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Article ; Online: Prevalence and concordance of oral and genital HPV by sexual orientation among US men.

Sonawane, Kalyani / Shyu, Shiang Shiuan / Damgacioglu, Haluk / Li, Ruosha / Nyitray, Alan G / Deshmukh, Ashish A

JNCI cancer spectrum

2024 Volume 7, Issue 1

Abstract: The objective of our study was to describe oral and genital human papillomavirus (HPV) infection prevalence and concordance by sexual orientation among US men using a nationally representative sample. We conducted a retrospective cross-sectional analysis ...

Abstract	The objective of our study was to describe oral and genital human papillomavirus (HPV) infection prevalence and concordance by sexual orientation among US men using a nationally representative sample. We conducted a retrospective cross-sectional analysis of the 2013-2016 National Health and Nutrition Examination Survey. The survey conducts a physical examination and collects oral rinse and genital swab specimens; demographic and health behaviors are self-reported. We used descriptive statistics and multivariate regression models to estimate HPV infection prevalence and the likelihood of HPV infection, respectively. All analyses were adjusted for National Health and Nutrition Examination Survey design and weights, and statistical significance was tested at a 2-sided P value of less than .05. Men who have sex with men had a statistically significantly higher prevalence of oral HPV (high-risk, 9-valent, 4-valent, and HPV 16 and 18), genital HPV (9-valent, 4-valent, and HPV 16 and 18), and concordant oral and genital HPV (high-risk and 9-valent) infections compared with heterosexual men. Improved HPV prevention among men is needed.
MeSH term(s)	Humans ; Male ; Female ; Papillomavirus Infections/prevention & control ; Homosexuality, Male ; Nutrition Surveys ; Retrospective Studies ; Prevalence ; Cross-Sectional Studies ; Risk Factors ; Sexual and Gender Minorities ; Sexual Behavior ; Genitalia
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2515-5091
ISSN (online)	2515-5091
DOI	10.1093/jncics/pkac088
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Article ; Online: Human Papillomavirus-Associated Anal Cancer Incidence and Burden Among US Men, According to Sexual Orientation, Human Immunodeficiency Virus Status, and Age.

Deshmukh, Ashish A / Damgacioglu, Haluk / Georges, Damien / Sonawane, Kalyani / Clifford, Gary M

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024 Volume 77, Issue 3, Page(s) 419–424

Abstract: Background: Men who have sex with men (MSM) without HIV are known to be at elevated relative risk for Human papillomavirus (HPV)-associated anal cancer in comparison to men who have sex with women (MSW), but are poorly characterized in terms of anal ... ...

Abstract	Background: Men who have sex with men (MSM) without HIV are known to be at elevated relative risk for Human papillomavirus (HPV)-associated anal cancer in comparison to men who have sex with women (MSW), but are poorly characterized in terms of anal cancer incidence due to absence of reporting of sexual behavior/identity at a population-level. Methods: By combining age-specific statistics from multiple data sources (anal cancer incidence among all males; anal cancer incidence among MSM and MSW with HIV; population size of men with HIV by sexual orientation), we developed a mathematical model to estimate anal cancer incidence, annual number of cases, and proportion by (a) sexual orientation (MSM versus MSW), (b) HIV status, and (c) age (<30, 30-44, 45-59, and ≥60 years). Results: Anal cancer incidence (per 100 000) among MSM without HIV was 1.4 (95% uncertainty interval [UI], 0.6 to 2.3), 17.6 (95% UI = 13.8-23.5), and 33.9 (95% UI = 28.3-42.3), at ages 30-44, 45-59 and ≥60 years, respectively. 19.1% of all male anal cancer occurred in MSM without HIV, increasing from 4% of anal cancer diagnosed at 30-44 years to 24% at ≥60 years; 54.3% occurred in MSW without HIV (increasing from 13% at age 30-44 to 67% at >60 years), and the remaining 26.6% in men (MSM and MSW combined) with HIV (decreasing from 83% at age 30-44 to 9% at >60 years). Conclusions: These findings should inform anal cancer prevention recommendations in male risk groups, including, for the first time, for the important group of MSM without HIV.
MeSH term(s)	Male ; Humans ; Female ; Adult ; Middle Aged ; Homosexuality, Male ; Human Papillomavirus Viruses ; HIV Infections/complications ; HIV Infections/epidemiology ; HIV Infections/diagnosis ; Incidence ; Anus Diseases/diagnosis ; Risk Factors ; Papillomavirus Infections/complications ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/diagnosis ; Sexual and Gender Minorities ; Sexual Behavior ; Anus Neoplasms/epidemiology ; Anal Canal ; HIV ; Papillomaviridae
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciad205
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Recent trends in cervical cancer incidence, stage at diagnosis, and mortality according to county-level income in the United States, 2000-2019.

