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  1. Book: Congrès de l'European Association of Urology (EAU) 2005 et de l'American Urological Association (AUA) 2005: l'actualité sur les inhibiteurs de la 5-alpha-réductase

    Desgrandchamps, François

    [congrès de l'European Association of Urology en mars 2005 à Istanbul et de l'American Urological Association en mai 2005 à San Antonio]

    (Annales d'urologie ; 39, Suppl. 2)

    2005  

    Institution European Association of Urology
    American Urological Association
    Author's details F. Desgrandchamps
    Series title Annales d'urologie ; 39, Suppl. 2
    Collection
    Language English
    Size S. S17 - S28
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT014499133
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 84/10 -39,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  2. Article: Troubles du bas appareil urinaire chez l’homme : comment les traiter ?

    Desgrandchamps, François

    La Revue du praticien

    2019  Volume 69, Issue 3, Page(s) 307–310

    Abstract: Lower urinary tract disorders in men: which management? Initial management of men lower urinary tract symptoms is based on a well conducted interview and the realization of a frequency-volume chart. Dietary intervention associated with behavioral ... ...

    Title translation Lower urinary tract disorders in men: which management?
    Abstract Lower urinary tract disorders in men: which management? Initial management of men lower urinary tract symptoms is based on a well conducted interview and the realization of a frequency-volume chart. Dietary intervention associated with behavioral reeducation can be of great efficacy in combination with usual drug treatments. In case of failure, transuretral electrical resection of the prostate remains the reference, with possible emerging instrumental alternatives such as Urolift or prostatic embolization.
    MeSH term(s) Embolization, Therapeutic ; Humans ; Lower Urinary Tract Symptoms ; Male ; Prostatic Hyperplasia ; Urinary Tract/pathology
    Language French
    Publishing date 2019-05-17
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  3. Article ; Online: Cancer localisé de la prostate : s’il n’est pas agressif, dépister ne veut plus dire traiter !

    Desgrandchamps, François / Masson-Lecomte, Alexandra

    La Revue du praticien

    2018  Volume 67, Issue 4, Page(s) 361–363

    Title translation Localized prostate cancer: if not aggressive, tracking does not mean treating.
    MeSH term(s) Humans ; Male ; Prostatic Neoplasms/therapy
    Language French
    Publishing date 2018-12-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  4. Article ; Online: Survival after sequential neoadjuvant chemotherapy followed by trimodal treatment or radical cystectomy for muscle-invasive bladder cancer.

    Reignier, Pierre-Louis / Gauthier, Hélène / Hennequin, Christophe / Aussedat, Quiterie / Xylinas, Evanguelos / Desgrandchamps, François / Culine, Stéphane / Masson-Lecomte, Alexandra / Dumont, Clément

    World journal of urology

    2023  Volume 41, Issue 11, Page(s) 3249–3255

    Abstract: Purpose: to assess the respective outcomes of patients with localized muscle-invasive bladder cancer (MIBC) treated by either radical cystectomy (RC) or trimodal treatment (TMT) depending on pathological response to previous neoadjuvant chemotherapy ( ... ...

    Abstract Purpose: to assess the respective outcomes of patients with localized muscle-invasive bladder cancer (MIBC) treated by either radical cystectomy (RC) or trimodal treatment (TMT) depending on pathological response to previous neoadjuvant chemotherapy (NAC) assessed on cystectomy specimen or post-NAC transurethral resection (TURB) specimen, respectively.
    Patient and methods: We retrospectively included all consecutive patients treated in one academic center with cisplatin-based NAC followed by RC or TMT for cT2-3N0M0 MIBC between 2014 and 2021. Primary endpoint was metastasis-free survival (MFS) in both treatment groups and according to pathological response to NAC. Local recurrence-free survival and conservative management failure (metastasis-free bladder-intact survival) for patients treated with TMT were assessed.
    Results: 104 patients were included, 26 treated with TMT and 78 with RC. The rate of complete pathological response was 47.4% in patients treated with RC (ypT0) and 66.7% in patients treated with TMT (ycT0). Median follow-up was 34.9 months. Four-year MFS was 72% in both treatment groups. Four-year MFS was 85% in both ypT0 RC patients and ycT0 TMT patients. ycT0 stage was associated with low rates of intravesical recurrence and conservative management failure.
    Conclusion: Patients with post-NAC ycT0 stage treated with TMT have favorable oncological outcomes similar to those of ypT0 patients treated with RC. Assessment of complete histological response with TURB after NAC may help in selecting the best candidates for bladder preservation with TMT.
    MeSH term(s) Humans ; Urinary Bladder/pathology ; Cystectomy ; Neoadjuvant Therapy ; Retrospective Studies ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/surgery ; Muscles ; Neoplasm Invasiveness/pathology
    Language English
    Publishing date 2023-07-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-023-04506-9
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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Néphrectomie totale ou partielle dans le cancer du rein ?

