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  1. Article ; Online: Gamma-Ray Spectrometry for the Measurement of Mass Attenuation Coefficient and Bulk Density of Soil: A Review

    Dhingra, Nitish

    Communications in Soil Science and Plant Analysis. 2023 Sept. 25, v. 54, no. 17 p.2329-2335

    2023  

    Abstract: The gamma-ray mass attenuation coefficient is a crucial parameter to characterize the penetration and propagation of gamma rays in complex, multiphased, and heterogeneous materials like soil. Microscopically, soils contain minerals, water, gases, and ... ...

    Abstract The gamma-ray mass attenuation coefficient is a crucial parameter to characterize the penetration and propagation of gamma rays in complex, multiphased, and heterogeneous materials like soil. Microscopically, soils contain minerals, water, gases, and other fluids that influence gamma-ray transmission. This paper discusses the potential of the Gamma Ray Spectroscopy (GRS) technique for precise measurement of various soil properties, focusing on soil’s mass attenuation coefficient and bulk density. The limitations and advantages of GRS over conventional methods are also highlighted.
    Keywords bulk density ; gamma radiation ; plant analysis ; soil ; spectroscopy ; gamma-ray spectrometry ; mass attenuation coefficient
    Language English
    Dates of publication 2023-0925
    Size p. 2329-2335.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 419718-5
    ISSN 1532-2416 ; 0010-3624
    ISSN (online) 1532-2416
    ISSN 0010-3624
    DOI 10.1080/00103624.2023.2223650
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2640: Show issues

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  2. Thesis ; Online: Scene Understanding and Gesture Recognition for Human-Machine Interaction

    Dhingra, Naina

    2022  

    Keywords info:eu-repo/classification/ddc/004 ; Data processing ; computer science
    Language English
    Publishing date 2022-05-30
    Publisher ETH Zurich
    Publishing country ch
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: International challenges of self-sufficiency in blood products.

    Dhingra, N

    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

    2013  Volume 20, Issue 2, Page(s) 148–152

    Abstract: To face known and emerging threats to public health, all countries have to overcome the challenges of providing sufficient supplies of blood and blood products of the highest quality and safety. Unfortunately, self-sufficiency is not yet a reality in ... ...

    Abstract To face known and emerging threats to public health, all countries have to overcome the challenges of providing sufficient supplies of blood and blood products of the highest quality and safety. Unfortunately, self-sufficiency is not yet a reality in many countries. In 2011, experts from WHO addressed the urgent need to establish strategies and mechanisms for achieving this goal. A summary of these recommendations is further discussed.
    MeSH term(s) Biological Products/supply & distribution ; Blood ; Blood Banks/economics ; Blood Banks/supply & distribution ; Blood Donors/supply & distribution ; Blood Safety/economics ; Blood Safety/standards ; Blood Transfusion/statistics & numerical data ; Commodification ; Consensus Development Conferences as Topic ; Developed Countries ; Developing Countries ; Directed Tissue Donation/trends ; Guidelines as Topic ; Health Policy ; Health Services Needs and Demand/trends ; Humans ; Inappropriate Prescribing ; Infection Control/methods ; Infection Control/standards ; Internationality ; Motivation ; Prescriptions ; Quality Control ; Remuneration ; Volunteers ; World Health Organization
    Chemical Substances Biological Products
    Language English
    Publishing date 2013-05
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 1204698-x
    ISSN 1953-8022 ; 1246-7820
    ISSN (online) 1953-8022
    ISSN 1246-7820
    DOI 10.1016/j.tracli.2013.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4097: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 308: Show issues

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  4. Article ; Online: Green synthesis of 2-benzylidene-1-benzofuran-3-ones and in vitro neuraminidase study using molecular docking.

    Devi, A P / Dhingra, N / Chundawat, R S / Ameta, K L

    SAR and QSAR in environmental research

    2022  Volume 33, Issue 7, Page(s) 499–512

    Abstract: An improved and green method has been developed for the synthesis of substituted 2-benzylidene-1-benzofuran-3-ones by treating 2-hydroxychalcones with ... ...

    Abstract An improved and green method has been developed for the synthesis of substituted 2-benzylidene-1-benzofuran-3-ones by treating 2-hydroxychalcones with CuBr
    MeSH term(s) Antiviral Agents/pharmacology ; Benzofurans ; Binding Sites ; Enzyme Inhibitors ; Molecular Docking Simulation ; Neuraminidase ; Quantitative Structure-Activity Relationship
    Chemical Substances 1-benzofuran ; Antiviral Agents ; Benzofurans ; Enzyme Inhibitors ; Neuraminidase (EC 3.2.1.18)
    Language English
    Publishing date 2022-06-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2023559-8
    ISSN 1029-046X ; 1062-936X
    ISSN (online) 1029-046X
    ISSN 1062-936X
    DOI 10.1080/1062936X.2022.2087733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Srs2 binding to PCNA and its sumoylation contribute to RPA antagonism during the DNA damage response.

