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  1. Article ; Online: The assessment of the clinical impact of using a single set of radiotherapy planning data for two kilovoltage therapy units.

    Peters, Iliana / Nelson, Vinod / Deshpande, Shrikant / Walker, Amy / Hiatt, Joshua / Roach, Dale / Erven, Tania / Rajapakse, Satya / Gray, Alison

    Physical and engineering sciences in medicine

    2023  Volume 47, Issue 1, Page(s) 49–59

    Abstract: Kilovoltage therapy units are used for superficial radiotherapy treatment delivery. Peer reviewed studies for MV linear accelerators describe tolerances to dosimetrically match multiple linear accelerators enabling patient treatment on any matched ... ...

    Abstract Kilovoltage therapy units are used for superficial radiotherapy treatment delivery. Peer reviewed studies for MV linear accelerators describe tolerances to dosimetrically match multiple linear accelerators enabling patient treatment on any matched machine. There is an absence of literature on using a single planning data set for multiple kilovoltage units which have limited ability for beam adjustment. This study reviewed kilovoltage dosimetry and treatment planning scenarios to evaluate the feasibility of using ACPSEM annual QA tolerances to determine whether two units (of the same make and model) were dosimetrically matched. The dosimetric characteristics, such as measured half value layer (HVL), percentage depth dose (PDD), applicator factor and output variation with stand-off distance for each kV unit were compared to assess the agreement. Independent planning data based on the measured HVL for each beam energy from each kV unit was prepared. Monitor unit (MU) calculations were performed using both sets of planning data for approximately 200 clinical scenarios and compared with an overall agreement between units of < 2%. Additionally, a dosimetry measurement comparison was completed at each site for a subset of nine scenarios. All machine characterisation measurements were within the ACPSEM Annual QA tolerances, and dosimetric testing was within 2.5%. This work demonstrates that using a single set of planning data for two kilovoltage units is feasible, resulting in a clinical impact within published uncertainty.
    MeSH term(s) Humans ; Radiometry ; Radiotherapy Planning, Computer-Assisted/methods ; Phantoms, Imaging ; Particle Accelerators ; Uncertainty
    Language English
    Publishing date 2023-10-16
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2662-4737
    ISSN (online) 2662-4737
    DOI 10.1007/s13246-023-01339-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identifying the location of locoregional recurrences after definitive radiotherapy for head and neck cancer using metabolic parameters of baseline and mid-treatment 18F-FDG-PET scans.

    Aren, Ewa / Trada, Yuvnik / Lee, Mark / Deshpande, Shrikant / Jameson, Michael G / Johnston, Meredith / Berry, Megan / Estall, Vanessa / Fowler, Allan

    Journal of medical imaging and radiation oncology

    2022  Volume 67, Issue 1, Page(s) 89–97

    Abstract: Introduction: Tumour recurrences after treatment of head and neck squamous cell carcinoma (HNSCC) are more likely to originate from regions of high-baseline FDG-PET uptake. Mid-treatment functional imaging can potentially predict for higher risk of ... ...

