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  1. Article ; Online: Is posterior urethral valve a chronic disease, not merely a chronic kidney disease? Reflections on models of (multidisciplinary) care.

    Deshpande, Aniruddh

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 38, Issue 11, Page(s) 3505–3507

    MeSH term(s) Humans ; Chronic Disease ; Renal Insufficiency, Chronic/therapy ; Urinary Tract ; Urethra ; Retrospective Studies ; Urethral Obstruction
    Language English
    Publishing date 2023-07-19
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-06092-9
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    Zs.A 2196: Show issues Location:
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  2. Article: Treatment modalities for paediatric functional daytime lower urinary tract disorders: an updated review.

    Wijekoon, Naveen / Deshpande, Aniruddh

    Therapeutic advances in urology

    2024  Volume 16, Page(s) 17562872241241848

    Abstract: Paediatric functional bladder disorders especially those causing daytime symptoms are a common cause of significant psychosocial and/or physical morbidity and impaired quality of life. Despite the availability of many therapeutic modalities, a ... ...

    Abstract Paediatric functional bladder disorders especially those causing daytime symptoms are a common cause of significant psychosocial and/or physical morbidity and impaired quality of life. Despite the availability of many therapeutic modalities, a significant number of children appear to be refractory to treatment and continue to have symptoms. In this review, we aim to evaluate the current evidence in the use of existing and novel therapeutic options for the management of daytime lower urinary tract disorders in children. We also aim to highlight the controversies around the terminology and diagnosis of paediatric lower urinary tract dysfunction (LUTD) and specific conditions. The article will then provide a reasonable critique of the existing and emerging treatment modalities in functional daytime LUTD in children including their mode of action, efficacy, indications, and recent advances. These include standard urotherapy, specific urotherapy comprised of biofeedback, alarm therapy and electrical neural stimulation and pharmacotherapy involving selective and non-selective anticholinergics, ß
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2492591-3
    ISSN 1756-2880 ; 1756-2872
    ISSN (online) 1756-2880
    ISSN 1756-2872
    DOI 10.1177/17562872241241848
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  3. Article ; Online: Authors' response to the editorial commentary on the study titled "Parental Decision Regret among Australian Parents after consenting to or Refusing Hypospadias Repair for their son: Results of a survey with controls".

    Deshpande, Aniruddh V

    Journal of pediatric urology

    2022  Volume 18, Issue 4, Page(s) 490

    MeSH term(s) Male ; Humans ; Hypospadias/surgery ; Australia ; Parents ; Emotions ; Surveys and Questionnaires
    Language English
    Publishing date 2022-07-31
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2237683-5
    ISSN 1873-4898 ; 1477-5131
    ISSN (online) 1873-4898
    ISSN 1477-5131
    DOI 10.1016/j.jpurol.2022.07.016
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    Zs.A 6387: Show issues Location:
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  4. Article ; Online: Conversations for the future in the follow-up of antenatally diagnosed renal pelvicalyceal dilatation.

    Deshpande, Aniruddh V

    Pediatric nephrology (Berlin, Germany)

    2020  Volume 36, Issue 1, Page(s) 5–8

    MeSH term(s) Dilatation ; Female ; Follow-Up Studies ; Humans ; Kidney/diagnostic imaging ; Pregnancy ; Ultrasonography, Prenatal
    Language English
    Publishing date 2020-10-07
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-020-04766-2
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  5. Article ; Online: Pharmacological interventions for the management of cystinuria: a systematic review.

    Bhatt, Nirmal Prasad / Deshpande, Aniruddh Vijay / Starkey, Malcolm Ronald

    Journal of nephrology

    2023  Volume 37, Issue 2, Page(s) 293–308

    Abstract: Background: Cystinuria is a rare genetic kidney stone disease, with no cure. Current treatments involve lowering urinary cystine levels and increasing cystine solubility. This systematic review evaluates the available literature regarding non-surgical ... ...