    Fan, Jiayi / Dhingra, Nalini / Yang, Tammy / Yang, Vicki / Zhao, Xiaolan

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Activation of the DNA damage checkpoint upon genotoxin treatment induces a multitude of cellular changes, such as cell cycle arrest, to cope with genome stress. After prolonged genotoxin treatment, the checkpoint can be downregulated to allow cell cycle ... ...

    Abstract Activation of the DNA damage checkpoint upon genotoxin treatment induces a multitude of cellular changes, such as cell cycle arrest, to cope with genome stress. After prolonged genotoxin treatment, the checkpoint can be downregulated to allow cell cycle and growth resumption. In yeast, downregulation of the DNA damage checkpoint requires the Srs2 DNA helicase, which removes the ssDNA binding complex RPA and the associated Mec1 checkpoint kinase from DNA, thus dampening Mec1 activation. However, it is unclear whether the 'anti-checkpoint' role of Srs2 is temporally and spatially regulated to both allow timely checkpoint termination and to prevent superfluous RPA removal. Here we address this question by examining regulatory elements of Srs2, including its phosphorylation, sumoylation, and protein-interaction sites. Our genetic analyses and checkpoint level assessment suggest that the RPA countering role of Srs2 is promoted by Srs2 binding to PCNA, which is known to recruit Srs2 to subsets of ssDNA regions. RPA antagonism is further fostered by Srs2 sumoylation, which we found depends on the Srs2-PCNA interaction. Srs2 sumoylation is additionally reliant on Mec1 and peaks after Mec1 activity reaches maximal levels. Collectively, our data provide evidence for a two-step model wherein checkpoint downregulation is facilitated by PCNA-mediated Srs2 recruitment to ssDNA-RPA filaments and the subsequent Srs2 sumoylation stimulated upon Mec1 hyperactivation. We propose that this mechanism allows Mec1 hyperactivation to trigger checkpoint recovery.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.28.587206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Persistent hiccups following thalamic hemorrhage: A case report.

    Shivkumar, Vikram / Nemade, Dipali / Dhingra, Neelu

    Heliyon

    2023  Volume 9, Issue 6, Page(s) e16409

    Abstract: Persistent hiccups (lasting more than 48 hours) can cause physical and emotional distress. They can result in dehydration, exhaustion, malnutrition, insomnia, wound dehiscence, ventilatory desynchronization, and hemodynamic changes. Hiccups are thought ... ...

    Abstract Persistent hiccups (lasting more than 48 hours) can cause physical and emotional distress. They can result in dehydration, exhaustion, malnutrition, insomnia, wound dehiscence, ventilatory desynchronization, and hemodynamic changes. Hiccups are thought to be due to a complex reflex arc involving peripheral nerves and central structures such as the brainstem, temporal lobe, basal ganglia, hypothalamus, and spinal cord levels C3-5. Medullary strokes, for instance, have been reported to cause hiccups. We report a patient with a thalamic bleed who developed persistent hiccups. A 56-year-old man was brought to the hospital in an unresponsive state. He was intubated for airway protection. CT brain showed a left thalamic hemorrhage with edema and mass effect on the 3rd ventricle, intraventricular extension of hemorrhage, and hydrocephalus. An external ventricular drain was placed successfully with adequate drainage. One week after admission, the patient developed persistent abdominal jerks. These jerks were occurring every 3-4 seconds and would last for hours with brief periods of remission. He was started on levetiracetam 1000 mg IV bid and then increased to 1500 mg IV BID without any improvement of symptoms. The patient was also placed on EEG which did not reveal any epileptiform abnormality but did show an EMG artifact. His electrolytes including sodium, and potassium, and corrected calcium levels were normal. He did not have any evidence of pneumonia or other infections. It was determined that these jerks were likely hiccups. Metoclopramide 10 mg IV was tried without any benefit. He was then started on Baclofen 10 mg PO TID which resulted in a significant improvement in hiccups. Our case suggests that thalamic lesions might also lead to persistent hiccups.
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Case Reports
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16409
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  7. Article ; Online: High-speed polarization-independent plasmonic modulator on a silicon waveguide.

    Dhingra, Nikhil / Mehrvar, Hamid / Berini, Pierre

    Optics express

    2023  Volume 31, Issue 14, Page(s) 22481–22496

    Abstract: The electrical bandwidth of an electro-optic modulator plays a vital role in determining the throughput of an optical communications link. We propose a broadband plasmonic electro-optic modulator operating at telecommunications wavelengths ( ... ...

    Abstract The electrical bandwidth of an electro-optic modulator plays a vital role in determining the throughput of an optical communications link. We propose a broadband plasmonic electro-optic modulator operating at telecommunications wavelengths (λ
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.489902
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  8. Article: Design of hACE2-based small peptide inhibitors against spike protein of SARS-CoV-2: a computational approach.

    Dhingra, Naveen / Bhardwaj, Ravindra / Bhardwaj, Uma / Kapoor, Kapish

    Structural chemistry

    2023  , Page(s) 1–14

    Abstract: COVID-19 which is caused by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has been declared pandemic in 2019. Though there is development of vaccines but there is an emergence requirement of drugs against SARS-CoV-2. Antiviral peptides ...

    Abstract COVID-19 which is caused by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has been declared pandemic in 2019. Though there is development of vaccines but there is an emergence requirement of drugs against SARS-CoV-2. Antiviral peptides can be rationally created and improved based on the known structures of viral proteins and their biological targets. In the given study, small peptide inhibitors with three amino acids are designed and docked against SARS-CoV-2 coronavirus using molecular docking approach. All the designed peptides bind at the active site but the highest binding affinity was observed for HisGluAsp. Molecular dynamics was performed to validate the stability and interactions of compound. The molecule has followed the druglikeness properties and with highest probability of being absorbed by the gastrointestinal tract. The results of the current investigation point to the possibility that the identified small peptides may prevent SARS-CoV-2 infection, although additional wet-lab tests are still required to confirm these results.
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018832-8
    ISSN 1572-9001 ; 1040-0400
    ISSN (online) 1572-9001
    ISSN 1040-0400
    DOI 10.1007/s11224-023-02125-z
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  9. Article ; Online: Comment on "Ten-year outcomes of antivascular endothelial growth factor therapy in neovascular age-related macular degeneration".

    Upasani, Deepa / Dhingra, Narendra

    Eye (London, England)

    2021  Volume 36, Issue 2, Page(s) 477

    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Endothelial Growth Factors/therapeutic use ; Humans ; Macular Degeneration/drug therapy ; Ranibizumab/therapeutic use
    Chemical Substances Angiogenesis Inhibitors ; Endothelial Growth Factors ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-020-01385-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3010: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 603: Show issues

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  10. Article ; Online: Ten-year outcome of anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration.

    Upasani, Deepa / Dhingra, Narendra

    Indian journal of ophthalmology

    2021  Volume 69, Issue 9, Page(s) 2350–2354

    Abstract: Purpose: The aim of this study was to report the 10-year visual outcome in eyes treated with anti-vascular endothelial growth factor (anti-VEGF) agents for neovascular age-related macular degeneration (nAMD) and to assess the impact of switching ... ...

    Abstract Purpose: The aim of this study was to report the 10-year visual outcome in eyes treated with anti-vascular endothelial growth factor (anti-VEGF) agents for neovascular age-related macular degeneration (nAMD) and to assess the impact of switching treatment as part of routine clinical care.
    Methods: Electronic records of treatment-naïve eyes initiated on intravitreal ranibizumab between January and December 2009 were accessed. The primary outcome measured was the change in visual acuity (VA) in Early Treatment of Diabetic Retinopathy Study letters. The frequency and reasons for treatment discontinuation during each year of follow-up and the impact of switching from ranibizumab to aflibercept were some of the secondary outcomes.
    Results: Of the 223 eyes (203 patients), 60 eyes completed 10 years of continuous follow-up. After a mean follow-up of 121.4 months, VA declined by 5.6 letters (95% confidence interval [CI] -0.25 to -11.1, P = 0.04). Final VA of ≥70 letters was seen in 20% of eyes and 35% had VA ≤ 35 letters. VA gain of ≥10 letters was seen in 23% and loss of ≥10 letters was seen in 40% of the eyes. Twenty-nine eyes remained on ranibizumab monotherapy and 31 switched to aflibercept. Switched eyes showed a visual decline of 7.1 letters (5.5 letters in monotherapy eyes, P = 0.32) and received a significantly higher number of injections (39.6 ± 9.9 vs. 24.4 ± 13.1, P < 0.0001). Patients discontinuing treatment were older and had lower baseline vision compared to completers.
    Conclusion: VA declined below the baseline after 10 years of follow-up and switching did not have any effect on the final visual outcome.
    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Humans ; Intravitreal Injections ; Macular Degeneration/drug therapy ; Retrospective Studies ; Vascular Endothelial Growth Factor A
    Chemical Substances Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2021-08-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_2868_20
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    Zs.B 329: Show issues Location:
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    Zs.MO 598: Show issues

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