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  1. Article ; Online: Antibodies against Histoplasma capsulatum and Aspergillus fumigatus among chronic TB patients in Indonesia: a cross-sectional study.

    Dewi, Intan M W / Fauziah, Nisa / Ekawardhani, Savira / Andriyoko, Basti / Adawiyah, Robiatul / Hartantri, Yovita / Soeroto, Arto Yuwono / Alisjahbana, Bachti / Denning, David W / Wahyuningsih, Retno

    Medical mycology

    2023  Volume 61, Issue 5

    Abstract: Chronic pulmonary fungal infections may occur in patients with previous history of pulmonary tuberculosis (TB), and are often clinically misclassified as TB, especially when bacteriological confirmation for Mycobacterium tuberculosis is absent. In this ... ...

    Abstract Chronic pulmonary fungal infections may occur in patients with previous history of pulmonary tuberculosis (TB), and are often clinically misclassified as TB, especially when bacteriological confirmation for Mycobacterium tuberculosis is absent. In this study, we investigated the prevalence of antibody against Histoplasma capsulatum and Aspergillus fumigatus in patients with confirmed and clinically chronic TB. Antibodies against H. capsulatum and A. fumigatus were measured from serum samples using enzyme-linked immunosorbent assay (ELISA). The presence M. tuberculosis in sputum was confirmed using smear microscopy, GeneXpert MTB/RIF assay, or culture. Antibodies against H. capsulatum and A. fumigatus were elevated in 16.9% and 26.9% of bacteriologically confirmed chronic TB patients, and 12.1% and 18.2% in those without bacteriological confirmation, respectively. Approximately one-third of patients who had positive anti-Histoplasma antibody also had elevated levels of antibody against Aspergillus fumigatus (P < .001). Our study highlights the importance of chronic pulmonary fungal infection in post-TB patients with recurrent respiratory symptoms.
    MeSH term(s) Animals ; Aspergillus fumigatus ; Histoplasma ; Cross-Sectional Studies ; Indonesia ; Sensitivity and Specificity ; Tuberculosis/diagnosis ; Tuberculosis/veterinary ; Mycobacterium tuberculosis ; Antibodies ; Sputum/microbiology
    Chemical Substances Antibodies
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1421796-x
    ISSN 1460-2709 ; 1369-3786
    ISSN (online) 1460-2709
    ISSN 1369-3786
    DOI 10.1093/mmy/myad036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Multifaceted Role of T-Helper Responses in Host Defense against Aspergillus fumigatus.

    Dewi, Intan M W / van de Veerdonk, Frank L / Gresnigt, Mark S

    Journal of fungi (Basel, Switzerland)

    2017  Volume 3, Issue 4

    Abstract: The ubiquitous opportunistic fungal ... ...

    Abstract The ubiquitous opportunistic fungal pathogen
    Language English
    Publishing date 2017-10-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof3040055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Platelets Modulate IFN-γ Production against

    Dewi, Intan M W / Aleva, Floor E / Kullaya, Vesla I / Garishah, Fadel M / de Mast, Quirijn / van der Ven, André J A M / van de Veerdonk, Frank L

    Journal of immunology (Baltimore, Md. : 1950)

    2019  Volume 204, Issue 1, Page(s) 122–127

    Abstract: Platelets are known to have immunomodulatory properties. They modulate immune responses of leukocytes against various pathogens, including fungi. ...

    Abstract Platelets are known to have immunomodulatory properties. They modulate immune responses of leukocytes against various pathogens, including fungi.
    MeSH term(s) Blood Platelets/immunology ; Candida albicans/drug effects ; Candida albicans/immunology ; Healthy Volunteers ; Humans ; Interferon-gamma/biosynthesis ; Interferon-gamma/immunology ; Interferon-gamma/pharmacology ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/immunology ; Prostaglandins/immunology
    Chemical Substances Prostaglandins ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2019-11-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1900599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways.

