05), 125 Vancouver B fractures (63 cemented vs. 62 uncemented, p > 0.05) and 17 Vancouver C fractures (9 cemented vs. 8 uncemented, p > 0.05). The Vancouver B2 fracture occurred most frequently (N = 95; 44 cemented vs. 51 uncemented, p > 0.05) and consists of four distinct fracture patterns: the previously described comminuted 'burst', clamshell and spiral patterns and the newly observed 'reverse' clamshell. The burst and spiral fracture patterns are significantly associated with cemented stems, and the clamshell pattern is significantly associated with uncemented stems. Conclusions: Vancouver A, B and C fractures occur equally in cemented and uncemented stems. Awareness of four distinct Vancouver B2 fracture patterns, including the newly observed reverse clamshell, will aid surgeons in predicting stem instability.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Hip/trends ; Bone Cements/adverse effects ; Female ; Femoral Fractures/diagnostic imaging ; Femoral Fractures/etiology ; Hip Prosthesis/adverse effects ; Hip Prosthesis/trends ; Humans ; Male ; Middle Aged ; Periprosthetic Fractures/diagnostic imaging ; Periprosthetic Fractures/etiology ; Prosthesis Design/adverse effects ; Prosthesis Design/trends ; Retrospective Studies
Chemical Substances	Bone Cements
Language	English
Publishing date	2020-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-020-01619-4
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Article ; Online: First-line anti-tubercutilosis drugs-loaded starch nanocrystals for combating the threat of M. tuberculosis H37Rv strain.

Desai, Shivang K / Mondal, Dhananjoy / Bera, Smritilekha

Carbohydrate research

2020 Volume 495, Page(s) 108070

Abstract	Nanoparticles-based drug delivery is at the forefront in the field of pharmaceutical and medicinal research to eradicate or alleviate the associated impediments, such as prolonged treatment time, high doses, toxicity and resistance problem of anti-tuberculosis drugs for the treatment of age-old tuberculosis disease. Herein, the first-line anti-tuberculosis drugs were loaded into the biodegradable starch nanocrystals and native starch to improve the therapeutic profile addressing the existing issues related to conventional drugs. The loading performance of anti-tuberculosis drugs with starch nanocrystals and native starch was found in the range of 65-95%. According to the release study, the native starch was not appropriate, however, the starch nanocrystals demonstrated sustained release drug delivery for isoniazid and pyrazinamide ranging from 50 to 93% for 24 h; the burst release for streptomycin was reported at pH 2 in 6.5 h while only 14% rifampicin was released at pH 8 buffer. An anti-mycobacterium analysis of strain H37Rv showed that minimum inhibition concentration of starch nanocrystals loaded with isoniazid and pyrazinamide (0.033 μg/mL and 1.25 μg/mL, respectively) were more effective than the parent isoniazid (0.2 μg/mL) and pyrazinamide (25.0 μg/mL) at pH 5.5.
MeSH term(s)	Antitubercular Agents/chemistry ; Antitubercular Agents/pharmacology ; Microbial Sensitivity Tests ; Molecular Conformation ; Mycobacterium tuberculosis/drug effects ; Nanoparticles/chemistry ; Pyrazinamide/chemistry ; Pyrazinamide/pharmacology ; Rifampin/chemistry ; Rifampin/pharmacology ; Starch/chemistry ; Starch/pharmacology ; Streptomycin/chemistry ; Streptomycin/pharmacology
Chemical Substances	Antitubercular Agents ; Pyrazinamide (2KNI5N06TI) ; Starch (9005-25-8) ; Rifampin (VJT6J7R4TR) ; Streptomycin (Y45QSO73OB)
Language	English
Publishing date	2020-06-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1435-7
ISSN	1873-426X ; 0008-6215
ISSN (online)	1873-426X
ISSN	0008-6215
DOI	10.1016/j.carres.2020.108070
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Article ; Online: Sturge-Weber Syndrome.

Desai, Shivang / Glasier, Charles

The New England journal of medicine

2017 Volume 377, Issue 9, Page(s) e11

MeSH term(s)	Brain/diagnostic imaging ; Brain/pathology ; Child ; Female ; Humans ; Magnetic Resonance Imaging ; Meninges/blood supply ; Meninges/diagnostic imaging ; Sturge-Weber Syndrome/diagnostic imaging ; Sturge-Weber Syndrome/pathology
Language	English
Publishing date	2017-08-31
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMicm1700538
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Article: Rare prostate cancer mimic on multiparametric MRI: Cowper's gland hyperplasia.

Desai, Shivang / Jia, Liwei / Diaz de Leon, Alberto / Costa, Daniel N

Urology case reports

2021 Volume 38, Page(s) 101675

Abstract: Multiparametric MRI and targeted biopsies of the prostate have been increasingly utilized in men with elevated PSA. It is important to recognize potential mimics of prostate cancer on MRI and on biopsy specimens. Familiarity with the location, imaging ... ...

Abstract	Multiparametric MRI and targeted biopsies of the prostate have been increasingly utilized in men with elevated PSA. It is important to recognize potential mimics of prostate cancer on MRI and on biopsy specimens. Familiarity with the location, imaging and histological appearance of Cowper's glands will prevent misdiagnosis and help avoid unnecessary biopsies. We present a case of Cowper's gland hyperplasia with a review of its imaging and histopathologic characteristics.
Language	English
Publishing date	2021-04-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2745459-9
ISSN	2214-4420
ISSN	2214-4420
DOI	10.1016/j.eucr.2021.101675
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Article ; Online: Spinal subdural hemorrhage in abusive head trauma: a pictorial review.

Garcia-Pires, Flavio / Jayappa, Sateesh / Desai, Shivang / Ramakrishnaiah, Raghu H / Choudhary, Arabinda K

Pediatric radiology

2021 Volume 51, Issue 6, Page(s) 980–990

Abstract: A growing body of evidence links abusive head trauma (AHT) to patterns of direct and indirect spinal injuries, such as spinal subdural hemorrhage (SDH). Identification of evidence of spinal injury such as spinal SDH plays a crucial role in the diagnosis ... ...

Abstract	A growing body of evidence links abusive head trauma (AHT) to patterns of direct and indirect spinal injuries, such as spinal subdural hemorrhage (SDH). Identification of evidence of spinal injury such as spinal SDH plays a crucial role in the diagnosis and subsequent management of the index child with AHT and his or her siblings. In a value-based practice of medicine, it can be argued that adding spine imaging to identify spinal SDH in the workup of AHT adds value to both the short- and long-term management of the patient. This pictorial review describes the normal appearance of spinal SDH and challenges of identifying spinal SDH, and it explores the mechanism of spinal SDH development in AHT.
MeSH term(s)	Child ; Child Abuse/diagnosis ; Craniocerebral Trauma/diagnostic imaging ; Female ; Hematoma, Subdural/diagnostic imaging ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Retrospective Studies
Language	English
Publishing date	2021-05-17
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	124459-0
ISSN	1432-1998 ; 0301-0449
ISSN (online)	1432-1998
ISSN	0301-0449
DOI	10.1007/s00247-020-04931-7
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