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  1. Article ; Online: The myofibroblast and Giulio Gabbiani: An inseparable couple celebrates their 50 years golden wedding anniversary.

    Desmoulière, Alexis / Hinz, Boris

    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

    2021  Volume 29, Issue 4, Page(s) 511–514

    Abstract: The term myofibroblast has been introduced 50 years ago by Gabbiani and coworkers in two subsequent studies that characterized these enigmatic cells morphologically and functionally. This editorial provides a brief historical overview on the discoverer ... ...

    Abstract The term myofibroblast has been introduced 50 years ago by Gabbiani and coworkers in two subsequent studies that characterized these enigmatic cells morphologically and functionally. This editorial provides a brief historical overview on the discoverer and the subject to introduce a theme issue on myofibroblasts that celebrates this important discovery. Owing to their central roles in promoting physiological wound healing but also excessive scarring of skin and internal organs, understanding myofibroblasts is key in developing strategies to manage scarless wound healing.
    MeSH term(s) Anniversaries and Special Events ; Cicatrix/pathology ; Humans ; Myofibroblasts/pathology ; Skin/pathology ; Wound Healing
    Language English
    Publishing date 2021-06-08
    Publishing country United States
    Document type Editorial ; Review
    ZDB-ID 1174873-4
    ISSN 1524-475X ; 1067-1927
    ISSN (online) 1524-475X
    ISSN 1067-1927
    DOI 10.1111/wrr.12942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Book ; Conference proceedings: Tissue repair and fibrosis

    Arora, P. D. / Desmoulière, Alexis

    the role of the myofibroblast

    (Current topics in pathology ; 93)

    1999  

    Event/congress Meeting on Mechanisms Involved in Tissue Repair and Fibrosis: Role of the Myofibroblast (Differentiation and Apoptosis) (1997, Lyon)
    Author's details A. Desmoulière ... (eds.). Contributors: P. D. Arora
    Series title Current topics in pathology ; 93
    Collection
    Keywords Wundheilung ; Myoblast ; Fibroblast ; Fibrose
    Subject Fibroplast ; Desmozyt ; Sarkoblast ; Myoplast ; Fibrosis ; Wunde
    Language English
    Size XVIII, 224 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book ; Conference proceedings
    HBZ-ID HT010091888
    ISBN 3-540-65244-2 ; 978-3-540-65244-1
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Sensitivity of a two-dimensional biomorphoelastic model for post-burn contraction.

    Egberts, Ginger / Desmoulière, Alexis / Vermolen, Fred / van Zuijlen, Paul

    Biomechanics and modeling in mechanobiology

    2022  Volume 22, Issue 1, Page(s) 105–121

    Abstract: We consider a two-dimensional biomorphoelastic model describing post-burn scar contraction. This model describes skin displacement and the development of the effective Eulerian strain in the tissue. Besides these mechanical components, signaling ... ...

    Abstract We consider a two-dimensional biomorphoelastic model describing post-burn scar contraction. This model describes skin displacement and the development of the effective Eulerian strain in the tissue. Besides these mechanical components, signaling molecules, fibroblasts, myofibroblasts, and collagen also play a significant role in the model. We perform a sensitivity analysis for the independent parameters of the model and focus on the effects on features of the relative surface area and the total strain energy density. We conclude that the most sensitive parameters are the Poisson's ratio, the equilibrium collagen concentration, the contraction inhibitor constant, and the myofibroblast apoptosis rate. Next to these insights, we perform a sensitivity analysis where the proliferation rates of fibroblasts and myofibroblasts are not the same. The impact of this model adaptation is significant.
    MeSH term(s) Wound Healing ; Skin ; Collagen ; Fibroblasts ; Myofibroblasts
    Chemical Substances Collagen (9007-34-5)
    Language English
    Publishing date 2022-10-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093052-5
    ISSN 1617-7940 ; 1617-7959
    ISSN (online) 1617-7940
    ISSN 1617-7959
    DOI 10.1007/s10237-022-01634-w
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  4. Article: Adipose-Derived Mesenchymal Stromal Cells in Regenerative Medicine: State of Play, Current Clinical Trials, and Future Prospects.

    Laloze, Jérôme / Fiévet, Loïc / Desmoulière, Alexis

    Advances in wound care

    2020  Volume 10, Issue 1, Page(s) 24–48

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Animals ; Burns/therapy ; Cell Plasticity ; Chronic Pain/therapy ; Cicatrix/therapy ; Clinical Trials as Topic ; Humans ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells/physiology ; Quality of Life ; Regenerative Medicine/methods ; Tissue Engineering/methods ; Wound Healing
    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2650541-1
    ISSN 2162-1934 ; 2162-1918
    ISSN (online) 2162-1934
    ISSN 2162-1918
    DOI 10.1089/wound.2020.1175
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  5. Article ; Online: The macrophage: a key player in the pathophysiology of peripheral neuropathies.