    Abstract Introduction: Tumour recurrences after treatment of head and neck squamous cell carcinoma (HNSCC) are more likely to originate from regions of high-baseline FDG-PET uptake. Mid-treatment functional imaging can potentially predict for higher risk of tumour recurrence. The aim of this study is to correlate the location of locoregional tumour recurrence with baseline FDG-PET metabolic volumes and mid-treatment FDG-PET metabolic volumes in patients with HNSCC following definitive radiotherapy.
    Methods: A total of 23 patients with 26 local and/or regional recurrences underwent baseline (W0-PET) and mid-treatment (W3-PET) 18F-FDG PET scans as part of their radiotherapy. FDG-PET-based metabolic volumes (MTV20%, MTV40%, MTV60%, MTV80%, SUV2.5, SUVpeak and PET_EDGE) were delineated onto the FDG-PET scans. The recurrence nidus was identified on FDG-PET at the time of recurrence (REC-PET). DIR-based fusion was performed for REC-PET to W0-PET, and REC-PET to W3-PET. The location of the recurrence nidus was correlated with the FDG-PET volumes. Further analysis included a comparison of the recurrence density to FDG-PET metabolic volumes.
    Results: Most recurrences occurred within the MTV20%, MTV40% and SUV 2.5 volumes. Sixty-nine per cent of recurrences (18 of 26) occurred within both the W0 MTV40% and W3 MTV40% volumes. A higher recurrence density was seen for iso-SUV contours closer to the maximum SUV for both W0 and W3. For a number of the FDG-PET volumes, including MTV20%, MTV40% and SUV2.5, the recurrence density was improved for W3 compared to W0, however, this improvement was small in magnitude. The average volume of MTV40% contours was considerably smaller than MTV20% and SUV2.5 contours.
    Conclusion: The metabolic parameters of SUV2.5, MTV20% and MTV40% delineated on the baseline and mid-treatment FDG-PET scans encompassed the majority of recurrences. The MTV40% is significantly smaller, hence, we prefer this volume for future dose escalation studies.
    MeSH term(s) Humans ; Fluorodeoxyglucose F18 ; Head and Neck Neoplasms ; Neoplasm Recurrence, Local ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Recurrence ; Squamous Cell Carcinoma of Head and Neck
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Language English
    Publishing date 2022-10-27
    Publishing country Australia
    Document type Clinical Trial, Phase I ; Journal Article
    ZDB-ID 2389687-5
    ISSN 1754-9485 ; 1440-1673 ; 1754-9477 ; 0004-8461
    ISSN (online) 1754-9485 ; 1440-1673
    ISSN 1754-9477 ; 0004-8461
    DOI 10.1111/1754-9485.13486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Efficacy and safety of glycopyrronium/formoterol delivered via a dry powder inhaler in patients with moderate to severe chronic obstructive pulmonary disease: Results from a multi-centre, open-label, randomised study.

    Salvi, Sundeep / Kumar, Anand / Agrawal, Sumit / Leuva, Amritlal / Shukla, Vineet Kumar / Deshpande, Shrikant Vishnu / Balamurugan, Santhalingam / Singh, Ajit / Tikkiwal, Sharad / Gupta, Sandeep K / Singh, Bhanu Pratap / Lopez, Meena / Sawant, Sandesh / Vaidya, Abhijit / Gogtay, Jaideep

    Lung India : official organ of Indian Chest Society

    2023  Volume 39, Issue 5, Page(s) 408–416

    Abstract: Background: We designed this randomised, open-label, parallel group, multi-centre study to investigate the efficacy and safety of glycopyrronium/formoterol, a long-acting muscarinic antagonist/long-acting β2-agonist fixed dose combination, delivered ... ...

    Abstract Background: We designed this randomised, open-label, parallel group, multi-centre study to investigate the efficacy and safety of glycopyrronium/formoterol, a long-acting muscarinic antagonist/long-acting β2-agonist fixed dose combination, delivered through a dry powder inhaler (DPI) in patients with chronic obstructive pulmonary disease (COPD).
    Material and methods: We randomised (1:1) patients with moderate to severe COPD (N = 356) to receive glycopyrronium 25 μg/formoterol 12 μg via DPI twice daily (GF-DPI) or glycopyrronium 50 μg monotherapy via DPI once daily (G-DPI). The primary study endpoint was the mean change from the baseline in pre-dose trough-forced expiratory volume in one second (FEV1) at 12 weeks.
    Results: At week 12, the mean increase from the baseline in pre-dose trough FEV1 was higher in the GF-DPI group (120 ml) than in the G-DPI (60 ml) group. The mean difference (MD) between treatment groups was 0.06 L (95% CI: 0.00-0.12 L, P < 0.0001 for non-inferiority). At week 12, the mean pre-dose forced vital capacity (FVC), 1 hour post-dose FEV1, and post-dose FVC increased significantly from the baseline only in the GF-DPI group (p < 0.0001). The reduction in the COPD assessment test score was greater in the GF-DPI group (p = 0.0379). The average daily number of puffs of rescue medication and the reduction in mean modified Medical Research Council scale, COPD, and Asthma Sleep Impact Scale score at week 12 were similar between groups (p > 0.05). Overall, 35 adverse events and two serious adverse events unrelated to study drugs were reported. Both groups had similar results for overall drug safety.
    Conclusion: The results demonstrate efficacy and safety of GF-DPI in Indian patients with moderate to severe COPD. Treatment with GF-DPI significantly improved the lung function and quality of life and was well tolerated.
    Language English
    Publishing date 2023-01-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_92_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Quantifying and Assessing the Dosimetric Impact of Changing Gas Volumes Throughout the Course of VMAT Radiation Therapy of Upper Gastrointestinal Tumors.

