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  1. Article ; Online: Collateral Status, Reperfusion, and Cerebral Edema After Thrombectomy for Stroke.

    Dhar, Rajat

    Neurocritical care

    2023  Volume 40, Issue 1, Page(s) 42–44

    MeSH term(s) Humans ; Brain Edema/etiology ; Stroke/surgery ; Brain Ischemia ; Thrombectomy ; Reperfusion ; Treatment Outcome ; Retrospective Studies ; Endovascular Procedures
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-023-01901-3
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  2. Article ; Online: Commentary on "Midline Shift Greater than 3 mm Independently Predicts Outcome After Ischemic Stroke".

    Dhar, Rajat

    Neurocritical care

    2021  Volume 36, Issue 1, Page(s) 18–20

    MeSH term(s) Brain Ischemia/therapy ; Humans ; Ischemic Stroke ; Stroke/therapy
    Language English
    Publishing date 2021-09-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-021-01355-5
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  3. Article ; Online: Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors. Reply.

    Dhar, Rajat / Marklin, Gary F

    The New England journal of medicine

    2024  Volume 390, Issue 6, Page(s) 575–576

    MeSH term(s) Humans ; Thyroxine/therapeutic use ; Tissue Donors ; Brain Death ; Brain
    Chemical Substances Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2314959
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  4. Article ; Online: Response.

    Dhar, Rajat

    Neurocritical care

    2020  Volume 33, Issue 3, Page(s) 859

    MeSH term(s) Brain Edema ; Brain Ischemia ; Humans ; Ischemic Stroke ; Stroke ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-020-01105-z
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  5. Article ; Online: Automated quantitative assessment of cerebral edema after ischemic stroke using CSF volumetrics.

    Dhar, Rajat

    Neuroscience letters

    2020  Volume 724, Page(s) 134879

    Abstract: Reduction in CSF volume from baseline to follow-up CT at or beyond 24 -hs can serve as a quantitative biomarker of cerebral edema after stroke. We have demonstrated that assessment of CSF displacement reflects edema metrics such as lesion volume, midline ...

    Abstract Reduction in CSF volume from baseline to follow-up CT at or beyond 24 -hs can serve as a quantitative biomarker of cerebral edema after stroke. We have demonstrated that assessment of CSF displacement reflects edema metrics such as lesion volume, midline shift, and neurologic deterioration. We have also developed a neural network-based image segmentation algorithm that can automatically measure CSF volume on serial CT scans from stroke patients. We have integrated this algorithm into an image processing pipeline that can extract this edema biomarker from large cohorts of stroke patients. Finally, we have created a stroke repository that can archive and process images from thousands of stroke patients in order to measure CSF volumetrics. We plan on applying this metric as a quantitative endophenotype of cerebral edema to facilitate early prediction of clinical deterioration as well as large-scale genetic studies.
    MeSH term(s) Brain Edema/diagnostic imaging ; Brain Edema/physiopathology ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/physiopathology ; Cerebrospinal Fluid/diagnostic imaging ; Cerebrospinal Fluid/physiology ; Humans ; Image Processing, Computer-Assisted/methods ; Ischemic Stroke/diagnostic imaging ; Ischemic Stroke/physiopathology ; Machine Learning ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2020-02-29
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2020.134879
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  6. Article ; Online: Commentary on "Temporal Dynamics of Cerebral Blood Flow During the Acute Course of Severe Subarachnoid Hemorrhage Studied by Bedside Xenon-Enhanced CT".

    Dhar, Rajat

    Neurocritical care

    2019  Volume 30, Issue 2, Page(s) 291–292

    MeSH term(s) Cerebrovascular Circulation ; Humans ; Subarachnoid Hemorrhage ; Subarachnoid Space ; Tomography, X-Ray Computed ; Xenon
    Chemical Substances Xenon (3H3U766W84)
    Language English
    Publishing date 2019-01-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-019-00698-4
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  7. Article ; Online: Letter to the Editor.

