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  1. Article ; Online: Dexamethasone to combat cytokine storm in COVID-19: Clinical trials and preliminary evidence.

    Sharun, Khan / Tiwari, Ruchi / Dhama, Jaideep / Dhama, Kuldeep

    International journal of surgery (London, England)

    2020  Volume 82, Page(s) 179–181

    Keywords covid19
    Language English
    Publishing date 2020-09-04
    Publishing country England
    Document type Letter
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2020.08.038
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  3. Article ; Online: Dexamethasone to combat cytokine storm in COVID-19

    Sharun, Khan / Tiwari, Ruchi / Dhama, Jaideep / Dhama, Kuldeep

    International Journal of Surgery

    Clinical trials and preliminary evidence

    2020  Volume 82, Page(s) 179–181

    Keywords Surgery ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2212038-5
    ISSN 1743-9191
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2020.08.038
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Dexamethasone: A boon for critically ill COVID-19 patients?

    Patel, Shailesh Kumar / Saikumar, Gutulla / Rana, Jigyasa / Dhama, Jaideep / Yatoo, Mohd Iqbal / Tiwari, Ruchi / Rodríguez-Morales, Alfonso J / Dhama, Kuldeep

    Travel medicine and infectious disease

    2020  Volume 37, Page(s) 101844

    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Critical Illness ; Dexamethasone/therapeutic use ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2
    Chemical Substances Anti-Inflammatory Agents ; Dexamethasone (7S5I7G3JQL)
    Keywords covid19
    Language English
    Publishing date 2020-08-10
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2020.101844
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    Zs.A 6236: Show issues Location:
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  5. Article: Dexamethasone: A boon for critically ill COVID-19 patients?

    Patel, Shailesh Kumar / Saikumar, Gutulla / Rana, Jigyasa / Dhama, Jaideep / Yatoo, Mohd Iqbal / Tiwari, Ruchi / Rodríguez-Morales, Alfonso J / Dhama, Kuldeep

    Travel Med Infect Dis

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #704024
    Database COVID19

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  6. Article ; Online: Dexamethasone

    Patel, Shailesh Kumar / Saikumar, Gutulla / Rana, Jigyasa / Dhama, Jaideep / Yatoo, Mohd Iqbal / Tiwari, Ruchi / Rodríguez-Morales, Alfonso J. / Dhama, Kuldeep

    Travel Medicine and Infectious Disease

    A boon for critically ill COVID-19 patients?

    2020  Volume 37, Page(s) 101844

    Keywords Public Health, Environmental and Occupational Health ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2020.101844
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Geriatric Population During the COVID-19 Pandemic: Problems, Considerations, Exigencies, and Beyond.

    Dhama, Kuldeep / Patel, Shailesh Kumar / Kumar, Rakesh / Rana, Jigyasa / Yatoo, Mohd Iqbal / Kumar, Akshay / Tiwari, Ruchi / Dhama, Jaideep / Natesan, Senthilkumar / Singh, Rajendra / Harapan, Harapan

    Frontiers in public health

    2020  Volume 8, Page(s) 574198

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic wreaked havoc worldwide, with more than 20 million confirmed cases and nearly 0. 75 million deaths as of 10th August 2020. Various factors determine the severity and symptoms of this infection. Older age ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic wreaked havoc worldwide, with more than 20 million confirmed cases and nearly 0. 75 million deaths as of 10th August 2020. Various factors determine the severity and symptoms of this infection. Older age and underlying diseases are the challenges being faced in controlling and treating COVID-19. In 2019, 703 million of the global population was older than 65 years of age. The estimated mortality due to COVID-19 in people older than 76 years of age is reportedly 18%. Frequent infections in older people, higher disease severity, and increased mortality are major challenges in the implementation of appropriate preventive measures and future strategies to protect against this disease in geriatric population. Poor health status, weak immune function, lowered organ function, increased probability of multiple underlying diseases, and poor attention to personal health can increase the susceptibility to various diseases in the geriatric population. Concerning inadequate immunity, the decrease expression of receptors and exaggerated pathophysiologic responses can be debilitating. However, future studies will reveal the hidden facets in these aspects in this COVID-19 catastrophe. In this article, we reviewed the main concerns of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the geriatric population, including the risk of acquiring severe COVID-19 resulting in mortality, variation in clinical manifestations, and other pandemic-related concerns. We also discussed the need for increasing attention toward the elderly, taking appropriate prevention and control measures, and considering geriatric-related adjustments in vaccine design and development.
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19 ; Humans ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.574198
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  8. Article: Possibility of SARS-CoV-2 transmission from the breast milk of COVID-19 affected women patients to their infants: worries and strategies to counter it.

    Patel, Shailesh Kumar / Pathak, Mamta / Rana, Jigyasa / Tiwari, Ruchi / Natesan, Senthilkumar / Dhama, Jaideep / Malik, Yashpal Singh / Rodriguez-Morales, Alfonso J / Dhama, Kuldeep / Pagliano, Pasquale

    Le infezioni in medicina

    2020  Volume 28, Issue 3, Page(s) 291–294

    Abstract: Not available. ...

