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Article ; Online: Integrity in nursing students: A concept analysis.

Devine, Christine A / Chin, Elizabeth Danells

2017 Volume 60, Page(s) 133–138

Abstract: Objective: The purpose of this review was to clarify the concept of nursing student integrity. Unlike published reviews that highlight the absence of integrity, the author sought to identify the positive defining characteristics of integrity.: Design!# ...

Abstract	Objective: The purpose of this review was to clarify the concept of nursing student integrity. Unlike published reviews that highlight the absence of integrity, the author sought to identify the positive defining characteristics of integrity. Design: Concept analysis. Data sources: A literature review was conducted using the Cumulative Index for Nursing and Allied Health, Social Science Index, Psyc Info and Medline. Inclusion criteria included peer reviewed articles, written in English, with no limitation on publication date. The search also revealed that a concept analysis of integrity had not been performed. Review methods: Walker and Avant's (2005) eight step modification of Wilson's (1963) classic concept analysis procedure was used as the organizing framework to explore how the concept of integrity is defined in the current literature. Results: Nursing student integrity was analyzed using Walker and Avant's method of concept analysis: concept definition, defining attribute, model, borderline, related and contrary cases, antecedents, consequences and empirical referents (Walker and Avant 2005). Defining attributes to nursing student integrity were honesty, ethical behavior and professionalism. Antecedents to integrity included an academic culture of respect, characterized by student-faculty relationships derived from mutual respect, trust and a shared learning goal. Conclusions: This review identified honesty, ethical behavior and professionalism as the defining attributes of integrity. The importance of faculty as role models of integrity was paramount in building a culture of honesty. Future research should explore faculty perceptions of their professional role as models of integrity, and faculty perceptions of behaviors that promote a culture of respect.
Language	English
Publishing date	2017-10-31
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	1062570-7
ISSN	1532-2793 ; 0260-6917
ISSN (online)	1532-2793
ISSN	0260-6917
DOI	10.1016/j.nedt.2017.10.005
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Article ; Online: Building Resilience Among Nursing Students.

Liljestrand, Rebecca L / Chandler, Genevieve E / Devine, Christine A / Pérez, Jennifer Rivera / Mchenga, Nellipher Lewis / Kalmakis, Karen A

Nurse educator

2023

Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1034267-9
ISSN	1538-9855 ; 0363-3624
ISSN (online)	1538-9855
ISSN	0363-3624
DOI	10.1097/NNE.0000000000001555
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Article ; Online: FROM THE LAB BENCH TO THE KITCHEN BENCH

Devine, Christine A. / Wang, Joshua / Burfeind, Dana

Proceedings of The Australian Conference on Science and Mathematics Education (formerly UniServe Science Conference); Proceedings of The Australian Conference on Science and Mathematics Education (2020); 21

SUPPORTING SCIENCE SKILLS TRAINING AT HOME

2020

Abstract: Lab based learning experiences provide rich opportunities for our students to practise science in an authentic context and help to equip them with the necessary technical skills for their future employment. The recent disruption caused by the COVID-19 ... ...

Abstract	Lab based learning experiences provide rich opportunities for our students to practise science in an authentic context and help to equip them with the necessary technical skills for their future employment. The recent disruption caused by the COVID-19 pandemic has highlighted the necessity of the science sector to respond to both the immediate and future challenges associated with the virus. Yet at the same time, opportunities to develop the necessary skill sets were absent; many academics forced to either remove the practical element from courses or supplement with videos and data sets for analysis. We developed the Kitchen Lab program to provide a safe-to-fail, learner-centred environment for students to further develop technical skills and confidence that will support their success. Workshops are curriculum aligned, inquiry-based, and free from assessment. In the current environment, Kitchen Lab could serve as a model to support others in maintaining authentic and physical laboratory learning opportunities for their students. This presentation will discuss the development and implementation of a blended delivery of science skills training in the co-curricular space in response to the enforced shutdown of face-to-face learning on campus. Challenges and opportunities to supporting hands-on skills in this space will be considered.
Keywords	laboratory skills ; confidence ; blended learning ; covid19
Subject code	028
Language	English
Publishing date	2020-09-26
Publisher	University of Sydney
Publishing country	au
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Distinct expression patterns of syndecans in the embryonic zebrafish brain.

Hofmeister, Wolfgang / Devine, Christine A / Key, Brian

Gene expression patterns : GEP

2013 Volume 13, Issue 3-4, Page(s) 126–132

Abstract: Axon pathfinding in the neuroepithelium of embryonic brain is dependent on a variety of short and long range guidance cues. Heparan sulfate proteoglycans such as syndecans act as modulators of these cues and their importance in neural development is ... ...

