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  1. Article ; Online: Thyroid cancers in children and adolescents in France: Incidence, survival and clinical management over the 2000-2018 period.

    Zbitou, Asma / Desandes, Emmanuel / Guissou, Sandra / Mallebranche, Coralie / Lacour, Brigitte

    International journal of pediatric otorhinolaryngology

    2022  Volume 162, Page(s) 111325

    Abstract: Introduction: Thyroid cancer is the first cause of endocrine malignancy among children. Over the past decades, an increase in the incidence rates (IR) has been observed around the world. Our study aimed to describe epidemiology, therapeutic management ... ...

    Abstract Introduction: Thyroid cancer is the first cause of endocrine malignancy among children. Over the past decades, an increase in the incidence rates (IR) has been observed around the world. Our study aimed to describe epidemiology, therapeutic management and survival rates of children and adolescents with thyroid cancer in France.
    Methods: A population-based study was conducted between 2000 and 2018 in children and adolescents less than 17 years with a diagnostic of thyroid cancer.
    Results: A total of 774 thyroid cancers were included: 579 papillary (PTC), 83 follicular (FTC), and 111 medullary carcinomas (MTC). PTC are more frequent in females and in adolescents whereas MTC mainly concerned children, mostly with a familial predisposition. Almost all patients underwent thyroidectomy, completed for most patients with PTC and FTC by radioiodine therapy. Cervical dissection was performed more frequently in patients having PTC and MTC compared to those with FTC. Between 2000 and 2018, thyroid cancers IR in children fluctuated between 1.3 and 3.2 per million, without any significant trend. The median follow-up time was 11.3 years in children, and 5.7 years in adolescents. The 5year-OS was greater than 98.5%.
    Conclusions: Population-based studies are crucial for better understanding and delineation of best management of rare diseases as thyroid cancers in pediatric and adolescent population. Considering the very favorable survival, a stratification should be proposed between cases at low risk and cases at high risk of relapse, in order to consider a strategy of therapeutic de-escalation in the most favorable cases.
    MeSH term(s) Adenocarcinoma, Follicular/epidemiology ; Adenocarcinoma, Follicular/therapy ; Adolescent ; Child ; Female ; Humans ; Incidence ; Iodine Radioisotopes ; Neoplasm Recurrence, Local ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/epidemiology ; Thyroid Neoplasms/therapy
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 2022-09-21
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 754501-0
    ISSN 1872-8464 ; 0165-5876
    ISSN (online) 1872-8464
    ISSN 0165-5876
    DOI 10.1016/j.ijporl.2022.111325
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  2. Article ; Online: Développement d’une solution d’intelligence artificielle pour améliorer le screening en recherche clinique.

    Gédor, Maud / Desandes, Emmanuel / Chesnel, Mélanie / Merlin, Jean-Louis / Marchal, Frédéric / Lambert, Aurélien / Baudin, Arnaud

    Bulletin du cancer

    2024  

    Abstract: Introduction: The recruitment step of all clinical trials is time consuming, harsh and generate extra costs. Artificial intelligence tools could improve recruitment in order to shorten inclusion phase. The objective was to assess the performance of an ... ...

    Title translation Development of an artificial intelligence system to improve cancer clinical trial eligibility screening.
    Abstract Introduction: The recruitment step of all clinical trials is time consuming, harsh and generate extra costs. Artificial intelligence tools could improve recruitment in order to shorten inclusion phase. The objective was to assess the performance of an artificial intelligence driven tool (text mining, machine learning, classification…) for the screening and detection of patients, potentially eligible for recruitment in one of the clinical trials open at the "Institut de Cancérologie de Lorraine".
    Methods: Computerized clinical data during the first medical consultation among patients managed in an anticancer center over the 2019-2023 period were used to study the performances of an artificial intelligence tool (SAS® Viya). Recall, precision and F1-score were used to determine the artificial intelligence algorithm effectiveness. Time saved on screening was determined by the difference between the time taken using the artificial intelligence-assisted method and that taken using the standard method in clinical trial participant screening.
    Results: Out of 9876 patients included in the study, the artificial intelligence algorithm obtained the following scores: precision of 96 %, recall of 94 % and a 0.95 F1-score to detect patients with breast cancer (n=2039) and potentially eligible for inclusion in a clinical trial. The screening of 258 potentially eligible patient's files took 20s per file vs. 5min and 6s with standard method.
    Discussion: This study suggests that artificial intelligence could yield sizable improvements over standard practices in several aspects of the patient screening process, as well as in approaches to feasibility, site selection, and trial selection.
    Language French
    Publishing date 2024-03-18
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2024.01.010
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  3. Article ; Online: Corrigendum to "Factors associated with 5- and 10-year survival among a recent cohort of childhood cancer survivors (France, 2000-2015)" [Cancer Epidemiol. 73 (2021) 101950].