    Dhar, Rajat

    Neurocritical care

    2018  Volume 28, Issue 2, Page(s) 257–258

    MeSH term(s) Humans ; Subarachnoid Hemorrhage ; Tomography, X-Ray Computed ; Xenon
    Chemical Substances Xenon (3H3U766W84)
    Language English
    Publishing date 2018-03-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-018-0517-9
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  8. Article ; Online: Navigating the Ocean of Big Data in Neurocritical Care.

    Dhar, Rajat / Meyfroidt, Geert

    Neurocritical care

    2022  Volume 37, Issue Suppl 2, Page(s) 157–159

    MeSH term(s) Big Data ; Critical Care ; Humans ; Oceans and Seas
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-022-01558-4
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  9. Article ; Online: Neurologic Complications of Transplantation.

    Dhar, Rajat

    Neurocritical care

    2017  Volume 28, Issue 1, Page(s) 4–11

    Abstract: Neurologic disturbances including encephalopathy, seizures, and focal deficits complicate the course 10-30% of patients undergoing organ or stem cell transplantation. While much or this morbidity is multifactorial and often associated with extra-cerebral ...

    Abstract Neurologic disturbances including encephalopathy, seizures, and focal deficits complicate the course 10-30% of patients undergoing organ or stem cell transplantation. While much or this morbidity is multifactorial and often associated with extra-cerebral dysfunction (e.g., graft dysfunction, metabolic derangements), immunosuppressive drugs also contribute significantly. This can either be through direct toxicity (e.g., posterior reversible encephalopathy syndrome from calcineurin inhibitors such as tacrolimus in the acute postoperative period) or by facilitating opportunistic infections in the months after transplantation. Other neurologic syndromes such as akinetic mutism and osmotic demyelination may also occur. While much of this neurologic dysfunction may be reversible if related to metabolic factors or drug toxicity (and the etiology is recognized and reversed), cases of multifocal cerebral infarction, hemorrhage, or infection may have poor outcomes. As transplant patients survive longer, delayed infections (such as progressive multifocal leukoencephalopathy) and post-transplant malignancies are increasingly reported.
    MeSH term(s) Central Nervous System Infections/chemically induced ; Central Nervous System Infections/epidemiology ; Central Nervous System Infections/etiology ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/etiology ; Immunosuppressive Agents/adverse effects ; Organ Transplantation/adverse effects ; Organ Transplantation/statistics & numerical data ; Posterior Leukoencephalopathy Syndrome/chemically induced ; Posterior Leukoencephalopathy Syndrome/epidemiology ; Posterior Leukoencephalopathy Syndrome/etiology ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Seizures/epidemiology ; Seizures/etiology ; Stem Cell Transplantation/adverse effects ; Stem Cell Transplantation/statistics & numerical data
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2017-02-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-017-0387-6
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  10. Article ; Online: A Recruitment Maneuver After Apnea Testing Improves Oxygenation and Reduces Atelectasis in Organ Donors After Brain Death.

    Dhar, Rajat / Braun, Porche / Kumar, Atul / Patel, Jayesh / Lee, Flavia L / Arshi, Baback

    Neurocritical care

    2024  

    Abstract: Background: Hypoxemia is the main modifiable factor preventing lungs from being transplanted from organ donors after brain death. One major contributor to impaired oxygenation in patients with brain injury is atelectasis. Apnea testing, an integral ... ...

    Abstract Background: Hypoxemia is the main modifiable factor preventing lungs from being transplanted from organ donors after brain death. One major contributor to impaired oxygenation in patients with brain injury is atelectasis. Apnea testing, an integral component of brain death declaration, promotes atelectasis and can worsen hypoxemia. In this study, we tested whether performing a recruitment maneuver (RM) after apnea testing could mitigate hypoxemia and atelectasis.
    Methods: During the study period, an RM (positive end-expiratory pressure of 15 cm H
    Results: Recruitment maneuver was performed in 54 patients after apnea testing, with a median immediate increase in PaO
    Conclusions: Recruitment maneuver after apnea testing reduces hypoxemia and atelectasis in organ donors after brain death. This effect may translate into more lungs being transplanted.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-024-01975-7
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