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  1. Article ; Online: Respiratory Infections.

    Detelich, Joshua F / Kempker, Jordan A

    Clinics in chest medicine

    2023  Volume 44, Issue 3, Page(s) 509–517

    Abstract: Pneumonia is one of the most common reasons for health care utilization in the United States. It can be caused by many different pathogens, but rarely is it able to be identified in specific cases. This has led most racial disparities research to focus ... ...

    Abstract Pneumonia is one of the most common reasons for health care utilization in the United States. It can be caused by many different pathogens, but rarely is it able to be identified in specific cases. This has led most racial disparities research to focus on community acquired pneumonia and microbes of public health concern such as influenza, tuberculosis, and COVID-19. Differences have been shown to exist from prevention with vaccines to management and outcomes. COVID-19 has led to a significant increase in the awareness of this topic.
    MeSH term(s) Humans ; United States ; COVID-19 ; Influenza Vaccines/therapeutic use ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Pneumonia/therapy ; Vaccination
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2023.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A young adult with COVID-19 and multisystem inflammatory syndrome in children (MIS-C)-like illness: a case report.

    Kofman, Aaron D / Sizemore, Emma K / Detelich, Joshua F / Albrecht, Benjamin / Piantadosi, Anne L

    BMC infectious diseases

    2020  Volume 20, Issue 1, Page(s) 716

    Abstract: Background: A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age.: Case ... ...

    Abstract Background: A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age.
    Case presentation: The patient presented with 1 week of weakness, dyspnea, and low-grade fevers, followed by mild cough, sore throat, vomiting, diarrhea, and lymph node swelling. She was otherwise healthy, with no prior medical history. Her hospital course was notable for profound acute kidney injury, leukocytosis, hypotension, and cardiac dysfunction requiring ICU admission and vasopressor support. MIS-C-like illness secondary to COVID-19 was suspected due to physical exam findings of conjunctivitis, mucositis, and shock. She improved following IVIG, aspirin, and supportive care, and was discharged on hospital day 5.
    Conclusion: MIS-C-like illness should be considered in adults presenting with atypical clinical findings and concern for COVID-19. Further research is needed to support the role of IVIG and aspirin in this patient population.
    MeSH term(s) Adult ; Aspirin/administration & dosage ; Aspirin/therapeutic use ; Betacoronavirus/genetics ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Cough/complications ; Diarrhea/complications ; Dyspnea/complications ; Female ; Fever/complications ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Immunoglobulins, Intravenous/therapeutic use ; Pandemics ; Pharyngitis/complications ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Polymerase Chain Reaction ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/complications ; Systemic Inflammatory Response Syndrome/drug therapy ; Systemic Inflammatory Response Syndrome/virology ; Treatment Outcome ; Vomiting/complications
    Chemical Substances Immunoglobulins, Intravenous ; Aspirin (R16CO5Y76E)
    Keywords covid19
    Language English
    Publishing date 2020-09-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-020-05439-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Home-to-hospital distance and outcomes among community-acquired sepsis hospitalizations.

    Detelich, Joshua F / Kyaw, Nang Thu / Judd, Suzanne E / Bennett, Aleena / Wang, Henry E / Kramer, Michael R / Waller, Lance A / Martin, Greg S / Kempker, Jordan A

    Annals of epidemiology

    2022  Volume 72, Page(s) 26–31

    Abstract: Purpose: To examine the hypothesis that longer distance from home-to-hospital is associated with worse outcomes among hospitalizations for community-acquired sepsis.: Methods: A secondary analysis of data from the REasons for Geographic and Racial ... ...