    Msheik, Zeina / El Massry, Mohamed / Rovini, Amandine / Billet, Fabrice / Desmoulière, Alexis

    Journal of neuroinflammation

    2022  Volume 19, Issue 1, Page(s) 97

    Abstract: Macrophages are present in all mammalian tissues and coexist with various cell types in order to respond to different environmental cues. However, the role of these cells has been underestimated in the context of peripheral nerve damage. More importantly, ...

    Abstract Macrophages are present in all mammalian tissues and coexist with various cell types in order to respond to different environmental cues. However, the role of these cells has been underestimated in the context of peripheral nerve damage. More importantly, macrophages display divergent characteristics, associated with their origin, and in response to the modulatory effects of their microenvironment. Interestingly, the advent of new techniques such as fate mapping and single-cell transcriptomics and their synergistic use has helped characterize in detail the origin and fate of tissue-resident macrophages in the peripheral nervous system (PNS). Furthermore, these techniques have allowed a better understanding of their functions from simple homeostatic supervisors to chief regulators in peripheral neuropathies. In this review, we summarize the latest knowledge about macrophage ontogeny, function and tissue identity, with a particular focus on PNS-associated cells, as well as their interaction with reactive oxygen species under physiological and pathological conditions. We then revisit the process of Wallerian degeneration, describing the events accompanying axon degeneration, Schwann cell activation and most importantly, macrophage recruitment to the site of injury. Finally, we review these processes in light of internal and external insults to peripheral nerves leading to peripheral neuropathies, the involvement of macrophages and the potential benefit of the targeting of specific macrophages for the alleviation of functional defects in the PNS.
    MeSH term(s) Animals ; Macrophages/pathology ; Mammals ; Peripheral Nerve Injuries/pathology ; Peripheral Nerves/pathology ; Schwann Cells/pathology ; Wallerian Degeneration/pathology
    Language English
    Publishing date 2022-04-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-022-02454-6
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  6. Article: Specific Features of Stromal Cells Isolated from the Two Layers of Subcutaneous Adipose Tissue: Roles of Their Secretion on Angiogenesis and Neurogenesis.

    Laloze, Jérôme / Lacoste, Marie / Marouf, Faris / Carpentier, Gilles / Vignaud, Laetitia / Chaput, Benoit / Varin, Audrey / Desmoulière, Alexis / Rovini, Amandine

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: Human-adipose-tissue-derived mesenchymal stromal cells (AD-MSCs) are currently being tested as autologous-cell-based therapies for use in tissue healing and regeneration. Recent studies have also demonstrated that AD-MSC-derived exosomes contribute to ... ...

    Abstract Human-adipose-tissue-derived mesenchymal stromal cells (AD-MSCs) are currently being tested as autologous-cell-based therapies for use in tissue healing and regeneration. Recent studies have also demonstrated that AD-MSC-derived exosomes contribute to tissue repair and peripheral nerve regeneration. Subcutaneous abdominal adipose tissue (AAT) is divided into two layers: the superficial layer (sAAT) and the deep layer (dAAT). However, it is unclear whether there are particular characteristics of each layer in terms of AD-MSC regenerative potential. Using AD-MSCs purified and characterized from three abdominoplasties, we compared their secretomes and exosome functions to identify which layer may be most suitable as a source for cell therapy. Phenotypical analysis of the AD-MSCs containing stromal vascular fraction did not reveal any difference between the two layers. The AD-MSC secretomes showed a very similar pattern of cytokine content and both layers were able to release exosomes with identical characteristics. However, compared to the secretome, the released exosomes showed better biological properties. Interestingly, dAAT exosomes appeared to be more effective on neuromodulation, whereas neither sAAT nor dAAT-derived exosomes had significant effects on endothelial function. It thus appears that AD-MSC-derived exosomes from the two abdominal adipose tissue layers possess different features for cell therapy.
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134214
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  7. Article ; Online: The myofibroblast, biological activities and roles in eye repair and fibrosis. A focus on healing mechanisms in avascular cornea.

    Rocher, Maxime / Robert, Pierre-Yves / Desmoulière, Alexis

    Eye (London, England)

    2019  Volume 34, Issue 2, Page(s) 232–240

    Abstract: Tissue healing is one of the mysteries of modern medicine. Healing involves complex processes and many cellular types, amongst which the myofibroblast plays a major role. In the eye, when needed, myofibroblasts can be found from the cornea to the retina, ...

