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Artikel ; Online: Modelling lipid rafts formation through chemo-mechanical interplay triggered by receptor-ligand binding.

Bernard, Chiara / Carotenuto, Angelo Rosario / Pugno, Nicola Maria / Fraldi, Massimiliano / Deseri, Luca

Biomechanics and modeling in mechanobiology

2023 Band 23, Heft 2, Seite(n) 485–505

Abstract: Cell membranes, mediator of many biological mechanisms from adhesion and metabolism up to mutation and infection, are highly dynamic and heterogeneous environments exhibiting a strong coupling between biochemical events and structural re-organisation. ... ...

Abstract	Cell membranes, mediator of many biological mechanisms from adhesion and metabolism up to mutation and infection, are highly dynamic and heterogeneous environments exhibiting a strong coupling between biochemical events and structural re-organisation. This involves conformational changes induced, at lower scales, by lipid order transitions and by the micro-mechanical interplay of lipids with transmembrane proteins and molecular diffusion. Particular attention is focused on lipid rafts, ordered lipid microdomains rich of signalling proteins, that co-localise to enhance substance trafficking and activate different intracellular biochemical pathways. In this framework, the theoretical modelling of the dynamic clustering of lipid rafts implies a full multiphysics coupling between the kinetics of phase changes and the mechanical work performed by transmembrane proteins on lipids, involving the bilayer elasticity. This mechanism produces complex interspecific dynamics in which membrane stresses and chemical potentials do compete by determining different morphological arrangements, alteration in diffusive walkways and coalescence phenomena, with a consequent influence on both signalling potential and intracellular processes. Therefore, after identifying the leading chemo-mechanical interactions, the present work investigates from a modelling perspective the spatio-temporal evolution of raft domains to theoretically explain co-localisation and synergy between proteins' activation and raft formation, by coupling diffusive and mechanical phenomena to observe different morphological patterns and clustering of ordered lipids. This could help to gain new insights into the remodelling of cell membranes and could potentially suggest mechanically based strategies to control their selectivity, by orienting intracellular functions and mechanotransduction.
Mesh-Begriff(e)	Ligands ; Mechanotransduction, Cellular ; Cell Membrane/metabolism ; Membrane Microdomains/chemistry ; Membrane Microdomains/metabolism ; Lipids/analysis ; Lipid Bilayers/analysis ; Lipid Bilayers/metabolism
Chemische Substanzen	Ligands ; Lipids ; Lipid Bilayers
Sprache	Englisch
Erscheinungsdatum	2023-12-07
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	2093052-5
ISSN	1617-7940 ; 1617-7959
ISSN (online)	1617-7940
ISSN	1617-7959
DOI	10.1007/s10237-023-01787-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Wrinkling instabilities for biologically relevant fiber-reinforced composite materials with a case study of Neo-Hookean/Ogden-Gasser-Holzapfel bilayer.

Nguyen, Nhung / Nath, Nandan / Deseri, Luca / Tzeng, Edith / Velankar, Sachin S / Pocivavsek, Luka

Biomechanics and modeling in mechanobiology

2020 Band 19, Heft 6, Seite(n) 2375–2395

Abstract: Wrinkling is a ubiquitous surface phenomenon in many biological tissues and is believed to play an important role in arterial health. As arteries are highly nonlinear, anisotropic, multilayered composite systems, it is necessary to investigate wrinkling ... ...