    Abstract Purpose: To examine the hypothesis that longer distance from home-to-hospital is associated with worse outcomes among hospitalizations for community-acquired sepsis.
    Methods: A secondary analysis of data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) prospective cohort of 30,239 white and Black US adults greater than or equal to 45 years old was conducted. Self-reported hospitalizations for serious infection between 2003 and 2012 fulfilling 2/4 systemic inflammatory response syndrome criteria were included. Estimated driving distance was derived from geocoded data and evaluated continuously and as quartiles of very close, close, far, very far (<3.1, 3.1-5.8, 5.9-11.5, and >11.5 miles respectively). The primary outcome was 30-day mortality while the secondary outcome was sequential organ failure assessment (SOFA) score on arrival.
    Results: Of the 912 hospitalizations for community-acquired sepsis had adequate data for analysis. The median (interquartile range) estimated driving distance was 5.8 miles (3.1,11.7), and 54 (5.9%) experienced the primary outcome. Compared to living very close, participants living very far had a mortality odds ratio of 1.30 (95% CI 0.64,2.62) and presenting SOFA score difference of 0.33 (95% CI -0.03,0.68).
    Conclusions: Among a national sample of community-acquired sepsis hospitalizations, there was no significant association between home-to-hospital distance and either 30-day mortality or SOFA score on hospital presentation.
    MeSH term(s) Adult ; Hospital Mortality ; Hospitalization ; Hospitals ; Humans ; Prospective Studies ; Retrospective Studies ; Sepsis/epidemiology
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1074355-8
    ISSN 1873-2585 ; 1047-2797
    ISSN (online) 1873-2585
    ISSN 1047-2797
    DOI 10.1016/j.annepidem.2022.05.001
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  4. Article ; Online: A young adult with COVID-19 and multisystem inflammatory syndrome in children (MIS-C)-like illness

    Kofman, Aaron D. / Sizemore, Emma K. / Detelich, Joshua F. / Albrecht, Benjamin / Piantadosi, Anne L.

    BMC Infectious Diseases

    a case report

    2020  Volume 20, Issue 1

    Abstract: Abstract Background A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age. Case ...

    Abstract Abstract Background A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age. Case presentation The patient presented with 1 week of weakness, dyspnea, and low-grade fevers, followed by mild cough, sore throat, vomiting, diarrhea, and lymph node swelling. She was otherwise healthy, with no prior medical history. Her hospital course was notable for profound acute kidney injury, leukocytosis, hypotension, and cardiac dysfunction requiring ICU admission and vasopressor support. MIS-C-like illness secondary to COVID-19 was suspected due to physical exam findings of conjunctivitis, mucositis, and shock. She improved following IVIG, aspirin, and supportive care, and was discharged on hospital day 5. Conclusion MIS-C-like illness should be considered in adults presenting with atypical clinical findings and concern for COVID-19. Further research is needed to support the role of IVIG and aspirin in this patient population.
    Keywords Infectious Diseases ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ISSN 1471-2334
    DOI 10.1186/s12879-020-05439-z
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: A young adult with COVID-19 and multisystem inflammatory syndrome in children (MIS-C)-like illness: a case report

    Kofman, Aaron D / Sizemore, Emma K / Detelich, Joshua F / Albrecht, Benjamin / Piantadosi, Anne L

    BMC Infect Dis

    Abstract: BACKGROUND: A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age. CASE ... ...

    Abstract BACKGROUND: A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age. CASE PRESENTATION: The patient presented with 1 week of weakness, dyspnea, and low-grade fevers, followed by mild cough, sore throat, vomiting, diarrhea, and lymph node swelling. She was otherwise healthy, with no prior medical history. Her hospital course was notable for profound acute kidney injury, leukocytosis, hypotension, and cardiac dysfunction requiring ICU admission and vasopressor support. MIS-C-like illness secondary to COVID-19 was suspected due to physical exam findings of conjunctivitis, mucositis, and shock. She improved following IVIG, aspirin, and supportive care, and was discharged on hospital day 5. CONCLUSION: MIS-C-like illness should be considered in adults presenting with atypical clinical findings and concern for COVID-19. Further research is needed to support the role of IVIG and aspirin in this patient population.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #801905
    Database COVID19

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  6. Article ; Online: Preparative, in vitro biocatalysis of triketide lactone chiral building blocks.