Amboree, Trisha L / Damgacioglu, Haluk / Sonawane, Kalyani / Adsul, Prajakta / Montealegre, Jane R / Deshmukh, Ashish A

International journal of cancer

2024 Volume 154, Issue 9, Page(s) 1549–1555

Abstract: Early evidence suggests that declining cervical cancer incidence reversed in low-income regions in the United States in recent years; however, it is unclear whether there are distinct patterns by race/ethnicity and stage at diagnosis and if the increase ... ...

Abstract	Early evidence suggests that declining cervical cancer incidence reversed in low-income regions in the United States in recent years; however, it is unclear whether there are distinct patterns by race/ethnicity and stage at diagnosis and if the increase has translated into rising mortality. Using Surveillance, Epidemiology, and End Results data, we evaluated trends in hysterectomy-corrected cervical cancer incidence rates (2000-2019) and mortality rates (2005-2019) by county-level income and race/ethnicity, with further stratification of incidence by stage at diagnosis. Following a period of decline, hysterectomy-corrected cervical cancer incidence increased 1.0%/year (95% CI = 0.1% to 4.5%) among Non-Hispanic White women in low-income counties. Particularly, a statistically significant 4.4%/year (95% CI = 1.7% to 7.5%) increase in distant-stage cancer occurred in this group. Additionally, recent increases in cervical cancer mortality (1.1%/year [95% CI = -1.4% to 3.7%]) were observed among this group and Non-Hispanic Black women in low-income counties (2.9%/year [95% CI = -2.3% to 18.2%]), but trends were not statistically significant. Among Hispanic women in low-income counties, distant-stage cervical cancer incidence increased 1.5%/year (95% CI = -0.6% to 4.1%), albeit not statistically significant. The increasing incidence of distant-stage cervical cancer and mortality in specific racial/ethnic groups suggests that the recent introduction of higher sensitivity screening tests may not explain increasing trends in low-income counties. Our findings suggest that the observed rise in cervical cancer incidence may reflect disruptions along the screening and treatment continuum. Future research to further comprehend these trends and continued enhancements in prevention are crucial to combat rising cervical cancer incidence and mortality in low-income counties in the United States.
MeSH term(s)	Female ; Humans ; Ethnicity ; Hispanic or Latino ; Incidence ; Income ; United States/epidemiology ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/epidemiology ; White ; Black or African American
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34860
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 576: Show issues

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Article ; Online: Cost Effectiveness of CDK4/6 Inhibitors in the First-Line Treatment of HR+/HER2- Metastatic Breast Cancer in Postmenopausal Women in the USA.

Masurkar, Prajakta P / Damgacioglu, Haluk / Deshmukh, Ashish A / Trivedi, Meghana V

PharmacoEconomics

2023 Volume 41, Issue 6, Page(s) 709–718

Abstract: Background and objective: Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors improve progression-free survival when combined with endocrine therapies in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative ... ...