    Poulalhon, Claire / Goujon, Stéphanie / Marquant, Fabienne / Faure, Laure / Guissou, Sandra / Bonaventure, Audrey / Désandes, Emmanuel / Rios, Paula / Lacour, Brigitte / Clavel, Jacqueline

    Cancer epidemiology

    2024  Volume 90, Page(s) 102572

    Language English
    Publishing date 2024-04-16
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2508729-0
    ISSN 1877-783X ; 1877-7821
    ISSN (online) 1877-783X
    ISSN 1877-7821
    DOI 10.1016/j.canep.2024.102572
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  4. Article ; Online: Prise en charge du cancer du sein avant 40 ans : quelle évolution en une décennie ? Étude rétrospective réalisée à l’Institut de cancérologie de Lorraine : 2002-2012.

    Soussoko, Mariam / Salleron, Julia / Desandes, Emmanuel / Lesur, Anne

    Bulletin du cancer

    2020  Volume 106, Issue 12S1, Page(s) S60–S74

    Abstract: Introduction: Breast cancer of young women has medico-psychological issues, particularly in the perspective of "after cancer" period. The objective of the study was to analyze the changes in management, in a decade including the publication of Cancer ... ...

    Title translation Breast cancer management before 40 years: what change in one decade? A retrospective study at the "Institut de cancérologie de Lorraine": 2002-2012.
    Abstract Introduction: Breast cancer of young women has medico-psychological issues, particularly in the perspective of "after cancer" period. The objective of the study was to analyze the changes in management, in a decade including the publication of Cancer Plans I and II.
    Methods: This retrospective unicentric study involved two populations of women aged 40 and treated at the "Institut de cancérologie de Lorraine" in 2002-2004 (P1) and 2012-2014 (P2). Epidemiological-demographic, histological, diagnostic and therapeutic sequences were analyzed.
    Results: 216 patients were included. The mean age was 35.7 years (range 22-40), with no significant epidemiological difference, except for an increased rate of obesity in P2. Preoperative biopsies became almost systematic and the pre-therapeutic care plan rate increased over the decade from 3.8% to 8% (p < 0.001). The rate of breast-conserving treatment remained stable. The sentinel lymph node rate increased from 4.4% in P1 to 31.9% in P2 (p < 0.001), while the rate of lymph node dissection decreased (p < 0.001) between the two periods. Resort to breast nurses, psycho-oncologists, fertility experts and oncogenetic consultations has also increased.
    Conclusion: There is an improvement in the care and management of young women under 40 because of the first Cancer Plans. A study about the impact on the prognosis and a reflection to improve the experience of illness for these women are to lead.
    MeSH term(s) Adult ; Age Factors ; Biopsy/trends ; Breast/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Cancer Care Facilities ; Cohort Studies ; Female ; Fertility Preservation/statistics & numerical data ; France/epidemiology ; Genetic Testing/statistics & numerical data ; Genetic Testing/trends ; Humans ; Mastectomy, Segmental/statistics & numerical data ; Mastectomy, Segmental/trends ; Obesity/epidemiology ; Pregnancy ; Prognosis ; Retrospective Studies ; Sentinel Lymph Node Biopsy/statistics & numerical data ; Sentinel Lymph Node Biopsy/trends ; Time Factors ; Young Adult
    Language French
    Publishing date 2020-02-13
    Publishing country France
    Document type Journal Article
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/S0007-4551(20)30049-7
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  5. Article ; Online: PAX-FOXO1 fusion status in children and adolescents with alveolar rhabdomyosarcoma: Impact on clinical, pathological, and survival features.

    Raze, Thomas / Lapouble, Eve / Lacour, Brigitte / Guissou, Sandra / Defachelles, Anne-Sophie / Gaspar, Nathalie / Delattre, Olivier / Pierron, Gaelle / Desandes, Emmanuel

    Pediatric blood & cancer

    2023  Volume 70, Issue 4, Page(s) e30228

    Abstract: Background: Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer and cases with fusion PAX3-FOXO1 and PAX7-FOXO1 seem to have a poor prognosis. The aim is to evaluate whether PAX-FOXO1 alterations influence clinical outcome in childhood ... ...

    Abstract Background: Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer and cases with fusion PAX3-FOXO1 and PAX7-FOXO1 seem to have a poor prognosis. The aim is to evaluate whether PAX-FOXO1 alterations influence clinical outcome in childhood and adolescence population with ARMS.
    Procedure: A population-based study was conducted between 2011 and 2016 in patients less than 17 years with a diagnosis of ARMS. Overall survival (OS) depending on fusion status with clinical factors was analyzed.
    Results: Out of 111 ARMS patients recorded in the French National Childhood Cancer Registry during the 2011-2016 period, 61% expressed PAX3-FOXO1, 15% expressed PAX7-FOXO1, 13% were FOXO1 fusion-positive without PAX specification, and 7% were PAX-FOXO1 negative (n = 4 missing data). Compared to patients with PAX7-FOXO1 positive ARMS, those with PAX3-FOXO1 positive tumor were significantly older (10-17 years: 57.4% vs. 29.4%), and had more often a metastatic disease (54.4% vs. 23.5%). Poorer 5-year OS for patients with PAX3-FOXO1 and PAX not specified FOXO1-positive tumor were observed (44.0% [32.0-55.4] and 35.7% [13.1-59.4], respectively). After adjustment for stage at diagnosis, patients with positive tumor for PAX3-FOXO1 were 3.6-fold more likely to die than those with positive tumor for PAX7-FOXO1.
    Conclusion: At the population level, PAX3-FOXO1 was associated with a significant higher risk of death compared to PAX7-FOXO1-positive and PAX-FOXO1-negative tumors, and could explain poorer 5-year OS observed in adolescence population diagnosed with ARMS. A continuous risk score derived from the combination of clinical parameters with PAX3-FOXO1 fusion status represents a robust approach to improving current risk-adapted therapy for ARMS.
    MeSH term(s) Child ; Humans ; Adolescent ; Rhabdomyosarcoma, Alveolar/pathology ; Paired Box Transcription Factors ; PAX7 Transcription Factor ; PAX3 Transcription Factor ; Forkhead Transcription Factors ; Forkhead Box Protein O1 ; Oncogene Proteins, Fusion ; Rhabdomyosarcoma
    Chemical Substances Paired Box Transcription Factors ; PAX7 Transcription Factor ; PAX3 Transcription Factor ; Forkhead Transcription Factors ; Forkhead Box Protein O1 ; Oncogene Proteins, Fusion ; FOXO1 protein, human
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.30228
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  6. Article ; Online: Epidemiology of Adolescents and Young Adults with Cancer in Europe.

    Desandes, Emmanuel / Stark, Daniel P

    Progress in tumor research

    2016  Volume 43, Page(s) 1–15

    Abstract: To design the services for adolescents and young adults (AYAs) with cancer, we need to understand the patterns of disease and the other clinical and managerial challenges of the patient group. Cancer occurring between the ages of 15 and 39 years is 4 ... ...

    Abstract To design the services for adolescents and young adults (AYAs) with cancer, we need to understand the patterns of disease and the other clinical and managerial challenges of the patient group. Cancer occurring between the ages of 15 and 39 years is 4 times less rare than cancer occurring during the first 15 years of life and consists of 2% of all invasive cancer in Europe, about 66,000 patients in Europe each year. AYAs have a unique distribution of cancer types, including the peak in incidence of Hodgkin lymphoma (HL) or germ cell tumors. The relative improvement in the survival rate in AYAs has not kept pace with that achieved in younger children, especially for acute leukemia, non-HLs, Ewing tumors and rhabdomyosarcoma. Etiological factors are under-researched and remain largely hypothetical. In this unique group of illnesses, improving AYA cancer management involves bridging interfaces. Since this has begun, outcomes have also begun to improve. The local nature of these interfaces determines the age group considered as AYA. Specific skills are necessary in the clinical, biological and psychosocial domains. Services need support from policy, clinical and administrative professionals. National policy and supranational groups such as SIOPE and ESMO are in constructive collaboration to develop this further.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Delivery of Health Care ; Disease Management ; Early Detection of Cancer ; Europe/epidemiology ; Humans ; Incidence ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/etiology ; Neoplasms/therapy ; Risk Factors ; Survival Rate ; Young Adult
    Language English
    Publishing date 2016
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2296-1887
    ISSN (online) 2296-1887
    DOI 10.1159/000447037
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  7. Article: Survival from adolescent cancer.

