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  1. Article ; Online: Inflammatory bowel diseases

    Devendra Desai

    Indian Journal of Medical Research, Vol 142, Iss 1, Pp 99-

    Microbiota versus the barrier

    2015  Volume 99

    Keywords Medicine ; R
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Low prevalence of primary sclerosing cholangitis in patients with inflammatory bowel disease in India

    Arshdeep Singh / Vandana Midha / Vikram Narang / Saurabh Kedia / Ramit Mahajan / Pavan Dhoble / Bhavjeet Kaur Kahlon / Ashvin Singh Dhaliwal / Ashish Tripathi / Shivam Kalra / Narender Pal Jain / Namita Bansal / Rupa Banerjee / Devendra Desai / Usha Dutta / Vineet Ahuja / Ajit Sood

    Intestinal Research, Vol 21, Iss 4, Pp 452-

    2023  Volume 459

    Abstract: Background/Aims Primary sclerosing cholangitis (PSC) represents the most common hepatobiliary extraintestinal manifestation of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). Limited data exist on PSC in ... ...

    Abstract Background/Aims Primary sclerosing cholangitis (PSC) represents the most common hepatobiliary extraintestinal manifestation of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). Limited data exist on PSC in patients with IBD from India. We aimed to assess the prevalence and disease spectrum of PSC in Indian patients with IBD. Methods Database of IBD patients at 5 tertiary care IBD centers in India were analyzed retrospectively. Data were extracted and the prevalence of PSC-IBD was calculated. Results Forty-eight patients out of 12,216 patients with IBD (9,231 UC, 2,939 CD, and 46 IBD unclassified) were identified to have PSC, resulting in a prevalence of 0.39%. The UC to CD ratio was 7:1. Male sex and pancolitis (UC) or colonic CD were more commonly associated with PSC-IBD. The diagnosis of IBD preceded the diagnosis of PSC in most of the patients. Majority of the patients were symptomatic for liver disease at diagnosis. Eight patients (16.66%) developed cirrhosis, 5 patients (10.41%), all UC, developed malignancies (3 colorectal cancer [6.25%] and 2 cholangiocarcinoma [4.16%]), and 3 patients died (2 decompensated liver disease [4.16%] and 1 cholangiocarcinoma [2.08%]) on follow-up. None of the patients mandated surgical therapy for IBD. Conclusions Concomitant PSC in patients with IBD is uncommon in India and is associated with lower rates of development of malignancies.
    Keywords colitis ; ulcerative ; cholangitis ; sclerosing ; prevalence ; inflammatory bowel diseases ; india ; Medicine ; R ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Subject code 610 ; 616
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Korean Association for the Study of Intestinal Diseases
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Rare biliary cystic tumors

    Abhirup Banerjee / Sudeep R. Shah / Abhiyutthan Singh / Anand Joshi / Devendra Desai

    Annals of Hepatology, Vol 15, Iss 3, Pp 448-

    a case series of biliary cystadenomas and cystadenocarcinoma

    2016  Volume 452

    Abstract: Cystic lesions of the liver are common and a major proportion is formed by parasitic cysts and simple cysts. Biliary cystic tumors (BCTs), namely biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC), are rare tumors which usually arise from ... ...

    Abstract Cystic lesions of the liver are common and a major proportion is formed by parasitic cysts and simple cysts. Biliary cystic tumors (BCTs), namely biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC), are rare tumors which usually arise from the intrahepatic biliary tree. BCAs have malignant potential and are difficult to differentiate from BCAC pre-operatively on radiological imaging. Here we have presented 4 patients with BCTs and reviewed the literature pertaining to them.The data of four patients with BCA/BCAC diagnosed and treated at our institute were retrieved from our database and records were reviewed for age, sex, history, imaging, surgery, pathology and follow-up. Mean age of the patients was 53.5 years (range 30-71 years). Two male and two female patients presented with abdominal pain, of which one male patient had pancreatitis at diagnosis. Characteristic features were seen on pre-operative imaging (cystic lesions with internal septations) and biliary communication was identified in the patient with pancreatitis. Three patients were diagnosed with a BCA on final histology, while one patient had a BCAC. Following surgical resection, all the patients are asymptomatic and disease free with a mean follow-up of 24 months (range 10-40 months). In conclusion, BCTs should be suspected in the presence of a well-encapsulated, cystic hepatic lesion with internal septations. Although pre-operative distinction between BCA and BCAC is difficult, the lesion, whenever possible, should be completely resected as long-term outcomes are good, especially with BCA.
    Keywords Biliary cystadenoma ; Biliary cystadenocarcinoma ; Biliary cystic tumors ; Rare liver tumors ; Specialties of internal medicine ; RC581-951
    Subject code 616
    Language English
    Publishing date 2016-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Colitis and Crohn’s Foundation (India)