    Scott, Joshua / Dundas, Kylie / Surjan, Yolanda / King, Odette / Arumugam, Sankar / Deshpande, Shrikant / Udovitch, Mark / Lee, Mark

    Advances in radiation oncology

    2021  Volume 6, Issue 3, Page(s) 100650

    Abstract: Purpose: This retrospective patient study assessed the consistency of abdominal gas presence throughout radiation therapy for patients with upper gastrointestinal cancer and determined the impact of variations in gas volume on the calculated dose ... ...

    Abstract Purpose: This retrospective patient study assessed the consistency of abdominal gas presence throughout radiation therapy for patients with upper gastrointestinal cancer and determined the impact of variations in gas volume on the calculated dose distribution of volumetric modulated arc therapy.
    Methods and materials: Eight patients with pancreatic cancer were included for analysis. A plan library consisting of 3 reference plans per patient (Ref
    Results: There was a significant decrease in gas present from CT to treatment CBCT, with a mean decrease in volume of 48.6% for the entire cohort. Dosimetrically, all accumulated target and organ-at-risk parameters, aside from the kidneys, exhibited the smallest mean deviation from the Ref
    Conclusions: Significant variation in gas volumes from CT to treatment can occur throughout volumetric modulated arc therapy for pancreatic cancer. Through the use of a plan library, it was determined that initial assessment of a patient's treatment plan with an assigned gas density of 0.0 provided the most accurate prediction of the accumulated dose.
    Language English
    Publishing date 2021-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 2452-1094
    ISSN 2452-1094
    DOI 10.1016/j.adro.2021.100650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Feasibility of bone marrow sparing volumetric modulated arc therapy to spare active bone marrow in cervical and vaginal cancer patients: a retrospective dosimetric analysis.

    Beavan, Michaela / Dundas, Kylie / Hudson, Felicity / Surjan, Yolanda / Lau, Annie / Deshpande, Shrikant / Lim, Karen / Do, Viet

    Journal of medical radiation sciences

    2021  Volume 68, Issue 4, Page(s) 379–388

    Abstract: Introduction: Chemoradiotherapy (CRT) is the standard treatment for locally advanced cervical and vaginal cancer. It is associated with high haematological toxicity (HT) that can lead to treatment interruptions and cancelled chemotherapy cycles, ... ...