    Bruno, Mariolina / Dewi, Intan M W / Matzaraki, Vicky / Ter Horst, Rob / Pekmezovic, Marina / Rösler, Berenice / Groh, Laszlo / Röring, Rutger J / Kumar, Vinod / Li, Yang / Carvalho, Agostinho / Netea, Mihai G / Latgé, Jean-Paul / Gresnigt, Mark S / van de Veerdonk, Frank L

    Computational and structural biotechnology journal

    2020  Volume 19, Page(s) 647–663

    Abstract: Candidiasis, aspergillosis, and mucormycosis cause the majority of nosocomial fungal infections in immunocompromised patients. Using an unbiased transcriptional profiling in PBMCs exposed to the fungal species causing these infections, we found a core ... ...

    Abstract Candidiasis, aspergillosis, and mucormycosis cause the majority of nosocomial fungal infections in immunocompromised patients. Using an unbiased transcriptional profiling in PBMCs exposed to the fungal species causing these infections, we found a core host response in healthy individuals that may govern effective fungal clearance: it consists of 156 transcripts, involving canonical and non-canonical immune pathways. Systematic investigation of key steps in antifungal host defense revealed fungal-specific signatures. As previously demonstrated,
    Language English
    Publishing date 2020-12-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2020.12.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways.

    Bruno, Mariolina / Dewi, Intan M W / Matzaraki, Vicky / Ter Horst, Rob / Pekmezovic, Marina / Rösler, Berenice / Groh, Laszlo / Röring, Rutger J / Kumar, Vinod / Li, Yang / Carvalho, Agostinho / Netea, Mihai G / Latgé, Jean-Paul / Gresnigt, Mark S / van de Veerdonk, Frank L

    19 ; 647 ; 663 ; Computational and structural biotechnology journal ; Netherlands

    2020  

    Abstract: Candidiasis, aspergillosis, and mucormycosis cause the majority of nosocomial fungal infections in immunocompromised patients. Using an unbiased transcriptional profiling in PBMCs exposed to the fungal species causing these infections, we found a core ... ...

    Abstract Candidiasis, aspergillosis, and mucormycosis cause the majority of nosocomial fungal infections in immunocompromised patients. Using an unbiased transcriptional profiling in PBMCs exposed to the fungal species causing these infections, we found a core host response in healthy individuals that may govern effective fungal clearance: it consists of 156 transcripts, involving canonical and non-canonical immune pathways. Systematic investigation of key steps in antifungal host defense revealed fungal-specific signatures. As previously demonstrated, Candida albicans induced type I and Type II interferon-related pathways. In contrast, central pattern recognition receptor, reactive oxygen species production, and host glycolytic pathways were down-regulated in response to Rhizopus oryzae, which was associated with an ER-stress response. TLR5 was identified to be uniquely regulated by Aspergillus fumigatus and to control cytokine release in response to this fungus. In conclusion, our data reveals the transcriptional profiles induced by C. albicans, A. fumigatus, and R. oryzae, and describes both the common and specific antifungal host responses that could be exploited for novel therapeutic strategies.
    Keywords A. fumigatus ; Antifungal core host response ; C. albicans ; Cytokines ; Host immune response ; Immunometabolism ; Opportunistic infections ; Pattern recognition receptors ; R. oryzae ; RNAseq ; Transcriptomics of pathogenic fungi
    Language English
    Publishing date 2020-12-26
    Publisher Elsevier
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Neuraminidase and SIGLEC15 modulate the host defense against pulmonary aspergillosis.

    Dewi, Intan M W / Cunha, Cristina / Jaeger, Martin / Gresnigt, Mark S / Gkountzinopoulou, Marina E / Garishah, Fadel M / Duarte-Oliveira, Cláudio / Campos, Cláudia F / Vanderbeke, Lore / Sharpe, Agustin Resendiz / Brüggemann, Roger J / Verweij, Paul E / Lagrou, Katrien / Vande Velde, Greetje / de Mast, Quirijn / Joosten, Leo A B / Netea, Mihai G / van der Ven, Andre J A M / Wauters, Joost /
    Carvalho, Agostinho / van de Veerdonk, Frank L

    Cell reports. Medicine

    2021  Volume 2, Issue 5, Page(s) 100289

    Abstract: Influenza-associated pulmonary aspergillosis (IAPA) has been reported increasingly since the advent of use of neuraminidase (NA) inhibitors following the 2009 influenza pandemic. We hypothesize that blocking host NA modulates the immune response ... ...

    Abstract Influenza-associated pulmonary aspergillosis (IAPA) has been reported increasingly since the advent of use of neuraminidase (NA) inhibitors following the 2009 influenza pandemic. We hypothesize that blocking host NA modulates the immune response against
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Aspergillus/drug effects ; Aspergillus fumigatus/drug effects ; Humans ; Immunoglobulins/drug effects ; Immunoglobulins/metabolism ; Leukocytes, Mononuclear/drug effects ; Lung/drug effects ; Membrane Proteins/drug effects ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Neuraminidase/antagonists & inhibitors ; Neuraminidase/pharmacology ; Oseltamivir/pharmacology ; Phagocytosis/drug effects ; Pulmonary Aspergillosis/drug therapy ; Mice
    Chemical Substances Antiviral Agents ; Immunoglobulins ; Membrane Proteins ; SIGLEC15 protein, human ; Oseltamivir (20O93L6F9H) ; Neuraminidase (EC 3.2.1.18)
    Language English
    Publishing date 2021-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2021.100289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Platelet function alterations in dengue are associated with plasma leakage

    Michels, Meta / Alisjahbana, Bachti / de Groot, Philip G. / Indrati, Agnes R. / Fijnheer, Rob / Puspita, Mita / Dewi, Intan M. W. / van de Wijer, Lisa / de Boer, Ellen M. S. / Roest, Mark / van der Ven, André J. A. M. / de Mast, Quirijn

    Thrombosis and Haemostasis

    2014  Volume 111, Issue 08, Page(s) 352–362

    Abstract: Severe dengue is characterised by thrombocytopenia, plasma leakage and bleeding. Platelets are important for preservation of endothelial integrity. We hypothesised that platelet activation with secondary platelet dysfunction contribute to plasma leakage. ...

    Abstract Severe dengue is characterised by thrombocytopenia, plasma leakage and bleeding. Platelets are important for preservation of endothelial integrity. We hypothesised that platelet activation with secondary platelet dysfunction contribute to plasma leakage. In adult Indonesian patients with acute dengue, we measured platelet activation status and the response to the platelet agonist TRAP using flow cytometerbased assays. Patients were monitored daily for plasma leakage by ultrasonography. Acute dengue was associated with platelet activation with an increased expression of the activated fibrinogen receptor (α IIb β 3 ), the lysosomal marker CD63 and the alpha-granule marker CD62P (P-selectin). Upon maximal platelet activation by TRAP, platelet function defects were observed with a significantly reduced maximal activated α IIb β 3 and CD63 expression and reduced platelet-monocyte and platelet-neutrophil complexes. Patients in the lowest tertile of activated α IIb β 3 and CD63 expression had an odds ratio for plasma leakage of 5.2 (95% confidence interval [CI] 1.3–22.7) and 3.9 (95% CI 1.1–13.7), respectively, compared to the highest tertile. Platelet-derived serotonin has previously been related to plasma leakage and we found increased intra-platelet serotonin concentrations in our patients. In conclusion, platelet activation with platelet function alterations can be found in patients with acute dengue and this may contribute to dengue-associated plasma leakage.
    Keywords Dengue virus infection ; platelet function ; flow cytometry ; plasma leakage ; serotonin
    Language English
    Publishing date 2014-01-01
    Publisher Schattauer GmbH
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1160/TH14-01-0056
    Database Thieme publisher's database

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