    Ajit Sood / Kirandeep Kaur / Ramit Mahajan / Vandana Midha / Arshdeep Singh / Sarit Sharma / Amarender Singh Puri / Bhabhadev Goswami / Devendra Desai / C. Ganesh Pai / Kiran Peddi / Mathew Philip / Rakesh Kochhar / Sandeep Nijhawan / Shobna Bhatia / N. Sridhara Rao

    Intestinal Research, Vol 19, Iss 2, Pp 206-

    a first nationwide inflammatory bowel disease registry

    2021  Volume 216

    Abstract: Background/Aims The national registry for inflammatory bowel disease (IBD) was designed to study epidemiology and prescribing pattern of treatment of IBD in India. Methods A multicenter, cross-sectional, prospective registry was established across four ... ...

    Abstract Background/Aims The national registry for inflammatory bowel disease (IBD) was designed to study epidemiology and prescribing pattern of treatment of IBD in India. Methods A multicenter, cross-sectional, prospective registry was established across four geographical zones of India. Adult patients with ulcerative colitis (UC) or Crohn’s disease (CD) were enrolled between January 2014 and December 2015. Information related to demographics; disease features; complications; and treatment history were collected and analyzed. Results A total of 3,863 patients (mean age, 36.7 ± 13.6 years; 3,232 UC [83.7%] and 631 CD [16.3%]) were enrolled. The majority of patients with UC (n = 1,870, 57.9%) were from north, CD was more common in south (n = 348, 55.5%). The UC:CD ratio was 5.1:1. There was a male predominance (male:female = 1.6:1). The commonest presentation of UC was moderately severe (n = 1,939, 60%) and E2 disease (n = 1,895, 58.6%). Patients with CD most commonly presented with ileocolonic (n = 229, 36.3%) inflammatory (n = 504, 79.9%) disease. Extraintestinal manifestations were recorded among 13% and 20% of patients in UC and CD respectively. Less than 1% patients from both cohorts developed colon cancer (n = 26, 0.7%). The commonly used drugs were 5-aminosalicylates (99%) in both UC and CD followed by azathioprine (34.4%). Biologics were used in only 1.5% of patients; more commonly for UC in north and CD in south. Conclusions The national IBD registry brings out diversities in the 4 geographical zones of India. This will help in aiding research on IBD and improving quality of patient care.
    Keywords inflammatory bowel disease ; national registry ; colitis ; ulcerative ; india ; crohn disease ; Medicine ; R ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Subject code 610
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Korean Association for the Study of Intestinal Diseases
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Isolated Crohn′s disease of the vulva

    Nina A Madnani / Devendra Desai / Nisha Gandhi / Kaleem J Khan

    Indian Journal of Dermatology, Venereology and Leprology, Vol 77, Iss 3, Pp 342-

    2011  Volume 344

    Keywords Dermatology ; RL1-803 ; Medicine ; R
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Use of thiopurines in inflammatory bowel disease

    Arshdeep Singh / Ramit Mahajan / Saurabh Kedia / Amit Kumar Dutta / Abhinav Anand / Charles N. Bernstein / Devendra Desai / C. Ganesh Pai / Govind Makharia / Harsh Vardhan Tevethia / Joyce WY Mak / Kirandeep Kaur / Kiran Peddi / Mukesh Kumar Ranjan / Perttu Arkkila / Rakesh Kochhar / Rupa Banerjee / Saroj Kant Sinha / Siew Chien Ng /
    Stephen Hanauer / Suhang Verma / Usha Dutta / Vandana Midha / Varun Mehta / Vineet Ahuja / Ajit Sood

    Intestinal Research, Vol 20, Iss 1, Pp 11-

    an update

    2022  Volume 30

    Abstract: Inflammatory bowel disease (IBD), once considered a disease of the Western hemisphere, has emerged as a global disease. As the disease prevalence is on a steady rise, management of IBD has come under the spotlight. 5-Aminosalicylates, corticosteroids, ... ...

    Abstract Inflammatory bowel disease (IBD), once considered a disease of the Western hemisphere, has emerged as a global disease. As the disease prevalence is on a steady rise, management of IBD has come under the spotlight. 5-Aminosalicylates, corticosteroids, immunosuppressive agents and biologics are the backbone of treatment of IBD. With the advent of biologics and small molecules, the need for surgery and hospitalization has decreased. However, economic viability and acceptability is an important determinant of local prescription patterns. Nearly one-third of the patients in West receive biologics as the first/initial therapy. The scenario is different in developing countries where biologics are used only in a small proportion of patients with IBD. Increased risk of reactivation of tuberculosis and high cost of the therapy are limitations to their use. Thiopurines hence become critical for optimal management of patients with IBD in these regions. However, approximately one-third of patients are intolerant or develop adverse effects with their use. This has led to suboptimal use of thiopurines in clinical practice. This review article discusses the clinical aspects of thiopurine use in patients with IBD with the aim of optimizing their use to full therapeutic potential.
    Keywords inflammatory bowel disease ; azathioprine ; mercaptopurine ; 6-thioguanine ; developing countries ; Medicine ; R ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Korean Association for the Study of Intestinal Diseases
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Colitis and Crohn’s Foundation (India) consensus statements on use of 5-aminosalicylic acid in inflammatory bowel disease