Abstract	Background and objective: Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors improve progression-free survival when combined with endocrine therapies in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer. However, the comparative cost effectiveness of utilizing three US Food and Drug Administration-approved CDK4/6 inhibitors is unknown. Therefore, we aimed to evaluate the cost effectiveness of individual CDK4/6 inhibitors (palbociclib, ribociclib, abemaciclib) with letrozole versus letrozole monotherapy in the first-line treatment of hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer in the USA. Methods: We constructed a Markov-based decision-analytic model to evaluate the cost effectiveness of CDK4/6 inhibitors plus endocrine therapies over a 40-year lifetime from a third-party payer perspective. The model incorporated health states (progression-free disease, progressive disease, and death), major adverse events (neutropenia), and cancer-specific and all-cause mortality. Using clinical efficacy and quality-of-life scores (utility) data from clinical trials, we estimated quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios using Medicare charges reported in US dollars per 2022 valuation and a discount rate of 3% applied to costs and outcomes. We performed deterministic and probabilistic sensitivity analyses to evaluate parametric and decision uncertainty. Results: Compared to letrozole, the model estimated an increase of 5.72, 5.87, and 6.39 in QALYs and costs of $799,178, $788,168, and $741,102 in combining palbociclib, ribociclib, and abemaciclib plus letrozole, respectively. Palbociclib or ribociclib plus letrozole were dominated by abemaciclib plus letrozole. Compared with letrozole, abemaciclib plus letrozole resulted in an incremental cost-effectiveness ratio of $457,538 per QALY with an incremental cost of $553,621 and an incremental QALY gain of 1.21. The results were sensitive to the cost of abemaciclib, disease progression utility, and patients' age. Conclusions: At a willingness to pay of $100,000/QALY gained, our model predicts that combining CDK4/6 inhibitors plus letrozole is not cost effective with a marginal increase in QALYs at a high cost. Lowering the cost of these drugs or identifying patients who can receive maximal benefit from CDK4/6 inhibitors would improve the value of this regimen in patients.
MeSH term(s)	Aged ; Humans ; Female ; United States ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Letrozole/therapeutic use ; Cost-Effectiveness Analysis ; Postmenopause ; Medicare ; Antineoplastic Combined Chemotherapy Protocols ; Receptor, ErbB-2/metabolism ; Cyclin-Dependent Kinase 4/therapeutic use
Chemical Substances	ribociclib (TK8ERE8P56) ; abemaciclib (60UAB198HK) ; Letrozole (7LKK855W8I) ; Receptor, ErbB-2 (EC 2.7.10.1) ; CDK4 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22)
Language	English
Publishing date	2023-03-15
Publishing country	New Zealand
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1100273-6
ISSN	1179-2027 ; 1170-7690
ISSN (online)	1179-2027
ISSN	1170-7690
DOI	10.1007/s40273-023-01245-y
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Zs.A 3579: Show issues

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Article ; Online: COVID-19 vaccination in the UK: Addressing vaccine hesitancy.

Sonawane, Kalyani / Troisi, Catherine L / Deshmukh, Ashish A

The Lancet regional health. Europe

2021 Volume 1, Page(s) 100016

Language	English
Publishing date	2021-01-13
Publishing country	England
Document type	Journal Article
ISSN	2666-7762
ISSN (online)	2666-7762
DOI	10.1016/j.lanepe.2020.100016
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Article ; Online: County-Level Trends in Cervical Cancer Incidence, Stage at Diagnosis, and Mortality in Kentucky.

Damgacioglu, Haluk / Burus, Todd / Sonawane, Kalyani / Hill, Elizabeth / Lang Kuhs, Krystle A / Deshmukh, Ashish A

JAMA network open

2023 Volume 6, Issue 10, Page(s) e2338333

MeSH term(s)	Female ; Humans ; Kentucky/epidemiology ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/epidemiology ; Incidence
Language	English
Publishing date	2023-10-02
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.38333
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Article ; Online: Human Papillomavirus Vaccination Among Young Adults Before and During the COVID-19 Pandemic.

Sonawane, Kalyani / Garg, Ashvita / Meissner, Eric G / Damgacioglu, Haluk / Hill, Elizabeth / Nyitray, Alan G / Deshmukh, Ashish A

JAMA network open

2024 Volume 7, Issue 2, Page(s) e2356875

MeSH term(s)	Young Adult ; Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pandemics/prevention & control ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/prevention & control ; Papillomavirus Vaccines/therapeutic use ; Human Papillomavirus Viruses ; Vaccination
Chemical Substances	Papillomavirus Vaccines
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.56875
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Article: Regular Healthcare Provider Status Does Not Moderate Racial/Ethnic Differences in Human Papillomavirus (HPV) and HPV Vaccine Knowledge.

