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  1. AU="Devaraj, Rashmi"
  2. AU="Jessen, Nanna Holt"
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  1. Article: Spectrum of Neurological Complications Following COVID-19 Vaccination in India.

    Devaraj, Rashmi / Shafi, Peerzada / Nagesh, Chinmay / Naidu, Amar / Satishchandra, Parthasarathy

    Journal of clinical neurology (Seoul, Korea)

    2022  Volume 18, Issue 6, Page(s) 681–691

    Abstract: Background and purpose: According to WHO statistics, approximately 6.9 billion people worldwide had been vaccinated against SARS-CoV-2 as at October 27, 2021, including around 1.0 billion people in India. Most Indian recipients received the Covishield ( ... ...

    Abstract Background and purpose: According to WHO statistics, approximately 6.9 billion people worldwide had been vaccinated against SARS-CoV-2 as at October 27, 2021, including around 1.0 billion people in India. Most Indian recipients received the Covishield (ChAdOx1-S/nCoV-19) vaccine, followed by the Covaxin (an inactivated SARS-CoV-2 antigen) vaccine. This study was conducted to characterize the neurological phenotypic spectrum of patients with adverse events following immunization with any of the available COVID-19 vaccines in India (Covishield or Covaxin) during the study period and their temporal relationship with vaccination.
    Methods: This ambispective multicenter hospital-based cohort study covered the period from March to October 2021. The study included all cases suspected of having neurological complications following COVID-19 vaccination.
    Results: We report a spectrum of serious postvaccination neurological complications comprising primary central nervous system demyelination (4 cases), cerebral venous thrombosis (3 cases), Guillain-Barre syndrome (2 cases), vaccine-induced prothrombotic immune thrombocytopenia syndrome (2 cases), cranial nerve palsies (2 cases), primary cerebral hemorrhage (1 case), vestibular neuronitis (1 case), chronic inflammatory demyelinating polyneuropathy (1 case), generalized myasthenia (1 case), and seizures (1 case).
    Conclusions: Although the benefits of vaccination far outweigh its risks, clinicians must be aware of possible serious adverse events associated with COVID-19 vaccinations.
    Language English
    Publishing date 2022-11-11
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2022.18.6.681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Spinal Dural Arteriovenous Fistula in a Young Male Associated with Craniospinal Leptomeningeal Spread of a Treated High-Grade Glioma.

    Nagesh, Chinmay P / Satischandra, Parthasarthy / Krishna, K N / Joshi, Girish / Devaraj, Rashmi / Herur, Ajay

    Neurology India

    2022  Volume 70, Issue Supplement, Page(s) S326–S330

    Abstract: Spinal dural arteriovenous fistulae (SDAVF) are most commonly idiopathic in origin but may occasionally be seen secondary to surgery, trauma, or inflammation. We report a case of 27-year-old male who came with features of a myelopathy. He was found to ... ...

    Abstract Spinal dural arteriovenous fistulae (SDAVF) are most commonly idiopathic in origin but may occasionally be seen secondary to surgery, trauma, or inflammation. We report a case of 27-year-old male who came with features of a myelopathy. He was found to have an SDAVF associated with leptomeningeal spread (LMS) of a previously treated high-grade cerebral glioma. Hemorrhagic presentation of gliomas, as in this case, is due to upregulation of vascular endothelial growth factor, which has also been postulated to play a role in the development of SDAVFs. This may suggest a possible mechanism of induction of secondary SDAVFs associated with such tumors. While the coexistence of intracranial neoplasms with vascular malformations has been reported previously, this is the first case report of LMS of a high-grade glioma associated with an SDAVF.
    MeSH term(s) Adult ; Humans ; Male ; Brain Neoplasms/complications ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Central Nervous System Vascular Malformations/etiology ; Central Nervous System Vascular Malformations/physiopathology ; Glioma/complications ; Glioma/physiopathology ; Glioma/secondary ; Glioma/therapy ; Magnetic Resonance Imaging ; Meningeal Carcinomatosis/complications ; Meningeal Carcinomatosis/physiopathology ; Meningeal Carcinomatosis/secondary ; Spinal Cord Diseases/etiology ; Spinal Cord Diseases/physiopathology ; Vascular Endothelial Growth Factor A/physiology
    Chemical Substances Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2022-11-30
    Publishing country India
    Document type Case Reports
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.360935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 698: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The importance of repeat digital subtraction myelography in the diagnosis of cryptogenic CSF-venous fistula causing spontaneous intracranial hypotension.