    Abstract Tissue healing is one of the mysteries of modern medicine. Healing involves complex processes and many cellular types, amongst which the myofibroblast plays a major role. In the eye, when needed, myofibroblasts can be found from the cornea to the retina, derived from a wide variety of different cells, and aimed at effectively repairing tissue damage. Myofibroblast differentiation requires transforming growth factor (TGF)-β1, the presence of specific extracellular matrix components such as the ED-A domain of fibronectin, and mechanical tension. Control of this process may, in some cases, be abnormal leading to development of fibrotic tissue, which alters and compromises the integrity of the original tissue. The eye is no exception to this rule with normal visual function, a highly demanding process, only possible in a fully integrated organ. The cornea, a transparent protective tissue and first dioptre of the eye, has the particularity of being entirely avascular and very richly innervated under normal physiological conditions. However, these anatomical features do not prevent it from developing myofibroblasts in the event of a deep corneal lesion. Activated by growth factors such as TGF-β1 and platelet-derived growth factor from the aqueous humour, tears or corneal epithelial cells, myofibroblasts can cause corneal scarring, sometimes with devastating consequences. Understanding the factors involved in healing and its signalling pathways, will potentially enable us to control corneal healing in the future, and thus avoid fibrotic ocular surface disease and the blindness that this may induce. Currently, this issue is the subject of very active research and development with the aim of discovering new antifibrotic therapies.
    MeSH term(s) Cornea/pathology ; Corneal Diseases/pathology ; Corneal Injuries ; Fibrosis ; Humans ; Myofibroblasts/pathology ; Transforming Growth Factor beta1
    Chemical Substances Transforming Growth Factor beta1
    Language English
    Publishing date 2019-11-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-019-0684-8
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  8. Article ; Online: Supplementation with Extracellular Vesicles Derived from Adipose-Derived Stem Cells Increases Fat Graft Survival and Browning in Mice: A Cell-Free Approach to Construct Beige Fat from White Fat Grafting.

    Laloze, Jérôme / Lupon, Elise / Girard, Paul / Gandolfi, Silvia / Fiévet, Loïc / Desmoulière, Alexis

    Plastic and reconstructive surgery

    2021  Volume 147, Issue 5, Page(s) 884e–886e

    MeSH term(s) Adipose Tissue ; Adipose Tissue, Beige ; Adipose Tissue, White ; Animals ; Dietary Supplements ; Extracellular Vesicles ; Graft Survival ; Mice ; Stem Cells
    Language English
    Publishing date 2021-04-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000007821
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  9. Article: Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging.

    Fournet, Maxime / Bonté, Frédéric / Desmoulière, Alexis

    Aging and disease

    2018  Volume 9, Issue 5, Page(s) 880–900

    Abstract: Glycation is both a physiological and pathological process which mainly affects proteins, nucleic acids and lipids. Exogenous and endogenous glycation produces deleterious reactions that take place principally in the extracellular matrix environment or ... ...

    Abstract Glycation is both a physiological and pathological process which mainly affects proteins, nucleic acids and lipids. Exogenous and endogenous glycation produces deleterious reactions that take place principally in the extracellular matrix environment or within the cell cytosol and organelles. Advanced glycation end product (AGE) formation begins by the non-enzymatic glycation of free amino groups by sugars and aldehydes which leads to a succession of rearrangements of intermediate compounds and ultimately to irreversibly bound products known as AGEs. Epigenetic factors, oxidative stress, UV and nutrition are important causes of the accumulation of chemically and structurally different AGEs with various biological reactivities. Cross-linked proteins, deriving from the glycation process, present both an altered structure and function. Nucleotides and lipids are particularly vulnerable targets which can in turn favor DNA mutation or a decrease in cell membrane integrity and associated biological pathways respectively. In mitochondria, the consequences of glycation can alter bioenergy production. Under physiological conditions, anti-glycation defenses are sufficient, with proteasomes preventing accumulation of glycated proteins, while lipid turnover clears glycated products and nucleotide excision repair removes glycated nucleotides. If this does not occur, glycation damage accumulates, and pathologies may develop. Glycation-induced biological products are known to be mainly associated with aging, neurodegenerative disorders, diabetes and its complications, atherosclerosis, renal failure, immunological changes, retinopathy, skin photoaging, osteoporosis, and progression of some tumors.
    Language English
    Publishing date 2018-10-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2017.1121
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  10. Article: Hepatic stellate cells: the only cells involved in liver fibrogenesis? A dogma challenged.

    Desmoulière, Alexis

    Gastroenterology

    2007  Volume 132, Issue 5, Page(s) 2059–2062

    MeSH term(s) Animals ; Carbon Tetrachloride ; Disease Models, Animal ; Gene Expression Profiling ; Gene Expression Regulation ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Ligation ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Mice
    Chemical Substances Carbon Tetrachloride (CL2T97X0V0)
    Language English
    Publishing date 2007-05
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2007.03.075
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