    Ajit Sood / Vineet Ahuja / Vandana Midha / Saroj Kant Sinha / C. Ganesh Pai / Saurabh Kedia / Varun Mehta / Sawan Bopanna / Philip Abraham / Rupa Banerjee / Shobna Bhatia / Karmabir Chakravartty / Sunil Dadhich / Devendra Desai / Manisha Dwivedi / Bhabhadev Goswami / Kirandeep Kaur / Rajeev Khosla / Ajay Kumar /
    Ramit Mahajan / S. P. Misra / Kiran Peddi / Shivaram Prasad Singh / Arshdeep Singh

    Intestinal Research, Vol 18, Iss 4, Pp 355-

    2020  Volume 378

    Abstract: Despite several recent advances in therapy in inflammatory bowel disease (IBD), 5-aminosalicylic acid (5-ASA) therapy has retained its place especially in ulcerative colitis. This consensus on 5-ASA is obtained through a modified Delphi process, and ... ...

    Abstract Despite several recent advances in therapy in inflammatory bowel disease (IBD), 5-aminosalicylic acid (5-ASA) therapy has retained its place especially in ulcerative colitis. This consensus on 5-ASA is obtained through a modified Delphi process, and includes guiding statements and recommendations based on literature evidence (randomized trials, and observational studies), clinical practice, and expert opinion on use of 5-ASA in IBD by Indian gastroenterologists. The aim is to aid practitioners in selecting appropriate treatment strategies and facilitate optimal use of 5-ASA in patients with IBD.
    Keywords inflammatory bowel disease ; 5-aminosalicylic acid ; crohn disease ; colitis ; ulcerative ; mesalamine ; Medicine ; R ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Korean Association for the Study of Intestinal Diseases
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: TPMT and DPD Polymorphisms

    T. F. Ashavaid / Rani Raghavan / Swarup Shah / Asha Kapadia / Sachin Almel / Devendra Desai

    Disease Markers, Vol 27, Iss 5, Pp 231-

    Efficient Screening Method for Indian Patients Considering Taking Thiopurine and 5-FU Drugs

    2009  Volume 238

    Abstract: Introduction: Development of DNA-based tests for TPMT/DPD polymorphisms can help clinicians and patients to make important decisions about cancer treatment. Also, due to lack of Indian data, we aimed at the development and validation of these tests in ... ...

    Abstract Introduction: Development of DNA-based tests for TPMT/DPD polymorphisms can help clinicians and patients to make important decisions about cancer treatment. Also, due to lack of Indian data, we aimed at the development and validation of these tests in Indian patients.
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2009-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Indian guidelines on imaging of the small intestine in Crohn’s disease

    Saurabh Kedia / Raju Sharma / Govind Makharia / Vineet Ahuja / Devendra Desai / Devasenathipathy Kandasamy / Anu Eapen / Karthik Ganesan / Uday C Ghosha / Naveen Kalra / R Karthikeyan / Kumble Seetharama Madhusudhan / Mathew Philip / Amarender Puri / Sunil Puri / Saroj K Sinha / Rupa Banerjee / Shobna Bhatia / Naresh Bhat /
    Sunil Dadhich / G K Dhali / B D Goswami / S K Issar / V Jayanthi / S P Misra / Sandeep Nijhawan / Pankaj Puri / Avik Sarkar / S P Singh / Anshu Srivastava / Philip Abraham / B S Ramakrishna

    Indian Journal of Radiology and Imaging, Vol 29, Iss 02, Pp 111-

    A joint Indian Society of Gastroenterology and Indian Radiology and Imaging Association consensus statement

    2019  Volume 132

    Abstract: The Indian Society of Gastroenterology (ISG) Task Force on Inflammatory Bowel Disease and the Indian Radiological and Imaging Association (IRIA) developed combined ISG-IRIA evidence-based best-practice guidelines for imaging of the small intestine in ... ...

    Abstract The Indian Society of Gastroenterology (ISG) Task Force on Inflammatory Bowel Disease and the Indian Radiological and Imaging Association (IRIA) developed combined ISG-IRIA evidence-based best-practice guidelines for imaging of the small intestine in patients suspected to have or having Crohn’s disease. The 29 consensus statements, developed through a modified Delphi process, are intended to serve as reference for teaching, clinical practice, and research.
    Keywords biologics ; computerized tomography enterography ; enterography ; imaging ; inflammatory bowel disease ; magnetic resonance imaging ; tuberculosis ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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