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  1. Book ; Online ; E-Book: Animal models of neurological disorders

    Bansal, Puneet Kumar / Deshmukh, Rahul

    principle and working procedure for animal models of neurological disorders

    2017  

    Author's details Puneet Kumar Bansal, Rahul Deshmukh editors
    Keywords Medicine ; Neurosciences ; Pharmacology ; Animal models in research ; Neurobiology
    Subject code 612.8
    Language English
    Size 1 Online-Ressource (xviii, 343 Seiten), Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019616996
    ISBN 978-981-10-5981-0 ; 9789811059803 ; 981-10-5981-0 ; 9811059802
    DOI 10.1007/978-981-10-5981-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Impact of alogliptin on lipopolysaccharide-induced experimental Parkinson's disease: Unrevealing neurochemical and histopathological alterations in rodents.

    Dhureja, Maanvi / Deshmukh, Rahul

    European journal of pharmacology

    2024  Volume 975, Page(s) 176635

    Abstract: Background: Degeneration of the nigrostriatal dopaminergic pathway has been seen as a significant cause of movement disability in Parkinson's disease (PD) patients. However, the exact reason for these degenerative changes has remained obscure. In recent ...

    Abstract Background: Degeneration of the nigrostriatal dopaminergic pathway has been seen as a significant cause of movement disability in Parkinson's disease (PD) patients. However, the exact reason for these degenerative changes has remained obscure. In recent years, incretins have been neuroprotective in various pathologies. In the current study, we have investigated the neuroprotective potential of alogliptin (Alo), a dipeptidyl peptidase-IV (DPP-IV) inhibitor, in a lipopolysaccharide (LPS) induced experimental model of PD.
    Experimental approach: LPS (5μg/5 μl) was infused intranigrally to induce PD in experimental rats. Post-LPS infusion, these animals were treated with Alo for 21 days in three successive dosages of 10, 20, and 40 mg/kg/day/per oral. The study is well supported with the determinations of motor functions biochemical, neurochemical, and histological analysis.
    Key results: Intranigral infusion of LPS in rats produced motor deficit. It was accompanied by oxidative stress, elevation in neuroinflammatory cytokines, altered neurochemistry, and degenerative changes in the striatal brain region. While Alo abrogated LPS-induced biochemical/neurochemical alterations, improved motor functions, and preserved neuronal morphology in LPS-infused rats.
    Conclusion: The observed neuroprotective potential of Alo may be due to its antioxidant and anti-inflammatory actions and its ability to modulate monoaminergic signals. Nonetheless, current findings suggest that improving the availability of incretins through DPP-IV inhibition is a promising strategy for treating Parkinson's disease.
    Language English
    Publishing date 2024-05-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2024.176635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Artificial Intelligence in Medicine.

    Deshmukh, Rahul / Rathi, Pravin

    The Journal of the Association of Physicians of India

    2022  Volume 70, Issue 3, Page(s) 11–12

    Abstract: Artificial intelligence as the name suggests is intelligence given to machines by man. AI learns and performs like humans without human instructions. We encounter AI in daily activities, like music and video suggestions in video applications, and ... ...

    Abstract Artificial intelligence as the name suggests is intelligence given to machines by man. AI learns and performs like humans without human instructions. We encounter AI in daily activities, like music and video suggestions in video applications, and personalize what we see on Facebook, Twitter, Instagram. AI makes our day-to-day life easier, efficient and it increases the speed and accuracy of our efforts. In this article, we reviewed previous articles and internet sites to understand the general principles of artificial intelligence. We included general articles and few articles related to medicine to understand the basics of AI and its application in the medical field. A literature search was done using the following search terms: 'AI' and 'AI in medicine'.
    MeSH term(s) Artificial Intelligence ; Humans ; Male ; Medicine
    Language English
    Publishing date 2022-04-19
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Vinpocetine restores cognitive and motor functions in Traumatic brain injury challenged rats.

    Bagri, Kajal / Deshmukh, Rahul

    Inflammopharmacology

    2022  Volume 30, Issue 6, Page(s) 2243–2259

    Abstract: Traumatic brain damage is common worldwide and the treatments are not well-defined. Vinpocetine is a synthetic derivative of the vinca alkaloid vincamine and is clinically being used for various brain disorders. Here in the current study, we have ... ...

