LIVIVO - Search results -

Search results

Result 1 - 10 of total 44

Search options

Article ; Online: Glycated Albumin Correlates With Time-in-Range Better Than HbA1c or Fructosamine.

Desouza, Cyrus V / Rosenstock, Julio / Kohzuma, Takuji / Fonseca, Vivian A

The Journal of clinical endocrinology and metabolism

2023 Volume 108, Issue 11, Page(s) e1193–e1198

Abstract: Context: Intermediate-term glycemic control metrics may represent a viable alternative to continuous glucose monitoring (CGM) in patients without access to CGM.: Objective: This work aimed to compare the relationship between CGM parameters and ... ...

Abstract	Context: Intermediate-term glycemic control metrics may represent a viable alternative to continuous glucose monitoring (CGM) in patients without access to CGM. Objective: This work aimed to compare the relationship between CGM parameters and glycated albumin (GA), glycated hemoglobin A1c (HbA1c), and fructosamine for 24 weeks. Methods: We conducted exploratory comparative analyses of CGM subgroup data from a previously published 24-week prospective study of assay performance in 8 US clinics. Participants included 34 individuals with type 1 (n = 18) and type 2 diabetes (n = 16) undergoing changes to improve glycemic control (n = 22; group 1) or with stable diabetes therapy (n = 12; group 2). Main outcome measures included Pearson correlations between CGM and glycemic indices and receiver operating characteristic (ROC) analysis of glycemic index values predictive of time in range (TIR) greater than 70%. Results: At weeks 4 and 8, GA correlations with TIR were higher than HbA1c correlations in group 1. In group 2, GA correlations with TIR were statistically significant, whereas HbA1c correlations were not. In both groups over the first 12 weeks, GA correlations with TIR were higher than fructosamine-TIR correlations. In the ROC analysis, GA predicted a TIR greater than 70% during weeks 2 to 24 (area under the curve >0.80); HbA1c was predictive during weeks 12 to 24. Cutoff values for TIR greater than 70% were 17.5% (sensitivity and specificity, 0.88) for GA and 7.3% (0.86) for HbA1c. Conclusion: GA is the most accurate predictor of TIR over 8 weeks compared with other glycemic indices, which may assist in clinical evaluation of changes in treatment where CGM is not possible and it is too early to use HbA1c (NCT02489773).
MeSH term(s)	Humans ; Glycated Hemoglobin ; Diabetes Mellitus, Type 2/drug therapy ; Fructosamine ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring ; Prospective Studies ; Glycated Serum Albumin ; Glycation End Products, Advanced ; Serum Albumin
Chemical Substances	Glycated Hemoglobin ; Fructosamine (4429-04-3) ; Blood Glucose ; Glycated Serum Albumin ; Glycation End Products, Advanced ; Serum Albumin
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgad298
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.134: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Glycemic control level alters working memory neural dynamics in adults with type 2 diabetes.

Embury, Christine M / Lord, Grace H / Drincic, Andjela T / Desouza, Cyrus V / Wilson, Tony W

Cerebral cortex (New York, N.Y. : 1991)

2023 Volume 33, Issue 13, Page(s) 8333–8341

Abstract: Poor glycemic control in type 2 diabetes has been associated with accentuated age-related cognitive decline, although the underlying neural mechanisms are not well understood. The current study sought to identify the impact of glycemic control on the ... ...

Abstract	Poor glycemic control in type 2 diabetes has been associated with accentuated age-related cognitive decline, although the underlying neural mechanisms are not well understood. The current study sought to identify the impact of glycemic control on the neural dynamics serving working memory in adults with type 2 diabetes. Participants (n = 34, ages = 55-73) performed a working memory task while undergoing MEG. Significant neural responses were examined relative to poorer (A1c > 7.0%) or tighter glycemic control (A1c < 7.0%). Those with poorer glycemic control showed diminished responses within left temporal and prefrontal regions during encoding and showed diminished responses within right occipital cortex during maintenance but showed an enhanced activity in the left temporal, occipital, and cerebellar regions during maintenance. Notably, left temporal activity in encoding and left lateral occipital activity in maintenance significantly predicted performance on the task such that diminished temporal activity led to longer reaction times, which were driven by the poorer glycemic control group. Greater lateral occipital activity during maintenance was associated with both lower accuracy and longer reaction times across all participants. These findings suggest that glycemic control has a robust impact on the neural dynamics serving working memory, with distinct effects by subprocess (e.g. encoding vs. maintenance) and direct effects on behavior.
MeSH term(s)	Humans ; Adult ; Memory, Short-Term/physiology ; Magnetoencephalography ; Brain Mapping ; Diabetes Mellitus, Type 2/complications ; Glycated Hemoglobin ; Glycemic Control
Chemical Substances	Glycated Hemoglobin
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhad119
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3235: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: A Pilot Study on the Proteomics Profile of Serum Exosome-Enriched Extracellular Vesicles from Normal versus Individuals with Obesity-Related Insulin Resistance.

Saraswathi, Viswanathan / Ai, Weilun / Kumar, Vikas / Sharma, Kanika / Gopal, Thiyagarajan / Kumar, Narendra / Malhi, Harmeet / Sehrawat, Tejasav / Desouza, Cyrus V

Biomedicines

2024 Volume 12, Issue 4

Abstract: Objective: Circulating exosome-enriched extracellular vesicles (EVs) have drawn considerable importance in obesity-related insulin-resistance (IR). We sought to compare the proteomics profile of serum exosomes from normal individuals and those with ... ...

Abstract	Objective: Circulating exosome-enriched extracellular vesicles (EVs) have drawn considerable importance in obesity-related insulin-resistance (IR). We sought to compare the proteomics profile of serum exosomes from normal individuals and those with obesity and IR. Methods: We isolated serum exosomes from male subjects with obesity and insulin resistance (Ob-IR, HOMA-IR > 2.0) and lean/overweight insulin-sensitive (Normal (N), HOMA-IR < 2.0) individuals. The differential protein expression between the two groups was detected by a label-free quantitative mass spectrometry analysis followed by GO annotation and ingenuity pathway analysis (IPA). Results: We identified 23 upregulated and 46 downregulated proteins between Ob-IR and N groups. Some of these proteins are involved in altering insulin signaling (VPS13C, TBC1D32, TTR, and ADIPOQ), inflammation (NFκB and CRP), and B-cell proliferation/activation (IGLV4-69, IGKV1D-13, and IGHV4-28). GO analysis revealed that the differentially expressed proteins (DEPs) are mainly involved in regulating immune cell activation and are located in extracellular space. IPA analysis showed that top molecules mediating IR, inflammation and B-cell activation were upregulated in Ob-IR subjects compared to N subjects. Conclusions: Serum exosomal proteins can be used as biomarkers to identify the future risk of diabetes and a therapeutic target to prevent or slow down the progression of diabetes in high-risk individuals.
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12040799
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Does drug therapy reverse endothelial progenitor cell dysfunction in diabetes?

Desouza, Cyrus V

Journal of diabetes and its complications

2013 Volume 27, Issue 5, Page(s) 519–525

Abstract: Endothelial progenitor cells (EPCs) are vital for the maintenance and repair of the endothelium. Decreased EPC number and function have been associated with increased cardiovascular (CVD) risk. Patients with diabetes have decreased number of circulating ... ...

Abstract	Endothelial progenitor cells (EPCs) are vital for the maintenance and repair of the endothelium. Decreased EPC number and function have been associated with increased cardiovascular (CVD) risk. Patients with diabetes have decreased number of circulating EPCs and decreased EPC function. This may account for some of the increased CVD risk seen in patients with diabetes that is not explained by traditional risk factors such as glycemic control, dyslipidemia and hypertension. Recent studies seem to indicate that drugs commonly used in diabetes patients such as metformin, thiazolidinediones, GLP-1 agonists, DPP-4 inhibitors, insulin, statins and ACE inhibitors may increase EPC number and improve EPC function. The mechanisms by which these drugs modulate EPC function may involve reduction in inflammation, oxidative stress and insulin resistance as well as an increase in nitric oxide (NO) bioavailability. This review will discuss the evidence in the literature regarding the above mentioned topics.
MeSH term(s)	Animals ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/physiopathology ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiopathology ; Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Stem Cells/drug effects ; Stem Cells/physiology
Chemical Substances	Hypoglycemic Agents
Language	English
Publishing date	2013-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	1105840-7
ISSN	1873-460X ; 1056-8727
ISSN (online)	1873-460X
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2013.04.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2225: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Differential impact of glycemic control and comorbid conditions on the neurophysiology underlying task switching in older adults with type 2 diabetes.

