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  1. AU="Desai, Urja"
  2. AU="Chini, Maria Giovanna"
  3. AU="Xiao, Difei"
  4. AU="Ryan, Chris"
  5. AU="Omar Bazighifan"
  6. AU="Corominas Galbany, Jordi"
  7. AU=Fox Norma E
  8. AU="Hamilton, Shelia M"
  9. AU="Nichols, J Wylie"
  10. AU="Pesce R."
  11. AU="Gambitta, P"
  12. AU="Imran, Aqeel"
  13. AU="Sharma, Yashoda"
  14. AU="Kosai, Jordyn"
  15. AU="Aroca Ferri, María"
  16. AU="Laba, Stephanie"
  17. AU="Kim, Ye-Sel"

Suchergebnis

Treffer 1 - 5 von insgesamt 5

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  1. Artikel ; Online: Current Drugs and their Therapeutic Targets for Hypoxia-inducible Factors in Cancer.

    Joshi, Esha / Pandya, Medha / Desai, Urja

    Current protein & peptide science

    2023  Band 24, Heft 6, Seite(n) 447–464

    Abstract: Hypoxia, a prevalent characteristic of both solid and liquid malignancies, is found to regulate how genes are expressed in a way that promotes cellular adaptability and survival. Metastasis is controlled by hypoxia-inducible factors (HIFs). HIFs are ... ...

    Abstract Hypoxia, a prevalent characteristic of both solid and liquid malignancies, is found to regulate how genes are expressed in a way that promotes cellular adaptability and survival. Metastasis is controlled by hypoxia-inducible factors (HIFs). HIFs are dimeric protein molecules made up of an oxygen (O
    Mesh-Begriff(e) Humans ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Basic Helix-Loop-Helix Transcription Factors/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Hypoxia/drug therapy ; Hypoxia/genetics ; Oxygen
    Chemische Substanzen Basic Helix-Loop-Helix Transcription Factors ; Oxygen (S88TT14065)
    Sprache Englisch
    Erscheinungsdatum 2023-06-01
    Erscheinungsland United Arab Emirates
    Dokumenttyp Journal Article
    ZDB-ID 2045662-1
    ISSN 1875-5550 ; 1389-2037
    ISSN (online) 1875-5550
    ISSN 1389-2037
    DOI 10.2174/1389203724666230601092245
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5884: Hefte anzeigen Standort:
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  2. Artikel ; Online: Role of epithelial - Stromal interaction protein-1 expression in breast cancer.

    Raval, Apexa P / Desai, Urja N / Joshi, Jigna S / Shah, Franky D

    Indian journal of pathology & microbiology

    2020  Band 63, Heft 3, Seite(n) 382–387

    Abstract: Background and aims: Epithelial stromal interaction protein-1 (EPSTI-1) is originally identified as stromal-fibroblast - induced gene in breast cancer. It was found to be involved in promotion of EMT, breast cancer invasion, metastasis and anchorage- ... ...

    Abstract Background and aims: Epithelial stromal interaction protein-1 (EPSTI-1) is originally identified as stromal-fibroblast - induced gene in breast cancer. It was found to be involved in promotion of EMT, breast cancer invasion, metastasis and anchorage-independent growth in vitro. Strong expression was observed in various tissues as well as higher expression was observed in invasive breast cancer compared to normal breast. EPSTI-1 expression was evaluated from 106 pre-therapeutic breast cancer patients. EPSTI-1 expression was correlated with known clinico-pathological parameters of breast cancer to explore its role in breast carcinogenesis.
    Subjects and methods: EPSTI-1 expression was analyzed from the collected synchronous tissues [tumors, Malignant Lymph nodes (LN) and adjacent normal tissues (ANT)] of breast carcinoma patients (N = 106). The statistical correlation was performed using SPSS 16.0.
    Results: In this study EPSTI-1 was significantly higher in LN compared to tumors (P < 0.001), and in tumors compared to ANT (P < 0.01) which is also reflected in ROC curve analysis (P < 0.0001). Further the small tumor size, stage I, grade I and tumors without stromal involvement exhibited significant lower expression compared to their counter parts.
    Conclusion: EPSTI-1 may have significant role in epithelial stromal interaction and disease extension. Moreover, it may be responsible for aggressive tumor behavior and involved in metastatic process which needs to be validated in larger cohort.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Female ; Gene Expression ; Humans ; Middle Aged ; Neoplasm Proteins/genetics ; Young Adult
    Chemische Substanzen EPSTI1 protein, human ; Neoplasm Proteins
    Sprache Englisch
    Erscheinungsdatum 2020-08-08
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/IJPM.IJPM_672_19
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Synergism of Curcumin and Cytarabine in the Down Regulation of Multi-Drug Resistance Genes in Acute Myeloid Leukemia.