    Abstract Not available.
    MeSH term(s) Betacoronavirus/genetics ; Betacoronavirus/isolation & purification ; Breast Feeding/methods ; Breast Milk Expression ; COVID-19 ; Coronavirus Infections/transmission ; Female ; Humans ; Infectious Disease Transmission, Vertical ; Milk, Human/virology ; Pandemics ; Pneumonia, Viral/transmission ; Pregnancy ; Pregnancy Complications, Infectious/virology ; RNA, Viral/isolation & purification ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-05-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2041081-5
    ISSN 1124-9390
    ISSN 1124-9390
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    Zs.A 5576: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: SARS-CoV-2 existence in sewage and wastewater: A global public health concern?

    Dhama, Kuldeep / Patel, Shailesh Kumar / Yatoo, Mohd Iqbal / Tiwari, Ruchi / Sharun, Khan / Dhama, Jaideep / Natesan, Senthilkumar / Malik, Yashpal Singh / Singh, Karam Pal / Harapan, Harapan

    Journal of environmental management

    2020  Volume 280, Page(s) 111825

    Abstract: The SARS-CoV-2/COVID-19 pandemic has spread across the globe and affected millions of individuals as of the efficient virus transmission potential mediated via multiple virus shedding routes. The presence of SARS-CoV-2 in the stool samples and its ... ...

    Abstract The SARS-CoV-2/COVID-19 pandemic has spread across the globe and affected millions of individuals as of the efficient virus transmission potential mediated via multiple virus shedding routes. The presence of SARS-CoV-2 in the stool samples and its prolonged shedding in environmental compartments like sewage and wastewater signifies a potential threat adding to the transmission cycle of this novel virus. The potential role played by the asymptomatic COVID-19 patients in transmitting the disease via the fecal-oral route is now under investigation. Hence, in the present scenario, wastewater-based epidemiology, and sewage surveillance may provide valuable insights into the prevalence of SARS-CoV-2 among the human population and could serve as a sensitive surveillance system and a crucial early warning tool. Further studies are required to determine the survival of SARS-CoV-2 in the environment, transmissibility through wastewater, and the potential to infect humans via the fecal-oral route. Appropriate frameworks with regards to evaluation and analysis of SARS-CoV-2 will help implement appropriate intervention strategies and necessary sanitation practices to ensure virus free clean water supply to have a check on the further spread of this pandemic virus.
    MeSH term(s) COVID-19 ; Humans ; Pandemics ; Public Health ; SARS-CoV-2 ; Sewage ; Wastewater
    Chemical Substances Sewage ; Waste Water
    Language English
    Publishing date 2020-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2020.111825
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    In stock of ZB MED Bonn / Germany

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  10. Article ; Online: Antibody-based immunotherapeutics and use of convalescent plasma to counter COVID-19: advances and prospects.

    Sharun, Khan / Tiwari, Ruchi / Iqbal Yatoo, Mohd / Patel, Shailesh Kumar / Natesan, Senthilkumar / Dhama, Jaideep / Malik, Yashpal S / Harapan, Harapan / Singh, Raj Kumar / Dhama, Kuldeep

    Expert opinion on biological therapy

    2020  Volume 20, Issue 9, Page(s) 1033–1046

    Abstract: Introduction: Coronavirus disease 2019 (COVID-19) has spread to several countries globally. Currently, there is no specific drug or vaccine available for managing COVID-19. Antibody-based immunotherapeutic strategies using convalescent plasma, ... ...

    Abstract Introduction: Coronavirus disease 2019 (COVID-19) has spread to several countries globally. Currently, there is no specific drug or vaccine available for managing COVID-19. Antibody-based immunotherapeutic strategies using convalescent plasma, monoclonal antibodies (mAbs), neutralizing antibodies (NAbs), and intravenous immunoglobulins have therapeutic potential.
    Areas covered: This review provides the current status of the development of various antibody-based immunotherapeutics such as convalescent plasma, mAbs, NAbs, and intravenous immunoglobulins against COVID-19. The review also highlights their advantages, disadvantages, and clinical utility for the treatment of COVID-19 patients.
    Expert opinion: In a pandemic situation such as COVID-19, the development of new drugs should focus on and expedite the strategies where safety and efficacy are proven. Antibody-based immunotherapeutic approaches such as convalescent plasma, intravenous immunoglobulins, and mAbs have a proven record of safety and efficacy and are in use for decades. Some of them are already being used to manage COVID-19 patients and found to be useful. However, the mAbs with virus neutralization potential is the need of the hour during this COVID-19 pandemic to be more specific and virus targeted. The research and investment need to be accelerated to bring them into clinical use for prophylactic and therapeutic purposes against COVID-19.
    MeSH term(s) Antibodies, Neutralizing/therapeutic use ; Betacoronavirus ; Coronavirus Infections/blood ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Humans ; Immunization, Passive ; Immunoglobulins, Intravenous/immunology ; Immunoglobulins, Intravenous/therapeutic use ; Immunotherapy/methods ; Immunotherapy/trends ; Pandemics/prevention & control ; Pneumonia, Viral/blood ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy
    Chemical Substances Antibodies, Neutralizing ; Immunoglobulins, Intravenous
    Keywords covid19
    Language English
    Publishing date 2020-08-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2020.1796963
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