Embury, Christine M / Lord, Grace H / Drincic, Andjela T / Desouza, Cyrus V / Wilson, Tony W

Aging

2022 Volume 14, Issue 12, Page(s) 4976–4989

Abstract: Type 2 diabetes is known to negatively affect higher order cognition and the brain, but the underlying mechanisms are not fully understood. In particular, glycemic control and common comorbidities are both thought to contribute to alterations in cortical ...

Abstract	Type 2 diabetes is known to negatively affect higher order cognition and the brain, but the underlying mechanisms are not fully understood. In particular, glycemic control and common comorbidities are both thought to contribute to alterations in cortical neurophysiology in type 2 diabetes, but their specific impact remains unknown. The current study probed the dynamics underlying cognitive control in older participants with type 2 diabetes, with and without additional comorbid conditions (i.e., cardiovascular disease, nephropathy, peripheral neuropathy, retinopathy), using a task switching paradigm and a dynamic functional brain mapping method based on magnetoencephalography (MEG). We hypothesized that neural dynamics would be differentially impacted by the level of glycemic control (i.e., diabetes itself) and the burden of additional comorbid conditions. Supporting this hypothesis, our findings indicated separable, but widespread alterations across frontal, parietal, temporal and cerebellum regions in neural task-switch costs in type 2 diabetes that were differentially attributable to glycemic control and the presence of comorbid conditions. These effects were spatially non-overlapping and the effects were not statistically related to one another. Further, several of the effects that were related to the presence of comorbidities were associated with behavioral performance, indicating progressive deficits in brain function with extended disease. These findings provide insight on the underlying neuropathology and may inform future treatment plans to curtail the neural impact of type 2 diabetes.
MeSH term(s)	Aged ; Brain ; Brain Mapping/methods ; Cognition/physiology ; Diabetes Mellitus, Type 2 ; Glycemic Control ; Humans ; Magnetoencephalography/methods
Language	English
Publishing date	2022-06-17
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204129
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Investigating Speed Deviation Patterns During Glucose Episodes

Joshi, Aparna / Merickel, Jennifer / Desouza, Cyrus V. / Rizzo, Matthew / Gunaratne, Pujitha / Sharma, Anuj

A Quantile Regression Approach

2023

Abstract: Given the growing prevalence of diabetes, there has been significant interest in determining how diabetes affects instrumental daily functions, like driving. Complication of glucose control in diabetes includes hypoglycemic and hyperglycemic episodes, ... ...

Abstract	Given the growing prevalence of diabetes, there has been significant interest in determining how diabetes affects instrumental daily functions, like driving. Complication of glucose control in diabetes includes hypoglycemic and hyperglycemic episodes, which may impair cognitive and psychomotor functions needed for safe driving. The goal of this paper was to determine patterns of diabetes speed behavior during acute glucose to drivers with diabetes who were euglycemic or control drivers without diabetes in a naturalistic driving environment. By employing distribution-based analytic methods which capture distribution patterns, our study advances prior literature that has focused on conventional approach of average speed to explore speed deviation patterns. Comment: 6 pages, 2 figures, 5 Tables, Accepted and Presented at IEEE ITSC 2023 Conference in Bilbao Spain
Keywords	Statistics - Applications ; Computer Science - Machine Learning
Publishing date	2023-10-03
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Racial differences in measures of glycemia in the Vitamin D and Type 2 Diabetes (D2d) Study: a secondary analysis of a randomized trial.

LeBlanc, Erin S / Pittas, Anastassios G / Nelson, Jason / Chatterjee, Ranee / Rasouli, Neda / Rhee, Mary K / Pratley, Richard E / Desouza, Cyrus V / Neff, Lisa M / Peters, Anne M / Dagogo-Jack, Samuel / Hsia, Daniel S

BMJ open diabetes research & care

2024 Volume 12, Issue 1

Abstract: Introduction: Understanding how race may influence the association between A1c and glycemia can improve diabetes screening. We sought to determine whether, for a given A1c level, glucose levels during an oral glucose tolerance test (OGTT) differed by ... ...

Abstract	Introduction: Understanding how race may influence the association between A1c and glycemia can improve diabetes screening. We sought to determine whether, for a given A1c level, glucose levels during an oral glucose tolerance test (OGTT) differed by race. Research design and methods: From data collected at 22 US clinical sites, we conducted a cross-sectional study of concurrently measured A1c and OGTT and observational longitudinal follow-up of the subset with high-risk pre-diabetes. Numerical integration methods were used to calculate area under the glycemic curve (AUC Results: 1016 black, 2658 white, and 193 Asian persons at risk of diabetes were included in cross-sectional analysis. Of these, 2154 with high-risk pre-diabetes were followed for 2.5 years. For a given A1c level, AUC Conclusions: Use of additional testing beyond A1c to screen for diabetes may better stratify diabetes risk in the diverse US population.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/diagnosis ; Prediabetic State/epidemiology ; Prediabetic State/diagnosis ; Vitamin D ; Cross-Sectional Studies ; Glycated Hemoglobin ; Blood Glucose/analysis ; Race Factors ; Vitamins ; White
Chemical Substances	Vitamin D (1406-16-2) ; Glycated Hemoglobin ; Blood Glucose ; Vitamins
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2732918-5
ISSN	2052-4897 ; 2052-4897
ISSN (online)	2052-4897
ISSN	2052-4897
DOI	10.1136/bmjdrc-2023-003613
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Does drug therapy reverse endothelial progenitor cell dysfunction in diabetes?

Desouza, Cyrus V

Journal of diabetes and its complications. 2013 , v. 27, no. 5

2013

Abstract	Endothelial progenitor cells (EPCs) are vital for the maintenance and repair of the endothelium. Decreased EPC number and function have been associated with increased cardiovascular (CVD) risk. Patients with diabetes have decreased number of circulating EPCs and decreased EPC function. This may account for some of the increased CVD risk seen in patients with diabetes that is not explained by traditional risk factors such as glycemic control, dyslipidemia and hypertension. Recent studies seem to indicate that drugs commonly used in diabetes patients such as metformin, thiazolidinediones, GLP-1 agonists, DPP-4 inhibitors, insulin, statins and ACE inhibitors may increase EPC number and improve EPC function. The mechanisms by which these drugs modulate EPC function may involve reduction in inflammation, oxidative stress and insulin resistance as well as an increase in nitric oxide (NO) bioavailability. This review will discuss the evidence in the literature regarding the above mentioned topics.
Keywords	agonists ; angiotensin-converting enzyme inhibitors ; bioavailability ; diabetes ; drug therapy ; endothelium ; glucagon-like peptide 1 ; glycemic control ; hyperlipidemia ; hypertension ; inflammation ; insulin ; insulin resistance ; maintenance and repair ; metformin ; nitric oxide ; oxidative stress ; patients ; risk factors ; stem cells ; thiazolidinediones
Language	English
Dates of publication	2013-09
Size	p. 519-525.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1105840-7
ISSN	1056-8727
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2013.04.007
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2225: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Myristic Acid Supplementation Aggravates High Fat Diet-Induced Adipose Inflammation and Systemic Insulin Resistance in Mice.

Saraswathi, Viswanathan / Kumar, Narendra / Ai, Weilun / Gopal, Thiyagarajan / Bhatt, Saumya / Harris, Edward N / Talmon, Geoffrey A / Desouza, Cyrus V

Biomolecules

2022 Volume 12, Issue 6

Abstract: Saturated fatty acids (SFAs) are considered to be detrimental to human health. One of the SFAs, myristic acid (MA), is known to exert a hypercholesterolemic effect in mice as well as humans. However, its effects on altering adipose tissue (AT) ... ...

Abstract	Saturated fatty acids (SFAs) are considered to be detrimental to human health. One of the SFAs, myristic acid (MA), is known to exert a hypercholesterolemic effect in mice as well as humans. However, its effects on altering adipose tissue (AT) inflammation and systemic insulin resistance (IR) in obesity are still unclear. Here, we sought to determine the effects of a high fat (HF) diet supplemented with MA on obesity-associated metabolic disorders in mice. Wild-type C57BL/6 mice were fed a HF diet in the presence or absence of 3% MA for 12 weeks. Plasma lipids, plasma adipokines, AT inflammation, systemic IR, glucose homeostasis, and hepatic steatosis were assessed. The body weight and visceral adipose tissue (VAT) mass were significantly higher in mice receiving the HF+MA diet compared to HF diet-fed controls. Plasma total cholesterol levels were marginally increased in HF+MA-fed mice compared to controls. Fasting blood glucose was comparable between HF and HF+MA-fed mice. Interestingly, the plasma insulin and HOMA-IR index, a measure of insulin resistance, were significantly higher in HF+MA-fed mice compared to HF controls. Macrophage and inflammatory markers were significantly elevated in the AT and AT-derived stromal vascular cells upon MA feeding. Moreover, the level of circulating resistin, an adipokine promoting insulin resistance, was significantly higher in HF+MA-fed mice compared with HF controls. The insulin tolerance test revealed that the IR was higher in mice receiving the MA supplementation compared to HF controls. Moreover, the glucose tolerance test showed impairment in systemic glucose homeostasis in MA-fed mice. Analyses of liver samples showed a trend towards an increase in liver TG upon MA feeding. However, markers of oxidative stress and inflammation were reduced in the liver of mice fed an MA diet compared to controls. Taken together, our data suggest that chronic administration of MA in diet exacerbates obesity-associated insulin resistance and this effect is mediated in part, via increased AT inflammation and increased secretion of resistin.
MeSH term(s)	Adipokines/metabolism ; Adipose Tissue/metabolism ; Animals ; Diet, High-Fat/adverse effects ; Dietary Supplements ; Glucose/metabolism ; Inflammation/metabolism ; Insulin/metabolism ; Insulin Resistance ; Insulins/metabolism ; Insulins/pharmacology ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Myristic Acid ; Obesity/metabolism ; Resistin/metabolism
Chemical Substances	Adipokines ; Insulin ; Insulins ; Resistin ; Myristic Acid (0I3V7S25AW) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-05-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12060739
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The effect of nonpharmaceutical weight-loss interventions in rural patients with diabetes: RE-POWER Diabetes.

Desouza, Cyrus V / Johnson-Rabbett, Brianna E / Gajewski, Byron / Brown, Alexandra / Ellerbeck, Edward F / VanWormer, Jeffrey J / Befort, Christie

Obesity (Silver Spring, Md.)

2022 Volume 30, Issue 4, Page(s) 884–892

Abstract: Objective: In this secondary analysis of the Rural Engagement in Primary Care for Optimizing Weight Reduction (RE-POWER) randomized trial, the authors determined the effectiveness of weight-loss interventions in people with diabetes compared with those ... ...

Abstract	Objective: In this secondary analysis of the Rural Engagement in Primary Care for Optimizing Weight Reduction (RE-POWER) randomized trial, the authors determined the effectiveness of weight-loss interventions in people with diabetes compared with those without diabetes living in rural areas. Methods: The RE-POWER study was a randomized trial designed to determine the effectiveness of nonpharmacological behavioral weight-loss interventions in rural participants with obesity, comparing the individual in-clinic visit model to in-person group sessions and phone group sessions over 24 months. In this secondary analysis, weight loss was compared in participants with and without diabetes. The effects of factors such as medications, insulin, and behavioral factors were compared. Results: Participants with diabetes were less likely to lose weight during the study compared with those without diabetes up to 18 months (4.12% vs. 5.31%; net difference = 1.46%; 95% CI: 0.63%-2.28%). Participants with diabetes on insulin lost less weight than patients with diabetes not on insulin at 6 months (4.52% vs. 6.88%; net difference = 2.35%; 95% CI: 0.55%-4.16%). The group with diabetes had significantly lower changes in blood pressure and lipid parameters versus the group without diabetes. Conclusions: Patients with diabetes in rural areas were less likely to lose weight, and metabolic parameters were less responsive to weight loss, compared with patients without diabetes.
MeSH term(s)	Diabetes Mellitus/epidemiology ; Diabetes Mellitus/therapy ; Humans ; Insulin/therapeutic use ; Obesity/therapy ; Rural Population ; Weight Loss/physiology
Chemical Substances	Insulin
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.23392
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4061: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 87: Show issues

Order via subito

Details ▾

To top

Your last searches

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito