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  1. AU="Despoina, Krokou"
  2. AU="Gardner, Andrew M."
  3. AU="Regina Célia Vilanova-Campelo"
  4. AU="Hughes, Jaime"
  5. AU="Gewirtz, Jonathan C."
  6. AU="Beecher, Darragh"
  7. AU="Humphreys, Alice"
  8. AU="Hellyanti, Tantri"
  9. AU="Roche, M."
  10. AU="Brusseau, Valentin"
  11. AU="LeBlanc, Jean-Charles"
  12. AU=Balestrino R AU=Balestrino R
  13. AU="Min Dai"
  14. AU=Azapira Negar
  15. AU="Hernández-Santana, Amalia"
  16. AU=Riad Abanoub
  17. AU="Battalora, Linda"
  18. AU="Winchester, Laura"
  19. AU="Agarwal, Amil R"
  20. AU="Louka, Eleni"
  21. AU="Mason, William J"
  22. AU="Krishnan, Nadiya"
  23. AU="David P. Looney"
  24. AU="Vitus Burimuah"
  25. AU="Anderson, Kevin J"
  26. AU="D'costa, Pradeep"
  27. AU="Dossou, Bonaventure F. P."
  28. AU="Wang, S Z"
  29. AU="Andreko, Susan K"
  30. AU="Ames, DeWayne"
  31. AU="Fokom Domgue, Joel"
  32. AU="Soubani, Ayman O"
  33. AU="Weir, Andrew"
  34. AU="McGowan, Alessia"
  35. AU=Hoepler Wolfgang AU=Hoepler Wolfgang
  36. AU="Pintér, Nándor K"
  37. AU=Linask Kersti K
  38. AU="Arya, Akanksha"
  39. AU="Jue, Nathaniel"
  40. AU="Favaro, Enrica"
  41. AU="Santana, Margarida M"
  42. AU="Wiegand, Ryan E"
  43. AU="Cosio, Daniela S"
  44. AU="Yasuda, Michiyuki"
  45. AU="Theodoratou, Evropi"
  46. AU="Ernfors, Patrik"
  47. AU="Pingel, Simon"
  48. AU="W. T. Lawrence"
  49. AU="Tietzmann, Marcel"
  50. AU="DeRenzo, Christopher"

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  1. Artikel: Sporadic parathyroid adenoma: an updated review of molecular genetics.

    Chorti, Angeliki / Cheva, Angeliki / Chatzikyriakidou, Anthoula / Achilla, Charoula / Boulogeorgou, Kassiani / Despoina, Krokou / Milias, Stefanos / Zarampoukas, Thomas / Papavramidis, Theodossis

    Frontiers in endocrinology

    2023  Band 14, Seite(n) 1180211

    Abstract: Introduction: Primary HPT (PHPT) is a common disorder, affecting approximately 1% of the general population. Parathyroid adenomas emerge as non-familial sporadic in 90% of cases. The aim of this review is to give a detailed update of molecular genetics ... ...

    Abstract Introduction: Primary HPT (PHPT) is a common disorder, affecting approximately 1% of the general population. Parathyroid adenomas emerge as non-familial sporadic in 90% of cases. The aim of this review is to give a detailed update of molecular genetics of sporadic parathyroid adenoma reported in international literature.
    Methods: A bibliographic research was conducted in PubMed, Google Scholar, and Scopus.
    Results: Seventy-eight articles were included in our review. CaSR, MEN1, CCND1/PRAD, CDKI, angiogenic factors like VEGF, FGF, TGFβ, and IGF1, and apoptotic factors are important genes in parathyroid adenomas pathogenesis that have been established by several studies. A huge list of proteins is differently expressed in parathyroid adenomas measured by Western Blotting, MALDI/TOF, MS spectrometry, and immunohistochemistry. These proteins take part in several cell processes such as cell metabolism, cytoskeleton structural stability, cell oxidative stress regulation, cell death, transcription, translation, cell connection, and cell signaling transmission, while they can be found over- or underexpressed in abnormal tissues.
    Conclusion: This review gives a detailed analysis of all reported data on genomics and proteomics of parathyroid adenoma. Further studies should be applied on understanding parathyroid adenoma pathogenesis and introducing new biomarkers for early detection of primary hyperparathyroidism.
    Mesh-Begriff(e) Humans ; Parathyroid Neoplasms/genetics ; Cell Cycle ; Blotting, Western ; Cell Death ; Molecular Biology
    Sprache Englisch
    Erscheinungsdatum 2023-05-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1180211
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Right Paraduodenal Hernia as a Cause of Acute Abdominal Pain in the Emergency Department

    Viktoria Lamprou / Despoina Krokou / Eleni Karlafti / Stavros Panidis / Leonidas Kougias / Georgios Tzikos / Aristeidis Ioannidis / Smaro Netta / Evanthia Thomaidou / Daniel Paramythiotis

    Diagnostics, Vol 12, Iss 2742, p

    A Case Report and Review of the Literature

    2022  Band 2742

    Abstract: Paraduodenal hernias (PDHs) represent an unusual cause of acute abdominal pain in the Emergency Department (ED) and are associated with high morbidity attributable to a challenging clinical and radiological diagnosis, as signs and symptoms mimic other ... ...

    Abstract Paraduodenal hernias (PDHs) represent an unusual cause of acute abdominal pain in the Emergency Department (ED) and are associated with high morbidity attributable to a challenging clinical and radiological diagnosis, as signs and symptoms mimic other frequent causes of acute abdominal pain. We report a right paraduodenal hernia in a 37-year-old female patient who presented to the ED complaining of abdominal pain located in the right lower abdomen and hypogastrium, accompanied by nausea. During diagnostic work up, the abdominal computed tomography scan revealed the presence of small bowel malrotation with concomitant right paraduodenal hernia. These findings were confirmed intraoperatively. We performed a brief literature review about the clinical manifestations and treatment options of right paraduodenal hernias, which retrieved only 30 articles related to this condition. Prompt diagnosis, radiological or intraoperative, of paraduodenal hernias is crucial because nearly 50% will progress to small bowel obstruction. Therefore, it is essential for every clinician to account for them in the differential diagnosis of acute abdominal pain in the ED.
    Schlagwörter acute abdomen ; internal hernia ; bowel malrotation ; bowel obstruction ; laparoscopy ; laparotomy ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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