    Abstract Introduction: Chemoradiotherapy (CRT) is the standard treatment for locally advanced cervical and vaginal cancer. It is associated with high haematological toxicity (HT) that can lead to treatment interruptions and cancelled chemotherapy cycles, reducing the potential effectiveness of this regimen. Bone marrow sparing (BMS) utilising volumetric modulated arc therapy (VMAT) is one method to reduce dose to the active bone marrow (ABM) so that HT rates are reduced. The aim of this paper was to assess whether BMS-VMAT can effectively spare the ABM whilst maintaining clinically acceptable target and organ-at-risk (OAR) doses.
    Methods: Twenty gynaecological cancer patients treated with definitive CRT at the Liverpool/Macarthur Cancer Therapy centres between 2015 and 2020 were retrospectively included. ABM was delineated based on fluorodeoxyglucose positron emission tomography (FDG-PET) imaging. Weekly blood tests and ABM dose parameters at the V10Gy, V20Gy, V30Gy, V40Gy and Dmean were assessed on original plans for any potential correlation with grade 2+ HT. Replanned with VMAT for BMS, various dose parameters were compared with the original plan to assess for any significant differences.
    Results: Active bone marrow doses were significantly reduced (P < 0.001 for all parameters) in BMS-VMAT plans, and significant improvements in target and OAR coverage were found compared with the original plans. Compared with VMAT only, target and OARs were comparable. No significant correlations between HT and ABM doses were found.
    Conclusion: Bone marrow sparing volumetric modulated arc therapy can significantly reduce dose to the active bone marrow whilst maintaining acceptable target and OAR doses. Future prospective trials are needed to evaluate the clinical impact of BMS on toxicity and compliance.
    MeSH term(s) Bone Marrow ; Feasibility Studies ; Female ; Humans ; Organs at Risk ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated/adverse effects ; Retrospective Studies ; Vaginal Neoplasms
    Language English
    Publishing date 2021-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2734841-6
    ISSN 2051-3909 ; 2051-3909
    ISSN (online) 2051-3909
    ISSN 2051-3909
    DOI 10.1002/jmrs.529
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  6. Article: Anterior ischemic optic neuropathy following dengue fever.

    Ramakrishnan, Reshma / Shrivastava, Saurabh / Deshpande, Shrikant / Patkar, Priyanka

    Oman journal of ophthalmology

    2016  Volume 9, Issue 3, Page(s) 160–163

    Abstract: Dengue fever is caused by a flavivirus. This infection is endemic in the tropics and warm temperate regions of the world. Ocular manifestations of dengue fever include subconjunctival, vitreous, and retinal haemorrhages; posterior uveitis; optic neuritis; ...

    Abstract Dengue fever is caused by a flavivirus. This infection is endemic in the tropics and warm temperate regions of the world. Ocular manifestations of dengue fever include subconjunctival, vitreous, and retinal haemorrhages; posterior uveitis; optic neuritis; and maculopathies, haemorrhage, and oedema. However anterior ischemic optic neuropathy is a rare presentation. Optic nerve ischemia most frequently occurs at the optic nerve head, where structural crowding of nerve fibers and reduction of the vascular supply may combine to impair perfusion to a critical degree and produce optic disc oedema. Here we present a case of anterior ischemic optic neurapathy associated with dengue fever.
    Language English
    Publishing date 2016-11-02
    Publishing country India
    Document type Case Reports
    ZDB-ID 2484272-2
    ISSN 0974-7842 ; 0974-620X
    ISSN (online) 0974-7842
    ISSN 0974-620X
    DOI 10.4103/0974-620X.192272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Mapping binding epitopes of monoclonal antibodies targeting major histocompatibility complex class I chain-related A (MICA) with hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry

    Huang, Richard Y.-C / Kuhne, Michelle / Deshpande, Shrikant / Rangan, Vangipuram / Srinivasan, Mohan / Wang, Yun / Chen, Guodong

    Analytical and bioanalytical chemistry. 2020 Mar., v. 412, no. 7

    2020  

    Abstract: Major histocompatibility complex class I chain-related A and B (MICA/B) are cell-surface proteins that act as ligands to natural killer cell receptors, NKG2D, expressed on immune cells. Prevention of proteolytic shedding of MICA/B to retain their ... ...

