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  1. Article: Does SIGLEC8 localize to the subcellular compartment like the Alzheimer's disease protective CD33 splice variant?

    Dhar, Chirag

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1124150

    Language English
    Publishing date 2023-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1124150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Testing for latent tuberculosis before starting patients on immune checkpoint inhibitors.

    Dhar, Chirag

    Indian journal of cancer

    2021  Volume 58, Issue 3, Page(s) 469–470

    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Latent Tuberculosis/chemically induced ; Latent Tuberculosis/virology ; Mycobacterium tuberculosis/drug effects ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neoplasms/virology
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2021-08-11
    Publishing country India
    Document type Letter
    ZDB-ID 410194-7
    ISSN 1998-4774 ; 0019-509X
    ISSN (online) 1998-4774
    ISSN 0019-509X
    DOI 10.4103/ijc.IJC_283_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 581: Show issues Location:
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  3. Article: Utilizing Publicly Available Cancer Clinicogenomic Data on CBioPortal to Compare Epidermal Growth Factor Receptor Mutant and Wildtype Non-Small Cell Lung Cancer.

    Dhar, Chirag

    Cureus

    2021  Volume 13, Issue 4, Page(s) e14683

    Abstract: Publicly available clinicogenomic data on platforms such as the cancer BioPortal (cBioPortal.org) allow for efficient analyses by researchers with little or no experience working with Big Data. cBioPortal.org also allows for appropriate statistical ... ...

    Abstract Publicly available clinicogenomic data on platforms such as the cancer BioPortal (cBioPortal.org) allow for efficient analyses by researchers with little or no experience working with Big Data. cBioPortal.org also allows for appropriate statistical testing and downloadable images for easy dissemination of findings. In this study, the cBioPortal.org platform was tested and its utility demonstrated by comparing cases of non-small cell lung cancer (NSCLC) with and without epidermal growth factor receptor gene (
    Language English
    Publishing date 2021-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.14683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chimney Sweeps’ Cancer in the 18th Century or the 21st Century Covid-19 Pandemic

    Banthiya, Sukriti / Dhar, Chirag

    How Hand-washing Has Been, Is, and Will Be the Simplest Epidemiological Intervention

    2020  

    Keywords covid19
    Publishing date 2020-07-01
    Publisher eScholarship, University of California
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: N-glycolylated carbohydrates in nature.

    Awofiranye, Adeola E / Dhar, Chirag / He, Peng / Varki, Ajit / Koffas, Mattheos A G / Linhardt, Robert J

    Glycobiology

    2022  Volume 32, Issue 11, Page(s) 921–932

    Abstract: N-glycolylated carbohydrates are amino sugars with an N-glycolyl amide group. These glycans have not been well studied due to their surprising rarity in nature in comparison with N-acetylated carbohydrates. Recently, however, there has been increasing ... ...

    Abstract N-glycolylated carbohydrates are amino sugars with an N-glycolyl amide group. These glycans have not been well studied due to their surprising rarity in nature in comparison with N-acetylated carbohydrates. Recently, however, there has been increasing interest in N-glycolylated sugars because the non-human sialic acid N-glycolylneuraminic acid (Neu5Gc), apparently the only source of all N-glycolylated sugars in deuterostomes, appears to be involved in xenosialitis (inflammation associated with consumption of Neu5Gc-rich red meats). Xenosialitis has been implicated in cancers as well as other diseases including atherosclerosis. Furthermore, metabolites of Neu5Gc have been shown to be incorporated into glycosaminoglycans (GAGs), resulting in N-glycolylated GAGs. These N-glycolylated GAGs have important potential applications, such as dating the loss of the Neu5Gc-generating CMAH gene in humans and being explored as a xenosialitis biomarker and/or estimate of the body burden of diet-derived Neu5Gc, to understand the risks associated with the consumption of red meats. This review explores N-glycolylated carbohydrates, how they are metabolized to N-glycolylglucosamine and N-glycolylgalactosamine, and how these metabolites can be incorporated into N-glycolylated GAGs in human tissues. We also discuss other sources of N-glycolylated sugars, such as recombinant production from microorganisms using metabolic engineering as well as chemical synthesis.
    MeSH term(s) Humans ; Neuraminic Acids ; N-Acetylneuraminic Acid/metabolism ; Amino Sugars ; Polysaccharides ; Inflammation
    Chemical Substances Neuraminic Acids ; N-Acetylneuraminic Acid (GZP2782OP0) ; Amino Sugars ; Polysaccharides
    Language English
    Publishing date 2022-08-04
    Publishing country England
    Document type Review ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1067689-2
    ISSN 1460-2423 ; 0959-6658
    ISSN (online) 1460-2423
    ISSN 0959-6658
    DOI 10.1093/glycob/cwac048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3150: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Warning Signs From the Crypt: Aberrant Protein Glycosylation Marks Opportunities for Early Colorectal Cancer Detection.

    Chandrasekar, Dharini / Guerrier, Christina / Alisson-Silva, Frederico / Dhar, Chirag / Caval, Tomislav / Schwarz, Flavio / Hommes, Daniel W

    Clinical and translational gastroenterology

    2023  Volume 14, Issue 7, Page(s) e00592

    Abstract: Colorectal cancer (CRC) remains a leading cause of cancer-related deaths despite being the most preventable and treatable forms of cancer when caught early through screening. There is an unmet need for novel screening approaches with improved accuracy, ... ...

    Abstract Colorectal cancer (CRC) remains a leading cause of cancer-related deaths despite being the most preventable and treatable forms of cancer when caught early through screening. There is an unmet need for novel screening approaches with improved accuracy, less invasiveness, and reduced costs. In recent years, evidence has accumulated around particular biological events that happen during the adenoma-to-carcinoma transition, especially focusing on precancerous immune responses in the colonic crypt. Protein glycosylation plays a central role in driving those responses, and recently, numerous reports have been published on how aberrant protein glycosylation both in colonic tissue and on circulating glycoproteins reflects these precancerous developments. The complex field of glycosylation, which exceeds complexity of proteins by several orders of magnitude, can now be studied primarily because of the availability of new high-throughput technologies such as mass spectrometry and artificial intelligence-powered data processing. This has now opened new avenues for studying novel biomarkers for CRC screening. This review summarizes the early events taking place from the normal colon mucosa toward adenoma and adenocarcinoma formation and associated critical protein glycosylation phenomena, both on the tissue level and in the circulation. These insights will help establish an understanding in the interpretation of novel CRC detection modalities that involve high-throughput glycomics.
    MeSH term(s) Humans ; Glycosylation ; Artificial Intelligence ; Colorectal Neoplasms/pathology ; Adenoma/diagnosis ; Adenoma/pathology ; Precancerous Conditions/pathology
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2581516-7
    ISSN 2155-384X ; 2155-384X
    ISSN (online) 2155-384X
    ISSN 2155-384X
    DOI 10.14309/ctg.0000000000000592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: From "Serum Sickness" to "Xenosialitis": Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc.

    Dhar, Chirag / Sasmal, Aniruddha / Varki, Ajit

    Frontiers in immunology

    2019  Volume 10, Page(s) 807

    Abstract: The description of "serum sickness" more than a century ago in humans transfused with animal sera eventually led to identification of a class of human antibodies directed against glycans terminating in the common mammalian sialic ... ...

    Abstract The description of "serum sickness" more than a century ago in humans transfused with animal sera eventually led to identification of a class of human antibodies directed against glycans terminating in the common mammalian sialic acid
    MeSH term(s) Animals ; Autoantibodies/immunology ; Humans ; Immune System Diseases/genetics ; Immune System Diseases/immunology ; Mixed Function Oxygenases/genetics ; Mixed Function Oxygenases/immunology ; N-Acetylneuraminic Acid/genetics ; N-Acetylneuraminic Acid/immunology ; Sialic Acids/genetics ; Sialic Acids/immunology
    Chemical Substances Autoantibodies ; N-(O-acetyl)glycoloylneuraminic acid ; Sialic Acids ; Mixed Function Oxygenases (EC 1.-) ; CMPacetylneuraminate monooxygenase (EC 1.14.18.2) ; N-Acetylneuraminic Acid (GZP2782OP0)
    Language English
    Publishing date 2019-04-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reply to Soulillou et al.: Difficulties in extrapolating from animal models exemplify unusual human atherosclerosis susceptibility and mechanisms via

    Kawanishi, Kunio / Dhar, Chirag / Varki, Ajit / Gordts, Philip L S M

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 4, Page(s) 1847–1848

    MeSH term(s) Animals ; Atherosclerosis ; Humans ; Mixed Function Oxygenases ; Models, Animal ; Neuraminic Acids
    Chemical Substances Neuraminic Acids ; Mixed Function Oxygenases (EC 1.-) ; CMPacetylneuraminate monooxygenase (EC 1.14.18.2)
    Language English
    Publishing date 2020-01-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1917278117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Diagnosing and staging epithelial ovarian cancer by serum glycoproteomic profiling.

    Dhar, Chirag / Ramachandran, Prasanna / Xu, Gege / Pickering, Chad / Čaval, Tomislav / Wong, Maurice / Rice, Rachel / Zhou, Bo / Srinivasan, Apoorva / Aiyetan, Paul / Chu, Chih-Wei / Moser, Kaitlyn / Herzog, Thomas J / Olawaiye, Alexander Babatunde / Jacob, Francis / Serie, Daniel / Lindpaintner, Klaus / Schwarz, Flavio

    British journal of cancer

    2024  

    Abstract: Background: There is a need for diagnostic tests for screening, triaging and staging of epithelial ovarian cancer (EOC). Glycoproteomics of blood samples has shown promise for biomarker discovery.: Methods: We applied glycoproteomics to serum of ... ...

    Abstract Background: There is a need for diagnostic tests for screening, triaging and staging of epithelial ovarian cancer (EOC). Glycoproteomics of blood samples has shown promise for biomarker discovery.
    Methods: We applied glycoproteomics to serum of people with EOC or benign pelvic masses and healthy controls. A total of 653 analytes were quantified and assessed in multivariable models, which were tested in an independent cohort. Additionally, we analyzed glycosylation patterns in serum markers and in tissues.
    Results: We identified a biomarker panel that distinguished benign lesions from EOC with sensitivity and specificity of 83.5% and 90.1% in the training set, and of 86.7 and 86.7% in the test set, respectively. ROC analysis demonstrated strong performance across a range of cutoffs. Fucosylated multi-antennary glycopeptide markers were higher in late-stage than in early-stage EOC. A comparable pattern was found in late-stage EOC tissues.
    Conclusions: Blood glycopeptide biomarkers have the potential to distinguish benign from malignant pelvic masses, and early- from late-stage EOC. Glycosylation of circulating and tumor tissue proteins may be related. This study supports the hypothesis that blood glycoproteomic profiling can be used for EOC diagnosis and staging and it warrants further clinical evaluation.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-024-02644-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Are sialic acids involved in COVID-19 pathogenesis?

    Dhar, Chirag / Sasmal, Aniruddha / Diaz, Sandra / Verhagen, Andrea / Yu, Hai / Li, Wanqing / Chen, Xi / Varki, Ajit

    Glycobiology

    2021  Volume 31, Issue 9, Page(s) 1068–1071

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; Sialic Acids
    Chemical Substances Sialic Acids
    Language English
    Publishing date 2021-10-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1067689-2
    ISSN 1460-2423 ; 0959-6658
    ISSN (online) 1460-2423
    ISSN 0959-6658
    DOI 10.1093/glycob/cwab063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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