LIVIVO - Search results -

Search results

Result 1 - 10 of total 18

Search options

Article ; Online: Clear-cell renal cell carcinoma single thyroid metastasis: A single-center retrospective analysis and review of the literature.

Ricci, Isabella / Barillaro, Francesco / Conti, Enrico / Intersimone, Donatella / Dessanti, Paolo / Aschele, Carlo

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2021 Volume 93, Issue 1, Page(s) 68–70

Abstract: Renal cell carcinoma (RCC) is known to cause metastasis to unusual sites, which can be both synchronous or metachronous. Thyroid gland is a rare site for metastasis. However, RCC is the most common primary neoplasm to metastasize to the Thyroid gland. ... ...

Abstract	Renal cell carcinoma (RCC) is known to cause metastasis to unusual sites, which can be both synchronous or metachronous. Thyroid gland is a rare site for metastasis. However, RCC is the most common primary neoplasm to metastasize to the Thyroid gland. Report of three cases and review of the literature.
MeSH term(s)	Aged ; Carcinoma, Renal Cell/secondary ; Female ; Humans ; Kidney Neoplasms/pathology ; Male ; Middle Aged ; Retrospective Studies ; Thyroid Neoplasms/secondary
Language	English
Publishing date	2021-03-19
Publishing country	Italy
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1120-8538 ; 1124-3562
ISSN (online)	2282-4197
ISSN	1120-8538 ; 1124-3562
DOI	10.4081/aiua.2021.1.68
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui VI Zs.182: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Assessment of interferon-γ in pleural fluid as a prognostic factor of survival in malignant pleural mesothelioma.

Dozin, Beatrice / Carbotti, Grazia / Roncella, Silvio / Ferro, Paola / Dessanti, Paolo / Canessa, Pier Aldo / Ferrini, Silvano / Fabbi, Marina

Cancer immunology, immunotherapy : CII

2021 Volume 70, Issue 11, Page(s) 3349–3355

Abstract: Backgound: Literature reports suggest that the host immune system may control Malignant Pleural Mesothelioma (MPM) growth, although its activity is limited by regulatory mechanisms. In this retrospective study, we analyzed the levels of pro-inflammatory ...

Abstract	Backgound: Literature reports suggest that the host immune system may control Malignant Pleural Mesothelioma (MPM) growth, although its activity is limited by regulatory mechanisms. In this retrospective study, we analyzed the levels of pro-inflammatory (IL-1, IL-6, TNF), immune-regulatory (IL-10) and Th1/CTL-related cytokines (IL-12p70, IFN-γ) in the pleural exudate and their relationship with overall survival (OS) in MPM. Methods: Cytokines were quantified by multiplexed immunoassay. Concentrations were dichotomized with respect to the median value. Correlation between cytokine level and OS was assessed using univariate (Kaplan-Meier curves) and multivariate (Cox regression) analyses. Results: Regarding outcome, tumor histology, therapies undergone and IFN-γ were independent prognostic factors of OS in a 72 MPM training cohort. Notably, high concentrations of IFN-γ halved death probability (HR of high vs low IFN-γ concentration = 0.491, 95%CI 0.3-0.8, p = 0.007). Also in patients with epithelioid histology and those receiving at least one line of therapy, high IFN-γ level was an independent factor predictive of OS (HR of high vs low IFN-γ concentration were 0.497, p = 0.007 and 0.324, p = 0.006, respectively). However, these data were not confirmed in a 77 MPM validation cohort, possibly due to the low IFN-γ levels encountered in this population, and the heterogeneous distribution of disease stages between the training and the validation cohorts. None of the other cytokines showed any effect on survival. Conclusions: High level of IFN-γ in pleural effusion may be associated with better survival in MPM patients and potentially serve as a prognostic biomarker. Larger prospective studies are needed to ascertain this hypothesis.
MeSH term(s)	Adult ; Aged ; Cytokines/analysis ; Female ; Humans ; Interferon-gamma/metabolism ; Male ; Mesothelioma, Malignant/immunology ; Mesothelioma, Malignant/mortality ; Mesothelioma, Malignant/pathology ; Middle Aged ; Pleural Effusion, Malignant/immunology ; Pleural Effusion, Malignant/metabolism ; Pleural Neoplasms/immunology ; Pleural Neoplasms/mortality ; Pleural Neoplasms/pathology ; Prognosis ; Retrospective Studies
Chemical Substances	Cytokines ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2021-05-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	195342-4
ISSN	1432-0851 ; 0340-7004
ISSN (online)	1432-0851
ISSN	0340-7004
DOI	10.1007/s00262-021-02965-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1237: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Solitary Fibrous Tumor of the Deep Parotid Gland.