Abstract	Axon pathfinding in the neuroepithelium of embryonic brain is dependent on a variety of short and long range guidance cues. Heparan sulfate proteoglycans such as syndecans act as modulators of these cues and their importance in neural development is highlighted by their phylogenetic conservation. In Drosophilia, a single syndecan is present on the surface of axon growth cones and is required for chemorepulsive signalling during midline crossing. Understanding the role of syndecans in the vertebrate nervous system is challenging given that there are four homologous genes, syndecans 1-4. We show here that syndecans 2-4 are expressed in the zebrafish embryonic brain during the major period of axon growth. These genes show differing expression patterns in the brain which provides putative insights into their functional specificity.
MeSH term(s)	Animals ; Axons/metabolism ; Brain/growth & development ; Brain/metabolism ; Embryonic Development/genetics ; Gene Expression Regulation, Developmental ; Neurogenesis/genetics ; Phylogeny ; Signal Transduction/genetics ; Syndecan-2/genetics ; Syndecan-3/genetics ; Syndecan-4/genetics ; Zebrafish/genetics ; Zebrafish/growth & development ; Zebrafish Proteins/genetics
Chemical Substances	Syndecan-3 ; Syndecan-4 ; Zebrafish Proteins ; sdc2 protein, zebrafish ; Syndecan-2 (149769-25-5)
Language	English
Publishing date	2013-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2058346-1
ISSN	1872-7298 ; 1567-133X
ISSN (online)	1872-7298
ISSN	1567-133X
DOI	10.1016/j.gep.2013.02.002
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Article: Distinct expression patterns of syndecans in the embryonic zebrafish brain

Hofmeister, Wolfgang / Devine, Christine A / Key, Brian

Gene expression patterns. 2013 , v. 13, no. 3-4

2013

Abstract	Axon pathfinding in the neuroepithelium of embryonic brain is dependent on a variety of short and long range guidance cues. Heparan sulfate proteoglycans such as syndecans act as modulators of these cues and their importance in neural development is highlighted by their phylogenetic conservation. In Drosophilia, a single syndecan is present on the surface of axon growth cones and is required for chemorepulsive signalling during midline crossing. Understanding the role of syndecans in the vertebrate nervous system is challenging given that there are four homologous genes, syndecans 1–4. We show here that syndecans 2–4 are expressed in the zebrafish embryonic brain during the major period of axon growth. These genes show differing expression patterns in the brain which provides putative insights into their functional specificity.
Keywords	Danio rerio ; brain ; crossing ; genes ; heparan sulfate ; neurodevelopment ; phylogeny ; proteoglycans ; vertebrates
Language	English
Dates of publication	2013-03
Size	p. 126-132.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2058346-1
ISSN	1872-7298 ; 1567-133X
ISSN (online)	1872-7298
ISSN	1567-133X
DOI	10.1016/j.gep.2013.02.002
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Article ; Online: Hedgehog Signaling Regulates Neurogenesis in the Larval and Adult Zebrafish Hypothalamus.

Male, Ira / Ozacar, A Tuba / Fagan, Rita R / Loring, Matthew D / Shen, Meng-Chieh / Pace, Veronica A / Devine, Christine A / Lawson, Grace E / Lutservitz, Alyssa / Karlstrom, Rolf O

eNeuro

2020 Volume 7, Issue 6

Abstract: Neurogenesis is now known to play a role in adult hypothalamic function, yet the cell-cell mechanisms regulating this neurogenesis remain poorly understood. Here, we show that Hedgehog (Hh)/Gli signaling positively regulates hypothalamic neurogenesis in ... ...

Abstract	Neurogenesis is now known to play a role in adult hypothalamic function, yet the cell-cell mechanisms regulating this neurogenesis remain poorly understood. Here, we show that Hedgehog (Hh)/Gli signaling positively regulates hypothalamic neurogenesis in both larval and adult zebrafish and is necessary and sufficient for normal hypothalamic proliferation rates. Hh-responsive radial glia represent a relatively highly proliferative precursor population that gives rise to dopaminergic, serotonergic, and GABAergic neurons.
MeSH term(s)	Animals ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Hypothalamus/metabolism ; Larva/metabolism ; Neurogenesis ; Signal Transduction ; Zebrafish/metabolism
Chemical Substances	Hedgehog Proteins
Language	English
Publishing date	2020-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2800598-3
ISSN	2373-2822 ; 2373-2822
ISSN (online)	2373-2822
ISSN	2373-2822
DOI	10.1523/ENEURO.0226-20.2020
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Article ; Online: Frizzled-3a and slit2 genetically interact to modulate midline axon crossing in the telencephalon.

Hofmeister, Wolfgang / Devine, Christine A / Rothnagel, Joseph A / Key, Brian

Mechanisms of development

2012 Volume 129, Issue 5-8, Page(s) 109–124

Abstract: The anterior commissure forms the first axon connections between the two sides of the embryonic telencephalon. We investigated the role of the transmembrane receptor Frizzled-3a in the development of this commissure using zebrafish as an experimental ... ...

Abstract	The anterior commissure forms the first axon connections between the two sides of the embryonic telencephalon. We investigated the role of the transmembrane receptor Frizzled-3a in the development of this commissure using zebrafish as an experimental model. Knock down of Frizzled-3a resulted in complete loss of the anterior commissure. This defect was accompanied by a loss of the glial bridge, expansion of the slit2 expression domain and perturbation of the midline telencephalic-diencephalic boundary. Blocking Slit2 activity following knock down of Frizzled-3a effectively rescued the anterior commissure defect which suggested that Frizzled-3a was indirectly controlling the growth of axons across the rostral midline. We have shown here that Frizzled-3a is essential for normal development of the commissural plate and that loss-of-function causes Slit2-dependent defects in axon midline crossing in the embryonic vertebrate forebrain. These data supports a model whereby Wnt signaling through Frizzled-3a attenuates expression of Slit2 in the rostral midline of the forebrain. The absence of Slit2 facilitates the formation of a midline bridge of glial cells which is used as a substrate for commissural axons. In the absence of this platform of glia, commissural axons fail to cross the rostral midline of the forebrain.
MeSH term(s)	Animals ; Axons/drug effects ; Axons/metabolism ; Base Sequence ; Body Patterning/drug effects ; Body Patterning/genetics ; Diencephalon/cytology ; Diencephalon/drug effects ; Diencephalon/metabolism ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/drug effects ; Embryo, Nonmammalian/metabolism ; Fertilization/drug effects ; Frizzled Receptors/genetics ; Frizzled Receptors/metabolism ; Gene Expression Regulation, Developmental/drug effects ; Gene Knockdown Techniques ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Models, Biological ; Molecular Sequence Data ; Morpholinos/pharmacology ; Neuroglia/drug effects ; Neuroglia/metabolism ; Phenotype ; Telencephalon/cytology ; Telencephalon/drug effects ; Telencephalon/embryology ; Telencephalon/metabolism ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Chemical Substances	Frizzled Receptors ; Fzd3a protein, zebrafish ; Intracellular Signaling Peptides and Proteins ; Morpholinos ; Slit2 protein, zebrafish ; Zebrafish Proteins
Language	English
Publishing date	2012-05-17
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1055986-3
ISSN	1872-6356 ; 0925-4773
ISSN (online)	1872-6356
ISSN	0925-4773
DOI	10.1016/j.mod.2012.05.004
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Article: Identifying axon guidance defects in the embryonic zebrafish brain.

Devine, Christine A / Key, Brian

Methods in cell science : an official journal of the Society for In Vitro Biology

2003 Volume 25, Issue 1-2, Page(s) 33–37

Abstract: The method described here outlines a simple protocol to investigate the in vivo function of axon guidance molecules during the development of the embryonic zebrafish brain. By 24 hours postfertilization, a simple scaffold of axon tracts and commissures ... ...

Abstract	The method described here outlines a simple protocol to investigate the in vivo function of axon guidance molecules during the development of the embryonic zebrafish brain. By 24 hours postfertilization, a simple scaffold of axon tracts and commissures can be visualised in the brain using acetylated alpha-tubulin, a panaxonal marker that stains all axons. The highly stereotypical trajectory of axons in the embryonic zebrafish brain provides an ideal system in which to study the molecular mechanisms of axon guidance, as defects in the axon scaffold can be clearly visualised. We describe here our approach to identify defects in the trajectory of axons that establish the initial template of tracts in the embryonic fore- and mid-brain. By combining immunohistochemical techniques and confocal microscopy on dissected wholemounts of embryonic brains we are able to observe at high resolution the complete scaffold of axon tracts. This approach provides a rapid and simple means of assessing axon guidance defects in the developing brain. Given the advantages of the zebrafish as a model system, and the range of molecular perturbation methods now available, this technique provides a valuable tool for assessing the phenotypic effects of gene perturbations in a biologically relevant context.
MeSH term(s)	Animals ; Axons/physiology ; Brain/anatomy & histology ; Brain/physiology ; Cell Movement/physiology ; Embryo, Nonmammalian/anatomy & histology ; Embryonic Induction/physiology ; Gene Expression Regulation, Developmental/physiology ; Neurons/cytology ; Neurons/physiology ; Zebrafish/anatomy & histology ; Zebrafish/embryology ; Zebrafish/physiology
Language	English
Publishing date	2003
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1237005-8
ISSN	1381-5741
ISSN	1381-5741
DOI	10.1023/B:MICS.0000006851.84998.e0
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Article: Zebrafish as an experimental model: strategies for developmental and molecular neurobiology studies.

Key, Brian / Devine, Christine A

Methods in cell science : an official journal of the Society for In Vitro Biology

2003 Volume 25, Issue 1-2, Page(s) 1–6

Abstract: Zebrafish provide a rapid and effective means for assessing gene function in the vertebrate nervous system. By employing gain- and loss-of-function techniques it is possible to obtain insights into the roles of both wild-type and heterologously expressed ...

Abstract	Zebrafish provide a rapid and effective means for assessing gene function in the vertebrate nervous system. By employing gain- and loss-of-function techniques it is possible to obtain insights into the roles of both wild-type and heterologously expressed genes. Such approaches enable rapid progression from gene discovery to gene expression and finally to gene function even when examining development of a tissue as complex as the nervous system. Exploiting the full potential of zebrafish as a bioassay for the nervous system will require, not only an understanding of the molecular and cellular basis of normal zebrafish development, but also an appreciation of comparative processes in other species. When applied to mutant animals, classic morphological approaches and contemporary molecular genetic techniques are providing a wealth of information on the development of the nervous system at the molecular, cell, system and behavioural levels. Zebrafish are now emerging as an important tool, supporting mouse genetical approaches for understanding neural function in vertebrates.
MeSH term(s)	Animals ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/physiology ; Models, Animal ; Models, Genetic ; Neurobiology ; Zebrafish/anatomy & histology ; Zebrafish/genetics ; Zebrafish/physiology
Language	English
Publishing date	2003
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1237005-8
ISSN	1381-5741
ISSN	1381-5741
DOI	10.1023/B:MICS.0000006849.98007.03
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Article ; Online: A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary.

Devine, Christine A / Sbrogna, Jennifer L / Guner, Burcu / Osgood, Marcey / Shen, Meng-Chieh / Karlstrom, Rolf O

Developmental biology

2008 Volume 326, Issue 1, Page(s) 143–154

Abstract: Hedgehog (Hh) signaling is necessary for the induction and functional patterning of the pituitary placode, however the mechanisms by which Hh signals are interpreted by placodal cells are unknown. Here we show distinct temporal requirements for Hh ... ...

Abstract	Hedgehog (Hh) signaling is necessary for the induction and functional patterning of the pituitary placode, however the mechanisms by which Hh signals are interpreted by placodal cells are unknown. Here we show distinct temporal requirements for Hh signaling in endocrine cell differentiation and describe a dynamic Gli transcriptional response code that interprets these Hh signals within the developing adenohypophysis. Gli1 is required for the differentiation of selected endocrine cell types and acts as the major activator of Hh-mediated pituitary induction, while Gli2a and Gli2b contribute more minor activator functions. Intriguingly, this Gli response code changes as development proceeds. Gli1 continues to be required for the activation of the Hh response anteriorly in the pars distalis. In contrast, Gli2b is required to repress Hh target gene expression posteriorly in the pars intermedia. Consistent with these changing roles, gli1, gli2a, and gli2b, but not gli3, are expressed in pituitary precursor cells at the anterior neural ridge. Later in development, gli1 expression is maintained throughout the adenohypophysis while gli2a and gli2b expression are restricted to the pars intermedia. Given the link between Hh signaling and pituitary adenomas in humans, our data suggest misregulation of Gli function may contribute to these common pituitary tumors.
MeSH term(s)	Animals ; Body Patterning/physiology ; Cell Differentiation/physiology ; Embryo, Nonmammalian/physiology ; Endocrine Cells/cytology ; Endocrine Cells/physiology ; Hedgehog Proteins/physiology ; Mutation/genetics ; Oncogene Proteins/genetics ; Oncogene Proteins/physiology ; Pituitary Gland/cytology ; Pituitary Gland/embryology ; Pituitary Gland, Anterior/cytology ; Pituitary Gland, Anterior/embryology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Trans-Activators/genetics ; Trans-Activators/physiology ; Transcription Factors/genetics ; Transcription Factors/physiology ; Veratrum Alkaloids/pharmacology ; Zebrafish/embryology ; Zebrafish Proteins/genetics ; Zebrafish Proteins/physiology ; Zinc Finger Protein GLI1 ; Zinc Finger Protein Gli2
Chemical Substances	Hedgehog Proteins ; Oncogene Proteins ; Trans-Activators ; Transcription Factors ; Veratrum Alkaloids ; Zebrafish Proteins ; Zinc Finger Protein GLI1 ; Zinc Finger Protein Gli2 ; gli2a protein, zebrafish ; cyclopamine (ZH658AJ192)
Language	English
Publishing date	2008-11-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1114-9
ISSN	1095-564X ; 0012-1606
ISSN (online)	1095-564X
ISSN	0012-1606
DOI	10.1016/j.ydbio.2008.11.006
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