    Harper, Andrew D / Bailey, Constance B / Edwards, Angela D / Detelich, Joshua F / Keatinge-Clay, Adrian T

    Chembiochem : a European journal of chemical biology

    2012  Volume 13, Issue 15, Page(s) 2200–2203

    Abstract: PKS biocatalysis: The terminal module of erythromycin synthase was used for the in vitro production of chiral triketide lactones. Combining cofactor regeneration, substrate truncation, and enzymatic promiscuity afforded a scalable strategy to generate ... ...

    Abstract PKS biocatalysis: The terminal module of erythromycin synthase was used for the in vitro production of chiral triketide lactones. Combining cofactor regeneration, substrate truncation, and enzymatic promiscuity afforded a scalable strategy to generate these molecules from abundant racemic and achiral precursors. The described biocatalytic platform thus facilitates the application and study of enzymes within PKS modules.
    MeSH term(s) Bacillus subtilis/enzymology ; Bacillus subtilis/genetics ; Biocatalysis ; Escherichia coli/genetics ; Gene Expression ; Lactones/chemistry ; Lactones/metabolism ; Polyketide Synthases/chemistry ; Polyketide Synthases/metabolism ; Stereoisomerism ; Streptomyces coelicolor/enzymology ; Streptomyces coelicolor/genetics ; Substrate Specificity
    Chemical Substances Lactones ; Polyketide Synthases (79956-01-7)
    Language English
    Publishing date 2012-10-15
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.201200378
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  7. Article ; Online: Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks.

    Piasecki, Shawn K / Taylor, Clint A / Detelich, Joshua F / Liu, June / Zheng, Jianting / Komsoukaniants, Arkady / Siegel, Dionicio R / Keatinge-Clay, Adrian T

    Chemistry & biology

    2011  Volume 18, Issue 10, Page(s) 1331–1340

    Abstract: Chiral building blocks are valuable intermediates in the syntheses of natural products and pharmaceuticals. A scalable chemoenzymatic route to chiral diketides has been developed that includes the general synthesis of α-substituted, β-ketoacyl N- ... ...

    Abstract Chiral building blocks are valuable intermediates in the syntheses of natural products and pharmaceuticals. A scalable chemoenzymatic route to chiral diketides has been developed that includes the general synthesis of α-substituted, β-ketoacyl N-acetylcysteamine thioesters followed by a biocatalytic cycle in which a glucose-fueled NADPH-regeneration system drives reductions catalyzed by isolated modular polyketide synthase (PKS) ketoreductases (KRs). To identify KRs that operate as active, stereospecific biocatalysts, 11 isolated KRs were incubated with 5 diketides and their products were analyzed by chiral chromatography. KRs that naturally reduce small polyketide intermediates were the most active and stereospecific toward the panel of diketides. Several biocatalytic reactions were scaled up to yield more than 100 mg of product. These syntheses demonstrate the ability of PKS enzymes to economically and greenly generate diverse chiral building blocks on a preparative scale.
    MeSH term(s) Alcohol Oxidoreductases/chemistry ; Alcohol Oxidoreductases/genetics ; Alcohol Oxidoreductases/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biotechnology/methods ; Catalysis ; Cysteamine/analogs & derivatives ; Cysteamine/chemistry ; NADP/metabolism ; Polyketide Synthases/chemistry ; Polyketide Synthases/metabolism ; Polyketides/chemical synthesis ; Stereoisomerism
    Chemical Substances Bacterial Proteins ; Polyketides ; NADP (53-59-8) ; Cysteamine (5UX2SD1KE2) ; Polyketide Synthases (79956-01-7) ; Alcohol Oxidoreductases (EC 1.1.-) ; polyketide synthase ketoreductase (EC 1.1.-)
    Language English
    Publishing date 2011-10-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 917827-2
    ISSN 1879-1301 ; 1074-5521
    ISSN (online) 1879-1301
    ISSN 1074-5521
    DOI 10.1016/j.chembiol.2011.07.021
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