Romano, Nicola / Ferrari, Alice / Moroni, Michele / Dessanti, Paolo / Bardine, Alex / D'Amato, Massimo / Stefanini, Teseo

Ear, nose, & throat journal

2020 Volume 101, Issue 7, Page(s) NP291–NP293

MeSH term(s)	Humans ; Parotid Gland/diagnostic imaging ; Parotid Gland/pathology ; Parotid Neoplasms/diagnostic imaging ; Parotid Neoplasms/pathology ; Parotid Neoplasms/surgery ; Solitary Fibrous Tumors/diagnostic imaging ; Solitary Fibrous Tumors/surgery
Language	English
Publishing date	2020-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/0145561320966068
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 107: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Primary melanoma of the bladder: Case report and review of the literature.

Barillaro, Francesco / Camilli, Marco / Dessanti, Paolo / Gorji, Nader / Chiesa, Fabio / Villa, Alessandro / Pastorino, Alessandro / Aschele, Carlo / Conti, Enrico

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2018 Volume 90, Issue 3, Page(s) 224–226

Abstract: Skin melanoma represents one of the most common and lethal solid tumor. It usually develops on the skin but it can occur in any tissues with melanine- containing-cells (extracutaneous malignant melanoma). Only 4-5% of malignant melanomas originate in ... ...

Abstract	Skin melanoma represents one of the most common and lethal solid tumor. It usually develops on the skin but it can occur in any tissues with melanine- containing-cells (extracutaneous malignant melanoma). Only 4-5% of malignant melanomas originate in extracutaneous tissues, and they have an extremely lethal behavior (1). These non-skin malignant melanomas are rare but extremely aggressive. Primary melanoma of the genitourinary tract accounts for less than 0.2% of all melanomas. To date only 28 cases of primary bladder melanoma (PMM) are described. We report a rare case of PMM of the bladder in a 72 years old man treated with radical cystectomy and immunotherapy with Nivolumab.
MeSH term(s)	Aged ; Antineoplastic Agents, Immunological/administration & dosage ; Combined Modality Therapy ; Cystectomy/methods ; Humans ; Immunotherapy/methods ; Male ; Melanoma/diagnosis ; Melanoma/pathology ; Melanoma/therapy ; Nivolumab/administration & dosage ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/therapy
Chemical Substances	Antineoplastic Agents, Immunological ; Nivolumab (31YO63LBSN)
Language	English
Publishing date	2018-09-30
Publishing country	Italy
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1124-3562 ; 1120-8538
ISSN (online)	2282-4197
ISSN	1124-3562 ; 1120-8538
DOI	10.4081/aiua.2018.3.224
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui VI Zs.182: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Potential role of serum mesothelin in predicting survival of patients with malignant pleural mesothelioma.

Fontana, Vincenzo / Pistillo, Maria Pia / Vigani, Antonella / Canessa, Pier Aldo / Berisso, Giovanni / Giannoni, Ugo / Ferro, Paola / Franceschini, Maria Cristiana / Carosio, Roberta / Tonarelli, Marika / Dessanti, Paolo / Roncella, Silvio

Oncology letters

2020 Volume 21, Issue 2, Page(s) 128

Abstract: Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor survival rates. Therefore, it is essential to have effective biological markers predicting the course of the disease and prognosis. The aim of the present study was to highlight the ... ...