    Abstract Background: Cystinuria is a rare genetic kidney stone disease, with no cure. Current treatments involve lowering urinary cystine levels and increasing cystine solubility. This systematic review evaluates the available literature regarding non-surgical interventions for cystinuria.
    Methods: Key electronic databases were searched for studies that described the clinical management of cystinuria with high diuresis, alkalinizing agents and thiol-based drugs that were published between 2000 and 2022. Observational studies were included if they contained clinical investigation with at least one previous or current episode of cystine stones, urine cystine levels > 250 mg/L and patients being managed with urinary dilution, alkalinizing agents or other pharmacological agents. All included studies were assessed for study design, patient characteristics and outcomes. A qualitative and critical analysis was performed whereby study quality was assessed using Methodological Index for Non-Randomized Studies (MINORS). Two authors performed the quality assessment and excluded the studies with a low MINORS score.
    Results: Fourteen studies met the review inclusion and quality criteria. Of the fourteen studies, two reported treatment using alkalinizing agents, six reported treatment using thiol-based drugs, and six reported combination treatment using alkalinizing agents and thiol-based drugs. These studies indicated that first-line therapies, including high fluid intake and urinary alkalinization, increased urine volume to > 3 L/day and urinary pH > 7.0, and were associated with reduced urinary cystine levels and cystine stone formation. Second-line therapy with cystine-binding thiol drugs, such as tiopronin and D-penicillamine, reduced urinary cystine levels, cystine crystal volume and increased cystine solubility, resulting in decreased cystine stone formation and stone recurrence rate. Further, combined intervention with alkalinizing agents and thiol-based drugs synergistically reduced stone recurrence.
    Conclusion: Cystinuria treatment may require a combined approach of high diuresis, alkalinization and pharmacological interventions with regular monitoring of urinary pH, cystine levels, cystine crystal volume and solubility. However, poor adherence to treatment is relatively frequent, hence the pressing urgency for improved therapies and treatments.
    MeSH term(s) Cystinuria/drug therapy ; Cystinuria/urine ; Humans ; Cystine ; Sulfhydryl Compounds/therapeutic use ; Sulfhydryl Compounds/urine ; Treatment Outcome ; Diuresis/drug effects
    Chemical Substances Cystine (48TCX9A1VT) ; Sulfhydryl Compounds
    Language English
    Publishing date 2023-11-13
    Publishing country Italy
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01795-6
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    Zs.A 3369: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The rationale for bladder washouts in children with neurogenic bladder.

    Singh, Gopal-Krsna / Deshpande, Aniruddh V / Schlegel, Gemma / Starkey, Malcolm Ronald / Taghavi, Kiarash

    Neurourology and urodynamics

    2024  Volume 43, Issue 4, Page(s) 1019–1024

    Abstract: Children with a neurogenic bladder are at risk of developing recurrent urinary tract infections and long-term kidney failure. Due to an altered lower urinary tract, children may be overtreated for simple bacteriuria or undertreated for a potentially ... ...

    Abstract Children with a neurogenic bladder are at risk of developing recurrent urinary tract infections and long-term kidney failure. Due to an altered lower urinary tract, children may be overtreated for simple bacteriuria or undertreated for a potentially severe urinary tract infection. This group of patients represent high users of healthcare, and are at risk of colonization and development of antibiotic resistance. Bladder washouts with non-antibiotic electrochemically activated solutions are a potential new prophylactic option for patients with bladder dysfunction when clean intermittent catheterization has resulted in chronic bacteriuria.
    MeSH term(s) Child ; Humans ; Bacteriuria ; Urinary Bladder, Neurogenic/etiology ; Urinary Bladder ; Urinary Tract Infections/etiology ; Intermittent Urethral Catheterization ; Urinary Catheterization/adverse effects
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.25450
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    Zs.A 1828: Show issues Location:
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  7. Article ; Online: Current strategies to predict and manage sequelae of posterior urethral valves in children.

    Deshpande, Aniruddh V

    Pediatric nephrology (Berlin, Germany)

    2017  Volume 33, Issue 10, Page(s) 1651–1661

    Abstract: Posterior urethral valves (PUV) constitute a significant urological cause of chronic kidney disease (CKD) in children. The condition is characterised by the unique pathophysiology of the evolution of bladder dysfunction after relief of obstruction, which ...

    Abstract Posterior urethral valves (PUV) constitute a significant urological cause of chronic kidney disease (CKD) in children. The condition is characterised by the unique pathophysiology of the evolution of bladder dysfunction after relief of obstruction, which contributes to CKD. Improvements in prenatal diagnosis followed by selective foetal intervention have not yet produced improvement in long-term renal outcomes, although better patient selection may alter this in the future. Proactive management with surveillance, pharmacotherapy, timed voiding, double voiding, and/or assisted bladder-emptying, is being increasingly offered to those with severe bladder dysfunction and has the potential of reducing the burden of renal disease. Clinicians are currently able to counsel regarding the prognosis using serum creatinine and other emerging markers. However, much of this work remains to be validated. Satisfactory graft survival rates are now reported with aggressive management of bladder dysfunction in children who are candidates for renal transplantation. Knowledge gaps exist in identifying early markers of renal injury, risk stratification, and in understanding patient and carer perspectives in PUV.
    MeSH term(s) Biomarkers/blood ; Child ; Creatinine/blood ; Disease Progression ; Humans ; Kidney Transplantation ; Prenatal Diagnosis ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/prevention & control ; Ultrasonography, Prenatal ; Urethra/abnormalities ; Urethra/diagnostic imaging ; Urethral Obstruction/complications ; Urethral Obstruction/diagnosis ; Urethral Obstruction/physiopathology ; Urethral Obstruction/therapy ; Urinary Bladder/physiopathology ; Urination/physiology ; Urological Agents/therapeutic use
    Chemical Substances Biomarkers ; Urological Agents ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2017-11-20
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-017-3815-0
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    Zs.A 2196: Show issues Location:
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  8. Article: Peritesticular scarring: An unusual presentation of hemophilia B.

    Khoshkhesal, Mona / Pham, Alan C G / Deshpande, Aniruddh V

    Urology annals

    2022  Volume 14, Issue 2, Page(s) 183–185

    Abstract: Hemophilia is an inherited clotting disorder that typically presents as spontaneous hemorrhage or prolonged, excessive bleeding following minor trauma. Abnormalities of the genitourinary tract are a rare manifestation of the disease. Here, we report a ... ...

    Abstract Hemophilia is an inherited clotting disorder that typically presents as spontaneous hemorrhage or prolonged, excessive bleeding following minor trauma. Abnormalities of the genitourinary tract are a rare manifestation of the disease. Here, we report a case of undiagnosed hemophilia B in a teenage boy presenting with worsening testicular pain and a dumbbell-shaped testis. Scrotal ultrasound identified the presence of a hypoechogenic band constricting the left testicle. Surgical exploration of the left testis was performed with release and sampling of the fibrous tunica vaginalis tissue responsible for the testicular deformity. Histopathological analysis revealed evidence of chronic interstitial inflammation with hypocellular keloid-like fiber formation suggestive of old hemorrhage. The procedure was complicated by a delayed scrotal hematoma. Coagulation studies confirmed a prolonged activated partial thromboplastin time and factor IX assay of 5%. Scrotal evacuation with the administration of intraoperative tranexamic acid achieved effective hemostasis. The patient is doing well with ongoing hematology review and prophylactic recombinant factor IX administration.
    Language English
    Publishing date 2022-04-18
    Publishing country India
    Document type Case Reports
    ISSN 0974-7796
    ISSN 0974-7796
    DOI 10.4103/ua.ua_19_21
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  9. Article ; Online: Editorial comment.

    Deshpande, Aniruddh V

    The Journal of urology

    2014  Volume 191, Issue 6, Page(s) 1870–1871

    MeSH term(s) Female ; Forecasting ; Humans ; Male ; Nocturia/epidemiology ; Nocturnal Enuresis/epidemiology ; Urodynamics/physiology
    Language English
    Publishing date 2014-06
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1016/j.juro.2013.12.059
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  10. Article ; Online: Effectiveness of standard urotherapy (basic bladder advice) and combination therapies in managing bladder dysfunction in children with treated behavioral disorders: Results of a prospective cohort (DABBED) study.

    Eliezer, Dilharan D / Samnakay, Naeem / Starkey, Malcolm R / Deshpande, Aniruddh V

    Lower urinary tract symptoms

    2021  Volume 13, Issue 4, Page(s) 490–497

    Abstract: Aims: We evaluated the efficacy of standard urotherapy and combination therapies in treatment of bladder dysfunction in children with treated behavioral disorders.: Methods: Prospective study of children (6-16 years) with bladder dysfunction and ... ...

    Abstract Aims: We evaluated the efficacy of standard urotherapy and combination therapies in treatment of bladder dysfunction in children with treated behavioral disorders.
    Methods: Prospective study of children (6-16 years) with bladder dysfunction and behavioral disorders was conducted between March 2018-2020. Eligible children were initially offered standard urotherapy and those with no response at 3 months were offered combination therapies. Symptomatic response, changes in Akbal score and PinQ score were reported at 6 months and outcomes were correlated to behavioral diagnoses and medications.
    Results: Thirty-nine consecutive children (male = 27, mean age [SD] 10.3 [±2.0] years) were recruited, of whom 29 completed the study (five lost to follow-up, three non-compliant to treatment, two excluded). Thirty-four (87%) children had attention deficit/hyperactivity disorder. Monosymptomatic nocturnal enuresis (n = 11) and non-monosymptomatic enuresis (n = 17) were the commonest diagnoses. Following 3-month review, 14 (38%) children continued to receive standard urotherapy, while 15 (41%) children were transitioned to combination therapy. At 6-month review, complete/partial response was seen in 62% (23/37) and no response in 16% (6/37); with 32% (12/37) responding to standard urotherapy alone. Akbal symptom scores (15.9-11.5; P < 0.01) and PinQ scores (26.0-19.5; P = 0.008) improved significantly at 6-month follow-up. Type of underlying behavioral disorder(s) or medications for behavioral disorder did not influence the outcomes.
    Conclusion: This study confirms that children with underlying behavioral disorders are able to have a good response to the appropriate therapy for their bladder dysfunction with a third of children responding to standard urotherapy alone.
    MeSH term(s) Child ; Combined Modality Therapy ; Humans ; Male ; Nocturnal Enuresis ; Prospective Studies ; Urinary Bladder ; Urinary Incontinence
    Language English
    Publishing date 2021-07-27
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2519111-1
    ISSN 1757-5672 ; 1757-5664
    ISSN (online) 1757-5672
    ISSN 1757-5664
    DOI 10.1111/luts.12400
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