Abstract	Wrinkling is a ubiquitous surface phenomenon in many biological tissues and is believed to play an important role in arterial health. As arteries are highly nonlinear, anisotropic, multilayered composite systems, it is necessary to investigate wrinkling incorporating these material characteristics. Several studies have examined surface wrinkling mechanisms with nonlinear isotropic material relationships. Nevertheless, wrinkling associated with anisotropic constitutive models such as Ogden-Gasser-Holzapfel (OGH), which is suitable for soft biological tissues, and in particular arteries, still requires investigation. Here, the effects of OGH parameters such as fibers' orientation, stiffness, and dispersion on the onset of wrinkling, wrinkle wavelength and amplitude are elucidated through analysis of a bilayer system composed of a thin, stiff neo-Hookean membrane and a soft OGH substrate subjected to compression. Critical contractile strain at which wrinkles occur is predicted using both finite element analysis and analytical linear perturbation approach. Results suggest that besides stiffness mismatch, anisotropic features associated with fiber stiffness and distribution might be used in natural layered systems to adjust wrinkling and subsequent folding behaviors. Further analysis of a bilayer system with fibers in the (x-y) plane subjected to compression in the x direction shows a complex dependence of wrinkling strain and wavelength on fiber angle, stiffness, and dispersion. This behavior is captured by an approximation utilizing the linearized anisotropic properties derived from OGH model. Such understanding of wrinkling in this artery wall-like system will help identify the role of wrinkling mechanisms in biological artery in addition to the design of its synthetic counterparts.
Mesh-Begriff(e)	Animals ; Anisotropy ; Arteries/physiology ; Biomechanical Phenomena ; Carotid Arteries/pathology ; Compressive Strength ; Computer Simulation ; Elasticity ; Finite Element Analysis ; Linear Models ; Lipid Bilayers ; Membranes ; Mesenteric Arteries/pathology ; Mice ; Models, Biological ; Models, Cardiovascular ; Rats ; Stress, Mechanical
Chemische Substanzen	Lipid Bilayers
Sprache	Englisch
Erscheinungsdatum	2020-06-13
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	2093052-5
ISSN	1617-7940 ; 1617-7959
ISSN (online)	1617-7940
ISSN	1617-7959
DOI	10.1007/s10237-020-01345-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The stretching elasticity of biomembranes determines their line tension and bending rigidity.

Deseri, Luca / Zurlo, Giuseppe

Biomechanics and modeling in mechanobiology

2013 Band 12, Heft 6, Seite(n) 1233–1242

Abstract: In this work, some implications of a recent model for the mechanical behavior of biological membranes (Deseri et al. in Continuum Mech Thermodyn 20(5):255-273, 2008) are exploited by means of a prototypical one-dimensional problem. We show that the ... ...

Abstract	In this work, some implications of a recent model for the mechanical behavior of biological membranes (Deseri et al. in Continuum Mech Thermodyn 20(5):255-273, 2008) are exploited by means of a prototypical one-dimensional problem. We show that the knowledge of the membrane stretching elasticity permits to establish a precise connection among surface tension, bending rigidities and line tension during phase transition phenomena. For a specific choice of the stretching energy density, we evaluate these quantities in a membrane with coexistent fluid phases, showing a satisfactory comparison with the available experimental measurements. Finally, we determine the thickness profile inside the boundary layer where the order-disorder transition is observed.
Mesh-Begriff(e)	Biomechanical Phenomena ; Elastic Modulus/physiology ; Elasticity ; Membranes/physiology ; Models, Biological ; Stress, Mechanical ; Thermodynamics
Sprache	Englisch
Erscheinungsdatum	2013-11
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2093052-5
ISSN	1617-7940 ; 1617-7959
ISSN (online)	1617-7940
ISSN	1617-7959
DOI	10.1007/s10237-013-0478-z
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Mechanobiology predicts raft formations triggered by ligand-receptor activity across the cell membrane.

Carotenuto, Angelo R / Lunghi, Laura / Piccolo, Valentina / Babaei, Mahnoush / Dayal, Kaushik / Pugno, Nicola / Zingales, Massimiliano / Deseri, Luca / Fraldi, Massimiliano

Journal of the mechanics and physics of solids

2020 Band 141, Seite(n) 103974

Abstract: Clustering of ligand-binding receptors of different types on thickened isles of the cell membrane, namely lipid rafts, is an experimentally observed phenomenon. Although its influence on cell's response is deeply investigated, the role of the coupling ... ...

Abstract	Clustering of ligand-binding receptors of different types on thickened isles of the cell membrane, namely lipid rafts, is an experimentally observed phenomenon. Although its influence on cell's response is deeply investigated, the role of the coupling between mechanical processes and multiphysics involving the active receptors and the surrounding lipid membrane during ligand-binding has not yet been understood. Specifically, the focus of this work is on
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-05-22
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2012341-3
ISSN	1873-4782 ; 0022-5096
ISSN (online)	1873-4782
ISSN	0022-5096
DOI	10.1016/j.jmps.2020.103974
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Multiscale geometry and mechanics of lipid monolayer collapse.

Carotenuto, Angelo Rosario / Nguyen, Nhung / Cao, Kathleen / Gaffney, Anna / Waring, Alan J / C Lee, Ka Yee / Owen, David / Fraldi, Massimiliano / Deseri, Luca / Pocivavsek, Luka

Current topics in membranes

2021 Band 87, Seite(n) 1–45

Abstract: Langmuir monolayers at gas/liquid interfaces provide a rich framework to investigate the interplay between multiscale geometry and mechanics. Monolayer collapse is investigated at a topological and geometric level by building a scale space M from ... ...

Abstract	Langmuir monolayers at gas/liquid interfaces provide a rich framework to investigate the interplay between multiscale geometry and mechanics. Monolayer collapse is investigated at a topological and geometric level by building a scale space M from experimental imaging data. We present a general lipid monolayer collapse phase diagram, which shows that wrinkling, folding, crumpling, shear banding, and vesiculation are a continuous set of mechanical states that can be approached by either tuning monolayer composition or temperature. The origin of the different mechanical states can be understood by investigating the monolayer geometry at two scales: fluorescent vs atomic force microscopy imaging. We show that an interesting switch in continuity occurs in passing between the two scales, C
Mesh-Begriff(e)	Lipids ; Pressure
Chemische Substanzen	Lipids
Sprache	Englisch
Erscheinungsdatum	2021-10-19
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1063-5823
ISSN	1063-5823
DOI	10.1016/bs.ctm.2021.08.003
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: Buckling Soft Tensegrities

Fraldi, Massimiliano / Palumbo, Stefania / Carotenuto, Angelo Rosario / Cutolo, Arsenio / Deseri, Luca / Pugno, Nicola

Fickle Elasticity and Configurational Switching in Living Cells

2019

Abstract: Tensegrity structures are special architectures made by floating compressed struts kept together by a continuous system of tensed cables. The multiplicity of shapes that tensegrity structures can assume and their intrinsic capability to be deployable and ...

Abstract	Tensegrity structures are special architectures made by floating compressed struts kept together by a continuous system of tensed cables. The multiplicity of shapes that tensegrity structures can assume and their intrinsic capability to be deployable and assembled, so storing (and releasing) elastic energy, have motivated their success as paradigm -pioneeringly proposed by Donald E. Ingber- to explain some underlying mechanisms regulating dynamics of living cells. The interlaced structure of the cell cytoskeleton, constituted by actin and intermediate filaments and microtubules which continuously change their spatial organization and pre-stresses through polymerization/depolymerization, seems to steer migration, adhesion and cell division by obeying the tensegrity construct. Even though rough calculations lead to estimate discrepancies when comparing axial stiffness of actin filaments and microtubules and recent works have shown bent microtubules, no one has yet tried to remove the hypothesis of rigid struts in tensegrities when used to idealize the cytoskeleton mechanics. With reference to the 30-element tensegrity cell paradigm, we introduce both compressibility and bendability of the struts and rewrite the theory to take into account nonlinear elasticity of both tendons and bars, so abandoning the classical linear stress-strain assumptions. By relaxing the hypothesis of rigidity of the struts, we demonstrate that some quantitative confirmations and many extreme and somehow counterintuitive mechanical behaviors actually exploited by cells for storing/releasing energy, resisting to applied loads and deforming by modulating their overall elasticity and shape through pre-stress changes and instability-guided configurational switching, can be all theoretically found.
Schlagwörter	Physics - Biological Physics ; Condensed Matter - Soft Condensed Matter
Thema/Rubrik (Code)	612
Erscheinungsdatum	2019-04-09
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Mechanobiology predicts raft formations triggered by ligand-receptor activity across the cell membrane