Abstract	Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor survival rates. Therefore, it is essential to have effective biological markers predicting the course of the disease and prognosis. The aim of the present study was to highlight the prognostic significance of serum soluble mesothelin-related protein (Se-SMRP) in patients with MPM at diagnosis. Se-SMRP was determined in 60 patients using an ELISA commercial kit. Se-SMRP levels were subdivided into three tertile-based categories and in each category overall survival (OS) indexes were determined using the Kaplan-Meier and Cox regression analyses. The association between Se-SMRP levels and OS was also assessed by restricted cubic spline (RCS) analysis. No notable differences in the Kaplan-Meier probabilities were identified across the Se-SMRP categories (<0.66 nM, 0.66-1.46 nM, >1.46 nM) although an upward trend in death rate ratios (RR) was pointed out by comparing the higher (RR=1.95) and intermediate (RR=1.86) categories with the lower category (RR=1.00). In addition, such an increasing tendency, particularly when the biomarker exceeded 1.0 nM, was confirmed by an RCS function of Se-SMPR levels fitted to survival data using the Cox regression equation. The present study provided evidence in favor of a prognostic value of Se-SMRP in patients with MPM.
Language	English
Publishing date	2020-12-18
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2020.12389
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Characterization of soluble PD-L1 in pleural effusions of mesothelioma patients: potential implications in the immune response and prognosis.

Carosio, Roberta / Fontana, Vincenzo / Mastracci, Luca / Ferro, Paola / Grillo, Federica / Banelli, Barbara / Canessa, Pier Aldo / Dessanti, Paolo / Vigani, Antonella / Morabito, Anna / Pfeffer, Ulrich / Poggi, Alessandro / Roncella, Silvio / Pistillo, Maria Pia

Journal of cancer research and clinical oncology

2020 Volume 147, Issue 2, Page(s) 459–468

Abstract: Purpose: Programmed death-ligand 1 (PD-L1) protein plays a central role in the antitumor immune response, and appears to be a predictor of prognosis and efficacy for PD-L1 and programmed death 1 (PD-1) blockade therapy. The immunoregulatory role and ... ...

Abstract	Purpose: Programmed death-ligand 1 (PD-L1) protein plays a central role in the antitumor immune response, and appears to be a predictor of prognosis and efficacy for PD-L1 and programmed death 1 (PD-1) blockade therapy. The immunoregulatory role and prognostic impact of PD-L1 soluble form (sPD-L1) have been investigated in biological fluids of patients with different tumors. In malignant pleural mesothelioma (MPM), circulating sPD-L1 has been recently reported in patients' sera, but no data are available in pleural effusions (PE). In our study, we evaluated the baseline expression levels of sPD-L1 in PE from 84 MPM patients and correlated them with PD-L1-status in matched tumors and patients' overall survival (OS). Methods: sPD-L1 in PE was determined by ELISA and tumor PD-L1 by immunohistochemistry. Association of sPD-L1 with OS was estimated using the Cox regression model. Results: We observed that sPD-L1 was variably expressed in all the PE and tended to be higher (by 30%) in patients with PD-L1-positive tumors (cut-off ≥ 1% stained cells) as compared to patients with PD-L1-negative tumors (geometric mean ratio = 1.28, P value = 0.288). sPD-L1 levels were significantly higher than those of sPD-1 (P value = 0.001) regardless of the MPM histotypes and they were positively correlated (r = 0.50, P value < 0.001). Moreover, high PE sPD-L1 concentrations were associated with a trend towards increased OS (hazard ratio 0.79, 95% CL 0.62-1.01, P value = 0.062). Conclusions: Our study documents the presence of sPD-L1 in PE of MPM patients, and suggests its possible biological and prognostic role in MPM.
MeSH term(s)	Aged ; Aged, 80 and over ; B7-H1 Antigen/analysis ; B7-H1 Antigen/physiology ; Female ; Humans ; Immunohistochemistry ; Male ; Mesothelioma, Malignant/immunology ; Mesothelioma, Malignant/mortality ; Middle Aged ; Pleural Effusion/metabolism ; Prognosis ; Programmed Cell Death 1 Receptor/analysis ; Proportional Hazards Models
Chemical Substances	B7-H1 Antigen ; CD274 protein, human ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2020-11-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-020-03457-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.10: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Determination of Mesothelin Levels in Pleural Effusion Does Not Help Predict Survival of Patients With Malignant Pleural Mesothelioma.

Anticancer research

2019 Volume 39, Issue 9, Page(s) 5219–5223

Abstract: Aim: This study evaluated the prognostic value of soluble mesothelin-related protein (SMRP) levels in pleural effusions (PE) from patients with pleural mesothelioma (MPM).: Patients and methods: SMRP level in PE was tested using an enzyme-linked ... ...