    Abstract Major histocompatibility complex class I chain-related A and B (MICA/B) are cell-surface proteins that act as ligands to natural killer cell receptors, NKG2D, expressed on immune cells. Prevention of proteolytic shedding of MICA/B to retain their integrity on the cell surface has become a therapeutic strategy in immuno-oncology. Given the unique mechanism of MICA/B shedding, structural characterization of MICA/B and therapeutic agent interaction is important in the drug discovery process. In this study, we describe the practical utility of hydrogen/deuterium exchange mass spectrometry (HDX-MS) in epitope mapping studies of a cohort of four monoclonal antibodies targeting MICA in a rapid manner. HDX-MS followed by electron-transfer dissociation allows high-resolution refinement of binding epitopes. This integrated strategy offers, for the first time, molecular-level understanding of MICA’s conformational dynamics in solution as well as the unique mechanism of actions of these antibodies in targeting MICA. Graphical abstract
    Keywords deuterium ; dissociation ; drugs ; electron transfer ; epitope mapping ; epitopes ; ligands ; major histocompatibility complex ; mass spectrometry ; mechanism of action ; monoclonal antibodies ; natural killer cells ; proteolysis ; receptors ; surface proteins ; therapeutics
    Language English
    Dates of publication 2020-03
    Size p. 1693-1700.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ISSN 1618-2642
    DOI 10.1007/s00216-020-02409-x
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Development of multi-purpose 3D printed phantoms for MRI.

    Rai, Robba / Wang, Yu Feng / Manton, David / Dong, Bin / Deshpande, Shrikant / Liney, Gary P

    Physics in medicine and biology

    2019  Volume 64, Issue 7, Page(s) 75010

    Abstract: This work describes the development and application of 3D printed MRI phantoms. Unlike traditional phantoms these test objects are made from solid materials which can be imaged directly without filling. The models were manufactured using both MRI visible ...

    Abstract This work describes the development and application of 3D printed MRI phantoms. Unlike traditional phantoms these test objects are made from solid materials which can be imaged directly without filling. The models were manufactured using both MRI visible and invisible materials. The MRI visible materials were imaged on a 3T system to quantify their T
    MeSH term(s) Artifacts ; Humans ; Magnetic Resonance Imaging/methods ; Neoplasms/diagnostic imaging ; Phantoms, Imaging ; Printing, Three-Dimensional/instrumentation ; Reproducibility of Results ; Software
    Language English
    Publishing date 2019-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ab0b49
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Sensitivity evaluation of two commercial dosimeters in detecting Helical TomoTherapy treatment delivery errors.

    Deshpande, Shrikant / Geurts, Mark / Vial, Philip / Metcalfe, Peter / Holloway, Lois

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

    2017  Volume 37, Page(s) 68–74

    Abstract: Purpose: To assess the sensitivity of two commercial dosimetry systems in detecting Helical TomoTherapy (HT) delivery errors.: Method: Two commercial dosimeters i) MatriXX: Results: The gamma pass rate decreases with increase in error magnitude ... ...

    Abstract Purpose: To assess the sensitivity of two commercial dosimetry systems in detecting Helical TomoTherapy (HT) delivery errors.
    Method: Two commercial dosimeters i) MatriXX
    Results: The gamma pass rate decreases with increase in error magnitude for both dosimeters. ArcCHECK was insensitive for couch speed error up to 2.5% and jaw width error up to -1.5mm while MatriXX
    Conclusion: No statistically significant (p>0.05) differences exist in detecting the simulated delivery errors between MatriXX
    Language English
    Publishing date 2017-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1122650-x
    ISSN 1724-191X ; 1120-1797
    ISSN (online) 1724-191X
    ISSN 1120-1797
    DOI 10.1016/j.ejmp.2017.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Challenges in antibody-drug conjugate discovery: a bioconjugation and analytical perspective.

    Rao, Chetana / Rangan, Vangipuram S / Deshpande, Shrikant

    Bioanalysis

    2015  Volume 7, Issue 13, Page(s) 1561–1564

    MeSH term(s) Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibody Specificity ; Humans ; Immunoconjugates/chemistry ; Immunoconjugates/immunology
    Chemical Substances Antibodies, Monoclonal ; Immunoconjugates
    Language English
    Publishing date 2015
    Publishing country England
    Document type Editorial
    ISSN 1757-6199
    ISSN (online) 1757-6199
    DOI 10.4155/bio.15.81
    Database MEDical Literature Analysis and Retrieval System OnLINE

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