    Abstract Traumatic brain damage is common worldwide and the treatments are not well-defined. Vinpocetine is a synthetic derivative of the vinca alkaloid vincamine and is clinically being used for various brain disorders. Here in the current study, we have investigated the neuroprotective potential of vinpocetine against traumatic brain injury. TBI was induced by the Marmarou weight drop method in rats. Brain damage was evaluated using cognitive and motor functions and the alterations in biomolecules. Injured rats were treated with different doses of vinpocetine (2.5, 5, and 10 mg/kg) for 4 weeks. Traumatic brain injury in rats produced significant deterioration of cognition and motor functions, which was accompanied by increased oxidative stress and significant alterations in brain monoamine levels as compared with the sham control group (p < 0.05). Vinpocetine alleviated TBI-induced oxidative burden, altered neurochemistry, and improved the cognitive and motor functions as compared with that of the TBI control group (p < 0.05). The observed neuroprotective potential of vinpocetine may be due to the observed antioxidant potential and its ability to restore the levels of brain neurochemicals under stressed conditions. The outcomes of the current study may help the repositioning of vinpocetine for preventing or treating traumatic brain injuries.
    MeSH term(s) Animals ; Rats ; Vinca Alkaloids/pharmacology ; Vinca Alkaloids/therapeutic use ; Brain Injuries, Traumatic/drug therapy ; Brain ; Cognition
    Chemical Substances vinpocetine (543512OBTC) ; Vinca Alkaloids
    Language English
    Publishing date 2022-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-022-01059-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dipeptidyl peptidase 4(DPP4) inhibitors stride up the management of Parkinson's disease.

    Maanvi / Kumari, Shilpa / Deshmukh, Rahul

    European journal of pharmacology

    2022  Volume 939, Page(s) 175426

    Abstract: Parkinson's disease (PD) is the ... ...

    Abstract Parkinson's disease (PD) is the 2
    Language English
    Publishing date 2022-11-26
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2022.175426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: β-lactam antibiotics to tame down molecular pathways of Alzheimer's disease.

    Kumari, Shilpa / Deshmukh, Rahul

    European journal of pharmacology

    2021  Volume 895, Page(s) 173877

    Abstract: Alzheimer's disease is a multifactorial disorder characterized by extracellular accumulation of amyloid-β (Aβ) and intracellular accumulations of neurofibrillary tangles. Numerous drug targets have been explored for therapeutic efficacy but failed to ... ...

    Abstract Alzheimer's disease is a multifactorial disorder characterized by extracellular accumulation of amyloid-β (Aβ) and intracellular accumulations of neurofibrillary tangles. Numerous drug targets have been explored for therapeutic efficacy but failed to deliver successful treatments clinically. However, over the years our understanding of the disease pathophysiology increased significantly. Many of the novel targets which can cure or modify disease pathology are being explored preclinically as well as clinically. On contrarily, the drug discovery and development process is lengthy and the cost involved makes it difficult for faster translation of therapeutic outcomes. Therefore, repurposing existing drugs for a new therapeutic indication is considered a better approach and helps in the fast translation of therapeutic information. The existing drugs have well-proven records on their safety, pharmacokinetics, etc. In recent years, beta (β)-lactam antibiotics have been repurposed for the management of neurodegenerative pathologies. Here in the current review, we have explored β-lactam antibiotics, their target sites, molecular mechanisms, and their therapeutic potential in Alzheimer's disease.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Anti-Bacterial Agents/therapeutic use ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Disease Progression ; Drug Repositioning ; Humans ; Nerve Degeneration ; Neuroprotective Agents/therapeutic use ; Signal Transduction ; beta-Lactams/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Neuroprotective Agents ; beta-Lactams
    Language English
    Publishing date 2021-01-14
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2021.173877
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  7. Article ; Online: A review: traditional herbs and remedies impacting pathogenesis of Parkinson's disease.

    Sharma, Vishavdeep / Bedi, Onkar / Gupta, Manisha / Deshmukh, Rahul

    Naunyn-Schmiedeberg's archives of pharmacology

    2022  Volume 395, Issue 5, Page(s) 495–513

    Abstract: Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons, leading to misbalance and loss of coordination. Current therapies are claimed only for symptomatic relief, on long-term use, which causes alteration in basal ... ...

    Abstract Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons, leading to misbalance and loss of coordination. Current therapies are claimed only for symptomatic relief, on long-term use, which causes alteration in basal ganglia, and give rise to various adverse effects like dyskinesia and extra pyramidal side effects, which is reversed and proved to be attenuated with the help of various herbal approaches. Therefore, in order to attenuate the dopaminergic complications, focus of current research has been shifted from dopaminergic to non-dopaminergic strategies. Herbs and herbal remedies seems to be a better option to overcome the complications associated with current dopaminergic therapies. In recent years, various herbs and herbal remedies based on Ayurveda, traditional Chinese and Korean remedies, have become the target of various researches. These herbs and their bioactive compound are being extensively used to treat PD in India, China, Japan, and Korea. The major focus of this current review is to analyze preclinical studies with reference to various herbs, bioactive compounds, and traditional remedies for the management of Parkinson disorder, which will give an insight towards clinical trials.
    MeSH term(s) Basal Ganglia ; Dopamine ; Dopaminergic Neurons/pathology ; Humans ; Parkinson Disease/drug therapy ; Parkinson Disease/pathology
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-03-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-022-02223-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Correction to: Embelin Attenuates Intracerebroventricular Streptozotocin-Induced Behavioral, Biochemical, and Neurochemical Abnormalities in Rats.

    Arora, Rimpi / Deshmukh, Rahul

    Molecular neurobiology

    2020  Volume 57, Issue 9, Page(s) 3991

    Abstract: The original version of this article unfortunately missed to include the other affiliation of the first author Rimpi Arora as listed below. ...

    Abstract The original version of this article unfortunately missed to include the other affiliation of the first author Rimpi Arora as listed below.
    Language English
    Publishing date 2020-07-04
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-020-02001-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2411: Show issues Location:
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  9. Article ; Online: A comparative study of uncomplicated acute non-A-E hepatitis with acute viral hepatitis and acute onset autoimmune hepatitis.

    Rane, Siddhesh Vijay / Jain, Shubham / Debnath, Partha / Deshmukh, Rahul / Nair, Sujit / Chandnani, Sanjay / Kamat, Rima / Rathi, Pravin

    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

    2024  

    Abstract: Background and aims: Non-A-E hepatitis (NAEH) not leading to acute liver failure (ALF) is poorly documented. The objective was to compare clinical and laboratory features of uncomplicated acute NAEH with acute viral (AVH) and autoimmune hepatitis (AIH) ... ...

    Abstract Background and aims: Non-A-E hepatitis (NAEH) not leading to acute liver failure (ALF) is poorly documented. The objective was to compare clinical and laboratory features of uncomplicated acute NAEH with acute viral (AVH) and autoimmune hepatitis (AIH) and histopathology in NAEH and AIH.
    Methods: Cases of hepatocellular jaundice were included. These were grouped into AVH, AIH and NAEH based on clinical, laboratory and, when indicated, liver biopsy findings. NAEH and AIH were followed up at three months.
    Results: Of 336 patients with hepatocellular jaundice, 15 (5%) were NAEH, 25 (7%) acute AIH and 45 (14%) AVH. Among NAEH patients, seven (46.7%) were males with a mean age of presentation 39 years. Jaundice (100%) was the most common presentation of NAEH. Peak bilirubin was 10.7 mg/dL. Peak aspartate and alanine aminotransferase (AST, ALT) were 512 and 670 U/L. Five (33.3%) patients had positive anti-nuclear antibody and one had anti-smooth muscle antibody. Mean immunoglobulin G (IgG) levels were 1829. On liver biopsy, all had ballooning degeneration, four (26.7%) had mild and three (20%) moderate interface hepatitis, four (26.7%) mild lymphoplasmacytic infiltrate, one (6.7%) rosette formation, bridging necrosis in none and stage 1 fibrosis in one. Comparing NAEH with AIH, AIH showed significantly older age at presentation, female predisposition, past history of jaundice, lower ALT, more autoantibodies, higher IgG, higher grade interface hepatitis, lymphoplasmacytic infiltrate, rosette formation and higher bilirubin, AST at three months. NAEH and viral hepatitis had similar features.
    Conclusion: Etiology of NAEH is unlikely to be autoimmune and is probably viral, unidentified as yet. Uncomplicated NAEH likely has self-limiting course even without specific treatment.
    Language English
    Publishing date 2024-03-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 632595-6
    ISSN 0975-0711 ; 0254-8860
    ISSN (online) 0975-0711
    ISSN 0254-8860
    DOI 10.1007/s12664-023-01474-1
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    Zs.A 2085: Show issues Location:
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  10. Article ; Online: Neurobiology of traumatic brain injury.

    Bagri, Kajal / Kumar, Puneet / Deshmukh, Rahul

    Brain injury

    2021  Volume 35, Issue 10, Page(s) 1113–1120

    Abstract: Traumatic brain injury (TBI) involves structural damage to the brain regions causing death or disability in patients with lifelong sufferings. Accidental injuries to the brain, besides structural damage, if any, cause activation of various deleterious ... ...

    Abstract Traumatic brain injury (TBI) involves structural damage to the brain regions causing death or disability in patients with lifelong sufferings. Accidental injuries to the brain, besides structural damage, if any, cause activation of various deleterious pathways leading to subsequent neuronal death and permanent dysfunction. However, immediate medical management/treatments could reduce the chances of disability and suffering to the patients. The objective of the current review is to review triggered molecular pathways following TBI and discuss possible targets that could restore brain functions. Understanding the pathologic process is always useful to device novel treatment strategies and may rescue the patient with TBI from death or associated co-morbidities. The current review significantly contributes to improve our understanding about the molecular pathways and neuronal death following TBI and helps us to provide possible targets that could be useful in the management/treatment of TBI.
    MeSH term(s) Brain ; Brain Injuries, Traumatic ; Cell Death ; Humans
    Language English
    Publishing date 2021-09-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639115-1
    ISSN 1362-301X ; 0269-9052
    ISSN (online) 1362-301X
    ISSN 0269-9052
    DOI 10.1080/02699052.2021.1972152
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