Abstract	Aim: This study evaluated the prognostic value of soluble mesothelin-related protein (SMRP) levels in pleural effusions (PE) from patients with pleural mesothelioma (MPM). Patients and methods: SMRP level in PE was tested using an enzyme-linked immunosorbent assay (ELISA) in 109 patients with MPM at diagnosis before any treatment. The Kaplan-Meier method and the Cox regression were applied to compare overall survival probabilities across tertile categories of SMRP level. Results: No significant differences in Kaplan-Meier overall survival probabilities among the SMRP categories were found. A statistically non-significant trend for increased death rate ratio (RR) was computed (p=0.327) when the higher (>46.5 nM, RR=1.38) and intermediate (8.5-46.5 nM, RR=1.18) SMRP categories were compared to the lower category (<8.5 nM, RR=1.00). Cox regression modelling including a restricted cubic spline showed a moderately rising non-linear trend in death rate. Conclusion: The SMRP level in PE does not appear to have prognostic significance and its detection is not recommended in routine clinical management of patients with MPM.
MeSH term(s)	Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor ; Female ; GPI-Linked Proteins/metabolism ; Humans ; Lung Neoplasms/complications ; Lung Neoplasms/diagnosis ; Lung Neoplasms/mortality ; Lung Neoplasms/therapy ; Male ; Mesothelioma/complications ; Mesothelioma/diagnosis ; Mesothelioma/mortality ; Mesothelioma/therapy ; Mesothelioma, Malignant ; Middle Aged ; Pleural Effusion, Malignant/diagnosis ; Pleural Effusion, Malignant/etiology ; Pleural Effusion, Malignant/metabolism ; Pleural Effusion, Malignant/therapy ; Pleural Neoplasms/complications ; Pleural Neoplasms/diagnosis ; Pleural Neoplasms/mortality ; Pleural Neoplasms/therapy ; Prognosis ; ROC Curve ; Treatment Outcome
Chemical Substances	Biomarkers, Tumor ; GPI-Linked Proteins ; mesothelin (J27WDC343N)
Language	English
Publishing date	2019-09-13
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.13719
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1642: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Comparison of the Diagnostic Performance of Fibulin-3 and Mesothelin in Patients with Pleural Effusions from Malignant Mesothelioma.

Battolla, Enrico / Canessa, Pier Aldo / Ferro, Paola / Franceschini, Maria Cristiana / Fontana, Vincenzo / Dessanti, Paolo / Pinelli, Valentina / Morabito, Anna / Fedeli, Franco / Pistillo, Maria Pia / Roncella, Silvio

Anticancer research

2017 Volume 37, Issue 3, Page(s) 1387–1391

Abstract: Background: In the literature, there exist conflicting data on the value of fibulin-3 (FBLN3) for the diagnosis of pleural effusion (PE) in malignant pleural mesothelioma (MPM). Therefore we compared the diagnostic performance of FBLN3 against that of ... ...

Abstract	Background: In the literature, there exist conflicting data on the value of fibulin-3 (FBLN3) for the diagnosis of pleural effusion (PE) in malignant pleural mesothelioma (MPM). Therefore we compared the diagnostic performance of FBLN3 against that of soluble mesothelin-related peptide (SMRP) in a cohort of Italian patients. Materials and methods: FBLN3 and SMRP were detected in PE from 33 patients with MPM, 64 with pleural benign lesions and 23 with non-MPM pleural metastases using a commercial enzyme-linked-immunosorbent(ELISA)-assay kit according to manufacturers' instructions. Results: Levels of FBLN3 were similar in PE from MPM and PE from other pathologies (geometric mean=68.1 vs. 66.2 ng/ml; p=0.872) in contrast to SMRP levels, which were significantly higher in PE from MPM (geometric mean=14.6 vs. 3.2 nM; p<0.001). Receiver operating characteristic analysis confirmed that SMRP showed a good performance (area under the curve=0.79, p<0.001), whereas FBLN3 was not able to discriminate MPM from other pathologies (area under the curve=0.44, p=0.838). Conclusion: FBLN3 detection in PE, in contrast to SMRP detection, is not useful as a biomarker for the diagnosis of PE from MPM.
MeSH term(s)	Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism ; Cohort Studies ; Enzyme-Linked Immunosorbent Assay ; Extracellular Matrix Proteins/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Italy ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Mesothelioma/metabolism ; Mesothelioma/pathology ; Mesothelioma, Malignant ; Middle Aged ; Multidrug Resistance-Associated Proteins/metabolism ; Pleural Effusion, Malignant/metabolism ; Pleural Effusion, Malignant/pathology ; Pleural Neoplasms/metabolism ; Pleural Neoplasms/pathology ; ROC Curve
Chemical Substances	ABCC5 protein, human ; Biomarkers, Tumor ; EFEMP1 protein, human ; Extracellular Matrix Proteins ; Multidrug Resistance-Associated Proteins
Language	English
Publishing date	2017-03-16
Publishing country	Greece
Document type	Comparative Study ; Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.11460
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1642: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Primary cardiac lymphoma presenting as sick sinus syndrome.