    Santy, Alexis / Masson-Lecomte, Alexandra / Desgrandchamps, François

    La Revue du praticien

    2019  Volume 68, Issue 1, Page(s) 48–51

    Abstract: Total or partial nephrectomy for renal tumors? Due to the raising incidence of small renal masses in the past decades and long term consequences of enlarged nephrectomy on renal function, partial nephrectomy has been recommended as reference treatment ... ...

    Title translation Total or partial nephrectomy for renal tumors?
    Abstract Total or partial nephrectomy for renal tumors? Due to the raising incidence of small renal masses in the past decades and long term consequences of enlarged nephrectomy on renal function, partial nephrectomy has been recommended as reference treatment for renal tumors less than 4 cm. Partial nephrectomy has shown to allow equivalent oncological control compared to enlarged nephrectomy and allows preservation of the patient's nephronic capital. However, this surgery is technically demanding and requires experience and rapidity to limit renal ischemia.
    MeSH term(s) Humans ; Incidence ; Kidney Neoplasms/surgery ; Nephrectomy ; Nephrons ; Treatment Outcome
    Language French
    Publishing date 2019-03-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  6. Article: Traitement par ultrasons focalisés de haute intensité et soins infirmiers.

    Desgrandchamps, François

    Soins; la revue de reference infirmiere

    2007  , Issue 713, Page(s) 43–44

    Title translation Treatment by focalized high intensity ultrasound and nursing care.
    MeSH term(s) Humans ; Male ; Neoplasm Staging ; Nurse's Role ; Patient Selection ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Ultrasound, High-Intensity Focused, Transrectal/adverse effects ; Ultrasound, High-Intensity Focused, Transrectal/methods ; Ultrasound, High-Intensity Focused, Transrectal/nursing
    Language French
    Publishing date 2007-03
    Publishing country France
    Document type Journal Article
    ZDB-ID 604655-1
    ISSN 0038-0814
    ISSN 0038-0814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2545: Show issues Location:
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  7. Article ; Online: The HLA-G immune checkpoint: a new immuno-stimulatory role for the α1-domain-deleted isoform.

    Tronik-Le Roux, Diana / Daouya, Marina / Jacquier, Alix / Schenowitz, Chantal / Desgrandchamps, François / Rouas-Freiss, Nathalie / Carosella, Edgardo D

    Cellular and molecular life sciences : CMLS

    2022  Volume 79, Issue 6, Page(s) 310

    Abstract: The heterogeneity of cancer cells, in part maintained via the expression of multiple isoforms, introduces significant challenges in designing effective therapeutic approaches. In this regard, isoforms of the immune checkpoint HLA-G have been found in ... ...

    Abstract The heterogeneity of cancer cells, in part maintained via the expression of multiple isoforms, introduces significant challenges in designing effective therapeutic approaches. In this regard, isoforms of the immune checkpoint HLA-G have been found in most of the tumors analyzed, such as ccRCC, the most common human renal malignancy. In particular, HLA-G∆α1, which is the only HLA-G isoform described that lacks the α1 extracellular domain, has been newly identified in ccRCC and now here in trophoblasts. Using a cellular model expressing HLA-G∆α1, we have uncovered its specific and overlapping functional roles, relative to the main HLA-G isoform, i.e., the full-length HLA-G1. We found that HLA-G∆α1 has several particular features: (i) although possessing the α3 domain, it does not associate with β2-microglobulin; (ii) it may not present peptides to T cells due to absence of the peptide-binding groove; and (iii) it exerts immune-stimulatory activity towards peripheral blood NK and T cells, while all known isoforms of HLA-G are immune-inhibitory checkpoint molecules. Such immune-stimulatory properties of HLA-G∆α1 on the cytotoxic function of peripheral blood NK cells are individual dependent and are not exerted through the interaction with the known HLA-G receptor, ILT2. Importantly, we are faced here with a potential antitumor effect of an HLA-G isoform, opposed to the pro-tumor properties described for all other HLA-G isoforms, which should be taken into account in future therapeutic designs aimed at blocking this immune checkpoint.
    MeSH term(s) Carcinoma, Renal Cell ; Cell Membrane/metabolism ; HLA-G Antigens/chemistry ; HLA-G Antigens/genetics ; Humans ; Kidney Neoplasms ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
    Chemical Substances HLA-G Antigens ; Protein Isoforms
    Language English
    Publishing date 2022-05-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04359-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 195: Show issues Location:
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  8. Article: The HLA-G immune checkpoint: a new immuno-stimulatory role for the α1-domain-deleted isoform

    Tronik-Le Roux, Diana / Daouya, Marina / Jacquier, Alix / Schenowitz, Chantal / Desgrandchamps, François / Rouas-Freiss, Nathalie / Carosella, Edgardo D.

    Cellular and molecular life sciences. 2022 June, v. 79, no. 6

    2022  

    Abstract: The heterogeneity of cancer cells, in part maintained via the expression of multiple isoforms, introduces significant challenges in designing effective therapeutic approaches. In this regard, isoforms of the immune checkpoint HLA-G have been found in ... ...

    Abstract The heterogeneity of cancer cells, in part maintained via the expression of multiple isoforms, introduces significant challenges in designing effective therapeutic approaches. In this regard, isoforms of the immune checkpoint HLA-G have been found in most of the tumors analyzed, such as ccRCC, the most common human renal malignancy. In particular, HLA-G∆α1, which is the only HLA-G isoform described that lacks the α1 extracellular domain, has been newly identified in ccRCC and now here in trophoblasts. Using a cellular model expressing HLA-G∆α1, we have uncovered its specific and overlapping functional roles, relative to the main HLA-G isoform, i.e., the full-length HLA-G1. We found that HLA-G∆α1 has several particular features: (i) although possessing the α3 domain, it does not associate with β2-microglobulin; (ii) it may not present peptides to T cells due to absence of the peptide-binding groove; and (iii) it exerts immune-stimulatory activity towards peripheral blood NK and T cells, while all known isoforms of HLA-G are immune-inhibitory checkpoint molecules. Such immune-stimulatory properties of HLA-G∆α1 on the cytotoxic function of peripheral blood NK cells are individual dependent and are not exerted through the interaction with the known HLA-G receptor, ILT2. Importantly, we are faced here with a potential antitumor effect of an HLA-G isoform, opposed to the pro-tumor properties described for all other HLA-G isoforms, which should be taken into account in future therapeutic designs aimed at blocking this immune checkpoint.
    Keywords antineoplastic activity ; cytotoxicity ; humans ; immunostimulants ; peptides ; therapeutics
    Language English
    Dates of publication 2022-06
    Size p. 310.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04359-2
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Cryothérapie sous anesthésie locale des tumeurs rénales.

    De Kerviler, Éric / Colleter, Loïc / Masson-Lecomte, Alexandra / Desgrandchamps, François

    La Revue du praticien

    2019  Volume 68, Issue 1, Page(s) 45–47

    Abstract: Cryoablation under local anesthesia of renal tumors. The incidence of small renal tumors is increasing. These small tumors measuring less than 4 cm are typically slow-growing. The development of non-invasive percutaneous ablative techniques represents an ...

    Title translation Cryoablation under local anesthesia of renal tumors.
    Abstract Cryoablation under local anesthesia of renal tumors. The incidence of small renal tumors is increasing. These small tumors measuring less than 4 cm are typically slow-growing. The development of non-invasive percutaneous ablative techniques represents an alternative to active surveillance or surgery in at risk patients who are candidates to nephron sparing techniques. The intrinsic anesthetic properties of cryoablation make the procedure feasible under local anesthesia.
    MeSH term(s) Anesthesia, Local ; Cryosurgery ; Humans ; Incidence ; Kidney Neoplasms/therapy
    Language French
    Publishing date 2019-03-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  10. Article: Rétention aiguë d'urine.

    Desgrandchamps, François

    La Revue du praticien

    2006  Volume 56, Issue 15, Page(s) 1711–1713

    Title translation Acute retention of urine.
    MeSH term(s) Acute Disease ; Humans ; Physical Examination ; Urinary Retention/diagnosis ; Urinary Retention/etiology ; Urinary Retention/therapy
    Language French
    Publishing date 2006-10-15
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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