    Shah, Krupa / Mirza, Sheefa / Desai, Urja / Jain, Nayan / Rawal, Rakesh

    Anti-cancer agents in medicinal chemistry

    2015  Band 16, Heft 1, Seite(n) 128–135

    Abstract: Background: The aim of the study was to find a role of Curcumin from natural source to overcome drug resistance as well as to reduce cytotoxicity profile of the drug in Acute Myeloid Leukemia patients.: Material and methods: Primary leukemic cells ... ...

    Abstract Background: The aim of the study was to find a role of Curcumin from natural source to overcome drug resistance as well as to reduce cytotoxicity profile of the drug in Acute Myeloid Leukemia patients.
    Material and methods: Primary leukemic cells were obtained from AML patient's bone marrow. These cells were then exposed to different concentration of cytarabine and curcumin to find out IC50 values and also its effect on MDR genes like MDR1, BCRP, LRP and FLT3 by RT-PCR method.
    Result & conclusion: Our results suggested that curcumin down regulates MDR genes. Gene expression was decreased by 35.75, 31.30, 27.97 % for MDR1, LRP, BCRP respectively. In FLT3, it was 65.86 % for wild type and 31.79 % for FLT3-ITD. In addition to this, curcumin has also shown anti-proliferative effect as well as synergistic effect in combination with Cytarabine on primary leukemic cells. Thus, we can conclude that curcumin can be used as MDR modulator as well as chemosensitizer in combination with cytarabine, standard chemotherapeutic drug, to reduce the cytotoxicity profile as IC50 value decreases when treated in combination.
    Mesh-Begriff(e) ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2 ; ATP-Binding Cassette Transporters/antagonists & inhibitors ; ATP-Binding Cassette Transporters/genetics ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Curcumin/chemistry ; Curcumin/pharmacology ; Cytarabine/chemistry ; Cytarabine/pharmacology ; Dose-Response Relationship, Drug ; Down-Regulation/drug effects ; Drug Resistance, Multiple/drug effects ; Drug Resistance, Multiple/genetics ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Drug Screening Assays, Antitumor ; Drug Synergism ; Humans ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/genetics ; Real-Time Polymerase Chain Reaction ; Structure-Activity Relationship ; Vault Ribonucleoprotein Particles/antagonists & inhibitors ; Vault Ribonucleoprotein Particles/genetics ; fms-Like Tyrosine Kinase 3/antagonists & inhibitors ; fms-Like Tyrosine Kinase 3/genetics
    Chemische Substanzen ABCB1 protein, human ; ABCG2 protein, human ; ATP Binding Cassette Transporter, Subfamily B ; ATP Binding Cassette Transporter, Subfamily G, Member 2 ; ATP-Binding Cassette Transporters ; Antineoplastic Agents ; Neoplasm Proteins ; Vault Ribonucleoprotein Particles ; major vault protein ; Cytarabine (04079A1RDZ) ; FLT3 protein, human (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1) ; Curcumin (IT942ZTH98)
    Sprache Englisch
    Erscheinungsdatum 2015-08-14
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2217610-X
    ISSN 1875-5992 ; 1871-5206
    ISSN (online) 1875-5992
    ISSN 1871-5206
    DOI 10.2174/1871520615666150817115718
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5583: Hefte anzeigen Standort:
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  4. Artikel: EGFR Mutation