Motto, Andrea / Ballo, Piercarlo / Zito, Domenico / Cadenotti, Luigi / Moroni, Michele / Dessanti, Paolo / Fedeli, Franco

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2008 Volume 26, Issue 36, Page(s) 6003–6005

MeSH term(s)	Aged ; Diagnosis, Differential ; Echocardiography ; Female ; Heart Neoplasms/diagnosis ; Humans ; Lymphoma, B-Cell/diagnosis ; Sick Sinus Syndrome/diagnosis ; Tomography, X-Ray Computed
Language	English
Publishing date	2008-12-20
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2008.19.4803
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mesothelin in serum and pleural effusion in the diagnosis of malignant pleural mesothelioma with non-positive cytology.

Franceschini, Maria Cristiana / Ferro, Paola / Canessa, Pier Aldo / Battolla, Enrico / Dessanti, Paolo / Valentino, Alessandro / Casolari, Laura / Fontana, Vincenzo / Pezzi, Riccardo / Fedeli, Franco / Pistillo, Maria Pia / Roncella, Silvio

Anticancer research

2014 Volume 34, Issue 12, Page(s) 7425–7429

Abstract: Background/aim: Mesothelin (SMRP) is regarded as a biomarker of malignant pleural mesothelioma (MPM). Herein, we analyzed the contribution of SMRP detection in pleural effusion and in serum to the diagnosis of MPM with non-positive cytology.: ... ...

Abstract	Background/aim: Mesothelin (SMRP) is regarded as a biomarker of malignant pleural mesothelioma (MPM). Herein, we analyzed the contribution of SMRP detection in pleural effusion and in serum to the diagnosis of MPM with non-positive cytology. Materials and methods: The present study included 52 cases of MPM, 43 of pleural benign lesions and 25 of non-MPM pleural metastases. SMRP was measured by MesoMark ELISA (Cis-Bio International Gif/Yvette; France). Results: In non-positive cytology, effusion-SMRP showed higher diagnostic performance than serum-SMRP. We found 38 out of 52 (73.1%) cases of non-positive cytology MPM, out of which 27 (71.0%) were positive for effusion-SMRP (cut-off=12.70 nM) and 18 (47.4%) for serum-SMRP (cut-off=1.08 nM). When cytology, effusion- and serum-SMRP were used in combination, an overall sensitivity in detection of MPM of 78.9% was achieved. The same sensitivity was obtained by combining cytology with effusion-SMRP alone, whereas the combination of serum-SMRP with cytology led to a sensitivity of 61.5%. Conclusion: Detection of both effusion- and serum-SMRP can contribute to improve the diagnosis of MPM with non-positive cytology. However, the analysis of SMRP in effusion makes it unnecessary to test SMRP in the serum.
MeSH term(s)	Aged ; Aged, 80 and over ; Asbestosis/blood ; Biomarkers, Tumor/blood ; Cytodiagnosis ; Female ; GPI-Linked Proteins/blood ; Humans ; Lung Neoplasms/blood ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Male ; Mesothelioma/blood ; Mesothelioma/diagnosis ; Mesothelioma/pathology ; Mesothelioma, Malignant ; Middle Aged ; Neoplasm Metastasis ; Pleural Effusion/pathology ; Pleural Neoplasms/blood ; Pleural Neoplasms/diagnosis ; Pleural Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor ; GPI-Linked Proteins ; mesothelin (J27WDC343N)
Language	English
Publishing date	2014-12-12
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1642: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito