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  1. Article ; Online: Ablation of CD8

    Swaminathan, Srividhya / Lineburg, Katie E / Panikkar, Archana / Raju, Jyothy / Murdolo, Lawton D / Szeto, Christopher / Crooks, Pauline / Le Texier, Laetitia / Rehan, Sweera / Dewar-Oldis, Michael J / Barnard, Peter J / Ambalathingal, George R / Neller, Michelle A / Short, Kirsty R / Gras, Stephanie / Khanna, Rajiv / Smith, Corey

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 6387

    Abstract: The emergence of the SARS-CoV-2 Omicron variant has raised concerns of escape from vaccine-induced immunity. A number of studies have demonstrated a reduction in antibody-mediated neutralization of the Omicron variant in vaccinated individuals. ... ...

    Abstract The emergence of the SARS-CoV-2 Omicron variant has raised concerns of escape from vaccine-induced immunity. A number of studies have demonstrated a reduction in antibody-mediated neutralization of the Omicron variant in vaccinated individuals. Preliminary observations have suggested that T cells are less likely to be affected by changes in Omicron. However, the complexity of human leukocyte antigen genetics and its impact upon immunodominant T cell epitope selection suggests that the maintenance of T cell immunity may not be universal. In this study, we describe the impact that changes in Omicron BA.1, BA.2 and BA.3 have on recognition by spike-specific T cells. These T cells constitute the immunodominant CD8
    MeSH term(s) Humans ; Immunodominant Epitopes ; SARS-CoV-2/genetics ; COVID-19 ; CD8-Positive T-Lymphocytes ; Antibodies, Viral ; Antibodies, Neutralizing ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Immunodominant Epitopes ; Antibodies, Viral ; Antibodies, Neutralizing ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-34180-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 vaccine booster induces a strong CD8+ T cell response against Omicron variant epitopes in HLA-A*02:01+ individuals

    Nguyen, Andrea T. / Szeto, Christopher / Chatzileontiadou, Demetra S.M. / Tong, Zhen Wei Marcus / Dewar-Oldis, Michael J. / Cooper, Lucy / Murdolo, Lawton D. / Chew, Keng Yih / Lineburg, Katie E. / Riboldi-Tunicliffe, Alan / Williamson, Rachel / Gardiner, Bradley J. / Jayasinghe, Dhilshan / Lobos, Christian A. / Ahn, You Min / Grant, Emma J. / Smith, Corey / McMahon, James / Good-Jacobson, Kim L. /
    Barnard, Peter J. / Short, Kirsty R. / Gras, Stephanie

    bioRxiv

    Abstract: The >30 mutated residues in the Omicron spike protein have led to its rapid classification as a new SARS-CoV-2 variant of concern. As a result, Omicron may escape from the immune system, decreasing the protection provided by COVID-19 vaccines. ... ...

    Abstract The >30 mutated residues in the Omicron spike protein have led to its rapid classification as a new SARS-CoV-2 variant of concern. As a result, Omicron may escape from the immune system, decreasing the protection provided by COVID-19 vaccines. Preliminary data shows a weaker neutralizing antibody response to Omicron compared to the ancestral SARS-CoV-2 virus, which can be increased after a booster vaccine. Here, we report that CD8+ T cells can recognize Omicron variant epitopes presented by HLA-A*02:01 in both COVID-19 recovered and vaccinated individuals, even 6 months after infection or vaccination. Additionally, the T cell response was stronger for Omicron variant epitopes after the vaccine booster. Altogether, T cells can recognize Omicron variants, especially in vaccinated individuals after the vaccine booster.
    Keywords covid19
    Language English
    Publishing date 2022-01-13
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2022.01.12.473243
    Database COVID19

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  3. Article ; Online: A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection.

    Augusto, Danillo G / Murdolo, Lawton D / Chatzileontiadou, Demetra S M / Sabatino, Joseph J / Yusufali, Tasneem / Peyser, Noah D / Butcher, Xochitl / Kizer, Kerry / Guthrie, Karoline / Murray, Victoria W / Pae, Vivian / Sarvadhavabhatla, Sannidhi / Beltran, Fiona / Gill, Gurjot S / Lynch, Kara L / Yun, Cassandra / Maguire, Colin T / Peluso, Michael J / Hoh, Rebecca /
    Henrich, Timothy J / Deeks, Steven G / Davidson, Michelle / Lu, Scott / Goldberg, Sarah A / Kelly, J Daniel / Martin, Jeffrey N / Vierra-Green, Cynthia A / Spellman, Stephen R / Langton, David J / Dewar-Oldis, Michael J / Smith, Corey / Barnard, Peter J / Lee, Sulggi / Marcus, Gregory M / Olgin, Jeffrey E / Pletcher, Mark J / Maiers, Martin / Gras, Stephanie / Hollenbach, Jill A

    Nature

    2023  Volume 620, Issue 7972, Page(s) 128–136

    Abstract: Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2 remain ... ...

    Abstract Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2 remain asymptomatic
    MeSH term(s) Humans ; Alleles ; Asymptomatic Infections ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/physiopathology ; COVID-19/virology ; Epitopes, T-Lymphocyte/immunology ; Peptides/immunology ; SARS-CoV-2/immunology ; HLA-B Antigens/immunology ; Cohort Studies ; T-Lymphocytes/immunology ; Immunodominant Epitopes/immunology ; Cross Reactions/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Epitopes, T-Lymphocyte ; Peptides ; HLA-B Antigens ; Immunodominant Epitopes ; spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06331-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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