    Joshi, Jigna / Raval, Apexa / Desai, Urja / Upadhyay, Vinal / Bhavsar, Mansi / Shah, Kanisha / Rawal, Rakesh / Panchal, Harsha / Shah, Franky

    Indian journal of clinical biochemistry : IJCB

    2019  Band 36, Heft 1, Seite(n) 51–58

    Abstract: In the era of the targeted therapy identification ... ...

    Abstract In the era of the targeted therapy identification of
    Sprache Englisch
    Erscheinungsdatum 2019-12-04
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-019-00864-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  5. Artikel ; Online: Enhancement of the cytotoxic effects of Cytarabine in synergism with Hesperidine and Silibinin in Acute Myeloid Leukemia: An in-vitro approach.

    Desai, Urja N / Shah, Krupa P / Mirza, Sheefa H / Panchal, Darshil K / Parikh, Sonia K / Rawal, Rakesh M

    Journal of cancer research and therapeutics

    2015  Band 11, Heft 2, Seite(n) 352–357

    Abstract: Objectives: Acute Myeloid Leukemia (AML) therapy continues to be a daunting challenge. Cytosine Arabinoside (Ara-C) is widely used to treat hematological malignancy in humans, but often becomes ineffective because of increased resistance to the drug ... ...

    Abstract Objectives: Acute Myeloid Leukemia (AML) therapy continues to be a daunting challenge. Cytosine Arabinoside (Ara-C) is widely used to treat hematological malignancy in humans, but often becomes ineffective because of increased resistance to the drug which may lead to a worse prognosis. Therefore new strategies are needed to understand the mechanism responsible for drug resistance and to develop new therapies to overcome it. Research evidence based on natural compounds used alone or in combination with current chemotherapeutic agents proved their efficacy to treat and prevent cancer. Hesperidin and Silibinin displayed anti-cancer activity against various types of cancers and cell lines and can be used in combination with Cytarabine with the aim to increase cytotoxicy profile and reduction in drug resistance. Experimental Work: Primary cells obtained from AML patient's bone marrow were used to develop in-vitro model and further exposed to various concentration of Cytarabine (10 nM-5000 nM), Hesperidin (0.5 μM-100 μM) and Silibinin (0.5 μM-100 μM) alone and in combination with Cytarabine (Hesperidin-25 μM, Silibinin10 μM) to check cytotoxicity using MTT assay. Synergistic effect was evaluated by Combination Index method.
    Result and conclusion: In-vitro study of Hesperidin and Silibinin indicated their cytotoxicity at IC 50 value 50.12 μM and 16.2 μM, respectively. Combination Index study revealed Hesperidin and Silibinin both showed synergistic potential and decreased the IC 50 value of Cytarabine by ~5.9 and ~4.5 folds, respectively. Both natural compounds showed potential anti-leukemic activity hence may be used for AML therapy alone or in combination with other chemotherapeutic agents.
    Mesh-Begriff(e) Antineoplastic Agents/pharmacology ; Bone Marrow/drug effects ; Cytarabine/pharmacology ; Drug Screening Assays, Antitumor/methods ; Drug Synergism ; Hesperidin/pharmacology ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Silymarin/pharmacology ; Tumor Cells, Cultured
    Chemische Substanzen Antineoplastic Agents ; Silymarin ; Cytarabine (04079A1RDZ) ; silybin (4RKY41TBTF) ; Hesperidin (E750O06Y6O)
    Sprache Englisch
    Erscheinungsdatum 2015-04
    Erscheinungsland India
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/0973-1482.157330
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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