    Desandes, Emmanuel

    Cancer treatment reviews

    2007  Volume 33, Issue 7, Page(s) 609–615

    Abstract: Background: Adolescent cancer is the leading cause of non-accidental mortality in young people. The tumour types occurring most commonly in this age group are distinctive and differ markedly from those developing in younger children and older adults.: ...

    Abstract Background: Adolescent cancer is the leading cause of non-accidental mortality in young people. The tumour types occurring most commonly in this age group are distinctive and differ markedly from those developing in younger children and older adults.
    Objective: The aim is to present survival data for the major types of cancer and for all malignancies combined in adolescents aged from 15 to 19 years, highlighting intercountry differences, temporal trends, and age/treatment regimen comparisons of survival rates.
    Results: Results from European and American data show that 5-year overall survival among adolescents with cancer is approximately 73-78%, close to that observed among children. As in paediatric series, there are geographical differences, with lower survival rates in Eastern European countries. Adolescents have substantially lower survival than children for acute lymphoid leukaemia, malignant non-Hodgkin lymphoma, Ewing's tumour, osteosarcoma, soft-tissue sarcoma. Temporal improvement in survival from children cancer is twice higher than survival from adolescents malignancies.
    Conclusion: Several reasons could explain these geographical differences, such as better referral, greater availability of complex and expensive treatment regimens, reflecting variations in health care systems and resources. Age-group variations could be explained by differences in biology and in treatment regimen, and lack of participation in clinical trials. Some are inherent in the psychosocial characteristics of these patients, such as delays in seeking medical attention, poor compliance with treatment. It is necessary to focus on cancer in adolescence, as the new frontier in oncology, and adolescents with cancer must be now the subject of specific survival analyses.
    MeSH term(s) Adolescent ; Global Health ; Humans ; Neoplasms/mortality ; Risk Factors ; Survival Rate/trends
    Language English
    Publishing date 2007-11
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2006.12.007
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    Zs.MO 611: Show issues

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  8. Article ; Online: Seasonality of main childhood embryonal tumours and rhabdomyosarcoma, France, 2000-2015.

    Awounou, Danielle / Lacour, Brigitte / Desandes, Emmanuel / Guissou, Sandra / Cassoux, Nathalie / Doz, François / Dufour, Christelle / Minard-Colin, Véronique / Schleiermacher, Gudrun / Taque, Sophie / Verschuur, Arnauld / Clavel, Jacqueline / Goujon, Stéphanie

    Cancer medicine

    2023  Volume 12, Issue 7, Page(s) 8789–8803

    Abstract: Few studies have investigated the seasonal patterns of embryonal tumours. Based on data from the French National Registry of Childhood Cancers, the present study aimed to investigate seasonal variations in embryonal tumour incidence rates by month of ... ...

    Abstract Few studies have investigated the seasonal patterns of embryonal tumours. Based on data from the French National Registry of Childhood Cancers, the present study aimed to investigate seasonal variations in embryonal tumour incidence rates by month of birth and by month of diagnosis. The study included 6635 primary embryonal tumour cases diagnosed before the age of 15 years over the period 2000-2015 in mainland France. Assuming monthly variations in incidence rates were homogeneous over 2000-2015, we used a Poisson regression model to test for overall heterogeneity in standardised incidence ratios (SIRs) by month of birth or diagnosis. The seasonal scan statistic method was used to detect monthly excesses or deficits of embryonal tumour cases over the whole study period. The annual reproducibility of the observed monthly variations was formally tested. An overall heterogeneity in incidence rates by month of birth was observed for rhabdomyosarcoma in boys only. Based on the month of diagnosis, a seasonality was evidenced for unilateral retinoblastoma, with a lower incidence rate in the summer (SIR
    MeSH term(s) Male ; Humans ; Adolescent ; Retinoblastoma ; Reproducibility of Results ; Rhabdomyosarcoma ; Incidence ; France/epidemiology ; Retinal Neoplasms
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.5624
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  9. Article ; Online: Residential proximity to vines and risk of childhood embryonal tumours in France - GEOCAP case-control study, 2006-2013.

    Awounou, Danielle / Mancini, Matthieu / Lacour, Brigitte / de Crouy-Chanel, Perrine / Aerts, Isabelle / Minard-Colin, Véronique / Schleiermacher, Gudrun / Verschuur, Arnauld / Guissou, Sandra / Desandes, Emmanuel / Guldner, Laurence / Clavel, Jacqueline / Goujon, Stéphanie

    Environmental research

    2023  Volume 240, Issue Pt 2, Page(s) 117417

    Abstract: Background: Exposure to pesticides has been suggested as a potential risk factor for childhood embryonal tumour. The existing literature has mainly focused on parental occupational exposure and domestic use of pesticides, and is very limited for ... ...

    Abstract Background: Exposure to pesticides has been suggested as a potential risk factor for childhood embryonal tumour. The existing literature has mainly focused on parental occupational exposure and domestic use of pesticides, and is very limited for residential exposures to agricultural pesticides. The study aimed to test the hypothesis of an increased risk of embryonal tumour in children living close to viticultural plots, likely to be subject to frequent pesticide applications.
    Methods: The study is part of the French national registry-based GEOCAP program. We included 2761 cases of neuroblastoma, retinoblastoma, Wilms tumour and rhabdomyosarcoma diagnosed before the age of 15 years in the 2006-2013 period, and 40,196 controls representative of the same age population during this period. Indicators of proximity to vines, the presence of vines and viticulture density within 1000 m of the geocoded addresses of residence, were evaluated combining three sources of data on agricultural land use in a geographic information system. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regressions and carried out several sensitivity analyses to test the stability of the results.
    Results: Approximately 10% of the controls lived within 1000 m of vines, with regional variations ranging from <1% to 38%. We observed a 5% increase in the risk of neuroblastoma for a 10% increase in viticulture density (OR = 1.05, 95% CI: 0.98-1.13), with a regional heterogeneity. The indicators of proximity to vines were not associated with the other non-CNS embryonal tumours.
    Conclusion: The study showed a slight increase in the risk of neuroblastoma in children living close to vines, suggesting that residential exposure to agricultural pesticides may be involved in the occurrence of these tumours.
    MeSH term(s) Humans ; Child ; Adolescent ; Case-Control Studies ; Neuroblastoma ; Pesticides/toxicity ; France/epidemiology ; Neoplasms, Germ Cell and Embryonal/chemically induced ; Neoplasms, Germ Cell and Embryonal/epidemiology
    Chemical Substances Pesticides
    Language English
    Publishing date 2023-10-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.117417
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  10. Article ; Online: Childhood head and neck cancer in France: Incidence, survival and trends from 2000 to 2015.

    Person, Luc / Lacour, Brigitte / Faure, Laure / Guissou, Sandra / Poulalhon, Claire / Orbach, Daniel / Goujon, Stéphanie / Berger, Claire / Clavel, Jacqueline / Desandes, Emmanuel

    International journal of pediatric otorhinolaryngology

    2021  Volume 150, Page(s) 110858

    Abstract: Introduction: Childhood head and neck cancers (HNC) are rare and represent a complex group of anatomical topographies. The aim of this study is to describe the distribution, the incidence and survival rates of children with malignant HNC in France.: ... ...

    Abstract Introduction: Childhood head and neck cancers (HNC) are rare and represent a complex group of anatomical topographies. The aim of this study is to describe the distribution, the incidence and survival rates of children with malignant HNC in France.
    Methods: A population-based study was conducted between 2000 and 2015 in children less than 15 years with a diagnosis of HNC using the French National Registry of Childhood Cancers database (RNCE). Age-standardized incidence rates (ASR) and survival analysis were performed.
    Results: The 1623 included HNC represented 5.6% of all cancers included in the RNCE. The thyroid was the leading tumor site category (26.6%), followed by head and neck soft tissue location (15.4%) and the nasopharynx (10.8%). The most common cancers were thyroid gland carcinomas (26.1%), rhabdomyosarcomas (23.9%) and Burkitt Lymphomas (8.6%). Nasopharynx cancers and soft-tissue sarcomas were statistically more frequent in boys, while thyroid carcinomas were significantly more frequent in girls. The annual ASR was 8.6 new cancer cases per million children. For all HNC combined, the 5-year overall survival (OS) was 87.7% [95%CI: 85.9-89.2]. There was no statistically significant variation in 5-year OS between 2000-2007 and 2008-2015.
    Conclusions: Epidemiological data on HNC distribution, incidence and survival contributes to better understand these tumors by quantifying their impact on the French population and assessing their burden. Regarding the exclusion of topographies and some histological origins performed by some authors, this report proposes new recommendations to study HNC in a pediatric population.
    MeSH term(s) Child ; Female ; France/epidemiology ; Head and Neck Neoplasms/epidemiology ; Humans ; Incidence ; Male ; Registries ; Survival Rate
    Language English
    Publishing date 2021-08-03
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 754501-0
    ISSN 1872-8464 ; 0165-5876
    ISSN (online) 1872-8464
    ISSN 0165-5876
    DOI 10.1016/j.ijporl.2021.110858
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