Amboree, Trisha L / Sonawane, Kalyani / Deshmukh, Ashish A / Montealegre, Jane R

Vaccines

2021 Volume 9, Issue 7

Abstract: Background: Racial/ethnic minorities generally have a lower knowledge of human papillomavirus (HPV) and the HPV vaccine than non-Hispanic Whites. They are also less likely to have a regular healthcare provider (HCP). Given the role of HCPs in ... ...

Abstract	Background: Racial/ethnic minorities generally have a lower knowledge of human papillomavirus (HPV) and the HPV vaccine than non-Hispanic Whites. They are also less likely to have a regular healthcare provider (HCP). Given the role of HCPs in disseminating health information, we evaluated whether racial/ethnic disparities in HPV knowledge are moderated by regular HCP status. Methods: Data from the Health Information National Trends Survey Five (HINTS 5) Cycles One and Two (2017-2018) were analyzed. HPV and HPV vaccine knowledge were compared by regular HCP status across race/ethnicities. Independent partially-adjusted multivariable logistic regression models were used to assess the association between race/ethnicity and knowledge after controlling for sociodemographic characteristics. The resulting adjusted odds ratios were compared to those from fully-adjusted models that included HCP status. Results: After adjusting for regular HCP status, differences in knowledge persisted between racial/ethnic groups. Compared to Whites, Hispanics and Other race/ethnicities had significantly lower odds of having heard of HPV. Blacks, Hispanics, and Other race/ethnicities had significantly lower odds of having heard of the HPV vaccine. Conclusion: Racial/ethnic minorities had significantly lower levels of knowledge despite HCP status. These data suggest the need to address disparities in health information and strengthen provider-patient communication regarding HPV and the HPV vaccine.
Language	English
Publishing date	2021-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines9070802
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Article ; Online: Incidence Trends of Kaposi Sarcoma Among Young Non-Hispanic Black Men by US Regions, 2001-2018.

Suk, Ryan / White, Donna L / Knights, Sheena / Nijhawan, Ank / Deshmukh, Ashish A / Chiao, Elizabeth Y

JNCI cancer spectrum

2022 Volume 6, Issue 6

Abstract: Despite the overall national decline in Kaposi sarcoma (KS) incidence in the United States among persons living with HIV, previous studies suggest there might be specific subgroups of the US population that are associated with higher KS incidence rates ... ...

Abstract	Despite the overall national decline in Kaposi sarcoma (KS) incidence in the United States among persons living with HIV, previous studies suggest there might be specific subgroups of the US population that are associated with higher KS incidence rates than others. Using the 2001-2018 National Program of Cancer Registries and Surveillance, Epidemiology, and End Results Program database, we assessed KS incidence trends among young men aged 20-34 years by race and ethnicity and geographic region. Statistical significance is 2-sided. The KS incidence rate increased nationally by 1.5% per year in non-Hispanic Black men, whereas the rate decreased statistically significantly by 3.5% per year in non-Hispanic White men. A statistically significant 3.3% per year increase among young non-Hispanic Black men in the South and no change among those living in non-South regions were observed. Targeted HIV prevention and treatment in young non-Hispanic Black men in the South and further research addressing the increased KS incidence and burden in this vulnerable population are needed.
MeSH term(s)	Male ; Humans ; United States/epidemiology ; Sarcoma, Kaposi/epidemiology ; Incidence ; Acquired Immunodeficiency Syndrome/complications ; Ethnicity ; Blacks
Language	English
Publishing date	2022-11-09
Publishing country	England
Document type	Journal Article
ISSN	2515-5091
ISSN (online)	2515-5091
DOI	10.1093/jncics/pkac078
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Article ; Online: Contemporary Patterns in HPV-Associated Cancer Incidence Among Young US Men.

Damgacioglu, Haluk / Wu, Chi-Fang / Lin, Yueh-Yun / Ortiz, Ana Patricia / Sonawane, Kalyani / Deshmukh, Ashish A

Journal of general internal medicine

2022 Volume 38, Issue 3, Page(s) 817–819

MeSH term(s)	Male ; Humans ; Papillomavirus Infections/epidemiology ; Incidence ; Neoplasms ; Risk Factors ; Prevalence
Language	English
Publishing date	2022-08-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639008-0
ISSN	1525-1497 ; 0884-8734
ISSN (online)	1525-1497
ISSN	0884-8734
DOI	10.1007/s11606-022-07755-3
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