Carotenuto, Angelo R. / Lunghi, Laura / Piccolo, Valentina / Babaei, Mahnoush / Dayal, Kaushik / Pugno, Nicola / Zingales, Massimiliano / Deseri, Luca / Fraldi, Massimiliano

J Mech Phys Solids

Abstract	Clustering of ligand-binding receptors of different types on thickened isles of the cell membrane, namely lipid rafts, is an experimentally observed phenomenon. Although its influence on cell's response is deeply investigated, the role of the coupling between mechanical processes and multiphysics involving the active receptors and the surrounding lipid membrane during ligand-binding has not yet been understood. Specifically, the focus of this work is on G-protein-coupled receptors (GPCRs), the widest group of transmembrane proteins in animals, which regulate specific cell processes through chemical signalling pathways involving a synergistic balance between the cyclic Adenosine Monophosphate (cAMP) produced by active GPCRs in the intracellular environment and its efflux, mediated by the Multidrug Resistance Proteins (MRPs) transporters. This paper develops a multiphysics approach based on the interplay among energetics, multiscale geometrical changes and mass balance of species, i.e. active GPCRs and MRPs, including diffusion and kinetics of binding and unbinding. Because the obtained energy depends upon both the kinematics and the changes of species densities, balance of mass and of linear momentum are coupled and govern the space-time evolution of the cell membrane. The mechanobiology involving remodelling and change of lipid ordering of the cell membrane allows to predict dynamics of transporters and active receptors –in full agreement with experimentally observed cAMP levels– and how the latter trigger rafts formation and cluster on such sites. Within the current scientific debate on Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) and on the basis of the ascertained fact that lipid rafts often serve as an entry port for viruses, it is felt that approaches accounting for strong coupling among mechanobiological aspects could even turn helpful in better understanding membrane-mediated phenomena such as COVID-19 virus-cell interaction.
Schlagwörter	covid19
Verlag	WHO
Dokumenttyp	Artikel
Anmerkung	WHO #Covidence: #420618
Datenquelle	COVID19

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Artikel ; Online: Power-law hereditariness of hierarchical fractal bones.

Deseri, Luca / Di Paola, Mario / Zingales, Massimiliano / Pollaci, Pietro

International journal for numerical methods in biomedical engineering

2013 Band 29, Heft 12, Seite(n) 1338–1360

Abstract: In this paper, the authors introduce a hierarchic fractal model to describe bone hereditariness. Indeed, experimental data of stress relaxation or creep functions obtained by compressive/tensile tests have been proved to be fit by power law with real ... ...

Abstract	In this paper, the authors introduce a hierarchic fractal model to describe bone hereditariness. Indeed, experimental data of stress relaxation or creep functions obtained by compressive/tensile tests have been proved to be fit by power law with real exponent 0 ⩽ β ⩽1. The rheological behavior of the material has therefore been obtained, using the Boltzmann-Volterra superposition principle, in terms of real order integrals and derivatives (fractional-order calculus). It is shown that the power laws describing creep/relaxation of bone tissue may be obtained by introducing a fractal description of bone cross-section, and the Hausdorff dimension of the fractal geometry is then related to the exponent of the power law.
Mesh-Begriff(e)	Algorithms ; Biomechanical Phenomena/physiology ; Bone and Bones/physiology ; Fractals ; Models, Biological ; Rheology
Sprache	Englisch
Erscheinungsdatum	2013-12
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2540968-2
ISSN	2040-7947 ; 2040-7939
ISSN (online)	2040-7947
ISSN	2040-7939
DOI	10.1002/cnm.2572
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Coherent Motion of Monolayer Sheets under Confinement and Its Pathological Implications.

Soumya, S S / Gupta, Animesh / Cugno, Andrea / Deseri, Luca / Dayal, Kaushik / Das, Dibyendu / Sen, Shamik / Inamdar, Mandar M

PLoS computational biology

2015 Band 11, Heft 12, Seite(n) e1004670

Abstract: Coherent angular rotation of epithelial cells is thought to contribute to many vital physiological processes including tissue morphogenesis and glandular formation. However, factors regulating this motion, and the implications of this motion if perturbed, ...

Abstract	Coherent angular rotation of epithelial cells is thought to contribute to many vital physiological processes including tissue morphogenesis and glandular formation. However, factors regulating this motion, and the implications of this motion if perturbed, remain incompletely understood. In the current study, we address these questions using a cell-center based model in which cells are polarized, motile, and interact with the neighboring cells via harmonic forces. We demonstrate that, a simple evolution rule in which the polarization of any cell tends to orient with its velocity vector can induce coherent motion in geometrically confined environments. In addition to recapitulating coherent rotational motion observed in experiments, our results also show the presence of radial movements and tissue behavior that can vary between solid-like and fluid-like. We show that the pattern of coherent motion is dictated by the combination of different physical parameters including number density, cell motility, system size, bulk cell stiffness and stiffness of cell-cell adhesions. We further observe that perturbations in the form of cell division can induce a reversal in the direction of motion when cell division occurs synchronously. Moreover, when the confinement is removed, we see that the existing coherent motion leads to cell scattering, with bulk cell stiffness and stiffness of cell-cell contacts dictating the invasion pattern. In summary, our study provides an in-depth understanding of the origin of coherent rotation in confined tissues, and extracts useful insights into the influence of various physical parameters on the pattern of such movements.
Mesh-Begriff(e)	Animals ; Cell Aggregation/physiology ; Cell Communication/physiology ; Cell Movement/physiology ; Computer Simulation ; Elasticity/physiology ; Epithelial Cells/cytology ; Epithelial Cells/physiology ; Focal Adhesions/physiology ; Humans ; Mechanotransduction, Cellular/physiology ; Models, Biological ; Neoplasm Invasiveness/physiopathology
Sprache	Englisch
Erscheinungsdatum	2015-12-21
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1004670
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: Coherent motion of monolayer sheets under confinement and its pathological implications

Soumya, S. S. / Gupta, Animesh / Cugno, Andrea / Deseri, Luca / Dayal, Kaushik / Das, Dibyendu / Sen, Shamik / Inamdar, Mandar M.

2015

Abstract	Coherent angular rotation of epithelial cells is thought to contribute to many vital physiological processes including tissue morphogenesis and glandular formation. However, factors regulating this motion, and the implications of this motion if perturbed remain incompletely understood. In the current study, we address these questions using a cell-center based model in which cells are polarized, motile, and interact with the neighboring cells via harmonic forces. We demonstrate that, a simple evolution rule in which the polarization of any cell tends to orient with its velocity vector can induce coherent motion in geometrically confined environments. In addition to recapitulating coherent rotational motion observed in experiments, our results also show the presence of radial movements and tissue behavior that can vary between solid-like and fluid-like. We show that the pattern of coherent motion is dictated by the combination of different physical parameters including number density, cell motility, system size, bulk cell stiffness and stiffness of cell-cell adhesions. We further observe that, perturbations in the form of cell division can induce a reversal in the direction of motion when cell division occurs synchronously. Moreover, when the confinement is removed, we see that the existing coherent motion leads to cell scattering, with bulk cell stiffness and stiffness of cell-cell contacts dictating the invasion pattern. In summary, our study provides an in-depth understanding of the origin of coherent rotation in confined tissues, and extracts useful insights into the influence of various physical parameters on the pattern of such movements
Schlagwörter	Quantitative Biology - Cell Behavior
Thema/Rubrik (Code)	612
Erscheinungsdatum	2015-07-23
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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