    Nagesh, Chinmay P / Devaraj, Rashmi / Joshi, Girish / Shafi, Peerzada / Krishna, K N / Satischandra, Parthasarthy

    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

    2021  Volume 27, Issue 5, Page(s) 727–732

    Abstract: Spontaneous intracranial hypotension (SIH) is a rare disorder that occurs secondary to acquired cerebrospinal fluid (CSF) leaks in the spine. Treatment involves either an epidural blood patch or surgical ligation. Essential to the selecting the optimal ... ...

    Abstract Spontaneous intracranial hypotension (SIH) is a rare disorder that occurs secondary to acquired cerebrospinal fluid (CSF) leaks in the spine. Treatment involves either an epidural blood patch or surgical ligation. Essential to the selecting the optimal management strategy is classifying the type of leak and accurate localization of its level. Hitherto, this has been achieved using conventional imaging methods such as static CT or MR myelography which are adequate for the demonstration of only high flow leaks. Digital subtraction myelography (DSM) is a novel technique which provides superior temporal and spatial resolution in the localization of more challenging slow flow leaks. However, DSM may also be initially non-diagnostic. We report a case of SIH in which repeat DSM revealed a type 3 CSF-venous fistula and demonstrate a possible mechanism of transient CSF leak block resulting in the initial false negative findings based on morphological changes in the culprit nerve sheath diverticulum-pseudomeningocoele complex. The patient underwent successful surgical ligation with clinicoradiological resolution of SIH.
    MeSH term(s) Cerebrospinal Fluid Leak/diagnostic imaging ; Fistula ; Humans ; Intracranial Hypotension/diagnostic imaging ; Intracranial Hypotension/etiology ; Myelography ; Spine
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1354913-3
    ISSN 2385-2011 ; 1591-0199 ; 1123-9344
    ISSN (online) 2385-2011
    ISSN 1591-0199 ; 1123-9344
    DOI 10.1177/1591019921991398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6325: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Spectrum of Movement Disorders in Niemann-Pick Disease Type C.

    Devaraj, Rashmi / Mahale, Rohan R / Sindhu, D M / Stezin, Albert / Kamble, Nitish / Holla, Vikram V / Netravathi, M / Yadav, Ravi / Pal, Pramod Kumar

    Tremor and other hyperkinetic movements (New York, N.Y.)

    2022  Volume 12, Page(s) 28

    Abstract: Introduction: Niemann-Pick disease type C (NPC) is an autosomal recessive neurovisceral lipid storage disorder caused by mutations in the ... NPC 1 ... or ... 2 ... genes. Movement disorders can occur as the first symptom and as predominant symptom mainly ...

    Abstract Introduction: Niemann-Pick disease type C (NPC) is an autosomal recessive neurovisceral lipid storage disorder caused by mutations in the NPC 1 or 2 genes. Movement disorders can occur as the first symptom and as predominant symptom mainly in juvenile-onset. The frequency and heterogeneity of movement disorders in NPC are not well described. We studied the frequency and spectrum of movement disorders in patients with NPC of different age of onset.
    Methods: Retrospective chart review of patients with NPC diagnosed based on the Suspicion Index tool and demonstration of foamy macrophages/sea-blue histiocytes in bone marrow aspirate.
    Results: We report 9 cases of NPC with 2 patients of late-infantile, 4 juvenile-onset and 3 of adult-onset. The mean age at onset of symptoms was 11.7 ± 10.4 (range 4-38 years) and the median duration of illness was 4 years. Vertical supranuclear gaze palsy (VSGP) was noted in 8 patients and VSGP with slowing of saccade in 1 patient. Splenomegaly was seen in 5 patients. Movement disorders as the first symptom occurred in 4 patients. Dystonia was the first symptom in 2 patients and cerebellar ataxia in 2 patients. Cerebellar ataxia occurred during the course of illness in 5 patients, dystonia in 6 patients. One patient with late-infantile NPC had stimulus-sensitive myoclonus.
    Conclusion: Movement disorders are common in NPC and occur as a presenting symptom. Cerebellar ataxia and dystonia are the most common movement disorder in NPC. Vertical supranuclear gaze palsy along with the movement disorders should lead to clinical suspicion of NPC.
    MeSH term(s) Adolescent ; Adult ; Cerebellar Ataxia ; Child ; Child, Preschool ; Dystonia ; Humans ; Lipids ; Movement Disorders/genetics ; Niemann-Pick Disease, Type C/diagnosis ; Paralysis ; Retrospective Studies ; Young Adult
    Chemical Substances Lipids
    Language English
    Publishing date 2022-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2674453-3
    ISSN 2160-8288 ; 2160-8288
    ISSN (online) 2160-8288
    ISSN 2160-8288
    DOI 10.5334/tohm.701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Aseptic Meningitis Followed by Bilateral Optic Neuritis: An Uncommon Phenotype of MOGAD.

    Devaraj, Rashmi / Shafi, Peerzada / Nagesh, Chinmay / Alladi, Suvarna / Satishchandra, Parthasarathy

    Neurology. Clinical practice

    2019  Volume 11, Issue 5, Page(s) e790–e793

    Language English
    Publishing date 2019-12-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000001129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Phenylketonuria: Our Experience in Nine Years at a Tertiary-level Referral Institute.

    Chandra, Sadanandvalli R / Christopher, Rita / Daryappa, Mane M / Devaraj, Rashmi

    Journal of pediatric neurosciences

    2018  Volume 13, Issue 1, Page(s) 62–70

    Abstract: Introduction: Phenyl ketonuria is an inborn error of amino acid metabolism resulting in excessive phenyl alanine levels in blood resulting in a spectrum of neurological defects.: Patients and methods: We retrospectively went through the records of ... ...

    Abstract Introduction: Phenyl ketonuria is an inborn error of amino acid metabolism resulting in excessive phenyl alanine levels in blood resulting in a spectrum of neurological defects.
    Patients and methods: We retrospectively went through the records of patients diagnosed as Phenyl ketonuria in the last nine years in our team and patients who's data could be accessed were analyzed in detail. Details of laboratory tests, imaging clinical features, course were recorded.
    Observation: A total of 32 patients were identified in nine years of which data was available only for 15 patients. Age at diagnosis varied from 2.5 years to 7 years. 73% were males. Global developmental delay, Microcephaly. Seizures blond hair, spasticity, regression, Ocular Hypertelorism, low set ears, Seborrhea, Hypotonia, Family history of mental retardation and Consanguinity was common one patient showed a large hypo pigmented area in left arm with eczematous rash.
    Results of lab tests: Urine ferric chloride test and DNPH was positive in all cases. Tandem mass spectroscopy showed elevated phenyl alanine, normal tyrosine and elevated PHE tyrosine ratio in all cases. MRI showed symmetrical Flair hyperintensities in T2 weighted images in the parieto occipital region hypo on T1 with no diffusion restriction in 11 cases and MRS was normal. Genetic testing showed one non consanguineous family having carrier state. Follow up is from 1 year to 5 years. Seizures controlled in all. Regular fallow up shows change in hair color and gain of mile stones. There was no mortality.
    Conclusion: Phenyl ketonuria is a controllable metabolic disease. However there is considerable delay before diagnosis resulting in persistence of sequelae in children with PKU as well as normal children born to PKU mothers which needs attention to prevent these complications.
    Language English
    Publishing date 2018-05-25
    Publishing country India
    Document type Journal Article
    ISSN 1817-1745
    ISSN 1817-1745
    DOI 10.4103/JPN.JPN_177_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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